Browsing by Author "Taş C."

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    Homocystinuria and early onset schizophrenia: A case report; [Homosistinüri ve erken başlangiçli şizofreni: Olgu sunumu]
    (2008) Taş C.; Esen-Danaci A.
    Although schizophrenia is known as a late adolescence or early adulthood disorder psychotic symptoms can be seen in children. Schizophrenia which begins before 17-18 years of age is named as "early onset schizophrenia" and before age of 13 is named as "very early onset schizophrenia". Studies on organic etiology of schizophrenia were increased after the description of early onset schizophrenia. It was determined that cerebral trauma, infections, demyelinization diseases, endocrinopathies, systemic diseases, vitamin deficiencies, drugs, epilepsy, sex chromosome abnormalities, and diseases with Mendelian inheritance can cause clinical symptoms like schizophrenia. In this article a homocystinuria case which was diagnosed as early onset schizophrenia according to its onset is presented.
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    Oxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder: An empirical cross-sectional study
    (Associacao Brasileira de Psiquiatria, 2014) Aydemir Ö.; Çubukçuoğlu Z.; Erdin S.; Taş C.; Onur E.; Berk M.
    Objective: This study aimed to evaluate the relationship between oxidative stress markers and cognitive functions and domains of psychosocial functioning in bipolar disorder.; Methods: Oxidative stress markers, cognitive functions, and domains of psychosocial functioning were evaluated in 51 patients with bipolar disorder who were in remission. Correlation analyses between these parameters were calculated with data controlled for duration of illness and number of episodes.; Results: There was no statistically significant correlation between oxidative stress markers and cognitive functions. In terms of psychosocial functioning, significant correlations were found between malondialdehyde and sense of stigmatization (r = -0.502); household activities and superoxide dismutase (r = 0.501); participation in social activities and nitric oxide (r = 0.414); hobbies and leisure time activities and total glutathione (r = -0.567), superoxide dismutase (r = 0.667), and neurotrophin 4 (r = 0.450); and taking initiative and self-sufficiency and superoxide dismutase (r = 0.597). There was no correlation between other domains of psychosocial functioning and oxidative stress markers.; Conclusion: These results imply that oxidative stress markers do not appear to correlate clearly with cognitive impairment and reduced psychosocial functioning. However, there were some associations between selected oxidative markers and activity-oriented functional markers. This may represent a true negative association, or may be an artifact of oxidative stress being a state rather than a trait marker. © 2014 Associação Brasileira de Psiquiatria.
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    The comparison of executive functions, social cognition and plasma oxytocin level between mothers' of schizophrenia patients and healthy control: Searching for a new endophenotype; [Şizofreni hastalarının anneleri ile sağlıklı kontrollerin yürütücü işlev, sosyal biliş ve plazma oksitosin düzeylerinin karşılaştırılması: Yeni bir endofenotip arayışı]
    (Cukurova University, Faculty of Medicine, 2017) Aydin O.; Balikçi K.; Taş C.; Ünal Aydin P.; Çökmüş F.P.; Esen Danaci A.
    Objective: Previous studies documented that there were a variety of endophenotypes that helped to diagnose as well as to predict functionality and treatment response. There is little, if any research that focused on investigating biochemical endophenotypes. Besides, the studies that include executive functions and social cognition, which were accepted as endophenotypes, have different results. In studies involving schizophrenia patients, the deficiency of oxytocin was found to be the most important hormone that would affect the treatment process. However, there have been no endophenotype studies that investigated the role of oxytocin hormone in the treatment process of schizophrenia patients. The purpose of the present study was twofold: (a) to detect new endophenotypes, and (b) to test endophenotypes that were previously found by focusing on the schizophrenia patients’ mothers. Methods: The participants were the healthy mothers of schizophrenia patients and healthy control group. They took the Reading the Mind in the Eyes Test, Wisconsin Card Sorting Test, and Wechsler Adult Intelligence Scale vocabulary subtest, respectively. In addition, participants’ blood samples were collected to include the level of plasma oxytocin as a biochemical in the data analyses. Results: Results revealed that there was a significant difference in plasma oxytocin levels for the healthy mother’s of schizophrenia patients and the healthy control group. Low level of plasma oxytocin level was found to be the only significant factor that differentiates the patients’ mothers and the healty control group. When the results of the Reading the Mind in the Eyes Test that measures executive functions, and the Wisconsin Card Sorting Test that measures social cognition were analyzed, no significant differences were found between the groups. Discussion: Our findings showed that oxytocin hormone could be a new endophenotype for schizophrenia. However, there is still a need for studies that focus on the investigation of detecting new endophenotypes. © 2017, Cukurova University, Faculty of Medicine. All rights reserved.
