Browsing by Author "Senol, F"

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    Selenium, nickel, and calcium levels in cancerous and non-cancerous prostate tissue samples and their relation with some parameters
    (SPRINGER HEIDELBERG) Çelen, I; Müezzinoglu, T; Ataman, OY; Bakirdere, S; Korkmaz, M; Nese, N; Senol, F; Lekili, M
    In the present study, tissue samples of patients with cancerous and non-cancerous prostate were analyzed for their Se, Ni, and Ca contents. Possible relationship between Se, Ni, and Ca concentrations and some parameters including preoperative prostate-specific antigen (PSA) levels, histopathological neurovascular invasion, extra-capsular extension, seminal vesicle invasion, positive surgical margins, PSA relapse after radical prostatectomy, and total Gleason scores were obtained. Inductively coupled plasma (ICP) optical emission spectrometry and ICP-mass spectrometry instruments were used for the determination of analytes interested. All the system parameters in digestion and measurement steps were optimized to obtain efficient digestion and sensitive measurements. There was no statistically meaningful difference observed in the concentration of selenium in cancerous and benign prostatic tissues (p = 0.347) while nickel levels in cancerous tissues were observed as significantly lower than benign tissues (p < 0.001). In addition, calcium concentration in cancerous tissue samples were found to be statistically lower than those in benign tissues (p < 0.001) with mean values of 657 and 1,431 mg/kg, respectively.
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    The effect of trace elements in prostate cancer
    (GALENOS YAYINCILIK) Çelen, I; Senol, F; Müezzinoglu, T
    Prostate cancer is the sixth prevailing cancer type seen all over the world. It is also the third most common cancer type among men. The aim of this study is to investigate the effects of exposure to trace elements in prostate cancer etiology and to evaluate the latest data in literature about the clinical consequences of the deposition of trace elements in prostate tissues. There is a variety of factors in prostate cancer etiology including age, ethnogenesis, family history, androgens and hormonal factors, food and environmental exposures. Nowadays it is believed that trace elements take part in the development of prostate cancer as a result of environmental pollution and exposure to carcinogenic materials. Trace elements participate in biological systems as components of enzymes or as catalysts carrying out some chemical reactions in living cells so it is known that excessive or inadequate intakes of many trace elements lead to a variety of diseases including cancer. The methods to measure the extent of exposure to trace elements include vocational history, measurements in existing pollution and air and personal survey signs. However it is difficult to compare these results with each other as result of the measurement differences in these methods. The capability of the methods used to determine the trace elements in biological and environmental systems depends on the type of the specimen (blood, urine, hair, nail) and the preparation of the specimen for the analysis. Cumulative exposure is very important in cancer etiology. Measurements in serum and plasma indicate short term exposure whereas measurements in toenails and red blood cells indicate long term exposure. Apart from that automatic analysis methods have been developed and commercial systems providing fast and numerous data with very little contribution of the user have been produced to meet the increasing needs. There is a variety of recent studies in literature on the determination of trace elements in tissues. However it is obvious that we need studies evaluating the exposures to trace elements together with their depositions in human tissues.