Browsing by Author "Sari, RA"

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    Familial pathologic myopia, corneal dystrophy, and deafness
    Kurt, E; Günen, A; Sadikoglu, Y; Ozturk, F; Tarhan, S; Sari, RA; Fistik, T; Ari, Z
    Background: Numerous syndromes with myopia and hearing loss have been described up to now. We present a family with pathologic myopia, corneal dystrophy, and deafness distinct from these syndromes. Cases: Ten patients in the same Turkish family were evaluated by ophthalmologic, audiologic, physical, radiologic, genetic, serologic, and biochemical examinations. Observations: Ophthalmic examination indicated that all the cases had myopia, 7 of them had pathologic myopia, 1 had intermediate, and 2 had mild. Four of the patients with pathologic myopia had corneal dystrophy that was bilaterally manifest as white opacities in the posterior stroma near Descemet's membrane in an axial distribution; 1 of these 4 patients also had a tilted disc. Otolaryngologic examination revealed conductive hearing loss in 3 cases, mixed hearing loss in 2. and sensorineural hearing loss in 1. The results of karyotypic analyses of all cases were normal. The pedigree analysis showed the disease was inherited through successive generations as an autosomal dominant trait. The results of biochemical, serologic, and radiologic investigations were normal. The same pathophysiologic process in all cases seemed to account for the myopia, the corneal dystrophy and the deafness. Conclusions: To our knowledge, this type of case has not been reported in the literature. Therefore, we named this syndrome familial pathologic myopia, corneal dystrophy and deafness. (C) 2001 Japanese Ophthalmological Society.
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    Relationship of retinopathy and hearing loss in type 2 diabetes mellitus
    Kurt, E; Öztürk, F; Günen, A; Sadikoglu, Y; Sari, RA; Yoldas, TK; Avsar, A; Inan, ÜÜ
    This study investigated whether the degree of diabetic retinopathy correlates with degree of sensorineural hearing loss. Seventy-five diabetic patients and 45 sex- and age-matched healthy controls were evaluated audiologically. Patients were classified into groups by severity of retinopathy. group 1 (n=28), no retinopathy, group 2 (n= 4), background retinopathy, and group 3 (n=23), proliferative, or end-stage retinopathy. Diabetics had a statistically significant difference at all frequencies of hearing loss, as compared with controls.
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    Relationship between serum lipoprotein (a) levels and retinopathy in patients with type 2 diabetes
    Kurt, E; Öztürk, F; Ari, Z; Yigitoglu, MR; Sari, RA; Ilker, SS
    We studied whether there was an association between development of background or proliferative retinopathy and changes in plasma lipid, lipoprotein, and lipoprotein (a) levels in 111 patients with type 2 diabetes mellitus and in 57 controls. Serum lipoprotein (a) levels were higher in patients with retinopathy than in individuals without retinopathy. Increased serum lipoprotein (a) levels correlated with higher degrees of retinopathy. Thus, lipoprotein (a) may play a role in the development of diabetic retinopathy.