Browsing by Author "Ozturkcan, S"

Now showing 1 - 18 of 18
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    Obsessive-compulsive disorder in a dermatology outpatient clinic
    Demet, MM; Deveci, A; Taskin, EO; Ermertcan, AT; Yurtsever, F; Deniz, F; Bayraktar, D; Ozturkcan, S
    Objective: The aims of present study were to (a) to determine the prevalence of obsessive-compulsive disorder (OCD) in dermatological patients, (b) to determine the possible relationship between dermatological lesions and OCD and (c) to determine the clinical and phenomenological features of the OCD subgroup. Method: The sample consisted of 166 out of 250 consecutively presenting dermatological patients who agreed to participate in the study. The subjects were assessed with the Structured Clinical Interview for DSM-IV Turkish Version (SCID-I) and also completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Results: Of the whole sample, 41 (24.7%) met DSM-IV criteria for OCD. Only 14.6% of them had previously been diagnosed as OCD. The mean score of Y-BOCS in the OCD group was 17.05 +/- 9.75. The most common obsessions were contamination (61 %) and pathologic doubt (53.7%), while washing (61%) and checking (51.2%) were the most frequent compulsions. Those suffering from diseases of sebaceous glands were the only group that showed a significant difference between the OCD and non-OCD group. onclusion: There is a high prevalence of OCD in dermatological patients, although the nature of the relationship between OCD and dermatology has not previously been ascertained. Genetic-based studies and future researches focused on individual anxiety, and sensitivity may provide information that better explains this relationship. (c) 2005 Elsevier Inc. All rights reserved.
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    Efficacy of leukotriene receptor antagonist in chronic urticaria patients with bronchial hyperreactivity
    Havlucu, Y; Yurtman Havlucu, D; Ozturkcan, S; Yorgancyoglu, A
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    Early diagnosed but late treated subungual melanoma
    Sahin, MT; Ozturkcan, S; Seyhan, A; Demireli, P; Turel-Ermertcan, A
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    Comparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing
    Ermertcan, AT; Inan, S; Ozturkcan, S; Bilac, C; Cilaker, S
    In this study, we compared the effects of collagenase and Centella asiatica in the rat model. Twenty-seven female rats were divided into three groups, and two full-thickness wounds were made for each animal. Collagenase ointment was applied topically to Group I and C. asiatica ointment to Group II rats. In Group III, no treatment was applied. On the third day of treatment, wounds on the left side of three animals of each group were excised. On the fifth and eighth day of the treatments, the same procedure was performed for the remaining animals. Indirect immunohistochemical examination was performed to detect transforming growth factor beta (TGF)-beta, endothelial and inducible nitric oxide synthase (eNOS and iNOS), vascular endothelial growth factor, TGF-alpha, laminin, fibronectin, collagen I, and interleukin-1 beta. According to the measurements of the wound areas and wound healing periodo, collagenase was superior to the control group. Immunohistochemical examinations showed strong (+++) iNOS and TGF-beta immunoreactivities in C. asiatica group. eNOS immunoreactivity was moderate (++) in this group. For the collagenase group, iNOS, eNOS, and TGF-beta immunoreactivities were moderate (++). In the collagenase group, while TGF-beta and iNOS immunoreactivities were weaker, laminin and fibronectin reactivities were stronger than in C. asiatica and control groups. Collagenase was superior to C. asiatica according to the immunohistochemical findings. Collagenase ointment significantly improves the quality of wound healing and scar formation and is a more appropriate treatment choice than extract of C. asiatica in the early stages of the wound healing process.
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    Calciphylaxis With Recalcitrant Ulcers in the Presence of Moderate Renal Insufficiency
    Bilac, C; Ozturk, F; Ermertcan, AT; Bilac, DB; Sahin, MT; Temiz, P; Gumuser, FG; Ozturkcan, S
    A 69 year-old woman with painful crural ulcers of 3 months duration presented at the authors' outpatient clinic. Dermatological examination revealed a necrotic ulceration with eschar formation localized on the anterior left crural region and the lateral malleolus of the right ankle. According to the clinical and histopathological findings, she was diagnosed with calciphylaxis. She had moderate renal insufficiency and secondary hyperparathyroidism due to hypertension. The ulcers improved significantly after 3 months of topical wound therapy. This case of calciphylaxis with recalcitrant ulcers in the presence of moderate renal insufficiency is presented to stress the importance of early diagnosis and management in this life-threatening dis-order.
