Browsing by Author "Sobaci, G"

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    Effect of propolis on endotoxin-induced uveitis in rabbits
    Öztürk, F; Kurt, E; Inan, ÜÜ; Emiroglu, L; Ilker, SS; Sobaci, G
    Purpose: To test the anti-inflammatory effect of propolis, a natural bee-produced compound, and compare it with corticosteroids fur the: treatment of endotoxin-induced uveitis (EIU). Methods: EIU was produced in all rabbits by unilateral intravitreal injection of 2,000 ng Salmonella typhimurium endotoxin. The animals were then divided randomly into three groups as follows: group A received no treatment (control), group B received methylprednisolone (5 mg/0.1 mL) (positive control); and group C received propolis (5 mg/0.16 mL) by anterior sub-Tenon injection at the time of uveitis induction and at 4 and 8 hours after induction. Inflammation was evaluated by clinical manifestations and by measuring the protein concentration and inflammatory cell content of the aqueous humor. Results: The clinical grade, cell count: and protein levels in the aqueous humor were: control group (6.0 +/- 0.8, 2,519 +/- 470 cells/mu L. 32.9 +/- 2.4 mg/mL); methylprednisolone group (1.8 +/- 0.7, 572 +/- 137 cells/mu L. 15.2 +/- 1.8 mg/mL); and propolis group (2.3 +/- 0.5, 503 +/- 124 cells/mu L, 13.8 +/- 1.5 mg/mL). Statistically significant differences were recorded in the treatment groups when compared to the control group (P < .001). The effects of methylprednisolone and propolIs on EIU were similar (P > .05). Conclusions: Propolis showed significant anti-inflammatory effects on EIU iii rabbits. The mechanism of its action warrants further investigation. Jpn J Ophthalmol 1999;43:285-289. (C) 1999 Japanese Ophthalmological Society.
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    Efficacy of topical lodoxamide vs sodium cromoglycate and dexamethasone in rabbits with passive allergic conjunctivitis
    Özturk, F; Güler, M; Ilker, SS; Sobaci, G
    A comparative study was conducted to evaluate the efficacy of lodoxamide tromethamine vs sodium cromoglycate and dexamethasone sodium phosphate in experimental allergic conjunctivitis in 45 rabbit eyes. The animals were randomly divided into 3 groups and treated with lodoxamide, cromoglycate, or dexamethasone. Blood-conjunctival permeability index and the weight of the conjunctiva were used to quantify the ocular inflammatory reaction. Lodoxamide was more effective than sodium cromoglycate but not dexamethasone in the treatment of acute allergic conjunctivitis.
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    Antineovascular effect of α-interferon on corneal neovascularization in rats
    Öztürk, F; Sobaci, G; Ilker, SS; Can, C
    Clinical and histologic effects of topical recombinant a-interferon (IFN) systemic IFN topical dexamethasone, and dexamethasone plus topical IFN on corneal neovascularization in response to silver nitrate cauterization were investigated in 110 eyes of 60 Wistar rats. The eyes were evaluated according to tire burn stimulus, neovascularization, and histologic inflammation grades 5 days after cauterization. Antineovascular effects of topical and systemic IFN were significantly greater than a placebo but less than dexamethasone alone or in combination with IFN.
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    An investigation of the effects of photothrombosis and photocoagulation on corneal neovascularization
    Sobaci, G; Guven, T; Yel, M; Ilker, SS
    This study reports on the intracellular effects of photocoagulation and photothrombosis applications on experimental corneal neovascularization created in rabbit eyes. Some vessels were left untreated as controls while others were subjected to argon laser photocoagulation and photothrombosis. The resulting ultrastructural changes, which take place relatively moderately in photocoagulation compared with those in photothrombosis, were responsible for the vessel blockage occurring at low energy levels in photothrombosis.