Browsing by Author "Sahin N."
Now showing 1 - 14 of 14
Results Per Page
Sort Options
Item Isolation, characterization and numerical taxonomy of novel oxalate-oxidizing bacteria(2002) Sahin N.; Gökler I.; Tamer A.Ü.The present work is aimed at providing additional new pure cultures of oxalate utilizing bacteria and its preliminary characterization for further work in the field of oxalate-metabolism and taxonomic studies. The taxonomy of 14 mesophilic, aerobic oxalotrophic bacteria isolated by an enrichment culture technique from soil, rhizospheres, and the juice of the petiole/stem tissue of plants was investigated. Isolates were characterized with 95 morphological, biochemical and physiological tests. Cellular lipid components and carotenoids of isolates were also studied as an aid to taxonomic characterization. All isolates were Gram-negative, oxidase and catalase positive and no growth factors were required. In addition to oxalates, some of the strains grow on methanol and/or formate. The taxonomic similarities among isolates, reference strains or previously reported oxalotrophic bacteria were analysed by using the Simple Matching (SSM) and Jaccard (SJ) Coefficients. Clustering was performed by using the unweighted pair group method with arithmetic averages (UPGMA) algorithm. The oxalotrophic strains formed five major and two single-member clusters at the 70-86% similarity level. Based on the numerical taxonomy, isolates were separated into three phenotypic groups. Pink-pigmented strains belonged to Methylobacterium extorquens, yellow-pigmented strains were most similar to Pseudomonas sp. YOx and Xanthobacter autotrophicus, and heterogeneous non-pigmented strains were closely related to genera Azospirillum, Ancylobacter, Burkholderia and Pseudomonas. New strains belonged to the genera Pseudomonas, Azospirillum and Ancylobacter that differ taxonomically from other known oxalate oxidizers were obtained. Numerical analysis indicated that some strains of the yellow-pigmented and nonpigmented clusters might represent new species.Item Identification of oxalotrophic bacteria by neural network analysis of numerical phenetic data(2006) Sahin N.; Aydin S.A new approach with artificial neural network (ANN) was applied to numerical taxonomy of bacteria using the oxalate as carbon and energy source. For this aim the characters effective in differentiating separate groups were selected from morphological, physiological and biochemical test results. Fourteen aerobic, Gram-negative, oxalate-utilizing isolates and four oxalate-utilizing reference strains (Ralstonia eutropha DSM 428, Methylobacterium extorquens DSM 1337T, Ralstonia oxalatica DSM 1105T, Oxalicibacterium flavum DSM 15506T) were included in the study. ANN program used here was developed in Borland C++ language. Iterations were performed on an IBM compatible PC computer. ANN architecture having feed-forward backpropagation algorithm was used for teaching generalized δ rule. The results show that ANN can have a large potential in solving the taxonomic problems of oxalate-utilizing bacteria.Item Pandoraea oxalativorans sp. nov., Pandoraea faecigallinarum sp. nov. and Pandoraea vervacti sp. nov., isolated from oxalate-enriched culture(2011) Sahin N.; Tani A.; Kotan R.; Sedláček I.; Kimbara K.; Tamer A.U.Five isolates, designated TA2, TA4, TA25 T KOx T and NS15 T were isolated in previous studies by enrichment in mineral medium with potassium oxalate as the sole carbon source and were characterized using a polyphasic approach. The isolates were Gram-reaction-negative, aerobic, non-spore-forming rods. Phylogenetic analyses based on 16S rRNA and DNA gyrase B subunit (gyrB) gene sequences confirmed that the isolates belonged to the genus Pandoraea and were most closely related to Pandoraea sputorum and Pandoraea pnomenusa (97.2-99.7% 16S rRNA gene sequence similarity). The isolates could be differentiated from their closest relatives on the basis of several phenotypic characteristics. The major