Browsing by Author "Soygür, H"

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    Effect of citalopram versus escitalopram on quality of life in the treatment of the acute phase of major depressive disorder: a comparative, open-label study
    Aydemir, Ö; Ergün, H; Kesebir, S; Soygür, H; Tulunay, C
    Effect of citalopram versus escitalopram on quality of life in the treatment of the acute phase of major depressive disorder: a comparative, open-label study Objective: In the treatment of major depressive disorder, in addition to the remission of symptoms, improvement in functionality and subjective quality of life of the patients is desirable. In this study, we aimed to evaluate and compare the changes in quality of life measures in citalopram- versus escitalopram-treated major depressive disorder patients, and to compare the scores of the patients who achieved remission at the end of treatment with standard scores of the Turkish population. Methods: The study was carried out in 74 outpatients with major depressive disorder. The mean age was 40.6 in the citalopram group and 24 (63.5%) of them were female. In the escitalopram group, the mean age was 38.6 and 62.2% of the group were female. Duration of illness was 3.19 years in the citalopram group and 3.49 years in escitalopram group. In the citalopram group 54.1% of the patients experienced single episodes, while 81.196 of the escitalopram group had single episodes. To assess the severity of depression, the Hamilton Depression Rating Scale (HAM-D) was utilized. For the assessment of quality of life, Short Form-36 (SF-36) and EuroQol-5D (EQ-5D) were used. Patients were randomized to either citalopram or escitalopram for the treatment and evaluated at the 2(nd), 4(th) and 6(th) weeks. Citalopram was started at a dose of 20 mg/day, and escitalopram was started at a dose of 10 mg/day. Treatment response was accepted as a 50% decrease in the index assessment and remission was accepted as HAM-D <= 7. After the 2(nd) week, in patients without a decrease of more than 25% in HAM-D scores as a treatment response, the medication dose was raised by 50%. In the statistical analyses, the T Test was performed for groups with normal distribution, whereas for groups without normal distribution, the Mann-Whitney U Test was performed. In addition for the assessment of change in the parameters, Cohen's d Test was calculated for effect size. Results: At the end of the 6(th) week, the mean dose for the citalopram treated patients was 24.6 mg/day and for the escitalopram treated patients it was 11.8 mg/day. All patients responded and the remission rate (HAM-D <= 7) was 63.5%. There was no statistical difference between the treatment groups in terms of response and remission. In the quality of life measures, all domain scores of both SF-36 and EQ-5D were found to improve significantly starting at the 4(th) week. The two treatment groups did not differ in terms of quality of life variables, but in the 2(nd) week in the escitalopram group more parameters of quality of life were found lobe improved. At the end of the 6(th) week, even though the patients had significantly increased scores, the effect size for all parameters was moderate. Patients who reached remission in both treatment groups (n=53) still had lower scores in the domains of SF-36 such as general health perception, social functioning, and emotional role difficulties compared to the standard values of Turkish population. Patients with recurrent episodes had more impairment at the end of the acute treatment. Conclusions: There was no significant difference between citalopram and escitalopram regarding the decrease in quality of life scores. While the scores of quality of life and functioning measures increased significantly, normalization was not obtained in either group in terms of quality of life.
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    Validating the Sexual Adjustment and Body Image Scale (Sabis) with Breast Cancer Patients
    Özalp, E; Karslioglu, EH; Aydemir, Ö; Soygür, H; Erkek, BM; Peker, SE; Kaymak, SU
    The purpose of this study was to develop and validate the Sexual Adjustment and Body Image Scale (SABIS), a self-report measure of body image and sexual adjustment for use with Turkish patients with breast cancer. We administered the SABIS to one hundred sixty-nine women who had undergone initial surgical treatment for primary breast cancer. The psychometric properties of the SABIS were examined, and it was found to be a reliable and valid assessment of body image and sexuality in patients with breast cancer following surgery; however, it did not cover all dimensions representing patients' sexuality and body image. Patients' sexual problems need to be assessed more comprehensively, using more culturally sensitive items.
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    Lessons Learned from Experiencing Mavi At Cafe (Blue Horse Cafe) during Six Years: A Qualitative Analysis of Factors Contributing to Recovery from the Perspective of Schizophrenia Patients
    Soygür, H; Yüksel, MM; Eraslan, P; Özden, SA
    Objective: In recent years, the recovery-oriented approaches (along with experiences and thoughts of patients and patient's relatives) have been taken into account for establishing mental health services and policies. This study aims to identify the factors contributing to recovery, as observed from the perspective of schizophrenia patients working at The Blue Horse Cafe which was founded by the Federation of Schizophrenia Associations. Method: The sample for the study consisted of 24 patients who worked at The Blue Horse Cafe. A phenomenological approach was used in the study, whereby interviews with patients were analyzed qualitatively. Results: Certain common factors, which were expressed as having contributed to recovery, were identified from the perspective of schizophrenia patients. These factors are: 1-The fact that the setting is informal and welcoming without being constrictive; 2-Predominance of the human element; 3-Hope and encouragement; 4-Being cared about; 5-Being able to reach someone when in need of support; 6-Friendly sharing; 7-Having a purpose, assuming responsibility, and being motivated; and 8-Giving meaning to life. Conclusion: The findings may serve as a stimulus since schizophrenia patients that contribute to recovery give mental health professionals the opportunity to question there need for a change in their professional roles. Additionally, schizophrenia patients that have experienced The Blue Horse Cafe draw attention to certain points and these points can serve as a guide, especially for establishing the working methods of Community Mental Health Centers.
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    Quality of Life In Major Depressive Disorder: A Cross-Sectional Study
    Aydemir, Ö; Ergün, H; Soygür, H; Kesebir, S; Tulunay, C
    Quality of Life In Major Depressive Disorder: A Cross-Sectional Study Objective: To investigate quality of life and its association with depression in patients with major depressive disorder. Method: The study included 74 patients diagnosed with major depressive disorder according to DSM-IV. The Hamilton Depression Rating Scale (HAM-D) was used to assess the severity of depression; and the, Medical Outcomes Study Short Form-36 (MOS SF-36) and EuroQol 5-D (EQ-5D) were used to measure quality of life. Results: In the assessment of quality of life, it was determined that Patients with major depressive disorder scored significantly lower on all domains of MOS SF-36 compared to Turkish normative data. The depressive disorder patients had lower EQ-5D health utility index scores, in comparison to Turkish normative data. There was a significant negative correlation between mean HAM-D score and all domains of MOS SF-36 and EQ-5D health utility index scores. When quality of life in depressive patients was compared according to episode type, patients with recurrent type major depressive disorder had lower quality of life in terms of physical functioning, general health perception, and physical component summary score than patients with single episode type major depressive disorder. Concusion: All domains of quality of life were lower in patients with major depressive disorder and quality of life decreased as severity of depression increased. Physical health perception was impaired to a greater degree in patients with recurrent major depressive disorder when compared with single episode depressive patients.