Browsing by Author "Sayit Bilgin B.E."

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    F-18 FDG PET/CT imaging artifacts; [F-18 FDG PET/BT görüntüleme artefaktları]
    (Istanbul Tip Fakultesi, 2015) Parlak Y.; Gümüşer G.; Sayit Bilgin B.E.
    F-18 FDG PET/CT are being used in increasing numbers in the diagnosis of the primary lesion, disease staging and evaluation of response to therapy of various cancers due to its high accuracy. However, PET/CT have various artifacts which affected image quality including PET and CT AC (attenuation correction) artifacts. For accurate identification of malignant lesions, to characterize these artifacts is clinically important. Our aim is to identify, to characterize and to investigate the effect of PET/CT image quality of these artifacts. © 2015 Onkoloji Derneği.
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    Synthesis, characterization and radiolabeling of folic acid modified nanostructured lipid carriers as a contrast agent and drug delivery system
    (Elsevier Ltd, 2017) Ucar E.; Teksoz S.; Ichedef C.; Kilcar A.Y.; Medine E.I.; Ari K.; Parlak Y.; Sayit Bilgin B.E.; Unak P.
    Nanostructured lipid carriers (NLCs) are the new generation of solid lipid drug delivery systems. Their suitability as contrast agents for gamma scintigraphy is an attracting major attention. The aim of current study was to prepare surface modified nanostructured lipid carrier system for paclitaxel (PTX) with active targeting and imaging functions. In accordance with the purpose of study, PTX loaded nanostructured lipid carriers (NLCs) prepared, modified with a folate derivative and radiolabeled with technetium-99 m tricarbonyl complex (99 mTc(CO)3 +). Cellular incorporation ratios of radiolabeled nanoparticles (99 mTc(CO)3-PTX-NLC) were investigated in vitro on three cancer cell lines. Additionally in vivo animal studies conducted to evaluate biological behavior of 99 mTc(CO)3-PTX-NLC on female Wistar Albino rats. Biodistribution results showed that the folate derivative modified 99 mTc(CO)3-PTX-NLC had considerably higher uptake in folate receptor positive organs. The data obtained from present study could be useful in the design of biodegradable drug carriers of PTX and folate receptor based tumor imaging agents. © 2016 Elsevier Ltd