Browsing by Author "Serifoglu, I"

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma A Multicentric Study
    Yilmaz, S; Demirci, NY; Metintas, S; Zamani, A; Karadag, M; Guçlu, OA; Kabalak, PA; Yilmaz, U; Ak, G; Kizilgoz, D; Ozturk, A; Yilmaz, U; Batum, O; Kavas, M; Serifoglu, I; Unsal, M; Komurcuoglu, BE; Cengiz, TI; Ulubay, G; Ozdemirel, TS; Ozyurek, BA; Kavurgaci, S; Alizoroglu, D; Celik, P; Erdogan, Y; In, E; Aksoy, A; Altin, S; Gunluoglu, G; Metintas, M
    Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.
  • No Thumbnail Available
    Item
    Turkish Thoracic Society Early Career Members Task Force Group's Virtual Congress Notes: European Respiratory Society International Congress 2020
    Kizilirmak, D; Karadogan, D; Yildirim, H; Akyil, FT; Eyüboglu, TS; Emiralioglu, N; Sertçelik, ÜÖ; Günaydin, FE; Ataoglu, Ö; Oguz, MS; Çakmakci, S; Özçelik, N; Öncel, A; Firincioglulari, A; Kara, BY; Ömer, D; Karaoglanoglu, S; Cetin, N; Karakas, FG; Gurkan, CG; Marim, F; Önyilmaz, T; Yulug, DP; Öztürk, NAA; Güçlü, ÖA; Küsbeci, TÇ; Serifoglu, I; Arikan, H; Töreyin, ZN; Çelik, P; Akgün, M
    In this article, Early Career Task Force Group members of the Turkish Thoracic Society summarize the European Respiratory Society 2020 virtual congress. Current developments in the field of respiratory diseases were compiled with the addition of sessions specific to coronavirus disease 2019 this year. Almost all of the congress sessions were examined, and the important and striking results of the congress were highlighted. Congress sessions were attended by expert researchers, and the prominent messages of each session were highlighted in short summaries. They were then grouped under relevant titles and ranked in order of meaning and relation. It was finalized by a team of researchers.
  • No Thumbnail Available
    Item
    What We Learned about COVID-19 So Far? Notes from Underground
    Akyil, FT; Karadogan, D; Gürkan, CG; Yüksel, A; Arikan, H; Eyüboglu, TS; Emiralioglu, N; Gürsoy, TR; Serifoglu, I; Toreyin, ZN; Marim, F; Kara, BY; Özakinci, H; Develi, E; Çakmakci, S; Kusbeci, TC; Karcioglu, O; Gulhan, PY; Erçelik, M; Er, B; Ataoglu, Ö; Polat, D; Kaya, I; Önyilmaz, TA; Aydin, A; Kizilirmak, D; Er, AB; Kilinç, M; Günaydin, FE; Gürz, S; Karaoglanoglu, S; Çelik, S; Esendagli, D; Toptay, H; Sertçelik, UÖ; Akgün, M
    The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concerning every aspect of COVID-19 is evolving rapidly, given the increasing data from all over the world. In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. Studies revealed that the genetic sequence of the novel coronavirus showed significant identity to SARS-CoV and MERS-CoV. Angiotensin-converting enzyme 2 receptor is an important target of the SARS-CoV-2 while entering an organism. Smokers were more likely to develop the disease and have a higher risk for ICU admission. The mean incubation period was 6.4 days, whereas asymptomatic transmission was reported up to 25 days after infection. Fever and cough were the most common symptoms, and cardiovascular diseases and hypertension were reported to be the most common comorbidities among patients. Clinical manifestations range from asymptomatic and mild disease to severe acute respiratory distress syndrome. Several patients showed typical symptoms and radiological changes with negative RT-PCR but positive IgG and IgM antibodies. Although radiological findings may vary, bilateral, peripherally distributed, ground-glass opacities were typical of COVID-19. Poor prognosis was associated with older age, higher Sequential Organ Failure Assessment score, and high D-dimer level. Chloroquine was found to be effective in reducing viral replication in vitro. Likewise, protease inhibitors, including lopinavir/ritonavir, favipiravir, and nucleoside analogue remdesivir were proposed to be the potential drug candidates in COVID-19 management. Despite these efforts, we still have much to learn regarding the transmission, treatment, and prevention of COVID-19.