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    The effect of theory of mind capacities of mothers of patients with schizophrenia on the severity of the diseases
    (Turkish Association of Nervous and Mental Health, 2018) Balikçi K.; Aydin O.; Taş C.; Esen Danaci A.
    Objective: Studies conducted with patients with schizophrenia and first-degree relatives show that, the pathology in theory of mind may be related to the risk of psychosis. The theory of mind capacities of the mothers may be effective in the prognosis of schizophrenia. The purpose of this study is to examine the effects of theory of mind capacities of patient mothers on the severity of the disease. Method: The study was conducted with 34 schizophrenic patients and their mothers, and 31 healthy mothers. Sociodemographic data was captures for all groups. In addition, PANSS was collected from patients and Reading the Mind in the Eyes Test was collected from the each patient mother. Results: There was no statistically significant difference between the age and education levels of the groups. The mothers of patients with schizophrenia performed significantly worse in the Reading the Mind in the Eyes Test than the control group. There was an inverse correlation between theory of mind capacity and the medication dose, PANSS general condition and PANSS total score. Discussion: The significant difference between the groups suggests that the impairment in the function of the theory of mind can be regarded as an endo-phenotype for schizophrenia. The low theory of mind capacities of the mothers of schizophrenia patients can cause the mothers to misunderstand the feelings of their patient which could lead to increase in disease severity and drugs use. © 2018 Turkish Association of Nervous and Mental Health.
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    Assessing the relationship between attachment, parental attitude and plasma oxytocin in schizophrenia patients and their unaffected siblings
    (Taylor and Francis Ltd, 2019) Aydın O.; Balıkçı K.; Taş C.; Ünal-Aydın P.; Taneli F.; Esen-Danacı A.
    Background: It is widely acknowledged that schizophrenia patients tend to have insecure attachment styles and improper parenting. However, the biological processes related to these adversities remain unclear and that the disturbance in oxytocin system is considered as one of the strongest predictors of such adversities. Methods: Thirty-four patients with schizophrenia and their unaffected thirty-four healthy siblings were recruited for the study and they were compared with thirty-one healthy controls. We examined attachment styles via Experience in Close Relationship-Revised Test and perceived parental attitudes with the My Memories of Upbringing-Short Version Test. In addition, we evaluated plasma oxytocin levels across groups. Results:The patients with schizophrenia had lower plasma oxytocin levels and obtained higher levels for attachment anxiety and avoidance with more parental rejection and over protection. There was a significantly negative relationship between the levels of plasma oxytocin in blood and parental over protection in the healthy sibling and healthy control groups. In contrast, there was a significantly positive relationship between the levels of plasma oxytocin in blood and parental over protection in the schizophrenia group. Results of the regression analyses revealed that the plasma oxytocin levels and over protection were notable factors in discriminating the groups from each other. Conclusion: Our findings suggested that disturbance in oxytocin is associated with susceptibility to schizophrenia predisposition. In sum, therapeutic interventions that address oxytocin and over protection may influence the outcomes in this severe mental disorder. © 2019, © 2019 The Nordic Psychiatric Association.