Browsing by Author "Saip S."

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    A whole genome screen for linkage in Turkish multiple sclerosis
    (Elsevier, 2003) Eraksoy M.; Kurtuncu M.; Akman-Demir G.; Kilinc M.; Gedizlioglu M.; Mirza M.; Anlar Ö.; Kutlu C.; Demirkiran M.; Idrisoglu H.A.; Compston A.; Sawcer S.; Tombul T.; Asker Ö.; Balkan S.; Seçkin D.; Aydin H.; Akman-Demir G.; Kiyat A.; Yapici Z.; Epçeliden T.; Çe P.; Goldenberg E.; Gültiken B.; Güvenç A.; Işik N.; Seleker T.; Idiman E.; Özakbaş S.; Irkeç C.; Nazlier B.; Forta H.; Seleker F.; Güner K.; Karabudak R.; Kilinç M.; Komsuoǧlu S.; Efendi H.; Mert M.; Mirza M.; Erdoǧan F.; Müngen B.; Bulut S.; Özer F.; Yayla V.; Petek-Balci B.; Saǧduyu A.; Sarica Y.; Demirkiran M.; Selçuki D.; Mavioǧlu H.; Siva A.; Altintaş A.; Saip S.; Sütlaş N.; Kuşçu Yandim D.; Tireli H.; Özalp K.; Türkoǧlu R.; Örken C.; Özmanoǧlu M.; Velioǧlu S.; Özdemir G.; Gücüyener D.; Özkan S.; Tunali G.; Turan F.; Utku U.; Turgut N.; Ümit S.; Us Ö.; Ince Günal D.; Ütkür Y.; Aluçlu U.; Yavaşoǧlu Ö.; Yücemen N.; Yücesan C.; Zadikoǧlu A.; Zorlu Y.
    Factors exerting recessive effects on susceptibility to complex traits are expected to be over-represented in communities having a higher frequency of consanguineous marriage. Multiple sclerosis, a typical complex trait, is relatively common in Turkey where cultural factors also determine a high rate of consanguineous marriage. Previous genetic studies of multiple sclerosis in Turkey have been confined to the search for associations with candidate genes. In order to exploit the special genetic features of the Turkish population, we performed a whole genome screen for linkage in 43 Turkish multiplex families employing 392 microsatellite markers. Two genomic regions where maximum lod score (MLS) values were suggestive of linkage were identified (chromosomes 13q and 18q23) along with a further 14 regions of potential linkage. Parametric analysis of these data using a recessive model, appropriate for populations with a high frequency of consanguinity, increased the LOD scores in four regions. © 2003 Elsevier B.V. All rights reserved.
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    Economic impact of primary headaches in Turkey: A university hospital based study: Part II
    (2006) Karli N.; Zarifoǧlu M.; Ertaş M.; Saip S.; Öztürk V.; Biçakçi Ş.; Boz C.; Selçuki D.; Oǧuzhanoǧlu A.; Neyal M.; Siva A.; Irkeç C.; Kaleaǧasi H.; Kansu T.; Sarica Y.; Taşdemir N.; Uzuner N.
    This study was planned to investigate the economic impact of headache on Turkish headache sufferers attending a tertiary care outpatient headache clinic. A total of 937 headache patients were included in this study and questioned using a questionnaire for the profile of patients and headache, quality of life of patients and economic impact of headache. The median total direct cost was found to be 88.0 USD and the median total cost was 160.7 USD. The drug treatment cost was the highest item followed by the specialist outpatient care cost. The average lost and inefficient work/school days was 1.5 (0-45) and 8.4 (0-100) days for one year. It was shown that loss of productivity was higher for migraine without aura group when compared with the episodic and chronic tension-type headache groups. The results of this nationwide university hospital based study showed that headache, especially migraine, has considerable economic impact on patients. © Springer-Verlag Italia 2006.