MCBÜ Açıkerişim Sistemi :: Browsing by Author "Taneli C."

Browsing by Author "Taneli C."

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Ovarian dysgerminoma with contralateral gonadoblastoma in a 46XY phenotypic female: Swyer syndrome
(1996) Taneli C.; Genc K.; Erikci V.; Balik E.; Erhan Y.; Ozdemir N.; Veral A.
A 15-year-old girl was admitted to the pediatric surgery department with primary amenorrhea and right inguinal swelling of one year duration. On physical examination, the patient presented with a female phenotype, but no breast development; somewhat hirsute with hypertrophic clitoris. Ultrasound examination disclosed a palpable mass originating from the right ovary. At operation, a right salpingo-ooferectomy was performed, and a biopsy specimen was obtained from the left ovary which did not appear normal. Histopathologic examination revealed a right ovarian disgerminoma and a left gonadoblastoma. One month after the first operation, a left gonadectomy was performed with accompanying cliteroplasty. An original case of Swyer syndrome is reported in a patient with female phenotype, dysgerminoma of the right and gonadoblastoma of the the left ovaries.
Askin tumors in children: A report of four cases
(Hippokrates Verlag GmbH, 1998) Taneli C.; Genç A.; Erikçi V.; Yüce G.; Batik E.
Primary malignant tumors of the chest are rare in the pediatric age group. Askin tumor belongs to the peripheral primitive neuroectodermal tumor family, and typically involves the periosteum, soft tissue and extrapulmonary tissue of the thoracic wall. We report our ten years experience with four cases of this rare tumor.
Long-term follow-up and evaluation of autoaugmentation cystoplasty (detrusorotomy) in an animal model
(1999) Taneli C.; Genç A.
Objective: To evaluate long-term follow-up of an autoaugmentation (detrusorotomy) technique, in puppies. Patients and methods: In 10 mongrel puppies, bladder capacities were reduced to nearly half their original volume by 10 per cent formalin instillations. In 7 puppies, the muscular coat of the bladder was split open widely down to the mucosal layer, from the bladder neck anteriorly, to the trigone posteriorly while the mucosa was kept exposed and intact. Three puppies were kept as controls. Results: Mean post- instillation bladder capacity was 15.40 ml. One week after detrusorotomy the bladder capacity averaged up to 20.00 ml; 3 weeks later up to 20.43 ml; and 3 months later up to 34.28 ml and were well up to 3 months. However, at the termination of an additional 9-month period, the bladders of 4 of the remaining five dogs were seen to decrease in volume except the one with an accidental omental adherence to the exposed mucosa which kept the detrusorotomy intact. Conclusion: Post-detrusorotomy volume could be retained if a graft, e.g. omentum, gut segment, amniotic membrane or lyophilized dura is inserted at the time of intervention, in-between the split musculature to line the exposed mucosa externally and to prevent re-adhesion of the muscular edges.
Analysis of meatal location in 300 boys
(2001) Genç A.; Taneli C.; Öksel F.; Balkan C.; Bilgi Y.
The high incidence of anterior hypospadias and the consideration of some of the parents that this location is a normal variation and the resistance to the surgical treatment led us to investigate the normal meatal location in boys. The location of external meatus was analyzed in 300 boys. The meatal location was classified as type A (anterior third/tip of the glans) type B (middle third) and type C (posterior third/glandular hypospadias). Of the 300 boys taken into study, in 282 (94%) meatus was located at the tip of the glans in 14 patients (4.6%) on the middle third, 'type B' and in 2 patients (0.6%) on the posterior third, 'type C'. The present study clearly demonstrated that the true location of urethral meatus should be at the tip of the glans. Type B is an acceptable location, which requires no operation and is seen in a very small percentage. Type C is a true glandular hypospadias and should certainly be corrected by glanuloplasty and meatal advancement. We are of the opinion that after surgery for anterior hypospadias meatal position presenting elsewhere than at the tip of the glans should not be considered a successful intervention.
Evaluation of the location of the anus by a modified technique in the neonate
(2002) Genç A.; Taneli C.; Tansuǧ N.; Kasirga E.; Yilmaz D.; Küçükoǧlu T.; Onaǧ A.
