Browsing by Author "Taneli B."

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    Zinc tolerance test patterns in normal children and in moderate and severe zinc deficiency states
    (Springer India, 1996) Oksel F.; Köksyo H.; Taneli B.
    Twenty-six normal, 38 moderately and 14 severely zinc-deficient children, aged 2-12 years, were examined by clinical and laboratory approaches. After fasting-blood sampling, 120 mg zinc sulphate (25 mg elemental zinc) were administered orally to each group of children, to obtain zinc tolerance curve patterns. Sampling proceeded to the 2nd and 4th hours of the loading test period. Plasma zinc was assessed on an atomic absorption spectrophotometer. In normal children, at the 2nd hour of loading, a significant (p < .001) elevation (1.764 ± 0.133 mg/l) in the mean (±SEM) plasma zinc level was noted; also at the 4th hour a significant (p < .001) decrease (1.506 ± 0.123 mg/l) in the mean plasma zinc level was shown. The mean plasma zinc level at the 4th hour was found higher than the mean fasting plasma zinc level (1.054 ± 0.061 mg/l), but lower than the mean level found at the 2nd hour. In moderately zinc-deficient children, tle rise in the 2nd hour and the fall in the 4th hour in the plasma zinc level were highly significant (p < .001 and p < .001, respectively) in relation to fasting blood level. However, in severely zinc deficient children, the intensity of the increase (0.746 ± 0.147 mg/l) in plasma zinc level at the 2nd hour was of lesser significance (p < .006) and the fall (0.424 ± 0.061) mg/l) at the 4th hour was not significant. Therefore, in children with normal plasma zinc levels, an increase of more than 0.50 mg/l was seen at the 2nd hour of loading. This rise was seen to persist at the 4th hour. However, in children with moderate zinc deficiency, although again an increase of 0.50 mg/l was seen at the 2nd hour this increase did not persist at the 4th hour; and the 4th-hour value showed a significant decrease in relation to the 2nd hour value. Whereas, in children with severe zinc deficiency the rise of plasma level at the 2nd hour was less than 0.5 mg/l and the fall at the 4th hour was to such a level which was not significant in relation to fasting zinc level. This could be due to enhanced uptake of zinc off the circulation by the depleted tissues in severe zinc deficiency.
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    Environmental exposure to cadmium and lead in the pediatric age group
    (1997) Onag A.; Oksel F.; Taneli B.; Hakerlerler H.
    Manisa, a city in the Aegean Province of Turkey, is a territory of world-wide famous viniculture and a region of dense industrial activity. Highway to Izmir, heavy with traffic passes through the city. Lead additives in automotive fuel (although government encourages use of unleaded gasoline), smog from low quality coal burnt in industrial establishments and heavy tobacco smoking warranted an investigation on ultra-trace elements, lead and cadmium. Thus, 101 children who were admitted consecutively were screened in view of lead and cadmium exposure. Jn 23 of these children between the ages of 0-2 years the mean (± SEM) serum cadmium level was 0.066 ± 0.008 μg/L, in 28 between the ages of 3-6 years was 0.078 ± 0.008 μg/L and in 50 between the ages of 7-15 years was 0.088 ± 0.006 μg/L. The difference in cadmium levels between the age groups of 0-2 years and 7-15 years was significant (p < 0.038). Serum lead levels in the same groups of children were 7.15 ± 0.10 μg/dl, 7.20 ± 0.10 μg/dl and 7.20 ± 0.10 μg/dl, respectively, with no significant difference. In conclusion, our study revealed that lead is not serious environmental contaminant for children, yet, in Manisa; however, the increasing trend seen in exposure to cadmium warrants serious consideration and urgent preventive measures.
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    Environmental exposure to cadmium and lead in the pediatric age group
    (1998) Onaǧ A.; Oksel F.; Taneli B.; Hakerlerler H.
    Lead additives in automotive fuel, smog from a nearby industrial center warranted an investigation on cadmium and lead in Manisa, a city of tabacco processing. Hundred and one children were screened in view of lead and cadmium exposure. In 23 children between the ages of 0-2 years the mean (±SEM) serum lead level was 7.15 ± 0.10 μg/dl, in 28 between the ages of 3-6 years was 7.20 ± 0.10 μg/dl and in 50 between the ages of 7-15 years was 7.20 ± 0.10 μg/dl, respectively, with no significant differences. Serum cadmium levels in the same groups of children was 0.066 ± 0.008 ng/ml, 0.078 ± 0.008 ng/ml 0.088 ± 0.006 ng/ml, respectively. The difference in cadmium levels between the age groups of 0-2 years and 7-15 years was significant (p<0.038). This significant increase in blood cadmium level is also shown by simple linear regression analysis: Cadmium (ng/ml) = 0.049 + 0.005 (age), and p<0.0001, F Ratio = 50.578, coefficient of correlation = 0.581. Our study revealed that lead is not a serious environmental contaminant for children, yet; however, the increasing trend seen in exposure to cadmium warrants serious consideration and urgant preventive measures.