Browsing by Author "Rodrigues M."

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    Persistent inhibition of cell growth on silver implanted glassy polymeric carbon
    (Materials Research Society, 2006) Zimmerman R.L.; Gürhan I.; Ozdal-Kurt F.; Sen B.H.; Rodrigues M.; Ila D.
    [No abstract available]
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    The influence of ion implantation on cell attachment to glassy polymeric carbon
    (American Institute of Physics Inc., 2006) Zimmerman R.; Gurhan I.; Ozdal-Kurt F.; Sen B.H.; Rodrigues M.; Ila D.
    In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that near surface implantation of silver in Glassy Polymeric Carbon (GPC) can completely inhibit cell attachment on implanted areas while leaving adjacent areas unaffected. Patterned ion implantation permits precise control of tissue growth on medical applications of GPC. We have shown that silver ion implantation or argon ion assisted surface deposition of silver inhibits cell growth on GPC, a desirable improvement of current cardiac implants. © 2006 American Institute of Physics.
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    Patterning of cell attachment to biocompatible glassy polymeric carbon by silver ion implantation
    (Materials Research Society, 2006) Zimmerman R.L.; Gurhan I.; Ila D.; Ozdal-Kurt F.; Sen B.H.; Rodrigues M.
    Although Glassy Polymeric Carbon (GPC) is ideally suited for implants in the blood stream, tissue that normally forms around the moving parts of a GPC heart valve. There is concern that the tissue lose adhesion and create the condition for embolisms downstream. We have shown that silver ion implantation or argon ion assisted surface deposition of silver inhibits cell growth on GPC, a desirable improvement of current cardiac implants. In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that near surface implantation of silver in GPC can completely inhibit cell attachment on implanted areas while leaving adjacent areas unaffected. Patterned ion implantation permits precise control of tissue growth on medical applications of GPC. © 2006 Materials Research Society.
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    Enhanced biocompatibility of GPC by ion implantation and deposition
    (2007) Zimmerman R.; Gürhan I.; Muntele C.; Ila D.; Rodrigues M.; Özdal-Kurt F.; Sen B.H.
    Biocompatible Glassy Polymeric Carbon (GPC) is used for artificial heart valves and in other biomedical applications. Although it is ideally suited for implants in the blood stream, tissue that normally forms around the moving parts of a GPC heart valve sometimes loses adhesion and creates embolisms downstream. We have previously shown that oxygen ion implantation slightly enhances cell adhesion to GPC. Here we compare silver ion implantation and silver deposition, each of which strongly inhibits cell attachment on GPC. Inhibition of cell adhesion is the more desirable improvement to current GPC cardiac implants. In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that traces of silver can favorably influence the surface of GPC for biomedical applications. © 2007.
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    Ion implantation inhibits cell attachment to glassy polymeric carbon
    (2007) Zimmerman R.; Deliloglu-Gurhan I.; Ozdal-Kurt F.; Sen B.H.; Rodrigues M.; Ila D.
    Implantation of MeV gold, oxygen, carbon ions into GPC alters the surface topography of GPC and enhances the already strong tendency for cells to attach to GPC. We have shown that implantation of silver ions near the surface strongly inhibits cell growth on GPC. Both enhanced adhesion of and inhibition of cell growth are desirable improvements on cardiac implants that have long been successfully fabricated from biocompatible glassy polymeric carbon (GPC). In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that ion beam assisted deposition (IBAD) of silver, as well as silver ion bombardment, can favorably influence the surface of GPC for biomedical applications. © 2007 Elsevier B.V. All rights reserved.
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    Investigation of cell growth on ion beam patterns on GPC surface
    (2009) Zimmerman R.; Muntele C.; Gurhan I.; Ozdal-Kurt F.; Sen B.H.; Rodrigues M.; Ila D.
    We have used implanted silver ions near the surface of Glassy Polymeric Carbon (GPC) to completely inhibit cell attachment and adhesion to GPC. The effect improves the safety and function of the GPC heart valve exposed to the blood stream. The strength, durability and low density make GPC a favored material for in vivo medical applications, including transcutaneous electrodes and replacement heart valves. However, the possible release of endothelial tissue that forms on the smooth surfaces of the GPC heart valve has the potential of creating an embolism. We have shown that L929 endothelial cells avoid silver implanted areas of GPC but attach and strongly adhere to areas close to silver implanted surfaces. Patterned ion implantation permits precise control of tissue growth on GPC and other biocompatible substrates. Cell growth inhibited by silver ion implanted patterns on an otherwise biocompatible substrate may be useful for in vitro studies of the way that cells sense and move away from inhospitable environments. © 2009.