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    Norfloxacin-induced toxic epidermal necrolysis
    Sahin, MT; Ozturkcan, S; Inanir, I; Filiz, EE
    OBJECTIVE: To report a case of toxic epidermal necrolysis (TEN) in a man who was treated with oral norfloxacin for prostatitis. CASE SUMMARY: A 40-year-old man presented with a severe skin reaction, which was diagnosed as TEN. He had received norfloxacin 800 mg/day over a 14-day period for prostatitis and, 10 days after finishing the treatment regimen, he developed cutaneous and mucous lesions typical of TEN. After a prolonged hospitalization and treatment with oral prednisolone therapy, fluid resuscitation, and wound dressing, the man recovered. DISCUSSION: TEN is an infrequent, yet often fatal, severe systemic and cutaneous disease that is most often an adverse drug reaction. There are few case reports of TEN induced by fluoroquinolones. A MEDLINE search (1966-February 2005) revealed no reports of toxic epidermal necrolysis, but one incidence of Stevens-Johnson syndrome due to norfloxacin therapy. An objective causality assessment suggests that TEN was probably related to norfloxacin in this patient. CONCLUSIONS: To our knowledge, this is the first case of TEN associated with the use of oral norfloxacin. We hope that this case report creates awareness that norfloxacin-induced TEN is possible.
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    Porocarcinoma: A rare cause of foot ulcer
    Bilac, C; Coban, M; Temiz, P; Ozturkcan, S
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    Alopecia and drugs
    Ozturkcan, S; Ates, M
    Hair loss is a common complaint, both in men and women, and use of prescription medications is widespread. When there is temporal association between the onset of hair loss and commencement of a medication, the medication is commonly thought to have caused the hair loss. Many reports in literature that attribute hair loss to particular medications have not adequately explored the nature of the hair loss and excluded other potential unrelated causes of hair loss. (Turkderm 2014; 48: Suppl 1:48-51)
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    Terra firma-forme dermatosis: A case report
    Ozturkcan, S; Inan, B; Bilac, C; Sahin, MT
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    Eosinophilic pustular folliculitis in infancy: Report of a new case
    Ozturkcan, S; Gulbasaran, F; Sahin, MT; Bilac, C
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    Comparison of the Effects of Contractubex® Gel in an Experimental Model of Scar Formation in Rats: An Immunohistochemical and Ultrastructural Study
    Sahin, MT; Inan, S; Ozturkcan, S; Guzel, E; Bilac, C; Giray, G; Muftuoglu, S
    Background: Contractubex gel, a commercial treatment for scars, consists of a mixture of onion extract (cepea extract), heparin sodium, and allantoin. It exerts a softening and smoothing effect on indurated, hypertrophic, painful, and cosmetically-disfiguring scar tissue. Aim: To compare and discuss the immunohistochemical and ultrastructural effects of treatment of an experimental scar in a rat model with Contractubex gel. Methods: Thirty-two Sprague-Dawley rats were divided into four groups. Skin biopsies were taken to develop full thickness wounds. After 10 days, Contractubex gel, heparin, and allantoin were topically applied daily to groups 2, 3, and 4, respectively. Group 1 was the control group. On the 30th day, scar tissues were excised to investigate the immunohistochemical and ultrastructural effects of these agents. For this purpose we used TGF-beta, laminin, and fibronectin primary antibodies. Results: Increased immunoreactivities of laminin, fibronectin, and TGF-beta in control group, moderate immunoreactivities in heparin and allantoin groups, and mild immunoreactivities in the Contractubex gel group were observed. In semi-thin sections, Group 2 showed the thinnest epidermis of the four groups. In electron micrographs of Group 2, completely keratinized and normally appearing cells could be seen. Conclusions: Immunohistochemical and ultrastructural observations demonstrated that the Contractubex gel significantly improved the quality of wound healing and reduction of scar formation. Also, it was a more appropriate treatment choice than heparin monotherapy and allantoin monotherapy in keloidal and hypertrophic scars.
