Browsing by Author "Seymenoǧlu G."
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Item Fluorescein dye disappearance test in patients with different degrees of epiphora(Wichtig Editore s.r.l., 2002) Toprak A.B.; Erkin E.F.; Kayikçioǧlu Ö.; Seymenoǧlu G.; Güler C.; Unlu H.H.PURPOSE. To assess the diagnostic efficacy of a modification of the fluorescein dye disappearance test (DDT) in patients with different degrees of epiphora. METHODS. DDT was performed by instilling a drop of 2% fluorescein in the eye. Schirmer tear test strips were placed in the lower conjunctival fornix, after 3 and 10 minutes. The colour dilution on the strips was compared to a scale with known standards and the most closely comparable colour dilution was chosen and recorded as the visual scale test (VST) grade of the strip. The grey-scale value (GV) of each strip was calculated by computer image analysis. The control group comprised 44 patients, mean age 44.8 years (SD 7.5, range 30-60). There were 13 patients in group 1 with moderate epiphora; mean age was 44.2 years (SD 9.5, range 30-60). There were 17 patients in group 2 with severe epiphora; mean age was 48.3 years (SD 7.7, range 37- 60). RESULTS. VST and GV differed significantly between controls and group 1 patients at 3 minutes (p=0.002, p=0.001), and between controls and group 2 patients at 3 minutes (p<0.001, p<0.001). There was no difference between groups 1 and 2 patients in VST and GV at 3 minutes. The differences were highly significant between controls and group 1 at 10 minutes (p=0.001, p=0.007), and between controls and group 2 at 10 minutes (p<0.001, p<0.001). The differences in GV and VST between groups 1 and 2 were significant at 10 minutes (p=0.026, p=0.018). CONCLUSIONS. This modified DDT permits identification of different degrees of epiphora in a non-invasive manner, it can therefore be used to evaluate the outcome of different treatment strategies.Item Ocular manifestations and surgical results in patients with Alport syndrome(2009) Seymenoǧlu G.; Baser E.F.We report the ocular manifestations of Alport syndrome and the surgical results in 4 patients. All 4 patients had anterior lenticonus; 2 also had posterior lenticonus in both eyes, 3 had flecked retina, and 1 had posterior polymorphous dystrophy. In both eyes of the 4 patients, phacoemulsification with intraocular lens (IOL) implantation was performed to treat anterior and posterior lenticonus. The postoperative visual acuity was excellent in all patients. We recommend phacoemulsification with IOL implantation as a safe and effective procedure in patients with lenticonus secondary to Alport syndrome. © 2009 ASCRS and ESCRS.Item Nd:YAG laser posterior hyaloidotomy in premacular subhyaloid haemorrhages with various etiologies; [Çeşitli etiyolojilere baǧli premaküler subhyaloid hemorajilerde Nd:YAG lazer arka hyaloidotomi](2010) Seymenoǧlu G.; Kayikçoǧlu Ö.; Cinali M.Three male and a female patient with acute visual loss due to premacular subhyaloid haemorrhage was treated with Nd:YAG laser posterior hyaloidotomy. Their etiologies, visual acuities, fundus photographs and complications were analysized. The etiologies of subhyaloid haemorrhage were valsalva retinopathy (in two cases), direct head trauma and retinal artery macroaneurysm, respectively. Visual acuity increased in all cases after the treatment. We did not observe any complications due to the laser application in the follow up period. Nd:YAG laser posterior hyaloidotomy is an easy, safe, effective and low cost procedure in comparison with the invasive surgical procedures in the treatment of premacular subhyaloid haemorrhages. It is considered to be a good alternative teratment to the vitreoretinal surgery.Item Ultrasound-assisted vitrectomy for late stage infectious endophthalmitis(2011) Kaykçoǧlu Ö.; Emre S.; Seymenoǧlu G.We described an ultrasound-assisted technique of pars plana vitrectomy in endophthalmitis cases with visualization problems of the retina related to the loss of ocular media clarity.We performed pars plana vitrectomy, assisted with a B-mode ultrasonography, on 5 eyes of 5 patients who were referred for late-stage postcataract endophthalmitis. After the implantation of a 6.0-mm infusion port