Browsing by Author "Selek S."

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    Validity and reliability of the Turkish version of CRAFFT Substance Abuse Screening Test among adolescents
    (Dove Medical Press Ltd, 2015) Kandemir H.; Aydemir Ö.; Ekinci S.; Selek S.; Kandemir S.B.; Bayazit H.
    Aim: This study aimed to validate the CRAFFT diagnostic test, against the Diagnostic and Statistical Manual of Mental Disorders – Fourth Edition, Axis 1-based diagnostic inventory in a Turkish population of adolescents. Method: The 124 adolescents who were 15–18 years old were enrolled to this study. CRAFFT was self-administered. Interviews took approximately 30 minutes, including the DSM-IV diagnostic interview for alcohol/drug dependence. Results: The mean age of subjects was 16.653 years (minimum: 15 years, maximum: 18 years). A score of 2 or higher in part B was found to be optimal for detecting youths with substance dependence problems (sensitivity: 0.82; specificity: 0.88) and it was sufficiently discriminative. Conclusion: The CRAFFT is a valid and reliable instrument for identifying Turkish-speaking youths at risk for substance use disorders. © 2015 Kandemir et al.
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    MicroRNA dysregulation in manic and euthymic patients with bipolar disorder
    (Elsevier B.V., 2020) Camkurt M.A.; Karababa İ.F.; Erdal M.E.; Kandemir S.B.; Fries G.R.; Bayazıt H.; Ay M.E.; Kandemir H.; Ay Ö.I.; Coşkun S.; Çiçek E.; Selek S.
    Background: Bipolar disorder (BPD) is a major psychiatric disorder with an unclear pathophysiology. Peripheral blood samples are easily drawn, making them are good candidates for diagnosing diseases. MicroRNAs are small non-coding RNA transcripts that regulate gene expression by binding to the 3′- UTR of mRNAs and directing their degradation. The aim of this study was to use blood plasma to investigate microRNA dysregulations in bipolar manic and euthymic patients. Subjects and Methods: Blood samples were collected from 58 patients with bipolar I disorder (19 manic, 39 euthymic) and 51 healthy controls. Results: Four microRNAs (miR-29a-3p, p = 0.035; miR-106b-5p, p = 0.014; miR-107, p = 0.011; and miR-125a-3p, p = 0.014) were upregulated in the entire bipolar group, compared to the healthy controls. Seven microRNAs (miR-9-5p, p = 0.032; miR-29a-3p, p = 0.001; miR-106a-5p, p = 0.034; miR-106b-5p, p = 0.003; miR-107, p < 0.001; miR-125a-3p, p = 0.016; and miR-125b-5p, p = 0.004) were more upregulated in bipolar manic patients compared to the healthy controls, and two microRNAs (miR-106a-5p, p = 0.013, and miR-107, p = 0.021) showed statistically significant upregulation in the manic patients compared to the euthymic patients. Conclusions: Our results showed greater miRNA dysregulation in the manic patients than in the euthymic patients. Two microRNAs could be more selective for bipolar manic episodes. Future studies should include depressive patients along with euthymic and manic patients. © 2019