Browsing by Author "Sahin, O"
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Item Imiquimod 5% cream for isolated lichen planus of the lipGencoglan, G; Inanir, I; Sahin, O; Gunduz, KLichen planus (LP) of the lips is a rare condition that is generally associated with other parts of the oral mucosa. Lip localization has an increased risk, since external trauma, smoking and ultraviolet light trigger malignant transformation. Only a few cases of isolated LP of the lips have been reported up to now, but results of larger series on oral LP suggest that it might be underestimated. Treatment of oral LP is usually difficult and lesions are generally resistant or recur, so that novel therapy alternatives are necessary. Here we report four cases of isolated LP of the lip successfully treated with imiquimod 5% cream. It was applied twice daily, 5 days a week, for 2 weeks. Two weeks after therapy, complete clinical and histopathological resolution was observed. No recurrence was observed during the 5, 10 and 18 months' follow-up period in cases 4, 3 and 1, respectively. Clinical and histopathological cure was also observed in case 2, but the patient showed clinical activation after 6 months. We suggest that imiquimod 5% cream is a safe and effective therapeutic treatment for oral LP.Item Synthesis and cytotoxic activities of organometallic Ru(II) diamine complexesKavukcu, SB; Sahin, O; Vatansever, HS; Kurt, FO; Korkmaz, M; Kendirci, R; Pelit, L; Türkmen, HA series of mono and bimetallic ruthenium(II) arene complexes bearing diamine (Ru1-6) were prepared and fully characterized by H-1, C-13, F-19, and P-31 NMR spectroscopy and elemental analysis. The crystal structure of the bimetallic complex (Ru-5) was determined by X-ray crystallography. Monometallic analogues (Ru1-3) were synthesized to investigate the contributions of ruthenium and the other organic groups (aren, ethylenediamine, butyl) to the activity. The electrochemical behaviors of mono and bimetallic complexes were obtained from the relationship between cyclic voltammetry (CV) and the biological activities of the compounds. The cytotoxic activities of the complexes (Ru1-6) were tested against wide-scale cancer cell lines, namely HeLa, MDA-MB-231, DU-145, LNCaP, Hep-G2, Saos-2, PC-3, and MCF-7, and normal cell lines 3T3-L1 and Vero. Diamine Ru(II) arene complexes have unique biological characteristics and they are promising models for new anticancer drug development. MTT analysis reveals that each synthesized Ru complex showed cytotoxic activity towards the different cancer cells. In particular, three Ru complexes (Ru-3, Ru-5 and Ru-6) showed less toxic effects on the cancer cells than the others. These novel Ru complexes affected both cancer and normal cell lines. As they had a toxic effect on the cells, the dosage applied should be tested before being used for in vivo applications. Cytotoxicity tests have shown that the bimetallic complex Ru-6 was effective on all cancer cells. The effect of bimetallic enhancement on cancer cell lines, the systematic variation of the intermetallic distance and the ligand donor properties of the mono and bimetallic complexes were explored based on the cytotoxic activity. The interaction with FS-DNA and the stability/aquation of the complexes (Ru-3 and Ru-6) were investigated with H-1 NMR spectroscopy. The binding modes between the complexes (Ru-3 and Ru-6) and DNA were investigated via UV-Vis spectroscopy.Item Prevalence of metabolic syndrome and its association with erectile dysfunction among urologic patientsBal, K; Öder, M; Sahim, AS; Karatas, CT; Demir, Ö; Can, E; Gümüs, BH; Özer, K; Sahin, O; Esen, AAOBJECTIVES To identify the prevalence of metabolic syndrome (MS) and its association with erectile dysfunction (ED) among urologic patients. METHODS The study population consisted of 393 male patients aged 40 to 70 years, who were admitted to the urology clinics of four different institutions from February to March 2005. The waist circumference (WC) and triglyceride (TG) and high-density lipoprotein (HDL) cholesterol levels were measured. Patients were divided into two groups: group I consisted of patients with a WC greater than 102 cm, and group 2 consisted of patients with a WC of less than 102 cm. The erectile status of the two groups was compared. RESULTS Of the 393 patients, 157 (39.9%) had MS. Of the 393 patients, 124 with MS (79%) and 146 without MS (61.9%) had ED. The presence of MS was significantly associated with ED (P < 0.001). In the presence of an increased WC with normal