Browsing by Author "Sen, G"

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    The Mediating Role of Autobiographical Memory in the Relationship Between Narcissism and Rejection Sensitivity
    Sen, G; Pakyurek, G
    Both grandiose and vulnerable narcissistic individuals perceive a threat to the self when they face real or imaginary rejection. The sensitivity to rejection may affect them differently. Thus, this research examines the role of grandiose and vulnerable narcissism in the retrieval of self-threatening memories. The study aims to test the mediating role of autobiographical memory (AM) in the relationship between rejection sensitivity (RS) and two dimensions of narcissism. A total of 369 university students (ages between 18 and 32) participated in the study. The Rejection Sensitivity Questionnaire was applied to the participants, triggering the memory of positive and negative autobiographical rejection. Then, the Autobiographical Memory Characteristics Questionnaire and the Pathological Narcissism Inventory were applied. The results showed that the autobiographical memory characteristics differ depending on the dimension of narcissism when they face rejection. This changes depending on having positive or negative content as well as recalling the sensory details especially emotional characteristics of the AM. The use of AM as a mediator in the relationship between narcissism and rejection sensitivity has provided a viewpoint beyond experimental and relational studies. The results have shed light on the role of narcissism and RS in the processing of autobiographical memories.
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    Life performance prediction of natural gas combined cycle power plant with intelligent algorithms
    Karaçor, M; Uysal, A; Mamur, H; Sen, G; Nil, M; Bilgin, MZ; Dogan, H; Sahin, C
    The efficient use of a system is enabled with the life performance estimations. Thus, the effective use of underground resources is realized especially natural gas. Based on this, life performance models were generated to aim of improving the efficient use of energy for a combined cycle power plant (CCPP) of 243 MW installed in Izmir, Turkey by using fuzzy logic (FL) and artificial neural network (ANN) in this study. Therefore, output power estimations were carried out. Depending on the developed models, an estimation of the energy that the CCPP can produce and provide to the interconnected system in the following years has been made. According to the obtained results, the error prediction rates of FL and ANN models were determined. It was found that while the energy relative error estimation value that can be produced between the years calculated in modeling using FL varies between 0.59% and 3.54%, this value was found to vary between 0.001% and 0.84% in modeling using ANN. This result shows that the ANN model is more suitable for the life performance estimations of such a nonlinear system.
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    Effects of JWH-018, A New Synthetic Cannabinoid on Hemodynamics, Histopathology and Behavior of Rats
    Sen, G; Tozduman, B; Tuglu, MI; Cöllü, F; Demet, MM; Kutlu, N; Çavusoglu, TG; Ekerbiçer, N
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    Damage Mechanisms in Rat Brain for JWH-018 from New Synthetic Cannabinoids
    Sen, G; Tozduman, B; Ekerbiçer, N; Çöllü, F; Temel, M; Demet, MM; Kutlu, N; Çavusoglu, TG; Tuglu, MI
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    Grandiose and vulnerable narcissism on interpersonal circumplex model: reactions to criticism in romantic relationship
    Sen, G; Bariskin, E
    Vulnerable narcissism (VN) and grandiose narcissism (GN) are characterized by different expressions of self in interpersonal relationships. This study aims to examine narcissism with its grandiose and vulnerable dimensions while considering reactions to criticism, which is a challenging interpersonal experience accompanied by the Interpersonal Circumplex Model (IPC) by the person and romantic partner. The study evaluates the dimensions of narcissism and is based on the responses of the participants and their partners (behavioral, cognitive, and emotional). The Pathological Narcissism Inventory (PNI) was administered to evaluate narcissistic characteristics. The Criticism Story of the Story Completion Inventory in Romantic Relationships (SCIRR) was used for criticism. The circular pattern between the responses of the participants and their partners was examined using the Interpersonal Schemas Scale (ISS). The results revealed that the vulnerable group gave more complementary responses emotionally and made more complementary predictions than the grandiose group in terms of the expected reactions from a romantic partner. The results were discussed in reference to basic motivations that serve as protection for self-esteem.
