Browsing by Author "Saatci, M"

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    Synthesis and in vitro characterization of superparamagnetic γ-Fe2O3-containing 13-93 bioactive glasses for bone cancer therapy
    Saatci, M; Deliormanli, AM; Atmaca, H
    Osteosarcoma is one of the most common types of bone cancer, which generally starts in the long bones. In this study, superparamagnetic maghemite-containing (2, 5, 10, 20 wt%) bioactive glass powders were prepared for the treatment of osteosarcoma. For this purpose, maghemite nanoparticles were synthesized using the co -precipitation technique, and maghemite-containing bioactive glass-ceramic composites were fabricated through the sol-gel process. The structural, morphological, thermal, and magnetic properties and the in vitro bioactivity of the prepared bioactive glasses were investigated. In vitro cytotoxicity was examined using SaOS-2 and MC3T3-E1 cells. The fluorouracil (5-FU) release behavior of the studied bioactive glass powders was also monitored in phosphate-buffered saline as a function of time. Results revealed that synthesized maghemite nanoparticles as well as the maghemite-containing bioactive glass-ceramic composites have superparamagnetic properties. They have high bioactivity, with up to 5 wt% maghemite content. Prepared bioactive glass com-posites have no cytotoxicity against osteosarcoma and pre-osteoblast cells at low concentrations. Drug-loaded bioactive glass powder showed sustained release behavior. Overall results indicated that prepared glass com-posites have a high potential to be used in magnetic hyperthermia and anticancer drug release applications for the treatment of bone cancer.
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    Synthesis, characterization, and 5-fluorouracil release behavior of superparamagnetic ?-Fe2O3/ZnO hetero-nanostructures for biomedical applications
    Saatci, M; Deliormanli, AM
    In this study, superparamagnetic maghemite (gamma-Fe2O3) nanosystems in the form of nanoparticles were fabricated through the co-precipitation method at different processing conditions. Additionally, novel gamma-Fe2O3/ZnO het-erostructures were fabricated using zinc acetate as the zinc source and polyvinyl pyrrolidone (PVP), and eth-ylenediaminetetraacetic acid (EDTA) as the capping agents. The results revealed that the size of the crystallites of the prepared maghemite nanopowders was between 6 nm and 7.8 nm depending on the synthesis temperature. The saturation magnetization value of maghemite nanopowders synthesized at 90 degrees C was measured to be 51.58 emu/g without hysteresis with negligible coercivity. FTIR analysis results proved the presence of ZnO in the maghemite core-based nanosystem. The formation of a ZnO coating using zinc acetate in the presence of PVP and EDTA as a capping agent caused a decrease in magnetization value to 12 emu/g. A ZnO coating provided better dispersion of maghemite nanoparticles and it also affected the drug (5-FU) delivery behavior. ZnO-coated nanoparticles showed prolonged and sustained drug release additionally, they continue to release the drug after 410 h. The 5-FU release kinetics of the prepared heterogeneous nanostructures fitted well with the Korsmeyer-Peppas model.