Browsing by Author "Töz, H"

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    THE RELATION BETWEEN EPICARDIAL ADIPOSE TISSUE WITH VOLUME MARKERS AND INFLAMMATION MARKERS, WITHIN DIALYSIS AND TRANSPLANT PATIENTS
    Colak, H; Kylyçaslan, B; Sert, I; Tanrysev, M; Ekmekci, C; Karaca, C; Kursat, S; Töz, H
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    Gingival Crevicular Fluid Osteocalcin, N-Terminal Telopeptides, and Calprotectin Levels in Cyclosporin A-Induced Gingival Overgrowth
    Becerik, S; Gürkan, A; Afacan, B; Özturk, VÖ; Atmaca, H; Töz, H; Atilla, G; Emingil, G
    Background: The aim of this cross-sectional study is to investigate gingival crevicular fluid (GCF) osteocalcin, crosslinked N-terminal telopeptide (NTx), and calprotectin levels in cyclosporin A (CsA)-induced gingival overgrowth (GO). Methods: Forty medicated patients with CsA including 20 with GO (CsA GO+), 10 without GO (CsA GO-), 10 with GO and chronic periodontitis (CsA CP) and 60 patients with CP alone, 20 patients with gingivitis, and 20 healthy patients were enrolled. Probing depth, clinical attachment level, plaque index, and papillary bleeding index were recorded. GCF calprotectin, osteocalcin, and NTx levels were analyzed by enzyme-linked immunosorbent assay. Parametric tests were used for statistical analysis. Results: The CsA GO+ and CP groups had significantly lower GCF osteocalcin levels and osteocalcin/NTx ratio than the healthy group, whereas GCF osteocalcin levels and osteocalcin/NTx ratio in the gingivitis group were higher than the CsA GO+, CsA GO-, CsA CP, and CP groups (P < 0.05). The CP group had elevated GCF calprotectin levels compared to the other study groups (P < 0.05). The CsA GO+ and CsA GO-groups also had higher GCF calprotectin levels compared to the CsA CP, gingivitis, and healthy groups (P < 0.05). Conclusions: Increased GCF calprotectin and decreased GCF osteocalcin levels in the CsA GO+ and CsA GO-groups might suggest that CsA plays a role on the levels of these markers. The similarity of GCF osteocalcin, NTx, and calprotectin levels in the CsA GO+ and CsA GO-groups might suggest that these molecules are not involved in the pathogenesis of GO. J Periodontol 2011; 82: 1490-1497.
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    Correlation of the Volume Control Parameters With Health Related Quality of Life in Renal Transplant Patients
    Colak, H; Sert, I; Ekmekci, C; Tugmen, C; Kurtulmus, Y; Kursat, S; Töz, H
    Introduction. Transplantation is the most effective treatment strategy for end-stage renal failure. We aimed to investigate the correlation of volume control parameters with health-related quality of life (HRQoL) in renal transplantation patients during the pre- and post-transplantation periods. Material and Methods. Seventy-seven patients who underwent renal transplantation from deceased donors between January 2011 and January 2013 were included in the study. The biochemical markers, complete blood count, and creatinine levels were measured during pretransplantation and at post-transplantation month 6. The Turkish version of the Short Form 36 (SF-36) health survey questionnaire was used for the assessment of HRQoL. Blood pressure (BP) and echocardiographic measurements were used to evaluate the volume status. Results. Significant improvements were achieved in all echocardiographic measurements, biochemical parameters except Ca++, and SF-36 questionnaire domain scores (DSs) except vitality in the post-transplantation period. Systolic BP (SBP), the left atrium index, vena cava inferior collapsibility index (VCCI), and diastolic BP were associated with vitality (P = .02, .03, .05, and .04, respectively); SBP was associated with social functioning (P < .01) and role emotional (P < .01); and left ventricular mass index was associated with mental health (P = .05) DSs during the pretransplantation period. In the post-transplantation period, VCCI, left ventricular mass index, and SBP were associated with general health (P = .02, .05, and .05, respectively); VCCI and SBP were also associated with mental health (P = .05 and .01, respectively); and left atrium index was associated with role emotional (P = .05) DSs. Conclusion. Concomitant improvement in the volemic status may contribute to improvements in HRQoL after renal transplantation.
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