Browsing by Author "Serin, E"

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    Venous thromboembolism prophylaxis in major orthopaedic surgery: A multicenter, prospective, observational study
    Altintas, F; Gürbüz, H; Erdemli, B; Atilla, B; Ustaoglu, RG; Öziç, U; Savk, O; Bayram, H; Memik, R; Akgün, I; Gögüs, A; Pestilci, F; Konal, A; Argün, M; Öztürk, I; Dabak, N; Bilgen, OF; Serin, E; Önder, Ç; Simsek, A; Tözün, R; Kinik, H
    Objectives: We investigated risk factors for venous thromboembolism (VTE), prophylaxis measures employed, and incidence of symptomatic deep venous thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing major orthopaedic surgery (MOS). Methods: An open, multicenter, prospective, observational study was conducted in 21 medical centers, comprising 899 patients. Of these. 316 patients (35.2%) underwent total hip arthroplasty (THA), 328 patients (36.5%) underwent total knee arthroplasty (TKA), and 255 patients (28.4%) underwent surgery for hip fractures (HF). Pharmacologic prophylaxis was employed in all the patients. Results: Risk factors for VTE were seen in 73.2% of the patents. the most common being obesity (72%) and prolonged immobilization (36.3%). Low-molecular-weight heparin (91.1%) and fondaparinux (8.9%) were used for prophylaxis, which was short-term in 273 patients (30.4%) and long-term in 626 patients (69.6%). Mechanical prophylaxis was performed with compression stockings in 610 patients (67.9%) and by intermittent pneumatic compression in 67 patients (7.5%). During three-months of follow-up, symptomatic DVT and PE were seen in eight (0.9%) and four patients (0.4%), respectively. Mortality occurred in 10 patients (1.1%). Complications of major and minor bleeding were seen in eight (0.9%) and 40 (4.5%) patients, respectively. Conclusion: Effective VTE prophylaxis is associated with low risk of clinically apparent DVT and PE in MOS.
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    Fatty acid and, conjugated linoleic acid profiles of infant formulas through direct transesterification of acyl lipids
    Tokusoglu, Ö; Durucasu, I; Akalin, AS; Serin, E; Aksit, S
    Fatty acid (FA) values, including C8:0, C10:0, C12:0, C13:0, C14:0, C16:0, C18:0, C18:1t, C18:1c, C18:2, C18:2 CLA, C20:0, C18:3 and C22:0, in sixteen infant formulas were determined through direct transesterification of acyl lipids with sodium methoxide by capillary gas chromatography. Total FA values ranged from 250.25-256.06 mg/g sample and the conjugated linoleic acid (CLA) (cis-9, trans-11 octadecadienoic acid) values were 1.41-2.02 mg/g sample (p < 0.01) in the infant formulas. The total saturated fatty acid, monounsaturated fatty acid and polyunsaturated fatty acid values were also obtained. The C18:3 (linolenic acid (n-3)) values were 0.63-0.88 mg/g sample, whereas the C18:2 (linoleic acid (n-6)) values ranged from 35.64-35.82 mg/g sample. FA standard mix including CLA had linear calibration curves through the origin (R-2 = 0.9999). The precision of the analytical method was (using C13:0, methyl tri-decanoate, as internal standard) within the 95% confidence limits and the mean recoveries determined for individual fatty acids in infant formulas varied from 99.8 to 100%.