Browsing by Author "Saǧduyu A."

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    A whole genome screen for linkage in Turkish multiple sclerosis
    (Elsevier, 2003) Eraksoy M.; Kurtuncu M.; Akman-Demir G.; Kilinc M.; Gedizlioglu M.; Mirza M.; Anlar Ö.; Kutlu C.; Demirkiran M.; Idrisoglu H.A.; Compston A.; Sawcer S.; Tombul T.; Asker Ö.; Balkan S.; Seçkin D.; Aydin H.; Akman-Demir G.; Kiyat A.; Yapici Z.; Epçeliden T.; Çe P.; Goldenberg E.; Gültiken B.; Güvenç A.; Işik N.; Seleker T.; Idiman E.; Özakbaş S.; Irkeç C.; Nazlier B.; Forta H.; Seleker F.; Güner K.; Karabudak R.; Kilinç M.; Komsuoǧlu S.; Efendi H.; Mert M.; Mirza M.; Erdoǧan F.; Müngen B.; Bulut S.; Özer F.; Yayla V.; Petek-Balci B.; Saǧduyu A.; Sarica Y.; Demirkiran M.; Selçuki D.; Mavioǧlu H.; Siva A.; Altintaş A.; Saip S.; Sütlaş N.; Kuşçu Yandim D.; Tireli H.; Özalp K.; Türkoǧlu R.; Örken C.; Özmanoǧlu M.; Velioǧlu S.; Özdemir G.; Gücüyener D.; Özkan S.; Tunali G.; Turan F.; Utku U.; Turgut N.; Ümit S.; Us Ö.; Ince Günal D.; Ütkür Y.; Aluçlu U.; Yavaşoǧlu Ö.; Yücemen N.; Yücesan C.; Zadikoǧlu A.; Zorlu Y.
    Factors exerting recessive effects on susceptibility to complex traits are expected to be over-represented in communities having a higher frequency of consanguineous marriage. Multiple sclerosis, a typical complex trait, is relatively common in Turkey where cultural factors also determine a high rate of consanguineous marriage. Previous genetic studies of multiple sclerosis in Turkey have been confined to the search for associations with candidate genes. In order to exploit the special genetic features of the Turkish population, we performed a whole genome screen for linkage in 43 Turkish multiplex families employing 392 microsatellite markers. Two genomic regions where maximum lod score (MLS) values were suggestive of linkage were identified (chromosomes 13q and 18q23) along with a further 14 regions of potential linkage. Parametric analysis of these data using a recessive model, appropriate for populations with a high frequency of consanguinity, increased the LOD scores in four regions. © 2003 Elsevier B.V. All rights reserved.
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    Knowledge and attitudes of general practitioners about depression
    (2008) Saǧduyu A.; Özmen E.; Aker T.; Ögel K.; Uǧuz Ş.; Tamar D.; Boratav C.; Liman O.
    Objectives: The purpose of this study is to learn more about general practititoners' knowledge, attitudes and social distance towards depression which is the most prevalent mental disorder seen in general practice. Method: The survey was conducted in 2002 using face-to-face interviews in offices of 300 general practitioners in Turkey. Data were derived from the questionnaire developed for the survey called "Attitudes Towards Mental Disorders". Results: Almost all of the practitioners believed that depression was treatable, and it could be completely cured according to 90% of the respondents. 80% of the practitioners considered "extreme sadness", near half of them "weak personality" and more than 90% "social handicaps" to be as the causes of depression. 66% believed that these patients would not improve unless social problems were solved. Attitudes of the subjects with relatives diagnosed depression, married, and older were more positive than the others with respect to social distance characteristics. Discussion: Although general practitoners with closer social distance held more positive attitudes towards depression than community people, the results suggest that incorrect knowledge and beliefs about etiology, nonmedical treatment methods and risk of dependency have a tendency to persist in this group. The results of this study underline the need for development of new education programmes aimed to decrease effects of stigmatization based upon information obtained more studies about attitudes and beliefs of physicians.