Browsing by Author "Pavord, I"

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    Effect of Individual Patient Characteristics and Treatment Choices on Reliever Medication Use in Moderate-Severe Asthma: A Poisson Analysis of Randomised Clinical Trials
    (SPRINGER) van Dijkman, SC; Yorgancioglu, A; Pavord, I; Brusselle, G; Pitrez, PM; Oosterholt, S; Fumali, S; Majumdar, A; Della Pasqua, O
    Introduction: Even though increased use of reliever medication, including short-acting beta agonists (SABA), provides an indirect measure of symptom worsening, there have been limited efforts to assess how different patterns of reliever use correlate with symptom control and future risk of exacerbations. Here, we evaluate the effect of individual baseline characteristics on reliever use in patients with moderate-severe asthma on regular maintenance therapy with fluticasone propionate (FP) or combination therapy with fluticasone propionate/salmeterol (FP/SAL) or budesonide/formoterol (BUD/FOR). Methods: A drug-disease model describing the number of 24-h puffs and overnight occasions was developed with data from five clinical studies (N = 6212). The model was implemented using a nonlinear mixed effects approach and a Poisson function, considering clinical and demographic baseline characteristics. Goodness of fit and model predictive performance were assessed. Heatmaps were created to summarise the effect of concurrent baseline factors on reliever utilisation. Results: The final model accurately described individual patterns of reliever use, which is significantly increased with time since diagnosis, smoking, higher Asthma Control Questionnaire (ACQ-5) score and higher body mass index (BMI) at baseline. Whilst the number of puffs decreases slowly after an initial drop relative to the start of treatment, exacerbating patients utilise significantly more reliever than those who do not exacerbate. The mean effect of FP/SAL (median dose: 250/50 mu g BID) on reliever use was slightly higher than that of BUD/FOR (median dose: 160/4.5 mu g BID), i.e. a 75.3% vs 69.3% reduction in reliever use, respectively. Conclusions: The availability of individual-level patient data in conjunction with a parametric approach enabled the characterisation of interindividual differences in the patterns of reliever use in patients with moderate-severe asthma. Taken together, individual demographic and clinical characteristics, as well as exacerbation history, can be considered an indicator of the degree of asthma control. High SABA reliever use suggests suboptimal clinical management of patients on maintenance therapy. Plain language summary In this study, we tried to understand how patients with moderate to severe asthma use their quick-relief inhalers (like albuterol), how it relates to their symptoms and the risk of having asthma attacks. To evaluate whether differences in reliever inhaler use between patients are associated with factors like smoking or their asthma symptoms at the beginning of treatment, we gathered data from five clinical studies (n = 6212 patients). These data allowed us to create a model that predicts how often patients use their reliever inhalers (expressed as number of puffs in 24 h) during maintenance therapy with inhaled corticosteroids alone or in combination with long-acting beta agonists. The final model showed that reliever inhaler use is higher in patients who have been diagnosed with asthma for > 10 years, are smokers, have higher asthma symptom scores, and are obese or extremely obese. Patients who had asthma attacks also used their reliever inhalers more often. In addition, to understand how relief inhalers are used in real-life situations, we also created heatmaps that include a wide range of patient characteristics. By using individual patient data together with this model, we have learned that smoking, asthma control, BMI, long history of asthma and previous asthma attacks significantly influence reliever use. This information can help physicians and healthcare professionals understand know how well someone's asthma is managed. A patient who uses their reliever inhaler often is likely not to have their asthma well controlled by their regular medications.
