Browsing by Author "Simsek, H"

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    The Effects of Meloxicam on Neural Tube Development in the Early Stage of Chick Embryos
    Cetinkal, A; Colak, A; Topuz, K; Demircan, MN; Simsek, H; Berber, U; Umur, AS; Selcuki, M; Vatansever, HS
    AIM: The aim of this study is to demonstrate the effect of meloxicam in early stage chick embryos on neural tube development. MATERIAL and METHODS: One hundred specific pathogen-free (SPF) chicken eggs were used to investigate the neurulation. SPF eggs were invastigated in four groups (n:25). All of the groups were incubated at 37.2 +/- 0.1 degrees C and 60 +/- 5% relative humidity for 30 hours, and an embryological development in the ninth stage as classified by Hamburger and Hamilton was obtained. In the end of the 30th hour, group A (control group) was administered 0.1 ml of saline (0.9% NaCl) in ovo and the other groups were administered meloxicam in increasing doses. At the end of 72 hours, all of the embryos were extracted from eggs and they underwent pathological examination with hematoxylin cosine and immuno-histopathological examinations with CD138 and tubulin beta II. RESULTS: While the groups A and B showed no neural tube defects, totally eight defective embryos were detected in the groups C and D (three in group C and five in group D. CONCLUSION: Our results suggested that meloxicam, a nonselective COX inhibitor, caused neural tube closure defects when injected at supratherapeutic doses. However, further studies with larger numbers of subjects are needed for its use in lower doses.
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    Decomposing socioeconomic inequalities in self assessed health in Turkey
    Sözmen, K; Baydur, H; Simsek, H; Ünal, B
    Introduction: This study aimed to measure socioeconomic inequalities in Self Assessed Health (SAH) and evaluate the determinants of such inequalities in terms of their contributions amongst the Turkish population. Methods: We used data from the Turkish part of World Health Survey 2003 with 10,287 respondents over 18 years old. Concentration index (CI) of SAH was calculated as a measure of socioeconomic inequalities in health, and contributions of each determinant to inequality were evaluated using a decomposition method. Results: In total 952 participants (9.3%) rated their health status as either bad or very bad. The CI for SAH was -0.15, suggesting that suboptimal SAH was reported more by those categorised as poor. The multiple logistic regression results indicated that having secondary, primary or less than primary school education, not being married and being in the lowest wealth quintile, significantly increased the risk of having poor SAH. The largest contributions to inequality were attributed to education level (70.7%), household economic status (9.7%) and geographical area lived in (8.4%). Conclusion: The findings indicate that socioeconomic inequalities measured by SAH are apparent amongst the Turkish population. Education and household wealth were the greatest contributing factors to SAH inequality. These inequalities need to be explicitly addressed and vulnerable subgroups should be targeted to reduce the socioeconomic disparities.
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    THE EFFECTS OF DIFFERENT LEVELS OF Fe-EDDHA APPLICATIONS IN A VINEYARD (Vitis vinifera L.) IN THE SEMI-ARID ENVIRONMENT
    Aydin, S; Yagmur, B; Yegenoglu, ED; Simsek, H
    Most of the production of seedless grapes ( Vitis vinifera L.) in Turkey is covered by the Aegean region, mainly in Manisa Province. It accounts for a significant part of the export (80%). One of the widespread micro element deficiencies in the soils of the Aegean Region in Turkey is Fe deficiency (Fe chlorosis). The inorganic Fe salts applied into the soils or sprayed on the leaves and organic chelates containing Fe such as FeEDTA or FeEDDHA have been used to correct Fe chlorosis in recent years. The aim of this study was to determine the effects of different FeEDDHA dosages on some yield quality parameters (total soluble solids %, pH, titratable acidity %, total Fe and active Fe content in leaves) of fresh grapes and some macro-and micro elements (N, P, K, Ca, Mg, Fe, Zn, Mn, Cu, active Fe) in leaves. In the study, four different doses of FeEDDHA (0, 20, 40, 60 g(-1)) were applied to the soil. It was found that there was less N deficiency but more P and K deficiency in the vineyard. Moreover, Ca, Mg, total Fe, Zn, Mn, and Cu deficiency were not observed in the vineyard. The yield of fresh grapes increased with the iron content, with the most efficient result obtained at a level of 20 g(-1) FeEDDHA.
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    QUALITY PARAMETERS OF VINEYARD IRRIGATION WATER IN A SEMI-ARID REGION: THE PLAIN OF ALASEHIR, TURKEY
    Yagmur, B; Aydin, S; Okur, B; Coban, H; Simsek, H
    Production of seedless raisins is extremely important in Aegean Region in Turkey. The Plain of Alasehir in province of Manisa in Aegean Region is extremely important for seedless raisin production since 25% of the seedless raisin has been grown in this area. The irrigation water samples were collected from 13 different water distribution locations in the Plain of Alasehir. Results showed that pH and EC (electrical conductivity) values were in a reasonable range except EC levels from two locations were slightly high. The vineyard irrigation water in the region was classified as type of C3S1. It was suggested that, the salt content might be monitored continuously since salinity might increase in the soil through the end of the irrigation season. The most common cations were Ca++ and Mg++, and anion was HCO3-. Trace elements and heavy metals were under the risk limits except Mn was high in three locations. Boron was high in nine sampling locations. Overall, irrigation waters in the Plain of Alasehir were suitable for vineyard irrigation as long as the contents of boron and salinity were continuously monitored.