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    The effect of ambient temperature on electric power generation in natural gas combined cycle power plant-A case study
    Sen, G; Nil, M; Mamur, H; Dogan, H; Karamolla, M; Karaçor, M; Kuyucuoglu, F; Yörükeren, N; Bhuiyan, MRA
    Natural gas combined cycle power plants (CCPPs) are widely used to meet peak loads in electric energy production. Continuous monitoring of the output electrical power of CCPPs is a requirement for power performance. In this study, the role of ambient temperature change having the greatest effect on electric production is experimentally investigated for a natural gas CCPP. The plant has generated electricity for fourteen years and setup at 240 MW in Aliaga, Izmir, Turkey. Depending on the seasonal temperature changes, the study data were obtained from each gas turbine (GT), steam turbine (ST) and combined cycle blocks (CCBs) in the ambient temperature range of 8-23 degrees C. In electric energy production, an important decrease was in the GTs because of the temperature increase. This decrease indirectly affected the electric energy production of the STs. As a result, the efficiency of each GT, ST and CCB decreased, although the quantity of fuel consumed by the controllers in the plant was reduced. As a result of this data, it has been recommended and applied that additional precautions have been taken in the power plant to bring the air entering the combustion chamber to ideal conditions and necessary air cooling systems have been installed. (C) 2018 The Authors. Published by Elsevier Ltd.
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    Efficacy and Safety of CT-P13 as First- and Second-Line Treatment in Patients with Ankylosing Spondylitis
    Uslu, S; Gülle, S; Sen, G; Capar, S; Senel, S; Dalkilic, E; Akar, S; Koca, SS; Tufan, A; Yazici, A; Yilmaz, S; Inanc, N; Birlik, M; Solmaz, D; Cefle, A; Goker, B; Direskeneli, H; Yolbas, S; Krogh, NS; Yilmaz, N; Erten, S; Bes, C; Gündüz, OS; Oztürk, MA; Haznedaroglu, S; Yavuz, S; Onen, F; Sari, I
    Background/Objectives: CT-P13 is a biosimilar version of infliximab, a monoclonal antibody. In individuals with ankylosing spondylitis (AS), CT-P13 has been shown to be effective and to have a well-tolerated safety profile. The aim of this study was to evaluate the long-term drug persistence, safety, and efficacy of infliximab biosimilar CT-P13 in patients with AS undergoing first-line (1st-line) and later (>= 2nd-line) treatment in clinical practice. Methods: We performed an observational cohort study that included AS patients based on the biological drug database in the TURKBIO Registry between 2014 and 2021. The patients were divided into two groups: those receiving CT-P13 as first-line treatment or as a switch (>= 2nd-line) from another TNF inhibitor (TNFi). Standard disease activity metrics were used to assess the effectiveness of CT-P13, and drug retention rates were investigated. Results: There were 179 AS patients using CT-P13 (47.4% male, mean age: 42.9 +/- 11.3 years). Of these patients, 123 (68.7%) were receiving CT-P13 as a first-line treatment. The mean length of treatment was 3.5 years. CT-P13 drug retention rates in the general patient population were 58.6% and 48.2% in the first-line and >= second-line treatment, respectively, after 3 years of follow-up. The most common reason for CT-P13 treatment discontinuation was lack of efficacy. The first-line CT-P13 group had statistically substantially higher ASAS20/40 response rates at three and six months. Nonetheless, both groups' response rates at one year were comparable. Conclusions: In this real-world data analysis, AS patients who were TNFi na & iuml;ve (1st-line) and subsequently treated (>= 2nd-line) with CT-P13 showed encouraging drug retention rates with acceptable long-term effectiveness and safety.