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    Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
    (BMC) Bousquet, J; Farrell, J; Crooks, G; Hellings, P; Bel, EH; Bewick, M; Chavannes, NH; de Sousa, JC; Cruz, AA; Haahtela, T; Joos, G; Khaltaev, N; Malva, J; Muraro, A; Nogues, M; Palkonen, S; Pedersen, S; Robalo-Cordeiro, C; Samolinski, B; Strandberg, T; Valiulis, A; Yorgancioglu, A; Zuberbier, T; Bedbrook, A; Aberer, W; Adachi, M; Agusti, A; Akdis, CA; Akdis, M; Ankri, J; Alonso, A; Annesi-Maesano, I; Ansotegui, IJ; Anto, JM; Arnavielhe, S; Arshad, H; Bai, C; Baiardini, I; Bachert, C; Baigenzhin, AK; Barbara, C; Bateman, ED; Beghé, B; Ben Kheder, A; Bennoor, KS; Benson, M; Bergmann, KC; Bieber, T; Bindslev-Jensen, C; Bjermer, L; Blain, H; Blasi, F; Boner, AL; Bonini, M; Bonini, S; Bosnic-Anticevitch, S; Boulet, LP; Bourret, R; Bousquet, PJ; Braido, F; Briggs, AH; Brightling, CE; Brozek, J; Buhl, R; Burney, PG; Bush, A; Caballero-Fonseca, F; Caimmi, D; Calderon, MA; Calverley, PM; Camargos, PAM; Canonica, GW; Camuzat, T; Carlsen, KH; Carr, W; Carriazo, A; Casale, T; Sarabia, AMC; Chatzi, L; Chen, YZ; Chiron, R; Chkhartishvili, E; Chuchalin, AG; Chung, KF; Ciprandi, G; Cirule, I; Cox, L; Costa, DJ; Custovic, A; Dahl, R; Dahlen, SE; Darsow, U; De Carlo, G; De Blay, F; Dedeu, T; Deleanu, D; Keenoy, ED; Demoly, P; Denburg, JA; Devillier, P; Didier, A; Dinh-Xuan, AT; Djukanovic, R; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, SR; Dykewicz, MS; El-Gamal, Y; Emuzyte, R; Fabbri, LM; Fletcher, M; Fiocchi, A; Wagner, AF; Fonseca, J; Fokkens, WJ; Forastiere, F; Frith, P; Gaga, M; Gamkrelidze, A; Garces, J; Garcia-Aymerich, J; Gemicioglu, B; Gereda, JE; Diaz, SG; Gotua, M; Grisle, I; Grouse, L; Gutter, Z; Guzmán, MA; Heaney, LG; Hellquist-Dahl, B; Henderson, D; Hendry, A; Heinrich, J; Heve, D; Horak, F; Hourihane, JOB; Howarth, P; Humbert, M; Hyland, ME; Illario, M; Ivancevich, JC; Jardim, JR; Jares, EJ; Jeandel, C; Jenkins, C; Johnston, SL; Jonquet, O; Julge, K; Jung, KS; Just, J; Kaidashev, I; Kaitov, MR; Kalayci, O; Kalyoncu, AF; Keil, T; Keith, PK; Klimek, L; N'Goran, BK; Kolek, V; Koppelman, GH; Kowalski, ML; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Lau, S; Larenas-Linnemann, D; Laune, D; Le, LTT; Lieberman, P; Lipworth, B; Li, J; Carlsen, KL; Louis, R; MacNee, W; Magard, Y; Magnan, A; Mahboub, B; Mair, A; Majer, I; Makela, MJ; Manning, P; Mara, S; Marshall, GD; Masjedi, MR; Matignon, P; Maurer, M; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, EO; Menzies-Gow, A; Merk, H; Michel, JP; Miculinic, N; Mihaltan, F; Milenkovic, B; Mohammad, GMY; Molimard, M; Momas, I; Montilla-Santana, A; Morais-Almeida, M; Morgan, M; Mösges, R; Mullol, J; Nafti, S; Namazova-Baranova, L; Naclerio, R; Neou, A; Neffen, H; Nekam, K; Niggemann, B; Ninot, G; Nyembue, TD; O'Hehir, RE; Ohta, K; Okamoto, Y; Okubo, K; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Panzner, P; Papadopoulos, N; Papi, A; Park, HS; Passalacqua, G; Pavord, I; Pawankar, R; Pengelly, R; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Poethig, D; Pohl, W; Popov, TA; Portejoie, F; Potter, P; Postma, D; Price, D; Rabe, KF; Raciborski, F; Pontal, FR; Repka-Ramirez, S; Reitamo, S; Rennard, S; Rodenas, F; Roberts, J; Roca, J; Mañas, LR; Rolland, C; Rodriguez, MR; Romano, A; Rosado-Pinto, J; Rosario, N; Rosenwasser, L; Rottem, M; Ryan, D; Sanchez-Borges, M; Scadding, GK; Schunemann, HJ; Serrano, E; Schmid-Grendelmeier, P; Schulz, H; Sheikh, A; Shields, M; Siafakas, N; Sibille, Y; Similowski, T; Simons, FER; Sisul, JC; Skrindo, I; Smit, HA; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Sterk, PJ; Sunyer, J; Thijs, C; To, T; Todo-Bom, A; Triggiani, M; Valenta, R; Valero, AL; Valia, E; Valovirta, E; Van Ganse, E; van Hage, M; Vandenplas, O; Vasankari, T; Vellas, B; Vestbo, J; Vezzani, G; Vichyanond, P; Viegi, G; Vogelmeier, C; Vontetsianos, T; Wagenmann, M; Wallaert, B; Walker, S; Wang, DY; Wahn, U; Wickman, M; Williams, DM; Williams, S; Wright, J; Yawn, BP; Yiallouros, PK; Yusuf, OM; Zaidi, A; Zar, HJ; Zernotti, ME; Zhang, L; Zhong, N; Zidarn, M; Mercier, J
    Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un Vleillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing.
