Browsing by Author "Sami Ilker S."

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    Antineovascular effect of α-interferon on corneal neovascularization in rats
    (2001) Öztürk F.; Sobaci G.; Sami Ilker S.; Can C.
    Clinical and histologic effects of topical recombinant α-interferon (IFN), systemic IFN, topical dexamethasone, and dexamethasone plus topical IFN on corneal neovascularization in response to silver nitrate cauterization were investigated in 110 eyes of 60 Wistar rats. The eyes were evaluated according to the burn stimulus, neovascularization, and histologic inflammation grades 5 days after cauterization. Antineovascular effects of topical and systemic IFN were significantly greater than a placebo but less than dexamethasone alone or in combination with IFN.
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    Efficacy of topical lodoxamide vs sodium cromoglycate and dexamethasone in rabbits with passive allergic conjunctivitis
    (2002) Öztürk F.; Güler M.; Sami Ilker S.; Sobaci G.
    A comparative study was conducted to evaluate the efficacy of lodoxamide tromethamine vs sodium cromoglycate and dexamethasone sodium phosphate in experimental allergic conjunctivitis in 45 rabbit eyes. The animals were randomly divided into 3 groups and treated with Iodoxamide, cromoglycate, or dexamethasone. Blood-conjunctival permeability index and the weight of the conjunctiva were used to quantify the ocular inflammatory reaction. Iodoxamide was more effective than sodium cromoglycate but not dexamethasone in the treatment of acute allergic conjunctivitis.
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    Comparison of pain response of patients undergoing panretinal photocoagulation for proliferati diabetic retinopathy: 532 nm standard laser vs. multispot pattern scan laser; [Proliferatif diyabetik retinopati nedeniyle panretinal fotokoagulasyon yapılan hastalarda aǧrı cevabının karşılaştırılması: 532 nm standart lazer vs multispot patern taramalı lazer]
    (Turkish Ophthalmology Society, 2013) Seymenoǧlu G.; Kayikçioǧlu O.; Başer E.; Sami Ilker S.
    Purpose: To compare pain response of patients undergoing panretinal photocoagulation (PRP) for proliferative diabetic retinopathy (PDR) using 532 nm standard laser versus multispot pattern scan laser and to evaluate the relationship between pain response and patient characteristics. Material and Method: Thirty-five patients had PRP with the Pascal system in a single session, while other 35 patients had PRP with conventional laser in 2 sessions. Parameters used in conventional laser were as follows: spot size 200 μm, exposure time 0.2 s, and power sufficient to produce visible grey-white burns. We used same spot size, 20-30 ms exposure time, and higher levels of laser power in order to get a similar endpoint in the Pascal system. The patients were required to evaluate the severity of pain on a visual analog scale (VAS) and verbally 5 minutes after PRP with Pascal and 5 minutes after the first session of PRP with conventional laser. The relationship between pain experienced and patient characteristics was evaluated. Results: At baseline, both groups did not differ significantly (p >0.05, for all) with respect to sex, age, duration of diabetes, most recent HbA1c, treatment regimen, or patient experience. The patients in the Pascal group had a mean pain score of 0.55±0.70 on verbal scale and 1.54±1.22 on VAS compared to 2.17±1.18 and 5.54±3.28, respectively in the conventional laser group which was, statistically, significantly different in both scales (p<0.05). Discussion: Our study confirms that new generation pattern scanning photocoagulators satisfactorily decrease the pain by shortening the exposure time while increasing the laser power.