cellular fatty acid profiles of the isolates comprised C 16: 0, C 18: 1 ω 7c, C17: 0 cyclo and summed feature 3 (C 16: 1ω7c and/or iso-C15: 0 2-OH). On the basis of DNA-DNA hybridization studies and phylogenetic analyses, the isolates represent three novel species within the genus Pandoraea, for which the names Pandoraea oxalativorans sp. nov. (TA25 T 5NBRC 106091 T 5CCM 7677 T 5DSM 23570 T), Pandoraea faecigallinarum sp. nov. (KOx T 5NBRC 106092 T 5CCM 2766 T 5DSM 23572 T) and Pandoraea vervacti sp. nov. (NS15 T 5NBRC 106088 T 5CCM 7667 T 5DSM 23571) are proposed. © 2011 IUMS.Item Isokinetic evaluation of knee extensor/flexor muscle strength in Behcet's patients(Sociedade Portuguesa de Reumatologia, 2015) Durmus B.; Emre S.; Sahin N.; Karincaoglu Y.; Dogan E.; Baysal O.; Ersoy Y.; Altay Z.Background: Behçet's disease (BD) is an idiopathic, multisystemic, progressive disease. The purpose of this study is to compare the knee flexor and extensor isokinetic muscle strengths of Behcet's patients with that of healthy subjects. Methods: Twenty-five (13 male and 12 female) patients with BD and 25 (15 male and 10 female) healthy individuals were included in the study. Velocities of 90°/sec, 120°/sec, and 150°/sec were used for the isokinetic muscle strength testing. Patients with active inflammatory knee arthritis were excluded. Peak torque (Nm) and peak torque adjusted to body weight (%) were taken into consideration for comparison between study groups. Results: Compared to healthy controls, there was a statistically significant decrease in both the bilateral knee extensor and flexor muscle isokinetic peak torques (Nm) as well as the peak torques adjusted to body weight (%) at velocities of 90°/sec, 120°/sec and 150°/sec in patients with BD (p < 0.05). However, there was no significant difference in the agonist-antagonist ratio of the isokinetic peak torques of knee muscles between the two groups. Conclusion: In light of these findings, we have concluded that both knee flexor and extensor isokinetic muscle strengths are lower in BD. We therefore recommend careful monitoring of patients with BD in terms of muscle strength.Item Montelukast is effective in preventing of ovarian hyperstimulation syndrome; an experimental study(Studio K Krzysztof Molenda, 2015) Eskicioğlu F.; Turan G.A.; Sivrikoz O.N.; Cengiz H.; Akan Z.; Sahin N.; Yilmaz O.; Yesil H.; Vatansever S.Objectives: To determine the efficacy of montelukast in comparison with cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in rats. Material and methods: An experimental OHSS model was formed in 35 female Wistar rats. Rats (22 days old) were randomized into 5 groups, each containing 7 animals. The control group received no therapy; the mild OHSS group was administered pregnant mare serum gonadotropin (PMSG) 10 IU for 4 days, hCG 10 IU on the 5th day; the severe OHSS group received PMSG 10 IU for 4 days, hCG 30 IU on the 5th day. The montelukast group: received montelukast 10 mg/kg/day and the cabergoline group was administered cabergoline 100μg/kg/day via oral gavage for 6 days (days 22-27), in addition to those of severe OHSS. All groups were sacrificed on 28th day. Body weight, ovarian diameter and weight, vascular permeability, vascular endothelial growth factor (VEGF), semiquantitative VEGF receptor-1, and VEGF receptor-2 (VEGFR-2) immunohistochemistry were evaluated. Results: Ovarian diameter and VEGF expression were significantly lower in the montelukast and cabergoline groups than in the severe OHSS group. While montelukast was more effective in limiting vascular permeability in the severe OHSS, cabergoline was superior to montelukast with respect to the limiting effect on increased body weight and VEGFR-2 expression. Conclusions: The VEGF/VEGFR-2 interaction plays an important role in OHSS pathogenesis. Montelukast limits VEGF expression, and cabergoline reduces both VEGF and VEGFR-2 expressions; they are both effective therapies for the prevention of severe OHSS. © Polskie