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    MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation
    (WILEY) Bousquet, J; Schunemann, HJ; Fonseca, J; Samolinski, B; Bachert, C; Canonica, GW; Casale, T; Cruz, AA; Demoly, P; Hellings, P; Valiulis, A; Wickman, M; Zuberbier, T; Bosnic-Anticevitch, S; Bedbrook, A; Bergmann, KC; Caimmi, D; Dahl, R; Fokkens, WJ; Grisle, I; Lodrup Carlsen, K; Mullol, J; Muraro, A; Palkonen, S; Papadopoulos, N; Passalacqua, G; Ryan, D; Valovirta, E; Yorgancioglu, A; Aberer, W; Agache, I; Adachi, M; Akdis, CA; Akdis, M; Annesi-Maesano, I; Ansotegui, IJ; Anto, JM; Arnavielhe, S; Arshad, H; Baiardini, I; Baigenzhin, AK; Barbara, C; Bateman, ED; Beghé, B; Bel, EH; Ben Kheder, A; Bennoor, KS; Benson, M; Bewick, M; Bieber, T; Bindslev-Jensen, C; Bjermer, L; Blain, H; Boner, AL; Boulet, LP; Bonini, M; Bonini, S; Bosse, I; Bourret, R; Bousquet, PJ; Braido, F; Briggs, AH; Brightling, CE; Brozek, J; Buhl, R; Burney, PG; Bush, A; Caballero-Fonseca, F; Calderon, MA; Camargos, PAM; Camuzat, T; Carlsen, KH; Carr, W; Sarabia, AMC; Chavannes, NH; Chatzi, L; Chen, YZ; Chiron, R; Chkhartishvili, E; Chuchalin, AG; Ciprandi, G; Cirule, I; de Sousa, JC; Cox, L; Crooks, G; Costa, DJ; Custovic, A; Dahlen, SE; Darsow, U; De Carlo, G; De Blay, F; Dedeu, T; Deleanu, D; Denburg, JA; Devillier, P; Didier, A; Dinh-Xuan, AT; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, SR; Dykewicz, MS; El-Gamal, Y; Emuzyte, R; Wagner, AF; Fletcher, M; Fiocchi, A; Forastiere, F; Gamkrelidze, A; Gemicioglu, B; Gereda, JE; Diaz, SG; Gotua, M; Grouse, L; Guzmán, MA; Haahtela, T; Hellquist-Dahl, B; Heinrich, J; Horak, F; Hourihane, JOB; Howarth, P; Humbert, M; Hyland, ME; Ivancevich, JC; Jares, EJ; Johnston, SL; Joos, G; Jonquet, O; Jung, KS; Just, J; Kaidashev, I; Kalayci, O; Kalyoncu, AF; Keil, T; Keith, PK; Khaltaev, N; Klimek, L; N'Goran, BK; Kolek, V; Koppelman, GH; Kowalski, ML; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Lau, S; Larenas-Linnemann, D; Laune, D; Le, LTT; Lieberman, P; Lipworth, B; Li, J; Louis, R; Magard, Y; Magnan, A; Mahboub, B; Majer, I; Makela, MJ; Manning, P; Keenoy, ED; Marshall, GD; Masjedi, MR; Maurer, M; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, EO; Merk, H; Miculinic, N; Mihaltan, F; Milenkovic, B; Mohammad, Y; Molimard, M; Momas, I; Montilla-Santana, A; Morais-Almeida, M; Mösges, R; Namazova-Baranova, L; Naclerio, R; Neou, A; Neffen, H; Nekam, K; Niggemann, B; Nyembue, TD; O'Hehir, RE; Ohta, K; Okamoto, Y; Okubo, K; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Palmer, S; Panzner, P; Papi, A; Park, HS; Pavord, I; Pawankar, R; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Pohl, W; Popov, TA; Portejoie, F; Postma, D; Potter, P; Price, D; Rabe, KF; Raciborski, F; Pontal, FR; Repka-Ramirez, S; Robalo-Cordeiro, C; Rolland, C; Rosado-Pinto, J; Reitamo, S; Rodenas, F; Roman