and creation of another pars plana sclerostomy, a 20-gauge vitrectomy tip was visualized in the midvitreus cavity. Core vitrectomy was performed followed by intravitreal antibiotic injection at the end of the surgery without complication in all cases.The study group of 5 patients had a mean age of 73.6 ± 7.9 years. Preoperative visual acuity was light perception positive in 2 eyes and light perception negative in 3 eyes. We obtained satisfactory cosmetic results in all patients, controlled intraocular infection, and prevented evisceration; however, there was no change in visual acuity after surgery.In this preliminary study, we obtained acceptable results with ultrasound-assisted vitrectomy, which may help retinal surgeons to operate on cases with ocular media opacity. Copyright © 2011 by Lippincott Williams & Wilkins.Item Congenital iris ectropion associated with juvenile glaucoma(2011) Seymenoǧlu G.; Başer E.Congenital iris ectropion is an uncommon malformation of the anterior segment of the eye. The authors describe a case of bilateral congenital iris ectropion associated with juvenile glaucoma in an otherwise healthy 9-year-old girl. Intra-ocular pressure (IOP) measured by Goldmann applanation tonometry was 40 mmHg in the right eye and 32 mmHg in the left eye. Despite maximum IOP lowering therapy, the desired IOP levels needed to prevent further progression of the glaucoma could not be achieved. Visual field testing and confocal scanning laser tomography showed glaucomatous neuropathy. Trabeculectomy with antimetabolites (mitomycin C 0.2 mg/ml) was performed in both eyes and IOP was normalized without IOP lowering medications during a follow-up of 4 years. The authors point out the importance of recognizing congenital iris ectropion early to prevent blindness in young patients and improve their prognosis. © 2010 Springer Science+Business Media B.V.Item Our first experience with pascal grid laser photocoagulation in diabetic macular edema; [Diyabetik maküla ödeminde pascal grid lazer fotokoagülasyonu ile ilk tecrübelerimiz](2011) Kayikçioǧlu O.; Seymenoǧlu G.; Zerdeci N.Purpose: To assess the efficacy and safety of patterned scan (Pascal) grid laser teratment in diffuse diabetic macular edema. Materials and Methods: Our study included 30 eyes of 25 patients with diffuse macular edema who were never treated before at our institution. All patients had detailed ophthalmologic examination at baseline and at 1, 3 and 6 months after treatment. Best corrected visual acuity (BCVA) was measured using Snellen chart and then converted to logMAR for statistical analysis. Macular thickness (MT) measurements were performed using spectral domain optical cohorence tomography at baseline and at every visit thereafter. Treatment was performed with Pascal system by using its specific grid pattern. Laser parameters and complications were recorded. Results: The mean age of the patients was 57.8±5.6 years. BCVA was 0.63±0.38 (logMAR) at baseline and 0.68±0.47 at 1 month, 0.64±0.47 at 3 months and 0.66±0.47 at 6 months after the treatment. MT was 370±164 μm at baseline and 383±180 μm at 1 month, 374±191 μm at 3 months and 356±196 μm at 6 months after the treatment. There was no statistically significant difference in BCVA and MT before and after the treatment in all visits. There was no complications recorded. Conclusion: Grid photocoagulation by the Pascal system is found to be safe in diffuse diabetic macular edema in short term follow up. BCVA and MT were maintained in all patients at the end of follow up. The efficacy of the treatment seems to be closely related with the metabolic control.Item The relationship between angiotensin converting enzyme insertion/deletion polymorphism and age-related macular degeneration(2011) Üçer B.; Kayikçioǧlu Ö.; Seymenoǧlu G.; Var A.; Çam S.Background: To assess the role of serum angiotensin converting enzyme (ACE) levels and ACE insertion /deletion (I/D) genetic polymorphism in Turkish age-related macular degeneration (AMD) patients and control subjects. Methods: This prospective study consisted of 78 patients with AMD and 68 control subjects. The I/D polymorphism of the ACE was carried out by polymerase chain reaction. Serum ACE levels were determined