Browsing by Author "Tanriverdi S."

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    Staphylococcal scalded skin syndrome in a neonate: Case report; [Neonatal stafilokoksik hasļanmiş deri sendromu]
    (2012) Tanriverdi S.; Tansuǧ N.; Pirim Ü.; Yangin E.
    Staphylococcal scalded skin syndrome is a toxin-mediated exfoliating skin condition predominated by desquamation and blistering, s aresult of exfoliative toxin productions by Staphylococcus aureus. Exfoliative exotoxins A and B produced by some of strain of S. aureus caused localized (bullous impetigo) or generalized (scalded skin syndrome) skin lesion. Scalded skin syndrome develops generalized erythema and is accentuated in flexural. At this stage areas of epidermis may separate in response to gentle shear force (Nikolsky sign). Scalded skin syndrome develops bullae with full of clear water briefly. The brightly erythematous skin may rapidly acquire by rupture bullae. Rupture lesions dries within 48 hours. We report a case of staphylococcal scalded skin syndrome after to draw heel blood for metabolic screening in a neonate. Copyright © 2012 by Türkiye Klinikleri.
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    Prevalence of fetal malnutrition and relationship between fetal malnutrition and fetal acidemia; [Fetal malnütrisyonun sikliǧi ve fetal asidemi ile olan i̇lişkisi]
    (2012) Tanriverdi S.; Karaboǧa B.; Karaca Ö.; Baytur Y.
    Objective: The aim of this study is determining prevalence of fetal malnutrition and relationship between fetal malnutrition and fetal acidemia at term newborn infants. Material and Methods: This study was performed on 121 term newborn infants who were born at the Department of Gynecology and Obstetrics, between September 2010 and May 2011. Fetal malnutrition was diagnosed using [Clinical Assessment of Fetal Nutritional Status Scoring (CANSCORE)] within 12 hours after birth and umblical artery blood-gas analysis was performed at birth. Results: Mean value of CANSCORE was 27.6±3.5 (18-44) at term newborn infants. CANSCORE score was determined as 24 and less in 12 (9.9%) infants who were evaluated as having fetal malnutrition. CANSCORE score was above 24 in other 109 (90.1%) infants. Ten of the 12 newborn infants with fetal malnutrition were [small for gestational age (SGA)]. There was no relationship between fetal malnutrition and low CANSCORE (P=0.000). The mean value of pH was 7.30±0.07 (7.01-7.41) at umblical artery blood-gas analysis. Fetal acidemia (pH<7.15) was observed in 8 (6.6%) infants. There was no significant relationship between the presence of fetal malnutrition and fetal acidemia (p=0.735). Conclusion: No relationship between fetal malnutrition and fetal acidemia was observed in this study. Copyright © 2012 by Türkiye Klinikleri.
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    Determination of Cystic Fibrosis Mutation Frequency in Preterm and Term Neonates with Respiratory Tract Problems
    (Sciendo, 2021) Tanriverdi S.; Polat M.; Onay H.
    Cystic fibrosis (CF) is an autosomal recessive disease. The genetic transition occurs with CF transmembrane conductance regulator (CFTR) gene mutation. We aimed to determine the frequency of CF mutations and also new mutations in the CFTR gene in neonates with respiratory distress. Newborn babies hospitalized due to respiratory distress were included in the patient group. The control group consisted of infants who had no respiratory distress. The CFTR genes of both groups were analyzed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. A total of 40 patients (20 in the patient group and 20 in the control group) were evaluated. The CFTR gene analysis was normal in 16 neonates in the patient group, whereas in others: A46D (c.137C>A) (n = 1), D1312G (c.3935A>G) (n = 1), R117H (c.350G>A) (n = 1), S1426P (c.4276T>C) (n = 1) heterozygotes were detected; CFTR gene analysis was normal at 14 neonates in the control group, whereas in others: E1228G (c.3683A>G) (n = 1), E217G (c.650A>G) (n = 1), E632TfsX9 (c1894_1895delAG) (n = 1), I807M (c.2421 A>G) (n = 2), S573F (c.1718C>T) (n = 1) heterozygotes were detected. There was no significant difference in the patient and control groups' CFTR gene analysis (p = 0.340). This study demonstrates the importance of CFTR gene analysis in asymptomatic newborn infants for follow-up and early diagnosis of CFTR-related disorders. In this study, a c.1894_1895delAG (E632TfsX9) heterozygous mutation detected in the CFTR gene in an asymptomatic newborn infant, was first encountered in the literature. © 2021 S Tanriverdi et al., published by Sciendo.