Purpose: The aim of the current study was to bring to notice the anterior displacement of the anus and to recommend the measurement of anal position index in the neonate by a modified method. Methods: Sixty newborns (34 girls and 26 boys) were taken into study, and the anal position index (API), which is the ratio of anus-fourchette (scrotum) distance to coccyx fourchette (scrotum) distance, was measured. To obtain the measurement, a transparent adhesive tape was placed along the midline on the long axis, covering the anus. The upper and lower tips and the center of the anal circle was marked and measured using a caliber. Results: API was found as 0.46 (SD ± 0.08) and 0.53 (SD ± 0.05) in female and male neonates, respectively. Because an index of 0.34 in girls and 0.46 in boys are considered abnormal, the 3 female babies in the study group with API indices of 0.18, 0.28, and 0.33 were subjected to further examination. The abnormality was seen not to be rare in the Aegean region. Conclusions: An abnormal index alone cannot be the sole cause of constipation mentioned in the literature and therefore not an indication for operation. Anal position index in the neonates could be measured more accurately by the current modified method. If an anterior location of the anus is found early in infancy the baby should undergo follow-up accordingly. © 2002 Elsevier Science Ltd. All rights reserved.
Congenital midline cervical cleft: A rare embryo pathogenic disorder
(2002) Genç A.; Taneli C.; Arslan O.A.; Daǧlar Z.; Mir E.
Congenital midline cervical cleft (CMCC) is a rare disorder of the ventral neck. The cleft consists of an epithelium-covered, longitudinal central depression with a protuberance at the cervical end. The adjacent skin is tethered by scar tissue forming a depression, which ends in a blind sinus at the caudal end. Although a variety of embryological mechanisms are proposed, its etiology is obscure. Up to the present time, fewer than 50 cases have been reported in the English literature. CMCC can be seen in association with several midline anomalies related to the branchial arches, including median cleft of the lower lip and mandible, and hypoplasia or absence of other midline neck structures. We present a 36-day-old boy with CMCC to illustrate its clinical presentation and the result at 24 months postoperatively. © Springer-Verlag 2002.
Histopathological evaluation of the urethra after the Snodgrass operation: An experimental study in rabbits
(2002) Genç A.; Taneli C.; Günşar C.; Türkdoǧan P.; Yilmaz O.; Arslan O.A.; Mir E.
Objective: To investigate the histopathological outcome of the incised urethral plate after tubularized incised-plate urethroplasty (the Snodgrass procedure to repair hypospadias) in a hypospadiac rabbit model, as it can produce meatal and neourethral strictures, and healing with scarring. Materials and methods: The study comprised 10 male New Zealand White rabbits (2.2-2.4 kg); under general anaesthesia the ventral urethra was completely excised 1 cm from the meatus proximally and a model of hypospadias formed. A full-thickness incision was then made in the distal dorsal urethra and the two sides of the incision marked by Indian ink tattooing. After placing a feeding tube (5 F) as a urethral catheter, both urethral wings were sutured ventrally by a 7/0 polydioxanone running suture, and the penile skin approximated by 5/0 chromic catgut. At 21 days and 3 months after surgery the penises were harvested. assessed histopathologically, and compared with those from control untreated rabbits of the same age and weight. Results: In the study group the incised area of the dorsal urethra was re-epithelialized; the regional tissue and vascularity were normal. Conclusion: In this rabbit model the dorsal urethral incisions healed with no scar tissue: only the ventral suture lines had minimal fibrosis and inflammatory reaction.
Urethral meatal dilatation using topical EMLA cream for anaesthesia [3]
(Blackwell Publishing Ltd., 2003) Genç A.; Tekin I.; Taneli F.; Arslan O.A.; Taneli C.; Mir E.
[No abstract available]
Foreign body extraction with endoscopy assisted tracheotomy: Case report; [Endoskopi yardimiyla trakeotomi ile yabanci cisim çikarilmasi: Olgu sunumu]
(2003) Günşar C.; Genç A.; Şencan A.; Taneli C.; Mir E.
The authors present a rare case of foreign body aspiration treated with a recently defined technique. Endoscopy assisted tracheotomy was used for the removal of a broken plastic pen top from a child and the surgical methods used in the treatment of tracheobronchial foreign body aspiration are discussed.
