Browsing by Author "Ozturk, G"

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    Pseudo-Kaposi's sarcoma (Mali type)
    Kapdagli, H; Gunduz, K; Ozturk, G; Kandiloglu, G
    A 75-year-old man presented with lesions on his right leg and on the dorsum of the penis, which had appeared 5 years ago following long distance travel. His right leg was swollen, and there was a dark-violet-colored, slightly elevated lesion extending to the thigh and penis (Fig. 1). Histologic examination revealed thickening of the arteriolar walls and diffuse proliferation of the vascular structures surrounding the arterioles and dissecting the dermal collagen fibers (Fig. 2). Immunohistochemical staining for Factor VIII R-A reacted positively with arteriolar endothelium, but was negative on thin-walled vascular spaces (Fig. 3). Femoral angiography showed multiple fine arteriovenous (A-V) shunts especially at the one-third distal lower region of the right leg.
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    T cell subpopulations and IL-2R in vitiligo
    Gunduz, K; Ozturk, G; Terzioglu, E; Sebik, F
    Immunological alterations have been implicated in the etiopathogenesis of vitiligo. The aim of this study was to determine peripheral lymphocyte subpopulations and interleukin-2 receptor (IL-2R) in patients with vitiligo. Forty-five vitiligo patients (24 female, 21 male) and 34 healthy controls (I I female, 23 male) were included into the study. Eight (17.8%) of the patients had the segmental type, and 37 (82.2%) had generalized vitiligo. The disease was active in 25 (55.6%) patients; the other 20 (44.4%) patients had static vitiligo. Flow cytometry was used to determine the percentages of total T-lymphocytes, B-lymphocytes, helper/inducer T cells, suppressor/cytotoxic T cells, natural killer (NK) cells, activated T cells and interleukin-2 receptor (IL-2R) with the use of CD3, CD19, CD4, CD8, CD 16, HLA-DR and CD25 monoclonal antibodies, respectively. The mean value of helper T cells showed a significant difference (p=0.01) between the two groups with the value being 32.5% in patients and 38.1% in control subjects. CD4/CD8 was significantly lower in vitiligo patients (p=0.04). There was also a statistically significant difference in the mean percentage of activated T cells between vitiligo patients and control subjects (4.7 and 8.1, respectively; p=0.001). No statistically significant differences were found when the values were compared between segmental and generalized vitiligo patients, or between active and static cases. In conclusion, T helper/inducer cells, CD4/CD8 ratio and activated (HILA-DR+) T cells are decreased in vitiligo patients, suggesting a role for changes in cellular immunity.
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    Erythrocyte superoxide dismutase, catalase activities and plasma nitrite and nitrate levels in patients with Behcet disease and recurrent aphthous stomatitis
    Gunduz, K; Ozturk, G; Sozmen, EY
    Behcet disease (BD) and recurrent aphthous stomatitis (RAS) are two distinct diseases of unknown aetiology which are both characterized by oral aphthae. The aim of this study was to determine the possible association of both diseases with antioxidant status and nitric oxide levels. Twenty-six patients (17 female, nine male) with RAS, 28 patients (17 female, 11 male) with BD and 31 (22 female, nine male) healthy control subjects were included in the study. Blood samples were studied for erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities and plasma nitric oxide (NO) levels. Erythrocyte SOD activity in BD patients was significantly higher than in RAS patients and controls. Although SOD activity in RAS patients was higher than in controls, the difference was not statistically significant. No significant differences in CAT activities or NO levels were found between the three groups. In conclusion, changes in SOD activity may be important in the inflammatory reactions observed in BD and RAS, but NO does not seem to play a primary role in the aetiopathogenesis.
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    Simultaneous analysis of biochemical markers in vitreous humour and serum: a preliminary study on the effect of storage time at -20°C
    Gurler, M; Ozturk, G; Kir, MZ; Ginis, Z; Erden, G; Akyol, S; Kaya, M; Karapirli, M; Akyol, O
    Vitreous humour (VH) is a quite stable and well-protected biological fluid from post-mortem degradation and contamination, making it a usable specimen in forensic pathology. We aimed to analyse the biochemical markers in VH stored for one month at -20 degrees C and to compare them with those of serum samples of the same deceased people. To the best of our knowledge this is the first time this has been reported in the literature. Serum levels of sodium, potassium and calcium, phosphorous and VH levels of calcium, creatinine, and urea were not statistically different between fresh and stored samples. There was no significant difference in VH urea and creatinine levels whereas serum levels were significantly decreased by the 15th and 30th days. In conclusion, urea and creatinine levels in VH showed adequate stability after one month of storage at -20 degrees C, whereas large variations were seen in the stability of inorganic components such as Na, K, Mg, Cl, and P. Our results indicate the validity of using post-mortem VH samples for urea and creatinine but not for VH stored at -20 degrees C for a limited time frame. The differences in sample handling before being stored at -20 degrees C may introduce bias on some components of VH.
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    Different Response Patterns to Inactivated, Subunit or Live Attenuated Vaccines in Children after Treatment for Malignancies and Bone Marrow Transplantation
    Anak, SS; Ozcan, EE; Kilic, A; Onel, M; Ozguven, A; Unuvar, A; Karakas, Z; Ozturk, G; Agacfidan, A; Devecioglu, O; Agaoglu, L; Kilinc, Y