by using the ELISA method. Results: There was no significant difference in the mean serum values of ACE between the control and patient groups (p = 0.107). The genotypic frequencies of ACE polymorphism in the control and patient groups were not significantly different either (p = 0.218). Conclusion: We could not show a significant role of serum ACE levels and ACE I/D genetic polymorphism in the etiopathogenesis of AMD in the Turkish population, and our findings did not support the idea that serum ACE levels and ACE DD genotype were risk factors for AMD. © 2011 Informa Healthcare USA, Inc.Item Corneal biomechanical properties during the menstrual cycle(2011) Seymenoǧlu G.; Baser E.F.; Zerdeci N.; Gülhan C.Purpose: To determine if corneal biomechanical properties change during phases of the menstrual cycle. Methods: Twenty-five healthy women of reproductive age with no ocular pathology or systemic diseases were recruited. Corneal hysteresis, corneal resistance factor, Goldman-correlated intraocular pressure, and corneal-compensated intraocular pressure were measured by a Reichert ocular response analyzer at three phases of the menstrual cycle, beginning on days 3 to 5 (follicular phase), again at ovulation (days 14-16, ovulatory phase), and at the end of the cycle (days 25-28, luteal phase). Results: Twenty-one participants completed the study. The mean corneal hysteresis values at follicular, ovulatory, and luteal phases were 10.7, 10.7, and 10.7 mmHg (p>0.05), and the mean corneal resistance factor values at the same time points were 9.9, 9.9, and 9.8 mmHg (p>0.05), respectively. Corneal-compensated intraocular pressure and Goldman-correlated intraocular pressure readings were stable during the course (p>0.05 for all). Conclusions: Corneal biomechanical properties and intraocular pressure as measured by an ocular response analyzer do not change statistically significantly during the different phases of the menstrual cycle. We conclude that measurements of the ocular response analyzer can be safely utilized in healthy female subjects without considering the possible effects of varying hormonal levels during the menstrual cycle. © 2011 Informa Healthcare USA, Inc.Item Resolution of vitreomacular traction following intravitreal triamcinolone acetonide injection in an eye with branch retinal vein occlusion(Dove Medical Press Ltd, 2012) Seymenoǧlu G.; Kayikçioǧlu O.; Şahin B.O.A 60-year-old woman with a past medical history of branch retinal vein occlusion presented with decreased vision and metamorphopsia in her left eye. A fundus examination revealed a tortuous retinal vein with a few retinal hemorrhages in the inferotemporal quadrant. Optical coherence tomography revealed a partially separated posterior vitreous membrane pulling up the fovea. The patient refused surgical treatment so intravitreal triamcinolone acetonide (4 mg/0.1 mL) was administered. The patient reported resolution of symptoms in her left eye following this treatment, but her visual acuity did not show any improvement. Optical coherence tomography scanning revealed a complete detachment of the posterior hyaloid with release of the vitreomacular traction. In patients with vitreomacular traction and branch retinal vein occlusion, the combination of the possible vitreous liquefaction and mechanical increase of vitreous volume caused by an intravitreal injection with a degree of reduction in retinal thickness may play a role in the resolution of vitreomacular traction. © 2012 Seymenoǧlu et al, publisher and licensee Dove Medical Press Ltd.Item Evaluation of macula with optical coherence tomography in patients with decreased visual acuity after successful retinal detachment surgery; [Başarılı Regmatojen Retina Dekolmanı Ameliyatlarından Sonra Görme Rehabilitasyonunun Saǧlanamadıǧı Olgularda Makulanın Optik Koherens Tomografi ile Deǧerlendirilmesi](Turkish Ophthalmology Society, 2012) Seymenoǧlu G.; Şahin B.