Browsing by Author "Serdar, M"

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    The Role of Fecal Calprotectin in Investigating Pediatric Ulcerative Colitis
    Unal, F; Semizel, E; Serdar, M; Ecevit, CÖ; Karaca, Y; Yilmaz, EM; Kocaefe, H; Kasirga, HE
    introduction: Fecal calprotectin (FCP) can be found in high concentrations in inflammatory bowel disease due to the increase in leucocyte turnover in intestinal wall or increase of migration of neutrophils into the lumen. In this study, we aimed to determine the FCP values of the ulcerative colitis (UC) patients at the time of diagnosis and to investigate the applicability and effectiveness of this non-invasive method in the diagnosis of the disease, routinely. Materials and Methods: A total of 19 patients with UC (10 females, 9 males, age: 11.5 +/- 3.5 years old) whoose stool samples collected during the diagnosis period and 20 healthy controls (10 female, 10 male, age: 10.3 +/- 4.5 years old) were included in the study. Stool samples were collected for FCP analysis by ELISA method at the time of diagnosis and before the treatment period. Results: FCP values of the UC group were statistically higher than the control group. FCP values of the UC and control groups were 398.4 mu g /gr stool (56.7-2450) and 19.4 mu g/gr stool (2-81), respectively (p<0.005). FCP values of the patient group with mild activity index (n=8), and moderate-severe activity index (n=11) according to the Pediatric Ulcerative Colitis Activity Index were 267.6-mu g/gr stool, and 435.2 mu g/gr stool, respectively (r2: 0.40, p<0.05). There was not statistical difference between the FCP values of the patients with pancolitis (422.6 mu g/gr stool) and with left-sided colitis, proctitis/sigmoiditis (371.7 mu g/gr stool) (p>0.05). High CRP values (89.4%), elevation of erythrocyte sedimentation rate (84.2%), leukocytosis (73.6%), thrombocytosis (68.4%), anemia (89.4%), and hypoalbuminemia (52.6%) were found. Conclusions: FCP values of the UC patients were found to be statistically higher than the control group, and increase in FCP values has been observed with increasing disease activity. Therefore, we believe that the determination of FCP could be useful at the time of diagnosis and during follow-up of the patients with UC.
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    A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers
    Ozarda, Y; Ichihara, K; Aslan, D; Aybek, H; Ari, Z; Taneli, F; Coker, C; Akan, P; Sisman, AR; Bahceci, O; Sezgin, N; Demir, M; Yucel, G; Akbas, H; Ozdem, S; Polat, G; Erbagci, AB; Orkmez, M; Mete, N; Evliyaoglu, O; Kiyici, A; Vatansev, H; Ozturk, B; Yucel, D; Kayaalp, D; Dogan, K; Pinar, A; Gurbilek, M; Cetinkaya, CD; Akin, O; Serdar, M; Kurt, I; Erdinc, S; Kadicesme, O; Ilhan, N; Atali, DS; Bakan, E; Polat, H; Noyan, T; Can, M; Bedir, A; Okuyucu, A; Deger, O; Agac, S; Ademoglu, E; Kaya, A; Nogay, T; Eren, N; Dirican, M; Tuncer, G; Aykus, M; Gunes, Y; Ozmen, SU; Kawano, R; Tezcan, S; Demirpence, O; Degirmen, E
    Background: A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality. Methods: Blood samples were collected nationwide in 28 laboratories from the seven regions (>= 400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA). Results: By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and.-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m(2). Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI. Conclusions: With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population.