Does sucralfate prevent apoptosis occurring in the ischemia/reperfusion-induced intestinal injury?
(2003) Şencan A.; Yilmaz Ö.; Özer E.; Günşar C.; Genç K.; Ulukuş Ç.; Taneli C.; Mir E.
Background/Purpose: We have shown in a previous study that sucralfate is beneficial in the prophylaxis and treatment of hypoxia/reoxygenation-induced intestinal injury. The aim of this study is to investigate whether sucralfate has any effect on the prevention of apoptosis in the ischemia/reperfusion (I/R)-induced intestinal injury. Methods: Rats were randomized into three groups. Group 1 and 2 were subjected to I/R. Group 1 (treatment group) received sucralfate while group 2 (treatment control group) did not. Group 3 served as a normal control group (sham group). The terminal ileum was harvested for histopathologic investigation by light microscopy. The presence of apoptotic enterocytes (DNA fragmentation in cell nuclei) was detected by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end-labeling (TUNEL) reaction. Results: In treatment control group, 3 of 7 rats had severe inflammation. None of the sucralfate-treated rats showed severe inflammation, 6 of them only showed mild inflammatory changes (p < 0.05). The apoptotic percentage was found to be 37.1 ± 9.4 in the sucralfate-treated group (group 1), whereas it was 45.4 ± 3.9 in the untreated group (group 2) (p < 0.05). The sham group had a completely normal intestinal architecture. Conclusions: The present study shows that 1) the experimental model of I/R-induced intestinal injury induces enterocyte apoptosis; 2) sucralfate decreases enterocyte apoptosis in the experimental model of I/R-induced intestinal injury which may play a key role in the pathophysiological events leading to failure of the intrinsic gut barrier defense mechanisms.
Does high-pressure carbon dioxide insufflation facilitate mucosal dissection in transanal endorectal pull-through? A rabbit model
(2003) Genç A.; Taneli C.; Türkdoǧan P.; Yilmaz Ö.; Arslan O.A.; Mir E.
The aim of the present study was to investigate whether high-pressure carbon dioxide insufflation facilitates mucosal dissection in the transanal endorectal pull-through (TEPT) operation performed in Hirschsprung's disease in a rabbit model. In the study, ten New Zealand rabbits were used. In six of the rabbits, CO2 under 50 mmHg pressure was insufflated into the submucosal area through a 25-gauge scalp needle inserted 0.3 cm over the dentate line. Two of the rabbits were taken for histopathological examination. In four rabbits, the TEPT operation was performed and in another four the operation was performed without CO2 insufflation. Histopathological examination in the CO2-insufflated group of rabbits showed that at transversal incisions mucosa was seen to be separated circumferentially from submucosa by high pressure CO2 and at longitudinal incision the separation was seen to be complete along the anal canal. It was noted that mucosal dissection was rapid, non-bloody and without induced mucosal tears or perforation; however, in the non-insufflated group the operation was time-consuming, bloody and more difficult to perform and needed meticulous care. In the present study, it was seen that submucosal high pressure CO2 insufflation in rabbits facilitates mucosal dissection in the TEPT operation and is easy to perform, time-saving and highly economical.
The effect of circumcision status on periurethral and glanular bacterial flora
(2004) Günşar C.; Kurutepe S.; Alparslan O.; Yilmaz Ö.; Daǧlar Z.; Şencan A.; Genç A.; Taneli C.; Mir E.