Ö.; Top C.G.; Kayikçioǧlu O.; Başer E.Purpose: To study the foveal microstructural changes that may explain the incomplete visual recovery in eyes with anatomically successful repair of rhegmatogenous retinal detachments (RRD) using spectral-domain optical coherence tomography (OCT) and to evaluate the correlation between foveal changes and postoperative visual acuity. Material and Method: Forty-four eyes of 43 patients with macula-off RRDs were examined in our study. Patients were examined on first, third and sixth months postoperatively. The patients had a complete ophthalmological examination and OCT images were obtained at all postoperative visits. The postoperative OCT findings were classified in 4 groups: Group 1: continuous inner segment/outer segment (IS/OS) line, Group 2: disrupted IS/OS line, Group 3: epiretinal membrane (ERM), Group 4: residual foveal detachment. Results: Postoperative OCT findings showed that group 1 consisted of 19 eyes (43.2%), group 2 consisted of 15 eyes (34.1%), group 3 consisted of 7 eyes (15.9%) and group 4 consisted of 3 eyes (6.8%). The mean best-corrected visual acuity (BCVA) was significantly higher (p<0.001). Discussion: Spectral-domain OCT provides valuable information which helps the understanding of foveal microstructural changes and explains the possible causes of poor postoperative visual acuity in eyes with anatomically successful RRD repair.Item Comparison of pain response of patients undergoing panretinal photocoagulation for proliferati diabetic retinopathy: 532 nm standard laser vs. multispot pattern scan laser; [Proliferatif diyabetik retinopati nedeniyle panretinal fotokoagulasyon yapılan hastalarda aǧrı cevabının karşılaştırılması: 532 nm standart lazer vs multispot patern taramalı lazer](Turkish Ophthalmology Society, 2013) Seymenoǧlu G.; Kayikçioǧlu O.; Başer E.; Sami Ilker S.Purpose: To compare pain response of patients undergoing panretinal photocoagulation (PRP) for proliferative diabetic retinopathy (PDR) using 532 nm standard laser versus multispot pattern scan laser and to evaluate the relationship between pain response and patient characteristics. Material and Method: Thirty-five patients had PRP with the Pascal system in a single session, while other 35 patients had PRP with conventional laser in 2 sessions. Parameters used in conventional laser were as follows: spot size 200 μm, exposure time 0.2 s, and power sufficient to produce visible grey-white burns. We used same spot size, 20-30 ms exposure time, and higher levels of laser power in order to get a similar endpoint in the Pascal system. The patients were required to evaluate the severity of pain on a visual analog scale (VAS) and verbally 5 minutes after PRP with Pascal and 5 minutes after the first session of PRP with conventional laser. The relationship between pain experienced and patient characteristics was evaluated. Results: At baseline, both groups did not differ significantly (p >0.05, for all) with respect to sex, age, duration of diabetes, most recent HbA1c, treatment regimen, or patient experience. The patients in the Pascal group had a mean pain score of 0.55±0.70 on verbal scale and 1.54±1.22 on VAS compared to 2.17±1.18 and 5.54±3.28, respectively in the conventional laser group which was, statistically, significantly different in both scales (p<0.05). Discussion: Our study confirms that new generation pattern scanning photocoagulators satisfactorily decrease the pain by shortening the exposure time while increasing the laser power.Item Comparison of spectral-domain optical coherence tomography and heidelberg retina tomograph III optic nerve head parameters in glaucoma(2013) Seymenoǧlu G.; Başer E.; Öztürk B.Background: To evaluate the agreement between the optic nerve head (ONH) measurements obtained by spectral-domain optical coherence tomography/scanning laser ophthalmoscope (SD-OCT/SLO) and the Heidelberg retinal tomograph III (HRT-III), and to compare the ONH measurements of both devices in different glaucoma types. Methods: In a prospective study, 30 patients with primary open-angle glaucoma (POAG) and 30 patients with pseudoexfoliation glaucoma (PXG) were enrolled. All patients underwent SD-OCT/SLO and HRT-III evaluation of the ONH during the same visit. Agreement between measurements of SD-OCT/SLO and HRT-III were evaluated by determination of intraclass correlation coeficients. In addition, mean ONH measurements obtained with both devices were compared between POAG and PXG patient groups. Results: Mean SD-OCT/SLO measurements