Towarzystwo Ginekologiczne.Item Myo-inositol is a promising treatment for the prevention of ovarian hyperstimulation syndrome (OHSS): an animal study(Springer Verlag, 2015) Turan G.A.; Eskicioglu F.; Sivrikoz O.N.; Cengiz H.; Adakan S.; Gur E.B.; Tatar S.; Sahin N.; Yilmaz O.Purpose: To evaluate the efficacy of myo-inositol (MI) pretreatment in OHSS. Methods: In this experimental OHSS rat model, 42 immature Wistar albino female rats were divided into 6 groups: (1) the control group, (2) the ovarian stimulation group, (3) the OHSS group, (4) the OHSS + Metformin group, (5) OHSS + MI group, (6) OHSS + Metformin + MI group. OHSS was established after treatment with metformin and myo-inositol for 14 days, in the meanwhile the treatment of metformin and myo-inositol was also continued. All animals were killed 48 h after hCG administration and were compared in terms of vascular permeability, ovarian weight and diameter, ovarian VEGF, COX-2 and PEDF expression (immunohistochemistry), serum PEDF and estradiol (E2) levels. Results: Vascular permeability, VEGF and COX-2 expressions were reduced in animals treated with MI and/or metformin. While PEDF expression was increased in the groups taking metformin, there was no difference in PEDF expression in the group taking MI and OHSS group. There was no significant difference in serum PEDF levels between groups. Blood E2 levels were decreased in groups treated with MI or metformin compared to the OHSS group. Conclusions: Our data demonstrate that myo-inositol is effective in preventing OHSS, similar to metformin. Although the two drugs are thought to act through distinct mechanisms, there is no apparent benefit to co-treatment with both drugs in an animal model of OHSS. Administration of myo-inositol prior to IVF treatment may favor the control of ovulation induction. Further studies are necessary to elucidate the mechanism of action and further support our findings. © 2015, The Author(s).Item Prophylactic vitamin D supplementation in ovarian hyperstimulation syndrome: an animal study(Springer Verlag, 2015) Turan G.A.; Eskicioglu F.; Sivrikoz O.N.; Cengiz H.; Gur E.B.; Tatar S.; Sahin N.; Yilmaz O.Purpose: To investigate the effect of vitamin D in ovarian hyperstimulation syndrome (OHSS). Methods: In this animal study, 28 immature female Wistar rats were divided into four groups: group 1 (control); group 2 (ovarian stimulation); group 3 (OHSS group); group 4 (OHSS + vitamin D group). All groups were killed 48 h after hCG administration and were compared in terms of vascular permeability, ovarian weight, ovarian diameter, vascular endothelial growth factor (VEGF) expression (immunohistochemistry) in ovarian tissue and pigment epithelium-derived factor (PEDF) level in the serum (ELISA test) with the Kruskal–Wallis and Mann–Whitney U tests. Results: VEGF expression in the vitamin D group was similar to that in the OHSS group. However, the PEDF level was significantly higher in the vitamin D group (p = 0.013). Conclusions: Prophylactic vitamin D supplementation is not sufficiently effective in preventing OHSS. Vitamin D effectively increases PEDF, which has an opposing effect on VEGF, which plays a key role in OHSS. Thus, the protective effect of Vitamin D on OHSS should be investigated with a vitamin D deficient model in the study group. © 2015, Springer-Verlag Berlin Heidelberg.Item Pregnancy rhinitis in Turkish women: Do gestational week, BMI and parity affect nasal congestion?