Introduction: Circumcision is a historical operation which is still performed for different purposes. The aim of this study is to investigate the changes in periurethral and glanular sulcus flora due to circumcision to determine the role of circumcision on urinary tract infections (UTIs). Patients and Methods: Fifty patients who were circumcised for social-religious reasons between January 2000 and January 2001 were evaluated in this prospective study. Two swabs were taken from the periurethral and glanular sulcus regions both just before circumcision and 4 weeks after, and the bacteria cultured were recorded. Results: We isolated pathogenic bacteria in the periurethral region of 32 (64%) patients (enterococci in 14 cases; Escherichia coli in 12 cases) before circumcision, and this number decreased to 5 (10%) after circumcision. Similarly, pathogenic bacteria were cultured from the glanular sulcus swabs of 33 (68%) patients (enterococci in 14 cases; E. coli in 10 cases), as well as coagulase-negative staphylococci in another 15 patients before circumcision. Following circumcision, we detected pathogenic bacteria in the glanular cultures of only 4 cases, whereas 40 children had non-pathogenic skin flora. Only 1 of 5 children with history of UTIs (n = 1) and retractable phimosis (n = 4) had periurethral pathogenic bacteria (Proteus spp.) in the post-circumcision period. The differences between pre- and post-circumcision values of the pathogenic bacterial colonizations were statistically significant in both groups sampled (p < 0.05). Conclusion: Non-circumcised patients have similar pathogenic bacterial colonizations in the periurethral and the inner preputial regions, although they have no phimosis. The origin of periurethral flora should be the deeper preputial regions. The flora greatly changed with skin commensals after circumcision. Circumcision might be beneficial from this point of view. Copyright © 2004 S. Karger AG, Basel.
Testis-fixation in prepubertal rats: Fibrin glue versus transparenchymal sutures reduces testicular damage
(2004) Şencan A.; Genç A.; Günşar C.; Daǧlar Z.; Yilmaz Ö.; Ulukuş Ç.; Özer E.; Taneli C.; Mir E.
Experimental studies have shown that different suture materials used in testis fixation cause some degree of inflammation in the testis. This study was planned to compare the histological changes that were caused by fibrin glue which is a tissue sealant and by silk and polypropylene for transparenchymal testis fixation. 28 prepubertal rats were divided into 4 groups. Testis was fixed to the tunica vaginalis by fibrin glue in group 1, by silk in group 2 and by polypropylene in group 3. Group 4 was planned as a control. Testicular inflammation and seminiferous tubular diameter were evaluated for histological changes. The least inflammation was observed in the fibrin glue group, while the most inflammation occurred in the silk group. Seminiferous tubular diameter was 241.55 ± 45.90 in the fibrin glue group, 151.90 ± 8.34 in the silk group and 161.36 ± 9.96 in the polypropylene group. In conclusion, fibrin glue, when used for testis fixation, causes less inflammation and less destruction of seminiferous tubular diameter compared with silk and polypropylene.
Modification of meatal advancement and glanuloplasty for correction of distal hypospadias
(2004) Taneli C.; Genç A.; Günsar C.; Sencan A.; Arslan O.A.; Daglar Z.; Mir E.
Objective: The meatal advancement and glanuloplasty (MAGPI) technique is still successfully used for the repair of distal hypospadias. The technique has been modified considerably since it was first described in 1981. The primary drawbacks of the procedure are the complications of meatal regression and meatal stenosis. The aim of this study was to present a modification of MAGPI for correction of distal hypospadias. Material and Methods: Ten cases with distal hypospadias were operated on using our modified MAGPI procedure. The modification involves excision of a pull-out, tag-shaped piece of glanular tissue through the vertical incision in the meatoplasty section of the original operation. By means of this excision, burying of the meatus into the glans was eased without inducing extra mobilization of the glans wings. As less glans tissue was left at the dorsal urethra the urethral meatus could be replaced in the center of the glans and better anatomic reconstruction could be attained. Results: After 1-3 years of follow-up, all the operated cases showed functionally and cosmetically satisfactory results. The cosmetic appearance achieved with our modified technique was better than that obtained with the classical MAGPI procedure. Conclusions: Using our MAGPI modification, the urethra was localized deeper in the glans and an elliptical (slit-like), wide meatus was obtained, the cosmetic appearance of which was more acceptable than that achieved with classical MAGPI.
Biochemical analysis of urethral collagen content after tubularized incised plate urethroplasty: An experimental study in rabbits
(Springer Verlag, 2004) Taneli F.; Ulman C.; Genc A.; Yilmaz O.; Taneli C.