were greater than those of HRT-III, except for mean and maximum cup depth. Intraclass correlation coefficient values for disc area, rim area, cup area, cup/disc area ratio, mean cup depth and maximum cup depth were 0.367, 0.213, 0.632, 0.681, 0.775 and 0.661, respectively. No significant differences were found between ONH parameters of POAG and PXG patients as measured with both devices (p > 0.01). Conclusion: ONH measurements with SD-OCT/SLO and HRT-III did not show clinically acceptable agreement in glaucoma patients. This precludes interchangeable use of these measurements in clinical practice. PXG and POAG patient groups displayed similar ONH measurements with both devices. Copyright © 2012 S. Karger AG, Basel.Item Surgically induced changes in corneal viscoelastic properties after 23-gauge pars plana vitrectomy using ocular response analyzer(2013) Seymenoǧlu G.; Uzun Ö.; Başer E.Purpose: To evaluate surgically induced changes in corneal viscoelastic properties of patients undergoing 23-gauge transconjunctival sutureless vitrectomy (23-G TSV). Methods: The study group consisted of 29 eyes of 29 patients undergoing 23-G TSV. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), corneal compensated intraocular pressure (IOPcc) and central corneal thickness (CCT) were measured by ocular response analyser (ORA), preoperatively and 1 and 3 months postoperatively. Goldmann applanation tonometry (GAT) was also performed in the same time periods. The ORA measurements before and after the surgery were compared statistically. In addition, the ORA measurements of a control group comprising of 29 normal subjects were also compared with the preoperative measurements of the patient group. Finally the relationship between the CH values and the CCT and GAT values was also assessed. Results: The preoperative ORA measurements of the study group were similar to those of the control groups' (p > 0.05 for all). In the study group, mean CH decreased and mean IOPcc increased significantly at 1 month compared with their respective preoperative values (p = 0.04 and p = 0.03, respectively). However CH and IOPcc measurements at 3 months were similar to the preoperative measurements (p > 0.05). Mean CRF, IOPg, GAT and CCT measurements did not change significantly during the study period (p > 0.05). CH was weakly correlated with CCT preoperatively, 1 and 3 months postoperatively (r = 0.33, r = 0.33, r = 0.43, p < 0.05 for all, respectively). There was also a weak but significant correlation between CH and GAT preoperatively (r = 0.42, p = 0.008), 1 month postoperatively (r = 0.36, p = 0.03), 3 months postoperatively (r = 0.40, p = 0.01). Conclusion: Corneal viscoelastic properties are not significantly influenced in the late postoperative period by 23-G TSV which is a minimal invasive vitreoretinal surgical technique. © 2013 Informa Healthcare USA, Inc.Item Idiopathic inflammatory neuroretinitis simulating optic nerve sheath dural ectasia(Informa Healthcare, 2013) Ilker S.S.; Seymenoǧlu G.; Tarhan S.; Uzun Ö.; Şencan S.We report a case of a 32-year-old female patient who presented with decreased vision on both eyes and headache. In fundus examination, both eyes had elevation of the optic disc and star shaped hard exudates in the macula. Magnetic resonance imaging was completely normal except the saccular dilatation of bilateral optic nerve sheath. The patient was treated with oral steroids following high-dose intravenous methylprednisolone. She displayed good anatomical and functional results during the follow-up. This case raises the possibility that optic nerve sheath enlargement, probably induced by an idiopathic inflammatory optic neuritis, may simulate dural ectasia of the optic nerve sheath. © 2013 Informa UK Ltd. All rights reserved.Item An unusual association of Goldenhar syndrome(2013) Seymenoǧlu G.; Başer E.; Tansuǧ N.; Demireli P.Goldenhar syndrome is well known for its classical triad of epibulbar dermoids or lipodermoids, auricular appendages and pretragal fistulas. Here we report a case of Goldenhar syndrome with an unusual association of a fibroepithelial polyp attached to a limbal dermoid. A case of Goldenhar syndrome in a 5-month-old male infant presented with the features of a