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    THE NUTRITIONAL CONDITIONS AND SOME HEAVY METAL CONTENTS OF THE VINEYARDS IN A SEMI-ARID AREA
    Aydin, S; Yagmur, B; Coban, H; Simsek, H
    Turkey is one of the most important seedless raisin producers in the world market. Approximately, 82% of the seedless raisin has been produced in the western part of Turkey since the climate (semi-arid) of this region is very appropriate to grow seedless grape. More specifically, the Plain of Alasehir, located in the Gediz Basin in Aegean Region has been known its high quality seedless raisin production. About 25% of the seedless raisin of the entire Aegean Region is produced in the Plain of Alasehir. Therefore, the Plain of Alasehir region was selected to determine some heavy metal contents (Cd, Co, Cr, and Pb) and certain macro and micro element contents (N, P, K, Ca, Mg, Fe, Zn, Mn, and Cu) of the leaf samples obtained from the vineyards in the area. The plant samples from 13 vineyards were analyzed by collecting the samples across the first plant bunch during the veraison period. In terms of nutrition profile, N deficiency was detected in 15% of vineyards while P deficiency was determined in 38.5% of the vineyards. Similarly, Fe deficiency was detected in the 30.8% of the vineyards. The contents of Zn, Mn, Cu, K, Ca, and Mg were sufficient in all of the vineyards. Some heavy metal contents of the leaf samples were analyzed and it was found that there was no pollution for the Cd, Co, and Pb in all the vineyards. Cr pollution was not detected in 93.2% of the samples.
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    Caffeine use in preterm neonates: national insights into Turkish NICU practices
    Unal, S; Beken, S; Ince, DA; Turan, O; Toygar, AK; Ecevit, A; Akcan, AB; Akin, MA; Aktas, S; Ciftdemir, NA; Altuncu, E; Altunhan, H; Arcagok, BC; Armangil, D; Ozer, EA; Aydin, B; Bezirganoglu, H; Bilgin, L; Calisici, E; Calkavur, S; Celik, K; Celik, Y; Cetinkaya, B; Cetinkaya, M; Demirel, A; Demirel, G; Dogan, NN; Dogan, P; Durukan, M; Engur, D; Ercan, TE; Gokmen, Z; Varal, IG; Gulasi, S; Gunlemez, A; Gursoy, T; Toptan, HH; Hamitoglu, S; Isleyen, F; Iyigun, I; Kader, S; Kahvecioglu, D; Kayki, G; Kostu, M; Kurnaz, D; Mammadaliyev, T; Akin, IM; Narli, N; Okulu, E; Okur, N; Olukman, O; Ovali, F; Ozcan, B; Ozdemir, A; Ozdemir, O; Ozkan, H; Sandal, G; Sarici, D; Sivrikaya, C; Bilgin, BS; Sundus, S; Onay, OS; Simsek, H; Tandircioglu, UA; Tanriverdi, S; Tekgunduz, KS; Terek, D; Tunc, G; Tunc, T; Tutak, E; Tufekcioglu, E; Erdogan, FT; Ulu, E; Isik, DU; Uras, N; Uslu, SI; Unal, I; Yilmaz, FH; Moniri, A
    Objective: Caffeine is a proven medication used for the prevention and treatment of apnea in premature infants, offering both short- and long-term benefits. International guidelines provide a range of recommendations regarding the preterm population eligible for caffeine prophylaxis, including the timing, dosage, and duration of treatment. Our national guidelines, published prior to the most recent updates of the international guidelines, recommend the use of caffeine citrate starting from the first day after delivery for preterm infants with a gestational age of <28 weeks. For infants up to 32 weeks, if positive pressure ventilation is required, the decision should be made on an individual basis. This study aims to describe the variability in caffeine usage across neonatal intensive care units in our country. Methods: An online survey was sent to neonatologist who are members of the Turkish Neonatology Society to describe the variability in caffeine usage in neonatal intensive care units in our country. Results: We collected responses from 74 units. Prophylactic caffeine usage was observed as; GA <= 27(6/7): 98.6%, GA 28(0/7)-28(6/7): 89.0%, GA 29(0/7)-29(6/7): 75.3%, GA 30(0/7)-31(6/7): 53.4%. 62.2% of units reported administering loading dose within the first two hours. The initial maintenance dose was 5 mg/kg in 64.8% of units, 10 mg/kg in 32.4% of units, and intermediate dose in 5.3% of units. 47.3% of units reported no routine dose adjustment. The postmenstrual age that caffeine treatment was stopped was found to be 34 (min-max; 32-36) weeks for infants without apnea and respiratory support, 36 (min-max; 34-52) weeks for infants without apnea but any respiratory support. The time to discharge after treatment cessation was found as; 1-4 days: 37.8%, 5-7 days: 68.9%. Among the 56 units with multiple responsible physicians, 32.1% reported intra-unit variations. Conclusion: The significant differences in caffeine usage characteristics between and within units highlight the need for clear recommendations provided by standardized guidelines.