The aim of the present study was the biochemical analysis of tissue hydroxyproline levels in incised urethral plates in order to show the total collagen content after the Snodgrass operation in the hypospadiac rabbit model. The study comprised 21 male New Zealand rabbits, (2.2-2.4 kg). The animals were randomly allocated to three groups each containing seven rabbits as follows: group 1, the ventral urethra was completely excised and a model of hypospadias formed. A full-thickness incision was made on the distal dorsal urethra, a feeding tube was placed as an urethral catheter and both urethral wings were sutured ventrally. Group 2, inserting an iris knife into the urethra, the ventral wall was incised mimicking an urethrotome. Group 3 consisted of normal control rabbits to determine the basal tissue hydroxyproline level. A slight increase in the hydroxyproline level was observed in the ventral part of the urethral tissue compared to the dorsal part in both groups 1 and 2; however, these differences were not significant. After the Snodgrass operation in the rabbit model, no significant differences were observed in the hydroxyproline levels of the dorsal and ventral parts of the urethra or between these and of the controls. Further studies are required in order to determine the mechanism underlying urethral healing through normal re-epithelization without excess collagen deposition after incised urethral plate urethroplasty.
Effect of adhesion barrier (Interceed TC7) on two-stage orchidopexy operation
(2004) Genc A.; Taneli F.; Yilmaz O.; Turkdogan P.; Arslan O.A.; Sencan A.; Taneli C.
Objective: In two-stage orchidopexy, adhesions formed after the first stage usually cause difficulty during the second operation and may even lead to injury to the testis itself or to the spermatic cord. We investigated whether the use of adhesion-preventing barriers in the abdominal or pelvic region during surgery could lessen adhesions formed during two-stage orchidopexy and thus ease dissection. Material and Methods: The study subjects comprised 21 male, albino, 30-day-old Wistar rats that were divided into three equal groups. In Group 1, the right testes were enveloped in adhesion barriers after dissection and sutured to the inguinal canal. In Group 2, the right testes were sutured to the inguinal canal without the barriers. In Group 3 (sham-operated group), all testes were dissected but no suturing was performed. Rats were sacrificed after 21 days and the ipsilateral testes were harvested. Results: Dissection of barrier-enveloped testes was relatively easy; however, no significant (p < 0.535) difference was seen in adhesion scores between Groups 1 and 2. Total tissue collagen was estimated by means of the hydroxyproline content. Tissue hydroxyproline levels were 16.04 ± 8.58, 13.20 ± 6.34 and 14.71 ± 5.51 μg/mg wet tissue in Groups 1-3, respectively and these differences were not significant. The histopathologic evaluation revealed significant differences only in the thickness of the tunica albuginea in Groups 1 and 2 (110.0 ± 30.0 vs 77.1 ± 21.3 μm, respectively; p < 0.038). Conclusion: The adhesion scores and the biochemical and histopathological examinations showed that an adhesion barrier is not beneficial in two-stage orchidopexy.
Intrascrotal paratesticular lymphangioma; [Skrotum içi testis dişi lenfanjiom]
(2004) Günşar C.; Şencan A.; Demir M.A.; Genç A.; Küçükoǧlu T.; Taneli C.; Mir E.
We present a case of cystic scratal lymphangioma who showed three different clinical presentations in fourty days. At his first admission, he had a soft, painless, transilluminating, scrotal mass which progressed to an acute scrotum like disease after inadequate excision. Following total excision of the mass, he had a local celhditis attack on the scrotal skin. His lesions healed without any sequela. For histopathological differential diagnosis we performed some immunohisiochcmical dyeing methods in addition to the classical hematoxylene-eosine stained sections. Scrotal lymphangioma should be kepi in mind for the differential diagnosis of inguinoscrotal lesions and with adequate, surgical interventions, the recurrences could be prevented.
Effect of alarm treatment on bladder storage capacities in monosymptomatic nocturnal enuresis
(2004) Taneli C.; Ertan P.; Taneli F.; Genç A.; Günsar C.; Sencan A.; Mir E.; Onag A.