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    Assessing safety and efficacy of TNFi treatment in late onset ankylosing spondylitis: a TURKBIO registry study
    Uslu, S; Gulle, S; Sen, G; Cefle, A; Yilmaz, S; Kocaer, SB; Inel, TY; Koca, SS; Yolbas, S; Ozturk, MA; Senel, S; Inanc, N; Dalkilic, HE; Gunduz, OS; Tufan, A; Akar, S; Birlik, AM; Sari, I; Akkoc, N; Onen, F
    Clinical data on the use of tumour necrosis factor inhibitors (TNFi) in late-onset ankylosing spondylitis (LoAS) are limited. The present study aimed to evaluate efficacy, safety, and treatment adherence associated with the initial use of TNFi therapy in biologic naive patients diagnosed with LoAS. Patients whose age of onset was >= 45 years and < 45 years were classified as having LoAS and YoAS, respectively, based on the age of symptom onset. There were 2573 patients with YoAS and 281 LoAS. Baseline disease activity measures were similar between the groups. No significant differences were seen between the two groups in response to treatment and in remaining on the first TNFi at 6, 12 and 24 months. In the LoAS group, the analysis showed that TNFi discontinuation was linked to VAS pain score (HR 1.04; 95% CI 1.01-1.06). Patient groups had similar rates of adverse events (YoAS: 8.7% vs. LoAS: 11.7%). In both biologic naive LoAS and YoAS patients, the study showed that the initial TNFi therapy was equally effective and safe.
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    Biological treatment in elderly and young patients with ankylosing spondylitis: TURKBIO real-life data results
    Uslu, S; Gülle, S; Urak,Ö; Sen, G; Dalkiliç, E; Senel, S; Akar, S; Inanç, N; Cefle, A; Avsar, AK; Yolbas, S; Yilmaz, S; Gündüz, OS; Sari, I; Birlik, M; Akkoç, N; Önen, F
    Objectives: This study aims to investigate the effect of age on disease activity and biological treatment in patients with ankylosing spondylitis (AS). Patients and methods: A total of 811 AS patients registered in the TURKBIO registry database between 2011 and 2019 were categorized according to their age at the time of entry into the registry and assigned to one of two groups: young patients, defined as <60 years of age (n=610), and those aged >= 60 years (n=201) were recorded as elderly patients. Demographic, clinical, and laboratory characteristics, along with disease activity markers and other follow-up parameters, as well as current and prior treatments, were electronically recorded during each visit using open -source software. Results: The mean age of the elderly patients was 67 +/- 5.8 years, while the mean age of the younger patients was 49.2 +/- 10.9 years. Male predominance was lower in the older AS group compared to the younger AS group (p=0.002). During follow-up period, 397 patients (comprising 318 young and 79 elderly individuals) had a history of using at least one biological disease -modifying agent (bDMARD). There was no significant difference between the groups in terms of DMARD and bDMARD-use distributions. First tumor necrosis factor inhibitor (TNFi) retention rates were found to be similar in both groups over 10 years of follow-up. Adverse events were found to be similar in young (19.9%) and elderly (26.8%) AS patients. Conclusion: Research in the TURKBIO cohort reveals that both older and younger patients with AS exhibited similar disease activity levels with comparable treatment approaches. Moreover, the results of TNFi treatments in elderly patients were the same as those observed in younger patients, with no notable increase in safety concerns.
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    29 October 2007, Cameli earthquake and structural damages at unreinforced masonry buildings
    Kaplan, H; Yilmaz, S; Akyol, E; Sen, G; Tama, YS; Cetinkaya, N; Nohutcu, H; Binici, H; Atimtay, E; Sarisin, A
    A recent earthquake of M=4.9 occurred on 29 October 2007 in C, ameli, Denizli, which is located in a seismically active region at southwest Anatolia, Turkey. It has caused extensive damages at unreinforced masonry buildings like many other cases observed in Turkey during other previous earthquakes. Most of the damaged structures were non-engineered, seismically deficient, unreinforced masonry buildings. This paper presents a site survey of these damaged buildings. In addition to typical masonry damages, some infrequent, event-specific damages were also observed. Reasons for the relatively wide spread damages considering the magnitude of the event are discussed in the paper.