Rodriguez, M; Romano, A; Rosario, N; Rosenwasser, L; Rottem, M; Sanchez-Borges, M; Scadding, GK; Serrano, E; Schmid-Grendelmeier, P; Sheikh, A; Simons, FER; Sisul, JC; Skrindo, I; Smit, HA; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Strandberg, T; Sunyer, J; Thijs, C; Todo-Bom, A; Triggiani, M; Valenta, R; Valero, AL; van Hage, M; Vandenplas, O; Vezzani, G; Vichyanond, P; Viegi, G; Wagenmann, M; Walker, S; Wang, DY; Wahn, U; Williams, DM; Wright, J; Yawn, BP; Yiallouros, PK; Yusuf, OM; Zar, HJ; Zernotti, ME; Zhang, L; Zhong, N; Zidarn, M; Mercier, J
    Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards.
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    Implications of treatable traits and treatment choices on exacerbation risk in moderate-severe asthma
    (EUROPEAN RESPIRATORY SOC JOURNALS LTD) Yorgancioglu, AA; Pavord, I; Brusselle, G; Pitrez, P; Oosterholt, S; Pg, A; Della Pasqua, O
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    Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (vol 6, 29, 2016)
    (BMC) Bousquet, J; Farrell, J; Crooks, G; Hellings, P; Bel, EH; Bewick, M; Chavannes, NH; de Sousa, JC; Cruz, AA; Haahtela, T; Joos, G; Khaltaev, N; Malva, J; Muraro, A; Nogues, M; Palkonen, S; Pedersen, S; Robalo-Cordeiro, C; Samolinski, B; Strandberg, T; Valiulis, A; Yorgancioglu, A; Zuberbier, T; Bedbrook, A; Aberer, W; Adachi, M; Agusti, A; Akdis, CA; Akdis, M; Ankri, J; Alonso, A; Annesi-Maesano, I; Ansotegui, IJ; Anto, JM; Arnavielhe, S; Arshad, H; Bai, C; Baiardini, I; Bachert, C; Baigenzhin, AK; Barbara, C; Bateman, ED; Beghé, B; Ben Kheder, A; Bennoor, KS; Benson, M; Bergmann, KC; Bieber, T; Bindslev-Jensen, C; Bjermer, L; Blain, H; Blasi, F; Boner, AL; Bonini, M; Bonini, S; Bosnic-Anticevitch, S; Boulet, LP; Bourret, R; Bousquet, PJ; Braido, F; Briggs, AH; Brightling, CE; Brozek, J; Buhl, R; Burney, PG; Bush, A; Caballero-Fonseca, F; Caimmi, D; Calderon, MA; Calverley, PM; Camargos, PAM; Canonica, GW; Camuzat, T; Carlsen, KH; Carr, W; Carriazo, A; Casale, T; Sarabia, AMC; Chatzi, L; Chen, YZ; Chiron, R; Chkhartishvili, E; Chuchalin, AG; Chung, KF; Ciprandi, G; Cirule, I; Cox, L; Costa, DJ; Custovic, A; Dahl, R; Dahlen, SE; Darsow, U; De Carlo, G; De