fibroepithelial polyp attached to a limbal dermoid, right-sided polydactylia with hypoplastic thumb, and accessory preauricular appendages on the left side. The association of a fibroepithelial polyp attached to a limbal dermoid with Goldenhar syndrome is a rare report in the literature. In these cases, regular follow-up with an ophthalmologist is important to monitor the visual development of the patient. Ideally, a multidisciplinary approach is required to manage the other associated anomalies. © 2012 Springer Science+Business Media Dordrecht.Item Vitreoretinal interface in asymptomatic fellow eyes of patients with unilateral macular holes; [Tek tarafli idiopatik maküla deliǧi olan olgularin asemptomatik diǧer gözlerinde vitreoretinal arayüzey özellikleri](2013) Seymenoǧlu G.; Ulusoy O.; Başer E.; Kayikçioǧlu Ö.; Kurt E.; Ilker S.S.Purpose: To compare the vitreoretinal interface of the asymptomatic fellow eyes of patients with unilateral idiopathic macular holes (MH) with the asymptomatic fellow eyes of patients with idiopathic epiretinal membranes (ERM) and with the healthy eyes. Materials and Methods: Thirty-tree patients with unilateral MH (group 1), 33 patients with unilateral ERM (group 2) and 33 healthy eyes were included in the study. All patients underwent a comprehensive ophthalmologic examination and spectral domain optical cohorence tomography (OCT) was performed on all eyes. The incidence of the features of the vitreoretinal interface and foveal micro-structures in the OCT images were compared among the asymptomatic fellow eyes of patients with unilateral MH, ERM and one of the randomly selected healthy eyes of normal individuals which have any ophthalmic pathology except refractive errors. A complete posterior vitreus detachment (PVD) was considered to be present if the Weiss ring was seen on biomicroscopy or a hiper-reflective band representing a posterior hyaloid membrane over the entire macula was seen on OCT. Results: The incidence of perifoveal PVD was 45.5% in group 1, 21.2% in group 2 and 24.2% in group 3. The OCT scans showed different types of foveal deformations associated with vitreofoveal adhesions in eyes without a total PVD. The incidence of the foveal deformations associated with vitreofoveal adhesions was significantly higher (p<0.039) in the fellow eyes of the unilateral MH group (27%) than that in the other groups (0%). The OCT scans also showed residual foveal deformations in eyes with total PVD. The incidence of residual foveal deformation in eyes with total PVD was similar between MH and ERM groups (33%-27%, p=0,75), but it was significantly higher in the MH (33%) and ERM (27%) groups than that in healthy eyes (19%, p<0.01). Conclusion: The higher incidence of foveal deformations in the asymptomatic fellow eyes of patients with unilateral MH with vitreofoveal adhesions suggests that patients in whom MH may develop have abnormally strong vitreofoveal adhesions sufficient to cause foveal deformation and macular holes.Item Cancer-associated retinopathy and its clinical features; [Kanser ilişkili retinopati ve klinik özellikleri](Gazi Eye Foundation, 2017) Ayhan Z.; Ünlü B.; Seymenoǧlu G.; Saatçi A.O.Purpose: To report the clinical features of a case with cancer-related retinopathy and review the disease. Method: Retrospective case report. Results: A 65-year-old woman was presented to us with a history of bilateral gradual vision deterioration and nyctalopia for three months'duration. She was previously diagnosed to have a neuroendocrine tumor in 2008 and received a multitude of systemic therapies including surgical resection, chemotherapy and radiotherapy. On examination, her best-corrected visual acuity was 0.3 with normal anterior segment and normal looking posterior pole OU. Bilateral peripheral consantric narrowing was present at the visual field test and depressed scotopic responses was revealed at the ERG test. The diagnosis was cancer-associated retinopathy. Unfortunately, she died in three months time due to multiple metastasis. Conclusion: Cancer-associated retinopathy should be considered in differential diagnosis of patients presenting with progressive vision loss and nyctalopia. © 2017 Gazi Eye Foundation. All rights reserved.