(Professional Medical Publications, 2016) Ulkumen B.; Artunc Ulkumen B.; Pala H.G.; Celik O.; Sahin N.; Karaca G.; Demirdag M.Objective: To determine the cumulative incidence of pregnancy rhinitis along with prevalence in different trimesters and to find out whether gestational age, BMI and parity have any effect on pregnancy related nasal congestion. Methods: In the prospective protocol at the obstetrics outpatient clinic, 167 pregnant women were enrolled consecutively. According to exclusion criteria, 67 of them were excluded. Visual-Analogue-Scale (VAS), Nasal-Obstructive-Symptom-Evaluation (NOSE) scale and Discharge-Inflammation-Polyps/Oedema (DIP) scoring were utilized for diagnosis of pregnancy rhinitis. Besides, weight, length, age, parity and week of pregnancy were recorded. Results: Total prevalence of pregnancy rhinitis was 17.17% and cumulative incidence was 38.89%. Our study revealed significant relation of NOSE score with both gestational week (r=0.474, p=0.001) and BMI (r=0.301, p=0.003). VAS score was significantly related with gestational week (r=0.409, p=0.001) and BMI (r=0.270, p=0.007). DIP score was found to be correlated only with gestational week (r=0.375, p=0.001). Conclusion: Cumulative incidence of pregnancy rhinitis was 38.89%. Nasal congestion was significantly associated with BMI and gestational week. Patients should be informed about unfavorable fetal and maternal outcomes of pregnancy related nasal congestion which is triggered by obesity and excessive weight gain in pregnancy. © 2016, Professional Medical Publications. All rights reserved.Item Erratum to Myo-inositol is a promising treatment for the prevention of ovarian hyperstimulation syndrome (OHSS): an animal study [Arch Gynecol Obstet, (2015), 292, (1163-1171), DOI 10.1007/s00404-015-3747-5](Springer Verlag, 2016) Turan G.A.; Eskicioglu F.; Sivrikoz O.N.; Cengiz H.; Adakan S.; Gur E.B.; Tatar S.; Sahin N.; Yilmaz O.[No abstract available]Item Erratum to Prophylactic vitamin D supplementation in ovarian hyperstimulation syndrome: an animal study [Arch Gynecol Obstet, (2015), 292, (421-427), DOI 10.1007/s00404-015-3625-1](Springer Verlag, 2016) Turan G.A.; Eskicioglu F.; Sivrikoz O.N.; Cengiz H.; Gur E.B.; Tatar S.; Sahin N.; Yilmaz O.[No abstract available]Item Prevalence of Childhood Affective disorders in Turkey: An epidemiological study(Elsevier B.V., 2018) Karacetin G.; Arman A.R.; Fis N.P.; Demirci E.; Ozmen S.; Hesapcioglu S.T.; Oztop D.; Tufan A.E.; Tural U.; Aktepe E.; Aksu H.; Ardic U.A.; Basgul S.; Bilac O.; Coskun M.; Celik G.G.; Demirkaya S.K.; Dursun O.B.; Durukan I.; Fidan T.; Gencoglan S.; Gokcen C.; Gokten E.S.; Gorker I.; Gormez V.; Gundogdu O.Y.; Gurkan C.K.; Herguner S.; Kandemir H.; Kilic B.G.; Kilincaslan A.; Mutluer T.; Nasiroglu S.; Ozcan O.O.; Ozturk M.; Sapmaz S.Y.; Suren S.; Sahin N.; Tahiroglu A.Y.; Toros F.; Unal F.; Vural P.; Yazici I.P.; Yazici K.U.; Yildirim V.; Yulaf Y.; Yuce M.; Yuksel T.; Akdemir D.; Altun H.; Ayik B.; Bilgic A.; Bozkurt O.H.; Cakir E.D.; Ceri V.; Demir N.U.; Dinc G.; Irmak M.Y.; Karaman D.; Kinik M.F.; Mazlum B.; Memik N.C.; Ozdemir D.F.; Sinir H.; Tasdelen B.I.; Taskin B.; Ugur C.; Uran P.; Uysal T.; Uneri O.S.; Yilmaz S.; Yilmaz S.S.; Acikel B.; Aktas H.; Alaca R.; Alic B.G.; Almbaidheen M.; Ari F.P.; Aslan C.; Atabay E.; Ay M.G.; Aydemir H.; Ayranci G.; Babadagi Z.; Bayar H.; Bayhan P.C.; Bayram O.; Bektas N.D.; Berberoglu K.K.; Bostan R.; Cakan Y.; Canli M.A.; Cansiz M.A.; Ceylan C.; Coskun N.; Coskun S.; Demir I.; Demir N.; Demirdogen E.Y.; Dogan B.; Donmez Y.E.; Donder F.; Efe A.; Eray S.; Erbilgin S.; Erden S.; Ersoy E.G.; Eseroglu T.; Firat S.K.; Gok E.E.; Goksoy S.C.; Guler G.; Gules Z.; Gunay G.; Gunes S.; Gunes A.; Guven G.; Horozcu H.; Irmak A.; Isik U.; Kahraman O.; Kalayci B.M.; Karaaslan U.; Karadag M.; Kilic H.T.; Kilicaslan F.; Kinay D.; Koc E.B.; Kocael O.; Mutlu R.K.; San Z.; Nalbant K.; Okumus N.; Ozbek F.; Ozdemir F.A.; Ozdemir H.; Ozgur B.G.; Ozkan S.; Ozyurt E.Y.; Polat B.; Polat H.; Sekmen E.; Sertcelik M.; Sevgen F.H.; Sevince O.; Shamkhalova U.; Suleyman F.; Simsek N.E.; Tanir Y.; Tekden M.; Temtek S.; Topal M.; Topal Z.; Turk T.; Ucar H.N.; Ucar F.; Uygun D.; Uzun N.; Vatansever Z.; Yazgili N.G.; Yildiz D.M.; Yildiz N.; Ercan E.S.Aim: To determine the prevalence of affective disorders in Turkey among a representative sample of Turkish population. Methods: This study was conducted as a part of the “The Epidemiology of Childhood Psychopathology in Turkey” (EPICPAT-T) Study, which was designed