Browsing by Author "Ozturk E.A."

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    Comparison of the multi-epitope recombinant antigen DIPOL and hydatid fluid for the diagnosis of patients with cystic echinococcosis
    (Elsevier B.V., 2022) Ozturk E.A.; Manzano-Román R.; Sánchez-Ovejero C.; Caner A.; Angın M.; Gunduz C.; Karaman Ü.; Altintas N.; Bozkaya H.; Unalp O.; Dokumcu Z.; Divarci E.; Casulli A.; Altintas N.; Siles-Lucas M.; Unver A.
    The use of serological tests containing multiple immunodominant antigens rather than single antigens have the potential to improve the diagnostic performance in Cystic Echinococcoses (CE) as a complement tool to clear the inconclusive imaging data. Here, we comparatively evaluated the diagnostic value of Hydatid Fluid (HF) and the recently described recombinant multi-epitope antigen DIPOL in IgG-ELISA in a clinically defined cohort of CE patients. The serum samples from 149 CE patients were collected just before surgical or Percutaneous- Aspiration- Injection- Reaspiration (PAIR) procedures. Additionally, serum samples of patients with other parasitic infections (n=49) and healthy individuals (n=21) were also included in the study as controls. To investigate the association between the genotype of the parasite and DIPOL, cyst materials from 20 CE patients were sequenced. In terms of overall sensitivity, HF was higher than DIPOL (82.55%,78.52%, respectively). However, while the sensitivity of HF was higher than DIPOL in patients with active and transitional cysts (83.3%, 75.4%, respectively), sensitivity of DIPOL in inactive cysts was higher compared to HF (95.6%, 78.3%, respectively). The sensitivity of DIPOL depending on cyst stage was statistically significant (P= 0.041). In terms of specificity, DIPOL was found to be better than HF (97.71%, 91.43%, respectively). By genotyping, the majority of 20 patients showed G1 genotype (80%). All patients harboring G3 and G1/G3 cyst genotypes were positive with both antigens, while 87.5% of patients with G1 genotype were seropositive with HF and 75% with DIPOL. The overall sensitivity and high specificity of DIPOL suggest that this recombinant protein containing immunodominant epitopes is a potential substitute for the HF by serological tests for the diagnosis of CE. © 2021
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    Best Practice Recommendations for Geriatric Dysphagia Management with 5 Ws and 1H
    (Korean Geriatrics Society, 2022) Umay E.; Eyigor S.; Bahat G.; Halil M.; Giray E.; Unsal P.; Unlu Z.; Tikiz C.; Vural M.; Cincin A.T.; Bengisu S.; Gurcay E.; Keseroglu K.; Aydeniz B.; Karaca E.C.; Karaca B.; Yalcin A.; Ozsurekci C.; Seyidoglu D.; Yilmaz O.; Alicura S.; Tokgoz S.; Selcuk B.; Sen E.I.; Karahan A.Y.; Yaliman A.; Ozkok S.; Ilhan B.; Oytun M.G.; Ozturk Z.A.; Akin S.; Yavuz B.; Akaltun M.S.; Sari A.; Inanir M.; Bilgilisoy M.; Çaliskan Z.; Saylam G.; Ozer T.; Eren Y.; Bicakli D.H.; Keskin D.; Ulger Z.; Demirhan A.; Calik Y.; Saka B.; Yigman Z.A.; Ozturk E.A.
    Background: Dysphagia is a geriatric syndrome. Changes in the whole body that occur with aging also affect swallowing functions and cause presbyphagia. This condition may progress to oro-pharyngeal and/or esophageal dysphagia in the presence of secondary causes that increase in incidence with aging. However, no study has been published that provides recommendations for use in clinical practice that addresses in detail all aspects of the management of dysphagia in geriatric individuals. This study aimed to answer almost all potential questions and problems in the management of geriatric dysphagia in clinical practice. Methods: A multidisciplinary team created this recommendation guide using the seven-step and three-round modified Delphi method via e-mail. The study included 39 experts from 29 centers in 14 cities. Results: Based on the 5W and 1H method, we developed 216 detailed recommendations for older adults from the per-spective of different disciplines dealing with older people. Conclusion: This consensus-based recommendation is a useful guide to address practical clinical questions in the diagnosis, rehabilita-tion, and follow-up for the management of geriatric dysphagia and also contains detailed com-mentary on these issues. © 2022 by The Korean Geriatrics Society.