Browsing by Author "Ozturk, EA"

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Comparison of the multi-epitope recombinant antigen DIPOL and hydatid fluid for the diagnosis of patients with cystic echinococcosis
    Ozturk, EA; Manzano-Román, R; Sánchez-Ovejero, C; Caner, A; Angin, M; Gunduz, C; Karaman, Ü; Altintas, N; Bozkaya, H; Unalp, O; Dokumcu, Z; Divarci, E; Casulli, A; Altintas, N; Siles-Lucas, M; Unver, A
    The use of serological tests containing multiple immunodominant antigens rather than single antigens have the potential to improve the diagnostic performance in Cystic Echinococcoses (CE) as a complement tool to clear the inconclusive imaging data. Here, we comparatively evaluated the diagnostic value of Hydatid Fluid (HF) and the recently described recombinant multi-epitope antigen DIPOL in IgG-ELISA in a clinically defined cohort of CE patients. The serum samples from 149 CE patients were collected just before surgical or Percutaneous-Aspiration-Injection-Reaspiration (PAIR) procedures. Additionally, serum samples of patients with other parasitic infections (n=49) and healthy individuals (n=21) were also included in the study as controls. To investigate the association between the genotype of the parasite and DIPOL, cyst materials from 20 CE patients were sequenced. In terms of overall sensitivity, HF was higher than DIPOL (82.55%,78.52%, respectively). However, while the sensitivity of HF was higher than DIPOL in patients with active and transitional cysts (83.3%, 75.4%, respectively), sensitivity of DIPOL in inactive cysts was higher compared to HF (95.6%, 78.3%, respectively). The sensitivity of DIPOL depending on cyst stage was statistically significant (P=0.041). In terms of specificity, DIPOL was found to be better than HF (97.71%, 91.43%, respectively). By genotyping, the majority of 20 patients showed G1 genotype (80%). All patients harboring G3 and G1/G3 cyst genotypes were positive with both antigens, while 87.5% of patients with G1 genotype were seropositive with HF and 75% with DIPOL. The overall sensitivity and high specificity of DIPOL suggest that this recombinant protein containing immunodominant epitopes is a potential substitute for the HF by serological tests for the diagnosis of CE.
  • No Thumbnail Available
    Item
    Best Practice Recommendations for Geriatric Dysphagia Management with 5 Ws and 1H
    Umay, E; Eyigor, S; Bahat, G; Halil, M; Giray, E; Unsal, P; Unlu, Z; Tikiz, C; Vural, M; Cincin, AT; Bengisu, S; Gurcay, E; Keseroglu, K; Aydeniz, B; Karaca, EC; Karaca, B; Yalcin, A; Ozsurekci, C; Seyidoglu, D; Yilmaz, O; Alicura, S; Tokgoz, S; Selcuk, B; Sen, EI; Karahan, AY; Yaliman, A; Ozkok, S; Ilhan, B; Oytun, MG; Ozturk, ZA; Akin, S; Yavuz, B; Akaltun, MS; Sari, A; Inanir, M; Bilgilisoy, M; Çaliskan, Z; Saylam, G; Ozer, T; Eren, Y; Bicakli, DH; Keskin, D; Ulger, Z; Demirhan, A; Calik, Y; Saka, B; Yigman, ZA; Ozturk, EA
    Background: Dysphagia is a geriatric syndrome. Changes in the whole body that occur with aging also affect swallowing functions and cause presbyphagia. This condition may progress to oropharyngeal and/or esophageal dysphagia in the presence of secondary causes that increase in incidence with aging. However, no study has been published that provides recommendations for use in clinical practice that addresses in detail all aspects of the management of dysphagia in geriatric individuals. This study aimed to answer almost all potential questions and problems in the management of geriatric dysphagia in clinical practice. Methods: A multidisciplinary team created this recommendation guide using the seven-step and three-round modified Delphi method via e-mail. The study included 39 experts from 29 centers in 14 cities. Results: Based on the 5W and 1H method, we developed 216 detailed recommendations for older adults from the perspective of different disciplines dealing with older people. Conclusion: This consensus-based recommendation is a useful guide to address practical clinical questions in the diagnosis, rehabilitation, and follow-up for the management of geriatric dysphagia and also contains detailed commentary on these issues.
  • No Thumbnail Available
    Item
    Educational intervention for the awareness improvement and control programme design on Echinococcosis in Izmir, Turkey
    Altintas, NA; Altintas, NU; Yilmaz, OS; Akil, M; Ozturk, EA; Unver, A
    In Turkey, cyst hydatid disease (CHD) or cystic echinococcosis (CE) is publicly known as dog cyst, a fatal and serious disease not only affects livestock husbandry and human health but also brings about economic loss to our country. According to the data of the Ministry of Health; number of annual cases was 408 in 2008, and this number reached 1,867 by the end of 2019. Cystic echinococcosis is especially taken up during childhood and emerged at an older age. They become exposed to the eggs of the tapeworm after close contact with an infected dog or its contaminated environment. The infected dogs also pass in their feces E. granulosus eggs that adhere to the dogs' hairs, and pass on to the children who are in the course of playful and intimate contact with the infected dogs. This study was to create the awareness of risk factors of CE among 10 different districts of Izmir province. Awareness raising seminars are essential component of this study because local people living in CE endemic areas, are crucial to continue and sustain the long-time effort that is needed to tackle this disease. In each district, 3 awareness raising seminars were held to the target groups: (a) in schools for students, teachers, administrators, (b) for general public, (c) for healthcare professionals. 4090 students attended to the trainings, 242 administrators and teachers who attended to the presentations together with the students, 524 people were attended to the trainings and 327 health workers attended to the trainings from different institutions. This study helped improving this situation by organising educational events for the rural populations for preventing transmission of the disease. This is the first educational intervention study regarding creating awareness on CE in Izmir Province which includes 10 districts between January 2019 to January 2020.