Browsing by Author "Tüzün, C"

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    Relationship Between Cyclic Citrullinated Peptide Antibodies Positivity and HLA-DRB1 Shared Epitope Alleles in Patients with Rheumatoid Arthritis in Turkey
    Dayan, I; Tikiz, C; Taneli, F; Ulman, C; Ulutas, G; Tüzün, C
    Objective: The most characteristic genetic risk factors for rheumatoid arthritis (RA), the HLA-DRB1 shared epitope (SE) alleles, encode for a common amino acid sequence in the peptide-presenting part of the HLA class II molecule. These SE alleles have been described recently to be a risk factor for the development of antibodies against citrullinated proteins in RA. The current study was performed to investigate the association between the cyclic citrullinated peptide antibodies (anti-CCP) and HLA-DR1 HLA-DRB1 shared epitope alleles in patients with RA in Turkey. Materials and Methods: Sixty patients with RA who were newly diagnosed or under conventional treatment in our clinic and 60 healthy volunteers as controls were enrolled in the study. In patients with RA anti-CCP levels were investigated with enzyme-linked immunosorbent assay and HLA-DRB1 subtyping and SE was assessed by polymerase chain reaction. Only anti-CCP was measured in healthy volunteers. Results: SE was positive in 50% of the patients with RA. Amongst the SE carriers, 30% of them were carrying double copy of SE. While anti-CCP was positive in 73,3% of patients with RA, this ratio was 0% in healthy volunteers. We determined that the existence of SE increases the positivity of anti-CCP (OR=4,3, 95% [CI], P=0.04), and a significant relationship was found between the anti-CCP positivity and the RF positivity. (OR=5,3, 95% [CI] P<0.05). Conclusion: The results of the present study revealed that Turkish patients with RA carrying SE with HLA-DRB1 genes is significantly related with the production of anti-CCP. The diagnostic sensitivity and specificity of anti-CCP for RA is determined as 73,3% and 100% respectively. (Turk J Rheumatol 2010; 25: 12-8)
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    Low back pain and posture
    Tüzün, C; Yorulmaz, I; Cindas, A; Vatan, S
    This study was designed to analyse postural aberrations of the back and lower back region in patients with acute and chronic low back pain and to investigate the accordance of clinical and radiological assessments. Fifty patients with acute and 50 with chronic low back pain and 50 controls were studied and a detailed spinal physical examination was performed. In addition, the angles of thoracic kyphosis, lumbar lordosis and sacral inclination were assessed radiologically. Differences among the three groups, correlations of radiological parameters with each other and with clinical parameters such as age, gender and body mass index, and the accordance of clinical and radiological postural assessments were investigated. It was concluded that there were no statistically significant differences among the groups for angles of thoracic kyphosis, lumbar lordosis and sacral inclination; however, we found significant correlations among all radiological parameters, especially between lumbar lordosis and sacral inclination. Both lumbar lordosis and sacral inclination were increased with body mass index, and lumbar lordosis and thoracic kyphosis were increased with age. Clinical assessments of thoracic kyphosis and lumbar lordosis were not in accordance with radiological assessments.
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    TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION THERAPY IN THE CHILDREN WITH NOCTURNAL ENURESIS
    Ünlü, Z; Tüzün, C; Taneli, C; Firat, A
    We evaluated the efficacy of transcutaneous nerve stimulation (TENS) therapy on wetting behaviors, social functioning and bladder storage capacities in children with enuresis nocturna. A total of 8 enuretic children aged 8-16 years old were selected for study on basis of poor outcome despite extensive trials of conventional treatments. 15 seances of TENS therapy applied on the suprapubic region. Changes in wetting behaviors and social functioning before and after the therapy were assessed with a 7-point scale. Patients were asked to record their urine output using a frequency/volume chart for two consecutive days before and after the therapy. Two of the children became dry two months after the therapy. The total scores of wetting behaviors and social status were increased in two patients at two months after the therapy. Maximum functional bladder capacity, mean day-time bladder capacity, maximum nocturnal bladder capacity were increased only in two patients after the treatment. Number of daytime voids were decreased in these patients. According to our preliminary results, it seems that TENS therapy in the children with nocturnal enuresis showed improvement in some degree. Further studies are needed which are performed in larger series.