serum HDL and TO levels, the relative risk of ED was 1.94. If the patient with an increased WC had a pathologic level of HDL or TG, the relative risk of ED increased up to 2.97-fold. The relative risk of ED in the presence of an increased WC, together with pathologic levels of HDI, and TO, was 3.38. CONCLUSIONS In our study, MS was strongly associated with ED. Fasting blood glucose levels, hypertension, and WC are the most significant risk factors predicting the risk of ED. A more pronounced increase in ED risk in the presence of abdominal obesity, together with altered TG and HDL cholesterol levels, may indicate a special metabolic background of ED regarding tipid metabolism.Item THE RELATIONSHIP BETWEEN MRI FINDINGS, PAIN AND DISABILITY IN THE PATIENTS WITH CERVICAL OSTEOARTHRITISAltan, L; Ökmen, BM; Tuncer, T; Akarirmak, U; Ayhan, F; Bal, A; Bozbas, G; Cerrahoglu, L; Cevik, R; Durmaz, B; Duruöz, T; Dülgeroglu, D; Gürer, G; Gürsoy, S; Hepgüler, S; Hizmetli, S; Kaçar, C; Kaptanoglu, E; Kocabas, H; Nas, K; Nur, H; Özçakir, S; Özdolap, S; Sindel, D; Sahin, O; Sendur, F; Tikiz, C; Ugurlu, HItem THE FREQUENCY AND ASSOCIATION OF KNEE, HIP, HAND AND SPINE OSTEOARTHRITIS IN TURKISH POPULATION: A PRELIMINARY RE PORT OF MULTICENTER LONGITUDINAL STUDYTuncer, T; Ugur, S; Nur, H; Kacar, C; Akarimak, U; Altan, L; Ayhan, F; Bal, A; Basaran, S; Bilgilisoy, M; Bozbas, G; Cerrahoglu, L; Cevik, R; Coskun, N; Dagli, Z; Durmaz, B; Duruoz, T; Dulgeroglu, D; Gurer, G; Gursoy, S; Hepguler, S; Hizmetli, S; Kaplanoglu, E; Kaya, T; Kocabas, H; Kuran, B; Melikoglu, M; Nas, K; Oncu, J; Ozcakir, S; Ozdolap, S; Saridogan, M; Sarikaya, S; Sindel, D; Sahin, O; Sendur, OF; Tikiz, C; Ugurlu, H; Yilmaz, FItem THE RADIOLOGICAL, CLINICAL AND FUNCTIONAL PROPERTIES OF HAND OSTEOARTHRITIS AND THEIR RELATION WITH RADIOLOGICAL FINDINGS IN A TURKISH POPULATION: TLAR-OA STUDYDuruöz, MT; Erdem, D; Tuncer, T; Altan, L; Ayhan, F; Bal, A; Cerrahoglu, L; Capkin, E; Cevik, R; Dulgeroglu, D; Gursoy, S; Hizmetli, S; Kacar, C; Kaptanoglu, E; Kaya, T; Kocabas, H; Nas, K; Ozcakir, S; Sindel, D; Sahin, O; Bozbas, GT; Tikiz, C; Ugurlu, HItem Performance of engineered cementitious composites under drop-weight impact: Effect of different mixture parametersYildirim, G; Khiavi, FE; Anil, Ö; Sahin, O; Sahmaran, M; Erdem, RTCurrent research focuses on the experimental and numerical determination of impact performance of engineered cementitious composites (ECC). Performance assessment of ECC beams with different mixture parameters was made. Mixtures were produced with different replacement rates of Class-F fly ash and slag with Portland cement, water to binder ratios and fiber types (polyvinyl alcohol [PVA] and nylon [N]). Experimental works were validated with incremental dynamic analyses performed by ABAQUS finite element software. Impact testing results were further supported by mechanical property results. Results reveal that each individual mixture parameter used is distinctively effective in modifying the properties under both sudden impact and slow static loading. In brief, enhanced impact resistance is noted when ECC is produced with slag, low amounts of pozzolanic materials, low W/B ratio, fiber addition and PVA fibers. Experimental results were also in line with the numerical results from ABAQUS largely. Significantly, cost-effective N fibers were also shown to be fully replaceable with costly PVA fibers without jeopardizing mechanical/impact performance, if mixture design parameters are adjusted suitably. Current research is likely to attract further research on the development of ECC that is with lower cost and comparable impact/mechanical performance with regards to widely studied more expensive counterparts in the literature.Item Correlation of clinical signs and magnetic resonance imaging findings in patients with lumbar spondylosisAltan, L; Ökmen, BM; Tuncer, T; Sindel, D; Çay, HF; Hepgüler, S; Sarikaya, S; Ayhan, F; Bal, A; Bilgilisoy, M; Çapkin, E; Cerrahoglu, L; Çevik, R; Dülgeroglu, D; Durmaz, B; Duruöz, T; Gürer, G; Gürsoy, S; Hizmetli, S; Kaçar, C; Kaptanoglu, E; Ecesoy, H; Melikoglu, M; Nas, K; Nur, H; Özcakir, S; Sahin, N; Sahin, O; Saridogan, M; Sendur, ÖF; Sezer, I; Bozbas, GT; Tikiz, C; Ugurlu, HObjectives: The purpose of the study was to contribute further to this debated topic by investigating the correlation of magnetic resonance imaging (MRI) findings with the clinical picture in lumbar spondylosis patients.Patients and methods: This multicenter retrospective study (as part of the epidemiological project