Objective: Despite a great number of studies, very little is known about the mechanism of action of enuresis alarm systems. Nevertheless, as a result of this treatment many children are able firstly to wake up before urination occurs and then, in time, to sleep through the night without voiding. The aim of this study was to investigate the effect of enuresis alarms on bladder storage capacities. Material and Methods: A total of 28 children aged >7 years who were not polyuric but who voided once every night, slept alone in their own bedroom and who were willing, along with their family members, to cooperate were recruited. Patients were asked to record their urine output using a frequency/volume chart for two consecutive days. After these records and the results of physical and laboratory examinations were taken into consideration, treatment was instituted with the bell-and-pad (alarm) system for a period of 12 weeks. At the end of this period, patients were asked to complete another frequency/volume chart. Results: The pre- and post-treatment maximum functional bladder capacity was 178.35 ± 87.86 ml and 243.03 ± 102.84 ml, respectively and the pre- and post-treatment mean day-time bladder capacity was 111.11 ± 45.87 and 148.445 ± 7.68 ml. Both of these differences were statistically significant (p < 0.0001 and <0.0001, respectively). The maximum nocturnal bladder capacity was found to be increased from 177.85 ± 84.95 to 255.25 ± 124.52 ml after treatment (p < 0.0001). Conclusion: Treatment with the alarm system for a period of 12 weeks was seen to be associated with a significant increase in bladder storage capacities (maximum nocturnal bladder capacity, maximum functional bladder capacity and mean day-time bladder capacity).
The effect of spermatic vessel ligation on testicular nitric oxide levels and germ cell-specific apoptosis in rat testis
(Elsevier GmbH, 2005) Taneli F.; Vatansever S.; Ulman C.; Yilmaz O.; Giray G.; Genç A.; Taneli C.
Management of high testis may vary but the most popular method in surgical treatment is the Fowler-Stephens maneuver. The aim of the present study was to investigate the effects of spermatic vessel ligation on testicular nitric oxide (NO) levels, expression of inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) and germ cell-specific apoptosis in both ipsilateral and contralateral testes in rats. Twenty-eight animals were randomly allocated into four groups (n=7 each). The spermatic vessels were ligated as a simulation of the Fowler-Stephens maneuver. The groups of animals were sacrificed at 2 h (group 1), 4 h (group 2) and 24 h (group 3) after ligation, respectively. Sham-operated animals served as controls (group 4). Biochemical assessment of testicular NO levels was performed by the Griess method. iNOS and eNOS expression and apoptosis were studied in ipsilateral and contralateral testes. Testicular NO levels at 24 h after the simulated Fowler-Stephens maneuver were found to be significantly increased in both ipsilateral and contralateral testes when compared with the sham-operated group. eNOS expression was clearly increased in ipsilateral testes, whereas moderate expression was detected in the contralateral seminiferous tubules at 24 h after ligation. Mild focal iNOS immunostaining was also observed in seminiferous tubules of the ipsilateral testis at 24 h after the simulated Fowler-Stephens maneuver. Apoptosis was dramatically increased in ipsilateral testes; however, it was only detected in single cells in the contralateral side at 24 h after ligation. In conclusion, the simulated Fowler-Stephens maneuver induces testicular nitric oxide synthesis and germ cell-specific apoptosis in the ipsilateral testis. These results suggest that high levels of NO induce apoptosis and may impair spermatogenesis thus explaining the unsuccessful outcome of the Fowler-Stephens maneuver. © 2004 Elsevier GmbH. All rights reserved.
Transcutaneous electrical nerve stimulation therapy in the children with nocturnal enuresis; [Enüresis nokturnali çocuklarda transkütan elektri̇ksel si̇ni̇r sti̇mülasyonu (TENS) tedavi̇si̇]
(Nobelmedicus, 2005) Ünlü Z.; Tüzün Ç.; Taneli C.; Firat A.
We evaluated the efficacy of transcutaneous nerve stimulation (TENS) therapy on wetting behaviors, social functioning and bladder storage capacities in children with enuresis nocturna. A total of 8 enuretic children aged 8-16 years old were selected for study on basis of poor outcome despite extensive trials of conventional treatments. 15 seances of TENS therapy applied on the suprapubic region. Changes in wetting behaviors and social functioning before and after the therapy were assessed with a 7-point scale. Patients were asked to record their urine output using a frequency/volume chart for two consecutive days before and after the therapy. Two of the children became dry two months after the therapy. The total scores of wetting behaviors and social status were increased in two patients at two months after the therapy. Maximum functional bladder capacity, mean day-time bladder capacity, maximum nocturnal bladder capacity were increased only in two patients after the treatment. Number of daytime voids were decreased in these patients. According to our preliminary results, it seems that TENS therapy in the children with nocturnal enuresis showed improvement in some degree. Further studies are needed which are performed in larger series.

Browsing by Author "Taneli C."

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