Browsing by Author "Sonmez C."

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    Evaluation of proinflammatory cytokine and neopterin levels in women with papillary thyroid carcinoma
    (Wichtig Publishing Srl, 2017) Beksac K.; Sonmez C.; Cetin B.; Kismali G.; Sel T.; Tuncer Y.; Kosova F.
    Introduction:Papillary thyroid cancer is a disease that has been associated with chronic inflammation. The purpose of this study is to measure the production of the proinflammatory cytokines IL-1β, IL-6 and IL-8 and neopterin, which is a novel biomarker for cellular immune response in papillary thyroid cancer. Materials and methods:The serum IL-1β, IL-6, IL-8 and neopterin values of 31 papillary thyroid cancer patients undergoing bilateral total thyroidectomy were measured before and 20 days after surgery. The values were compared with those of 39 healthy controls. Results:Serum IL-1β levels were similar across groups. IL-6 (p<0.001), IL-8 (p = 0.015) and neopterin levels (p = 0.002) were higher in presurgical samples and returned to normal following surgery. Conclusions:The proinflammatory cytokines IL-6 and IL-8, but not IL-1β, were produced in greater amounts in papillary thyroid cancer. Serum neopterin seems to be a valid biological marker supporting the presence of papillary thyroid cancer. © 2016 Wichtig Publishing.
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    An important source of preanalytical error in medical laboratories: Centrifugation
    (De Gruyter Open Ltd, 2021) Sonmez C.; Gümüs A.; Senes M.; Aykal G.; Taneli F.; Aksungar F.; Avci E.; Coskun C.; Çinaroglu I.; Colak A.; Eker P.; Güçel F.; Hakligor A.; Inal B.B.; Orhan B.; Yilmaz C.
    Centrifugation separates particles within the specimen according to their shape, dimensions, and density and basically can be defined as a separation method. The centrifuge is an essential device in medical laboratories to prepare the serum, plasma, and urine samples for analysis. It is basically an electric device composed of the stationary (motor) and the motile (rotor) part. The centrifugation depends on two main variables: relative centrifugal force (RCF) and centrifugation time. The physical impact separating the specimen into its components in the centrifuge known as RCF is expressed as the multiples of gravitational acceleration (×g). RPM, defined as the number of rotations of the centrifuge perminute, shows the speed of the centrifuge. RCF value can be calculated by using RPM, and the centrifuge radius. Because models and sizes of centrifuges vary considerably, the use of gravity (g) forces instead of RPM is suggested. The centrifuges can be classified according to their usage, speed, technical specifications, and rotor type. An accurate and precise centrifugation process is essential to prevent errors in the preanalytical phase. The purpose of this document is to ensure the standardization of a good, precise protocol for the centrifugation process among the medical laboratories. © 2021 De Gruyter. All rights reserved.