Browsing by Author "Sahin, H"
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Item Experimental and computational investigation of graphene/SAMs/n-Si Schottky diodesAydin, H; Bacaksiz, C; Yagmurcukardes, N; Karakaya, C; Mermer, O; Can, M; Senger, RT; Sahin, H; Selamet, YWe have investigated the effect of two different self-assembled monolayers (SAMs) on electrical characteristics of bilayer graphene (BLG)/n-Si Schottky diodes. Novel 4bis(diphenylamino)-1, 1':3-terpheny1-5' carboxylic acids (TPA) and 4,4-di-9H-carbazol-9-y1-1,1':3'1'-terpheny1-5' carboxylic acid (CAR) aromatic SAMs have been used to modify n-Si surfaces. Cyclic voltammetry (CV) and Kelvin probe force microscopy (KPFM) results have been evaluated to verify the modification of n-Si surface. The current-voltage (I-V) characteristics of bare and SAMs modified devices show rectification behaviour verifying a Schottky junction at the interface. The ideality factors (n) from ln(I)-V dependences were determined as 2.13,1.96 and 2.07 for BLG/n-Si, BLG/TPA/n-Si and BLG/CAR/n-Si Schottky diodes, respectively. In addition, Schottky barrier height (SBH) and series resistance (Rs) of SAMs modified diodes were decreased compared to bare diode due to the formation of a compatible interface between graphene and Si as well as n-n interaction between aromatic SAMs and graphene. The CAR-based device exhibits better diode characteristic compared to the TPA-based device. Computational simulations show that the BLG/CAR system exhibits smaller energy-level-differences than the BLG/TPA, which supports the experimental findings of a lower Schottky barrier and series resistance in BLG/CAR diode. (C) 2017 Elsevier B.V. All rights reserved.Item The impact of second generation antipsychotics on psychosocial functioning in bipolar disorderAydemir, O; Cetinay-Aydin, P; Gulec-Oyeckin, D; Gulseren, S; Putgul-Koybasi, G; Sahin, HItem Can Aortic and Renal Arteries Calcium Scores Be New Factors to Predict Post-Operative Renal Function After Nephron Sparing Surgery?Akarken, I; Bilen, CY; Özden, E; Gülsen, M; Üçer, O; Sahin, HSeveral nonmodifiable factors are associated with worse postoperative renal function in patients that have undergone nephron sparing surgery. Also, a positive correlation between renal disease and the calcification of renal arteries has been shown. This study aimed to investigate whether the calcification of renal arteries and aorta may be risk factors for developing chronic kidney disease after nephron sparing surgery Introduction: This study aims to investigate whether the calcification of renal arteries and aorta may be risk factors for developing chronic kidney disease (CKD) after Nephron sparing surgery (NSS). Materials and Methods: The patients that underwent either open or laparoscopic NSS from 2000 to 2019 in 4 different centers were retrospectively assessed. Of these patients, 328 had a non-contrast-enhanced computer tomography. Calcium scores of the renal arteries and abdominal aorta were measured in the non-contrast-enhanced images with the calcium score plugin (version 2.0) of Horos (TM). Univariate and multivariate logistic regression analysis was performed to determine significant risk factors for developing CKD at the last check-up. Roc curve analysis was performed to determine the optimal cut-off values of age and abdominal aorta calcium scores. Results: A total of 302 patients, of which 52 (16,6%) with CKD and 252 (83,4%) without CKD at the last check-up, were included in the analysis. The mean warm ischemia duration was significantly higher in patients with CKD (18,79 +/- 6,72 vs 16,38 +/- 5,57 minutes, p=0,016). The mean size of the tumor diameter and the number of the patients with >= stage T1b were higher in the group with CKD (p=0,024 and 0,005, respectively). The median calcium scores of the aorta and renal arteries were higher in the group with CKD (p <0,001 and p< 0,001, respectively). In multivariate analysis, age >60 years (OR:3,65, p=0,022), calcium score of the aorta (OR:4,07, p=0,029), tumor diameter (OR:1,03, p=0,026) and pre-operative CKD stage (OR:10,13, p, 0,001) found the be significant factors for predicting last check-up CKD. Conclusion: The calcium score of the aorta may be used as an additional risk factor to predict post-operative CKD risk after NSS with sensitivity over 80%. (C) 2021 Elsevier Inc. All rights reserved.Item Efficacy of switching to eletriptan in migraine patients unsuccessfully treated with NSAIDsErtas, M; Komurculu, N; Artug, R; Selcuki, D; Karaali-Savrun, F; Goksan, B; Gokcay, F; Sirin, H; Aksoy, O; Irkec, C; Gur, M; Neyal, M; Mavioglu, A; Kansu, T; Kocasoy-Orhan, E; Sahin, H; Ozbenli, TItem The Impact of Psychotropic Drugs on Psychosocial Functioning in Bipolar DisorderAydemir, O; Aydin, PC; Oyeckin, DG; Gulseren, S; Koybasi, GP; Sahin, HObjective: Even though bipolar patients achieve remission, they do not reach. premorbid psychosocial functioning. Factors such as residual depressive symptoms and number of episodes may cause this effect. The impact of treatment modalities has not been adequately studied. The aim of this study was to evaluate the impact of treatment modalities on psychosocial functioning in remitted bipolar patients. Methods: The study was carried out with 108 patients diagnosed as having bipolar disorder. All patients were in remission and the remission state was confirmed by rating scales. In the assessment of functioning, the Functioning Assessment Short Test (FAST) covering domains such as autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relations, and leisure time activities was applied. The treatment modalities were mood stabilizers (MS) versus mood stabilizers plus second-generation antipsychotics (MS+SGA). While 38% (n=41) of the patients were on MS only, 67 patients (62%) were on MS+SGA. In the statistical analysis, multiple linear regression analysis was performed. Results: In multiple linear regression analyses, the models concerning autonomy, interpersonal relations, and leisure time were statistically significant. In patients on MS+SGA, autonomy (Beta=3.086, p<0.01), interpersonal relations (Beta=2.807, p<0.01) and leisure time activities (Beta=3.293, p<0.01) were affected negatively. Similarly, total HAM-D score had negative effects on the same domains. Conclusion: Beside residual depressive symptoms, second-generation antipsychotics used in the treatment seem to affect psychosocial functioning negatively.Item The impact of second-generation antipsychotics on psychosocial functioning in bipolar disorderAydemir, O; Cetinay-Aydin, P; Gulec-Oyeckin, D; Gulseren, S; Putgul-Koybasi, G; Sahin, H