by the Turkish Association of Child and Adolescent Mental Health. The inclusion criterion was being a student between the second and fourth grades in the schools assigned as study centers. The assessment tools used were the K-SADS-PL, and a sociodemographic form that was designed by the authors. Impairment was assessed via a 3 point-Likert type scale independently rated by a parent and a teacher. Results: A total of 5842 participants were included in the analyses. The prevalence of affective disorders was 2.5 % without considering impairment and 1.6 % when impairment was taken into account. In our sample, the diagnosis of bipolar disorder was lacking, thus depressive disorders constituted all the cases. Among depressive disorders with impairment, major depressive disorder (MDD) (prevalence of 1.06%) was the most common, followed by dysthymia (prevalence of 0.2%), adjustment disorder with depressive features (prevalence of 0.17%), and depressive disorder-NOS (prevalence of 0.14%). There were no statistically significant gender differences for depression. Maternal psychopathology and paternal physical illness were predictors of affective disorders with pervasive impairment. Conclusion: MDD was the most common depressive disorder among Turkish children in this nationwide epidemiological study. This highlights the severe nature of depression and the importance of early interventions. Populations with maternal psychopathology and paternal physical illness may be the most appropriate targets for interventions to prevent and treat depression in children and adolescents. © 2018Item The evaluation of pretreatment neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms; [Avaliação da relação neutrófilo-linfócito e relação neutrófilo-linfócito derivada no pré-tratamento em pacientes com neoplasias laríngeas](Elsevier Editora Ltda, 2019) Eskiizmir G.; Uz U.; Onur E.; Ozyurt B.; Karaca Cikrikci G.; Sahin N.; Oran A.; Celik O.Introduction: Systemic inflammatory biomarkers are promising predictive and prognostic factors for solid cancers. The neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio are used to predict inflammation and used as biomarker in several malignancies. Objective: The purpose of this study was to demonstrate the diagnostic, predictive and prognostic role of neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms. Methods: A retrospective study was conducted on medical records involving 229 patients with benign, premalignant and malignant laryngeal neoplasms between 2002 and 2015. The diagnostic, predictive and prognostic role of neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were evaluated using uni– and multivariate analysis. Results: The neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were not statistically different between patients with benign, premalignant and malignant laryngeal neoplasms. Both neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were predictive factors for stage, lymph node metastasis, and distant metastasis. Patients with high neutrophil–lymphocyte ratio value (≥4) had a poor prognosis when compared with patients with low neutrophil–lymphocyte ratio value (5 year, Overall Survival: 69.0% vs. 31.1%, p < 0.001; 5 year, disease free survival: 70.0% vs. 32.7%, p ˂ 0.001; 5 year, locoregional recurrence free survival: 69.7% vs. 32.0%, p < 0.001). Furthermore, neutrophil–lymphocyte ratio was an independent prognostic factor for 5 year: Overall survival (HR = 2.396; 95% CI 1.408–4.077; p = 0.001), Disease free survival (HR = 2.246; 95% CI 1.322–3.816; p = 0.006) and locoregional recurrence free survival (HR = 2.210; 95% CI 1.301–3.753; p = 0.003). Conclusion: Pretreatment neutrophil–lymphocyte ratio is a useful and reliable predictive and prognostic biomarker for patients with laryngeal carcinoma. © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-FacialItem Prevalence, comorbidities and mediators of childhood anxiety disorders in urban Turkey: a national representative epidemiological