Browsing by Author "Suer K."

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    Evaluation of the Pol/S gene overlapping mutations in chronic hepatitis B patients in northern Cyprus
    (Polish Society of Microbiologists, 2019) Arikan A.; Sayan M.; Sanlidag T.; Suer K.; Akcali S.; Guvenir M.
    Mutations associated with the pol and the S gene can emerge as a consequence of the high replication capacity and proofreading deficiencies of hepatitis B virus during replication. The current study was constructed to evaluate primary, partial, compensatory and the escape mutations in chronic hepatitis B patients in Northern Cyprus. The samples of HBsAg positive treatment naïve 100 patients were involved in this study. HBV pol gene region was sequenced, amplified and HBV pol/S gene mutations were determined. The samples of thirty-two patients were excluded because of their low viral load (HBV < 1000 ıu/ml). Among the sequenced 68 samples, there was a partial mutation (1.5%) and 36.7% displayed a resistance profile to lamivudine, adevofir, and telbivudine. Immune response escape, vaccine escape, HBIg and diagnosis escape mutations were determined in 24%, 10%, 6%, and 4% samples of the patients, respectively. Additionally, there were six different combined mutations. These data underscored that there is no concern for primary mutations in Northern Cyprus, however, we have identified a compensatory mutation (rtV173M) that may have primary mutation characteristics by combining with other mutation patterns. Additionally, HBsAg escape mutants demonstrated that detection of the S gene together with the pol gene mutations might be beneficial and important to monitor the surveillance of S variants. © 2019 Ayse Arikan et al.
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    Dynamics and control of HIV/AIDS in cyprus using real data
    (Springer Verlag, 2019) Hincal E.; Sanlidag T.; Saad F.T.; Suer K.; Baba I.A.; Sayan M.; Kaymakamzade B.; Sultanoglu N.
    This article presents a mathematical model that studies the dynamics of HIV in North and South Cyprus. The global stability of the two equilibrium points involved are disease-free and endemic, and are performed using Lyapunov function. We have showed that the stability is dependent on the magnitude of the basic reproduction number R 0 . If R 0 < 1, the disease free equilibrium point is globally asymptotically stable and the disease vanishes, whereas if R 0 ≥ 1, the endemic equilibrium point is globally asymptotically stable and epidemics will occur. Real data obtained from the Turkish Republic of Northern Cyprus Ministry of Health is used to examine and predict the progress of HIV in North Cyprus, as well as comparing our results with South Cyprus using their published data. Reported HIV positive cases of only Turkish and Greek Cypriots were included from the data obtained from Turkish Republic of Northern Cyprus Ministry of Health and South Cyprus data, respectively. The results showed that, the basic reproduction number of North and South Cyprus are 0.00012 and 0.00034 respectively; which are less than one; hence, this indicates that there is currently no epidemic in the country. Furthermore, the number of HIV positive individuals in North Cyprus is likely to increase by almost 50%, whereas for South Cyprus an increase of 100% of the initial value (of 2017) is estimated in the next 20 years. Thus, the authorities should take the necessary actions and strategic measures for controlling the spread of the disease. © 2019, Springer Nature Switzerland AG.
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    Current situation of covid-19 in northern cyprus; [Situation actuelle de la covid-19 dans la partie nord de chypre]
    (World Health Organization, 2020) Sultanoglu N.; Baddal B.; Suer K.; Sanlidag T.
    Background: The public health burden of the novel coronavirus disease 2019 (COVID-19) is expected to increase and ur-gent strict measures by decision-makers is critical for the containment of the novel coronavirus (SARS-CoV-2) outbreak worldwide. Aims: This study aimed to give a real-time analysis of COVID-19 presence in northern Cyprus. Methods: All official SARS-CoV-2 positive cases were tracked and reported in terms of the origin, nationality, and transmission routes. Preventive measures taken after the first reported case were analyzed for their effectiveness as control strategies. Results: The index case of SARS-CoV-2 in northern Cyprus was identified as a female German tourist. First local case had travel history from the United Kingdom after which local transmission occurred. Rapid and strict containment measures have currently delayed a peak in observed cases. Conclusions: Rapid implementation of social-distancing measures, good hygiene measures and travel/gathering bans in northern Cyprus has been effective in controlling the outbreak. © World Health Organization (WHO) 2020.