Browsing by Author "Simsek T."

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    A Turkish Gynecologic Oncology Group study of fertility-sparing treatment for early-stage endometrial cancer
    (John Wiley and Sons Ltd, 2012) Dursun P.; Erkanli S.; Güzel A.B.; Gultekin M.; Tarhan N.C.; Altundag O.; Demirkiran F.; Beşe T.; Yildirim Y.; Bozdag G.; Yarali H.; Simsek T.; Ozcelik B.; Ortaç F.; Taskin S.; Guvenal T.; Ozgul N.; Haberal A.; Vardar M.A.; Dede M.; Yenen M.; Altintas A.; Arvas M.; Ayhan A.
    Objective: To analyze the results of fertility-sparing treatment of early-stage endometrial cancer (EC) in patients treated at Turkish gynecologic oncology centers, and to present a review of the literature. Methods: Thirteen healthcare centers in Turkey were contacted to determine if they were eligible to participate in the study. Centers that were eligible and agreed to participate were sent a database form to record the demographic characteristics, clinicopathologic findings, and follow-up results for their EC patients. Results: Eleven Turkish healthcare centers provided data on 43 EC patients. Mean duration of treatment was 5 months and mean follow-up was 49 months. In total, 35 (81.4%) patients were tumor free following primary progesterone therapy. Mean time from the end of progesterone therapy to pregnancy was 10.6 ± 4.3 months (range, 3-18 months). Two patients had tumor recurrence during follow-up. The pregnancy rate among the 31 women who actively sought pregnancy was 41.9% (n = 13). Conclusion: Conservative management of early-stage EC in women of reproductive age using oral progestins was effective and did not compromise oncological outcome. Pregnancy in the study patients was achieved spontaneously and artificially. © 2012 International Federation of Gynecology and Obstetrics.
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    Multicenter analysis of gestational trophoblastic neoplasia in Turkey
    (Asian Pacific Organization for Cancer Prevention, 2014) Ozalp S.S.; Telli E.; Oge T.; Tulunay G.; Boran N.; Turan T.; Yenen M.; Kurdoglu Z.; Ozler A.; Yuce K.; Ulker V.; Arvas M.; Demirkiran F.; Bese T.; Tokgozoglu N.; Onan A.; Sanci M.; Gokcu M.; Tosun G.; Dikmen Y.; Ozsaran A.; Terek M.C.; Akman L.; Yetimalar H.; Kilic D.S.; Gungor T.; Ozgu E.; Yildiz Y.; Kokcu A.; Kefeli M.; Kuruoglu S.; Yuksel H.; Guvenal T.; Hasdemir P.S.; Ozcelik B.; Serin S.; Dolanbay M.; Arioz D.T.; Tuncer N.; Bozkaya H.; Guven S.; Kulaksiz D.; Varol F.; Yanik A.; Ogurlu G.; Simsek T.; Toptas T.; Dogan S.; Camuzoglu H.; Api M.; Guzin K.; Caliskan E.; Doger E.; Cakmak B.; Ilhan T.T.
    Background: To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. Materials and Methods: A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated. Results: From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients. Conclusions: Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.
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    Unusual presentation of congenital dermal sinus: Tethered cord with paramedian cutaneous ostia
    (Lippincott Williams and Wilkins, 2015) Mete M.; Simsek T.; Umur A.S.; Selçuki M.; Umur N.; Gurgen S.G.
    Congenital dermal sinus tract is a rare dysraphism with an incidence of 1/2500-3000 ratio. The sinus ostium located in the midline of the posterior of the body from the occiput to the lumbosacral region. Paramedian congenital dermal sinus tract with paramedian ostium are rare. Here, we describe a 2-year-old boy who presented with paramedian pigmented lesion with an ostium on the left lumbosacral region. During surgery we noted that sinus tract attached to thick lipomatous filum terminale. © 2013 Wolters Kluwer Health, Inc.