of the TLAR-OASG [Turkish League Against Rheumatism-Osteoarthritis Study Group]) included 514 patients (101 males, 413 females; mean age: 63.6 +/- 10.8 years; range, 40 to 85 years) who were diagnosed as lumbar spondylosis by clinical examination and direct X-ray between December 2016 and June 2018. Demographic characteristics of patients, Visual Analog Scale for pain, presence of radiating pain, Roland-Morris disability questionnaire, straight leg raise test, deep tendon reflexes, neurogenic intermittent claudication symptoms, any decrease of muscle strength, and abnormality of sensation were recorded. Lumbar MRI findings of the patients were recorded as positive or negative in terms of disc herniation, intervertebral disc degeneration, root compression, osteophytes, spinal stenosis. Statistical analysis was done to assess the correlation between the clinical symptoms, physical examination, and MRI findings.Results: Correlation analysis of the MRI results and the clinical findings showed a significant correlation between straight leg raise test and root compression (p<0.001, r=0.328) and a significant correlation between neurogenic intermittent claudication and spinal stenosis (p<0.001, r=0.376). Roland-Morris disability questionnaire had a significant correlation with all MRI findings (p<0.05, r<0.200). Conclusion: The results of this study corroborate the notion that diligent patient history and physical examination are more valuable than MRI findings, even though a higher incidence of abnormal MRI findings have been obtained in patients with disability and dermatomal radiating pain.Item Evaluation and follow-up of patients diagnosed with hypophysitis: a cohort studyHacioglu, A; Karaca, Z; Uysal, S; Ozkaya, HM; Kadioglu, P; Selcukbiricik, OS; Gul, N; Yarman, S; Koksalan, D; Selek, A; Canturk, Z; Cetinarslan, B; Corapcioglu, D; Sahin, M; Unal, FTS; Babayeva, A; Akturk, M; Ciftci, S; Piskinpasa, H; Dokmetas, HS; Dokmetas, M; Sahin, O; Eraydin, A; Fenkci, S; Ozturk, S; Akarsu, E; Omma, T; Erkan, B; Burhan, S; Koroglu, EP; Saygili, F; Kan, EK; Atmaca, A; Elbuken, G; Uc, ZA; Gorar, S; Hekimsoy, Z; Pekkolay, Z; Bostan, H; Bayram, F; Yorulmaz, G; Sener, SY; Turan, K; Celik, O; Dogruel, H; Ertorer, E; Iyidir, OT; Topaloglu, O; Cansu, GB; Unluhizarci, K; Kelestimur, FObjective Primary hypophysitis might be challenging to diagnose, and there is a lack of evidence regarding optimal treatment strategies due to rarity of the disease. We aim to investigate the clinical features and compare the outcomes of different management strategies of primary hypophysitis in a large group of patients recruited on a nationwide basis.Design A retrospective observational study.Methods The demographic, clinical, and radiologic features and follow-up data were collected in study protocol templates and analyzed.Results One hundred and thirteen patients (78.8% female, median age: 36 years) were included. Lymphocytic (46.7%) and granulomatous hypophysitis (35.6%) were the prevailing subtypes out of 45 patients diagnosed after pathologic investigations. Headache (75.8%) was the most common symptom, and central hypogonadism (49.5%) was the most common hormone insufficiency. Of the patients, 52.2% were clinically observed without interventions, 18.6% were started on glucocorticoid therapy, and 29.2% underwent surgery at presentation. Headache, suprasellar extension, and chiasmal compression were more common among glucocorticoid-treated patients than who were observed. Cox regression analysis revealed higher hormonal and radiologic improvement rates in the glucocorticoid-treated group than observation group (hazard ratio, 4.60; 95% CI, 1.62-12.84 and HR, 3.1; 95% CI, 1.40-6.68, respectively). The main indication for surgery was the inability to exclude a pituitary adenoma in the presence of compression symptoms, with a recurrence rate of 9%.Conclusion The rate of spontaneous improvement might justify observation in mild cases. Glucocorticoids proved superior to observation in terms of hormonal and radiologic improvements. Surgery may not be curative and might be considered in indeterminate, treatment-resistant, or severe cases.Item Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary ReportKaptanoglu, E; Sahin, O; Tuncer, T; Hizmetli, S; Altan, L; Ayhan, F; Bal, A; Bilgilisoy, M; Bozbas, G; Cerrahoglu, L; Cevik, R; Duruoz, T; Dulgeroglu, D; Gurer, G; Gursoy, S; Hepguler, S; Kacar, C; Kaya, T; Melikoglu, M; Nas, K; Ozcakir, S; Ozdolap, S; Saridogan, M; Sarikaya, S; Sindel, D; Sendur, OF; Tikiz, C; Ugurlu, H