Browsing by Author "Rahman B."

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    Structural and luminescent properties of Er3+ and Tb3+-doped sol–gel-based bioactive glass powders and electrospun nanofibers
    (Springer, 2021) Deliormanlı A.M.; Rahman B.; Oguzlar S.; Ertekin K.
    In this study, sol–gel-based erbium (Er3+), terbium (Tb3+) and Er3+: Tb3 co-doped 1393 bioactive glass powders and electrospun nanofibers were prepared. Structural and morphological properties of the bioactive glasses as well as the photoluminescence characteristics were investigated in detail. The median particle size and average diameter of the prepared glass powders and fibers were in the range of ~ 1.5–3.5 μm and 280–660 nm, respectively. The steady-state photoluminescence and decay kinetics of the samples were investigated under excitation (374 nm) where only Er3+ and Tb3+ ions close to Si nanoclusters can be excited. All the samples prepared in the study exhibited bright green emission upon excitation at 374 nm. Results showed that the dopant concentration and the sample morphology have significant influence on the photoluminescence and decay properties of the glasses. Sol–gel-derived bioactive glass particles exhibited stronger emission intensity, whereas electrospun nanofibers showed extended decay times. In vitro bioactivity experiments revealed that Er3+ and Tb3+ doping did not inhibit the conversion of the glass samples to hydroxyapatite treated in simulated body fluid for 30 days. It was concluded that Er3+ and Tb3+-containing 1393 bioactive glasses have a potential to be used in tissue engineering applications as well as bioimaging studies. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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    Erbium (III)- and Terbium (III)-containing silicate-based bioactive glass powders: physical, structural and nuclear radiation shielding characteristics
    (Springer Science and Business Media Deutschland GmbH, 2021) Deliormanli A.M.; Issa S.A.M.; Al-Buriahi M.S.; Rahman B.; Zakaly H.M.H.; Tekin H.O.
    Erbium (III)- and terbium (III)-containing (1, 3 and 5 wt%) silicate-based bioactive glass powders were synthesized using sol–gel method. Their structural and physical properties were investigated. Radiation attenuation properties of the prepared glass samples were examined using Monte Carlo simulations. The photon transmission properties of the prepared bioactive specimens were obtained via Phy-X PSD program and FLUKA simulation. Results showed that all of the glasses synthesized in the study were amorphous. The true density values were measured in the range of 2.57–2.68 g/cm3. Simulation studies revealed that the lowest neutron cross section was observed for the pure 13–93 bioactive glass sample and the maximum neutron cross section was noted for the prepared bioactive specimens of 5% Er and 5% Tb. Bioactive glass powders synthesized in the study have potential to be used as radiation shielding material in tissue engineering applications. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
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    Evaluation of In Vitro Bioactivity, Cytotoxicity, and Drug Release Behavior of Er2O3 and Tb2O3-Containing Bioactive Glass Particles and Nanofibers
    (Springer, 2022) Rahman B.; Deliormanlı A.M.; Atmaca H.
    Silicate-based bioactive glasses doped with Er3+ and Tb3+ ions (1, 3, and 5 wt%) were synthesized in the form of powders and nanofibers using sol–gel and electrospinning methods, respectively. In vitro bioactivity of the prepared powders and fibers was analyzed in simulated body fluid (SBF) for various periods, and the biological response of the osteoblastic MC3T3-E1 cells to the bioactive glass samples was studied using MTT assay and microscopic observations. The amoxicillin release behavior of the prepared glasses was examined in phosphate-buffered saline as a function of time. The results revealed that the incorporation of Er3+ and Tb3+ improved the hydroxyapatite forming ability of the prepared bioactive glass samples for up to 30 d of immersion in SBF. In vitro cytotoxicity experiments showed that Tb3+-containing glass samples were biocompatible at all concentrations; however, in the case of Er3+-containing glass particle-based samples, a decrease in cell viability was observed starting from 3 wt% Er3+. SEM observations revealed cellular adhesion and spreading on the bioactive glass scaffolds. Drug delivery experiments demonstrated that after 24 h, ~ 35 to 38% of the drug was released into the medium for both bioactive glass powder and nanofiber-based samples. Bioactive glasses synthesized in the study have the potential to be used in bone tissue engineering applications. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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    Investigation of the structural, photoluminescence properties, bioactivity and 5-fluorouracil delivery behavior of Dy3+ and Dy:Eu3+-doped bioactive glasses
    (Elsevier Ltd, 2023) Deliormanlı A.M.; Rahman B.; Oguzlar S.; Ongun M.Z.
