Browsing by Author "Sütçü, R"
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Item A novel association between TGFβ1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetesUluçay, S; Çam, FS; Batir, MB; Sütçü, R; Bayturan, Ö; Demircan, KObjective: Coronary artery disease is characterized by atherosclerosis in the vessel wall. Recently, it has been thought that increasing LDL-binding capacity of subendothelial proteoglycan fragments that are formed by protease activity can be responsible for the initiation of atherosclerosis. ADAMTS4 is a member of the versican-degrading proteinases. In vitro studies demonstrated that TGF beta inhibits the expression of ADAMTS4 in macrophages. In this study, we aimed to investigate the role and association between TGF beta 1 and ADAMTS4 in coronary artery disease. Methods: A total of 84 cases with atheroma plaque and 72 controls without plaque were analyzed. The severity of disease was determined by Gensini score. TGF beta 1 gene polymorphisms were genotyped by the PCR-RFLP method. TGF beta 1 and ADAMTS4 serum levels were measured by ELISA method. Statistical analyses of genotypes and their relationship with serum levels were performed by chi-square, student t test and ANOVA. Results: ADAMTS4 levels were higher in cases compared with controls (p < 0.05). In the patient group, ADAMTS4 levels were higher than in controls and correlated with TGF beta 1 serum levels (r = 0.29; p < 0.05) and severity of disease (r = 0.20; p < 0.05). The TGF beta 1 gene CCA haplotype was associated with 3.3-fold increase in coronary artery disease (OR = 3.26 95% CI 1.22-8.68; p < 0.05). Unexpectedly, ADAMTS4 serum levels were also higher in diabetic cases (p = 0.05). Conclusion: This study has demonstrated that ADAMTS4 may be responsible for the pathogenesis of atherosclerosis. This is the first report about the association between ADAMTS4 and TGF beta 1 serum levels in the progression of atherosclerosis in CAD. Furthermore, it is seen that TGF beta 1 haplotype can cause a genetic susceptibility to CAD in the Turkish population. To our knowledge, this is also the first report suggesting higher serum ADAMTS4 levels in diabetic patients.Item Evaluation of Endothelial Nitric Oxide Synthase Gene Polymorphism (T-786 C) in Patients with Slow Coronary FlowYücel, H; Dogan, A; Türker, Y; Içli, A; Akcay, S; Ersoy, I; Uysal, BA; Sütçü, RItem Lack of Association between the Glu298Asp Polymorphism of Endothelial Nitric Oxide Synthase and Slow Coronary FlowYücel, H; Dogan, A; Türker, Y; Içli, A; Akçay, S; Ersoy, I; Aksoy, F; Sütçü, RItem No Association between the Methyleletetrahydrofolate Reductase A1298C Variants and Atrial Fibrillation with Ischemic Stroke in Turkish PopulationIçli, A; Erten, N; Arslan, A; Yücel, H; Akçay, S; Yasar, E; Uysal, BA; Bas, HA; Aksoy, F; Sütçü, RItem GENETIC POLYMORPHISMS OF THE HUMAN PLATELET ANTIGENS-1 IN ISOLE CORONARY ARTERY ECTASIAIçli, A; Altinbas, A; Türker, Y; Yücel, H; Akçay, S; Aksoy, F; Sütçü, R; Bas, HAItem HUMAN PLATELET ALLOANTIGENS HPA-1 POLYMORPHISMS ASSOCIATED WITH CORONARY ARTERY DISEASEIçli, A; Altinbas, A; Türker, Y; Yücel, H; Aksoy, F; Ersoy, I; Akçay, S; Sütçü, R; Arslan, AItem Prothrombin Gene Mutation (G20210A) is Not Associated with Nonvalvular Atrial Fibrillation with Ischemic Stroke in Turkish PopulationIçli, A; Erten, N; Akçay, S; Sütçü, R; Arslan, A; Yasar, EItem THE RELATIONSHIP BETWEEN ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM (T-786 C) AND ISOLE CORONARY ARTERY ECTASIAIçli, A; Altinbas, A; Türker, Y; Yücel, H; Akçay, S; Aksoy, F; Ersoy, I; Sütçü, RItem EVALUATION OF LYMPHOTOXIN-ALPHA C804A GENE POLYMORPHISMS IN PATIENTS WITH ISOLE CORONARY ARTERY ECTASIAIçli, A; Altinbas, A; Türker, Y; Akçay, S; Yücel, H; Aksoy, F; Sütçü, R; Uysal, BAItem POLYMORPHISMS OF THE APOLIPOPROTEIN B GENE R3500Q IN PATIENTS WITH CORONARY ARTERY DISEASEIçli, A; Aksoy, F; Yücel, H; Akçay, S; Sütçü, R; Arslan, A; Adali, MK; Altinbas, AItem The Relationship between Endothelial Nitric Oxide Synthase Gene Polymorphism (G894T) and Isole Coronary Artery EctasiaIçli, A; Altinbas, A; Türker, Y; Yücel, H; Akçay, S; Sütçü, R; Aksoy, F; Arslan, A; Tayyar, S; Uysal, BAItem The Beta-Fibrinogen 455 G/A Gene Polymorphism Associated with Coronary Artery DiseaseIçli, A; Altinbas, A; Türker, Y; Sütçü, R; Akçay, S; Yücel, H; Görgülü, Ö; Bas, HA; Aksoy, F; Uysal, BAItem Beta Fibrinogen-455 G>A Gene Polymorphism in Coronary Artery EctasiaIçli, A; Altinbas, A; Yücel, H; Türker, Y; Akçay, S; Sütçü, R; Görgülü, Ö; Bas, HA; Aksoy, FItem The role of prothrombotic factors in children with hemiplegic cerebral palsyYildirim, AT; Sütçü, R; Köroglu, M; Delibas, N; Kisioglu, N; Akar, N; Ilhan, IEAim. Hemiplegic cerebral palsy (HCP) is a condition occurring as a consequence of a non-progressive damage of the brain with incomplete anatomical and physical development during the early period of life. Its etiology is multifactorial, with the cause remaining unexplained in the majority of cases. This study aims to investigate whether thrombophilic factors correlates with the etiology in children with HCP. Methods. We included 36 children with HCP in the patient group, and 41 healthy children with no neurologic disorders in the control group. No significant difference was found between the two groups in terms of factor V leiden, methylenetetrahydrofolate reductase and prothrombin 20210A mutation frequency and protein C, protein S and antithrombin III levels. Results. Homocysteine levels were significantly higher in the group of patients with HCP as compared to the control group (P=0.012). Because we could not identify the origin of hyperhomocysteinemia as congenital or acquired, the impact of hyperhomocysteinemia on HCP was considered insignificant. Each thrombophilic disorder was assessed in terms of relatedness to atrophy, periventricular leukomalacia, infarct, congenital anomaly and porencephalic cyst, respectively. No significant correlation was detected between thrombophilic disorders and cranial imaging findings. Conclusion. Our study has shown that thrombophilic factors are not involved in the etiology of HCP.Item EVALUATION OF LYMPHOTOXIN-ALPHA C804A GENE POLYMORPHISMS IN PATIENTS WITH CORONARY HEART DISEASEIçli, A; Altinbas, A; Türker, Y; Yücel, H; Akçay, S; Sütçü, R; Arslan, A; Aksoy, F