study(Springer Science and Business Media Deutschland GmbH, 2023) Mutluer T.; Gorker I.; Akdemir D.; Ozdemir D.F.; Ozel O.O.; Vural P.; Tufan A.E.; Karacetin G.; Arman A.R.; Fis N.P.; Demirci E.; Ozmen S.; Hesapcioglu S.T.; Oztop D.; Tural U.; Aktepe E.; Aksu H.; Ardic U.A.; Basgul S.; Bilac O.; Coskun M.; Celik G.G.; Demirkaya S.K.; Dursun O.B.; Durukan I.; Fidan T.; Gokcen C.; Gormez V.; Gundogdu O.Y.; Herguner S.; Kandemir H.; Kilic B.G.; Kilincaslan A.; Nasiroglu S.; Sapmaz S.Y.; Sahin N.; Tahiroglu A.Y.; Toros F.; Unal F.; Yazici I.P.; Yazici K.U.; Isik U.; Ercan E.S.Purpose: The aim of this study is to evaluate the prevalence of anxiety disorders, its correlation with sociodemographic characteristics, its comorbidities with other psychiatric disorders and its predictors in school-aged children. Methods: This study is part of a representative, multi-centered national study that is planned by the Turkish Association of Child and Adolescent Mental Health to evaluate the prevalence of psychopathology among elementary school students in Turkey between the years 2014–2015. Children are screened via Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children Present and Lifetime Version. Impairment is assessed by a 3-point Likert type scale independently by the parent and the teacher. The final sample included 5842 children with the mean age of 8.7 years. Results: The prevalence of any anxiety disorder without considering impairment is 16.7% and considering impairment is 5.2% in children according to our study. We found significant differences for comorbid Attention Deficit Hyperactivity Disorder, Disruptive Behavior Disorder, Mood Disorders, Tic Disorders, Obsessive Compulsive Disorder, Enuresis Nocturna, Encopresis, and Intellectual Disability. Having a history of paternal physical disorder, living in the regions of Marmara, Mediterranean and Black Sea were found to be the main predictors of having childhood anxiety disorders according to the logistic regression analysis. Conclusion: Better understanding of childhood anxiety disorders, comorbid conditions and predictors will result in earlier diagnosis and more appropriate treatment. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.Item functional outcome in late adolescence/early adulthood of patients with autism spectrum disorder and its relationships with parental burnout and depression: A preliminary multi-center, cross-sectional study(Elsevier Ltd, 2023) Kutuk M.O.; Tufan A.E.; Kilicaslan F.; Vural P.; Gokcen C.; Alsen Guney S.; Kutuk B.; Ozyurt G.; Inal N.; Mutluer T.; Acikalin E.Y.; Ozer F.H.; Pamuk E.N.; Yesilmese S.C.; Karadag M.; Hangul Z.; Bilginer C.; Sahin N.; Bilac O.; Kandemir H.; Ercan E.S.; Eseroglu Soylemez T.; Acikel S.B.; Guler Aksu G.; Dag P.; Toros F.; Mutlu C.; Kardas O.; Kardas B.; Kizildag S.; Demirci E.; Ozmen S.; Sevicin L.; Karagoz Y.S.; Isik U.; Aktepe E.; Altun H.; Yektas Ç.; Polat Tuysuz B.; Buber A.; Cansiz M.A.; Ogutlu H.; Eray S.; Taner H.A.; Altintas E.; Kutuk O.The aim of this study is to determine the functioning of adults with autism spectrum disorders (ASDs) diagnosed in childhood and depression and burnout levels among their parents. A total of 261 adults with ASDs and their parents were recruited for the study. Both parents completed the Beck Depression and Maslach Burnout Inventories and reported the functioning of their adult offspring with ASDs. Only 5.4 % of our sample reported “good” or “very good” outcomes. The most common psychiatric comorbidities were intellectual disabilities and attention-deficit/hyperactivity disorder. Maternal burnout and depression scores were significantly elevated compared to those of fathers. There is an undeniable urgent need for more research to identify the needs of adults and families suffering from ASD. Modifications for those with ASD may have to be made for support in workplaces, achieving driving licenses, using public transportation and attendance at tertiary education. © 2023 The Authors