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    EFFECTIVENESS AND SAFETY OF ANTI-TNF AGENTS IN TREATMENT OF MODERATE TO SEVERE PSORIASIS VULGARIS: RESULTS OF WORK PRODUCTIVITY AND DAILY ACTIVITY IMPAIRMENT
    Koc, E; Ozarmagan, G; Alper, S; Ozgoztasi, O; Tekin, NS; Balci, DD; Onsun, N; Tuzun, Y; Atakan, N; Ozturkcan, S; Kokturk, A
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    Relationship of psoriatic arthritis with nail and scalp involvement in Turkish psoriasis patients: Multicentered cross-sectional study
    Askin, O; Engin, B; Ozdede, A; Kartal, SP; Ugurlu, S; Akbulut, TO; Ekinci, AP; Aydogdu, IH; Ozden, MG; Kok, H; Dogan, S; Ozturkcan, S; Borlu, M; Baskan, EB; Yilmaz, N; Ak, T; Topkarci, Z; Serdaroglu, S
    Psoriasis is a common multisystem inflammatory disease, and arthritis is an essential component of the disorder, requiring early diagnosis and prompt treatment for successful management. In this study, we aimed to investigate the relationship between nail and scalp involvement and other covariates with psoriatic arthritis (PsA). This cross-sectional study, conducted from June 2021 through December 2021, included 763 patients from 11 different centers in Turkey. The severity of involvement was evaluated using psoriasis area severity index (PASI), nail psoriasis severity index (NAPSI), and psoriasis scalp severity index (PSSI) scores. Predictors for PsA were evaluated using univariate and multivariate logistic regression models. PsA (n = 155, 21.5%) was significantly more common in patients having a family history of psoriasis (43.2% vs 30.9%, P = .004), nail involvement (68.4% vs 52.3%, P < .001), and coexistence of nail and scalp involvement (53.7% vs 39.6%, P = .002). Furthermore, patients with PsA had considerably higher PASI (7 vs 5.6, P = .006), NAPSI (5 vs 2, P < .001), and PSSI scores (7 vs 4, P = .002) and longer disease duration (months) (126 vs 108, P = .009). In multivariate analysis, female gender [OR: 3.01, 95% CI (1.861-4.880), P < .001], nail involvement [OR: 2.06, 95% CI (1.293-3.302), P = .002)], and body mass index (BMI) [OR: 1.06, 95% CI (1.017-1.100), P = .005] were identified as independent predictors for PsA. Female gender, nail involvement, and high BMI are significant predictors for PsA and warrant detailed rheumatological assessment. Notably, being female is the strongest predictor of increased risk of PsA in our survey. Scalp involvement appears not to be associated with PsA. Also, the presence of PsA seems related to a more severe skin involvement phenotype.
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    Efficiency of Bioflavonoids in the Prevention of Experimental Myringosclerosis
    Ilknur, AE; Dundar, R; Basoglu, S; Inan, S; Aktas, S; Aslan, H; Ozkul, Y; Ozturkcan, S; Katilmis, H
    Objectives/Hypothesis: It has been noted that some materials with anti-inflammatory and antioxidant effects decrease sclerotic lesions in experimental myringosclerosis. Our purpose in this study is to investigate the effect of micronized purified flavonoid fraction (MPFF), an antioxidant with anti-inflammatory effects, in experimental myringosclerosis in guinea pigs. Materials and Methods: Two study groups were formed. The first group was administered 100mg/kg/day MPFF by catheter for five days before myringotomy and 10 days after myringotomy, while the second group was administered distilled water by the same method, before and after myringotomy. On the 15th day of the study, after the tympanic membranes were examined otomicroscopically for myringosclerosis, they were removed by dissection together with the bone annulus, for histochemical and immunohistochemical examinations. Results: In the MPFF group, the otomicroscopical sclerosis score, inflammation score and tympanic membrane thickness were significantly less than those in the untreated group (p<0.05). It was also determined that the immunoactivity of the anti-VEGF, anti-TGF-beta, anti-eNOS, anti-iNOS, and anti-IL1-beta primary antibodies, which are known to have an important role in angiogenesis and inflammation, significantly decreased in the MPFF group (p<0.05). Conclusion: In conclusion, this study shows that orally administered MPFF can be efficient in the prevention of experimental myringosclerosis in guinea pigs.