Blay, F; Dedeu, T; Deleanu, D; Keenoy, ED; Demoly, P; Denburg, JA; Devillier, P; Didier, A; Dinh-Xuan, AT; Djukanovic, R; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, SR; Dykewicz, MS; El-Gamal, Y; Emuzyte, R; Fabbri, LM; Fletcher, M; Fiocchi, A; Wagner, AF; Fonseca, J; Fokkens, WJ; Forastiere, F; Frith, P; Gaga, M; Gamkrelidze, A; Garces, J; Garcia-Aymerich, J; Gemicioglu, B; Gereda, JE; Diaz, SG; Gotua, M; Grisle, I; Grouse, L; Gutter, Z; Guzmán, MA; Heaney, LG; Hellquist-Dahl, B; Henderson, D; Hendry, A; Heinrich, J; Heve, D; Horak, F; Hourihane, JOB; Howarth, P; Humbert, M; Hyland, ME; Illario, M; Ivancevich, JC; Jardim, JR; Jares, EJ; Jeandel, C; Jenkins, C; Johnston, SL; Jonquet, O; Julge, K; Jung, KS; Just, J; Kaidashev, I; Khaitov, MR; Kalayci, O; Kalyoncu, AF; Keil, T; Keith, PK; Klimek, L; N'Goran, BK; Kolek, V; Koppelman, GH; Kowalski, ML; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Lau, S; Larenas-Linnemann, D; Laune, D; Le, LTT; Lieberman, P; Lipworth, B; Li, J; Carlsen, KL; Louis, R; MacNee, W; Magard, Y; Magnan, A; Mahboub, B; Mair, A; Majer, I; Makela, MJ; Manning, P; Mara, S; Marshall, GD; Masjedi, MR; Matignon, P; Maurer, M; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, EO; Menzies-Gow, A; Merk, H; Michel, JP; Miculinic, N; Mihaltan, F; Milenkovic, B; Mohammad, GMY; Molimard, M; Momas, I; Montilla-Santana, A; Morais-Almeida, M; Morgan, M; Mösges, R; Mullol, J; Nafti, S; Namazova-Baranova, L; Naclerio, R; Neou, A; Neffen, H; Nekam, K; Niggemann, B; Ninot, G; Nyembue, TD; O'Hehir, RE; Ohta, K; Okamoto, Y; Okubo, K; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Panzner, P; Papadopoulos, N; Papi, A; Park, HS; Passalacqua, G; Pavord, I; Pawankar, R; Pengelly, R; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Poethig, D; Pohl, W; Popov, TA; Portejoie, F; Potter, P; Postma, D; Price, D; Rabe, KF; Raciborski, F; Pontal, FR; Repka-Ramirez, S; Reitamo, S; Rennard, S; Rodenas, F; Roberts, J; Roca, J; Mañas, LR; Rolland, C; Rodriguez, MR; Romano, A; Rosado-Pinto, J; Rosario, N; Rosenwasser, L; Rottem, M; Ryan, D; Sanchez-Borges, M; Scadding, GK; Schunemann, HJ; Serrano, E; Schmid-Grendelmeier, P; Schulz, H; Sheikh, A; Shields, M; Siafakas, N; Sibille, Y; Similowski, T; Simons, FER; Sisul, JC; Skrindo, I; Smit, HA; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Sterk, PJ; Sunyer, J; Thijs, C; To, T; Todo-Bom, A; Triggiani, M; Valenta, R; Valero, AL; Valia, E; Valovirta, E; Van Ganse, E; van Hage, M; Vandenplas, O; Vasankari, T; Vellas, B; Vestbo, J; Vezzani, G; Vichyanond, P; Viegi, G; Vogelmeier, C; Vontetsianos, T; Wagenmann, M; Wallaert, B; Walker, S; Wang, DY; Wahn, U; Wickman, M; Williams, DM; Williams, S; Wright, J; Yawn, BP; Yiallouros, PK; Yusuf, OM; Zaidi, A; Zar, HJ; Zernotti, ME; Zhang, L; Zhong, N; Zidarn, M; Mercier, J