    Nowadays fluorescent biomaterials gained crucial interest in the biomedical field. Here we report the sol-gel synthesis and characterization of Dy3+ and Dy:Eu3+ co-doped bioactive glass powders. Structural, morphological, and photoluminescence (PL) characteristics of the prepared powders were investigated in detail. Additionally, in vitro hydroxyapatite forming ability and the anticancer drug (5-Fluorouracil) release behavior were investigated with respect to time. The influence of drug loading and delivery on the PL properties was monitored. Results showed that the highest PL intensity was obtained for the 5%Dy:Eu3+ co-doped glass samples. The incorporation of rare-earth ions into the glass network did not cause a significant difference in the structural properties. In vitro conversion experiments, performed in simulated body fluid, indicated that the incorporation of Dy3+ to the glass network enhanced the hydroxyapatite deposition however Dy:Eu3+ co-doping slightly decreased the bioactivity. Drug-loaded bioactive glass powders exhibited sustained drug release behavior to the phosphate buffered saline (PBS) medium. An increase was obtained in the fluorescence intensities for 5-FU-loaded samples followed by a further increase in emissions for the powders released drug to the PBS medium. The findings of the study may be useful for monitoring the degradation of bioactive glasses, conversion to hydroxyapatite as well as drug delivery after implantation. © 2023 Elsevier B.V.
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    Fabrication and characterization of novel multifunctional superparamagnetic and fluorescent bioactive glasses for biomedical applications
    (Elsevier Ltd, 2023) Deliormanlı A.M.; Rahman B.
    Magnetic-fluorescent nanosystems have wide applications in the biomedical field due to their dual ability of unique biomolecular fluorescent recognition and magnetic modes. In this study fabrication of superparamagnetic-fluorescent bioactive glasses in the form of particle, nanofiber, and 3D scaffold was performed by the inclusion of maghemite (γ-Fe2O3) nanoparticle and photoluminescent rare earth element ions (Eu3+, Gd3+, and Yb3+). Bioactive glasses in the form of particle, nanofiber, and 3D scaffolds were manufactured using sol-gel, electrospinning, and robocasting techniques, respectively. Morphological, structural, magnetic, and luminescence properties of the fabricated bioactive glasses have been investigated comprehensively using electron microscopy, x-ray diffractometer, vibrating sample magnetometer, Fourier transform infrared, and fluorescence spectrometers. The compressive strength of the robocast 3D glass scaffolds was measured. In vitro hydroxyapatite deposition on the surface of the bioactive glasses soaked in simulated body fluid for various times up to 28 days was also examined. Results showed that all of the bioactive glasses prepared in the study with different morphological characteristics have superparamagnetic properties. Saturation magnetization (Ms) values of the glasses were in the range of 7.20–12.50 emu/g. Additionally, all of the studied glass samples showed fluorescence behavior. The highest photoluminescence emission peak intensity was recorded for the Eu3+-doped robocast 3D glass scaffolds which is followed by nanofibrous and particulate forms of bioactive glass. Results of the in vitro bioactivity experiments showed that hydroxyapatite formation occurred on all of the bioactive glass samples and the highest hydroxyapatite formation rates were obtained for the fibrous glass samples due to their higher surface area. © 2023 Elsevier B.V.
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    In vitro cytotoxicity of magnetic-fluorescent bioactive glasses on SaOS-2, MC3T3-E1, BJ fibroblast cells, their hemolytic activity, and sorafenib release behavior
    (Elsevier Ltd, 2024) Deliormanlı A.M.; Rahman B.; Atmaca H.
    In the study, the fabrication of superparamagnetic-fluorescent bioactive glasses in the form of the particle, nanofiber, and 3D scaffolds was performed by including maghemite (γ-Fe2O3) nanoparticles and photoluminescent rare earth element ions (Eu3+, Gd3+, and Yb3+) using sol-gel, electrospinning, and robocasting techniques, respectively. The in vitro cytotoxicity of the magnetic-fluorescent bioactive glasses on osteosarcoma SaOS-2, pre-osteoblast MC3T3-E1, and BJ fibroblast cells, as well as their hemolytic activity and sorafenib tosylate loading and release behavior, were investigated. The cytotoxicity of the bioactive glass samples was tested using the MTT assay. Additionally, the alkaline phosphatase activity of the studied glasses was examined as a function of time. The mineralization behavior of the pre-osteoblast cell-seeded glass samples was analyzed using Alizarin red S staining. Results revealed that the in vitro cytotoxicity of the studied bioactive glasses in the form of particles and nanofibers depended on the sample concentration, whereas in the case of the 3D scaffolds, no cytotoxic response was observed on the osteosarcoma, pre-osteoblast, and fibroblast cells. Similarly, particle and nanofiber-based glass samples induced dose-dependent hemolysis on red blood cells. Drug loading rates were much lower for the 3D scaffolds compared to the particle and nanofiber-based samples. Drug release rates ranged from 25 % to 90 %, depending on the bioactive glass morphology and the pH of the release medium. It was concluded that the studied bioactive glasses have the potential to be used in tissue engineering applications and cancer therapy. © 2024 Elsevier B.V.