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    Evaluation of macronutrient content of fresh and frozen human milk over 6 months
    (Taylor and Francis Ltd., 2021) Tanriverdi S.; Koroglu O.; Uygur Ö.; Yalaz M.; Kultursay N.
    Aim: In this study; we aimed to see the time-dependent changes in the macronutrient content of early frozen breast milk and also to compare it with fresh breast milk in the first 6 months. Materials and method: We evaluated the milk samples of 43 mothers who delivered at term. Milk samples after the first 15 days following delivery were expressed and collected dividing into seven aliquots to be stored frozen at −20 °C. Every month freshly collected new milk samples were analyzed together with one aliquot of the stored samples, up to 6 months. The energy, protein, lipid, and carbohydrate contents of samples were analyzed by Miris Human Milk Analyzer. Results: In the first 3 months, fresh milk had higher caloric and lipid content when compared to frozen samples. The protein content of fresh milk decreased after 2 months and became lower than frozen samples. The energy and lipid content of frozen milk decreased over time but protein and carbohydrate contents stayed stable. Carbohydrate content of fresh and frozen samples did not show major changes. Conclusion: It may be more suitable to consume the frozen milk that was collected in the early weeks of delivery within first 2 months. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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    Early Immunomodulatory Effects of Different Natural Surfactant Preparations in Preterms With Respiratory Distress
    (Frontiers Media S.A., 2022) Yalaz M.; Tanriverdi S.; Uygur Ö.; Altun Köroğlu Ö.; Azarsiz E.; Aksu G.; Kültürsay N.
    Background: Respiratory distress syndrome (RDS) is the most common respiratory disease in premature infants. Exogenous natural surfactant preparations are used in the treatment of RDS. In recent years, it has become increasingly evident that surfactant plays an immunoregulatory role. Objectives: The aim of this study was to evaluate cytokine and chemokine response following three different regimens of natural surfactant treatment in preterm newborns with RDS. Methods: Premature newborns below 32 weeks of gestation who were intubated for RDS and given early surfactant rescue therapy were included in the study. Newborns were randomly divided into three groups and Beractant 100 mg/kg (B-100), Poractant alfa 100 mg/kg (Pα-100) and Poractant alfa 200 mg/kg (Pα-200) were administered intratracheally. Blood samples and transtracheal aspirates (TA) were collected just before and 4–6 h after the surfactant treatment. Total eosinophil count, inducible T Cell alpha chemoattractant (ITaC), macrophage inflammatory protein 3 beta (MIP3b), interleukins (IL) 5, 8, 9, 10, 13, immunoglobulin E (IgE), interferon gamma (IFN-γ), eotaxin and tumor necrosis factor beta-1 (TGF-β1) were measured from blood and tracheal aspirate samples. Results: A total of 45 infants, 15 in each group, were included in the study. Mean gestational age, birth weight, antenatal, demographic and clinical characteristics of the study groups were similar. IFNγ concentration and eosinophil counts in TA decreased after surfactant replacement in all groups, especially in the infants treated with Pα-100 and Pα-200. Eotaxin, TGF beta and IL-8 concentrations in TA increased significantly in the infants treated with Pα-100 and Pα-200. IL-9 levels in TA decreased in the B-100 group but increased in the Pα-100 and Pα-200 groups. Blood levels of cytokines and chemokines showed significantly decreased levels of ITaC and MIP3b only in the B-100 group, but no significant change was observed in the Pα-100 and Pα-200 groups. Conclusion: In our study, the different immunomodulatory effects of natural surfactant preparations on newborn lung is proven. We found that Poractant α, one of the natural surfactant preparations, shifted the lung immune system toward TH2. Copyright © 2022 Yalaz, Tanriverdi, Uygur, Altun Köroğlu, Azarsiz, Aksu and Kültürsay.
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    Does Fetal Malnutrition Affect Ghrelin, Leptin, Adiponectin and Insulin Levels in the Cord Blood of Newborns?
    (Galenos Publishing House, 2022) Tanriverdi S.; Ersoy B.; Taneli F.; Özer E.
    Aim: Fetal malnutrition is a condition characterized clinically by the inability of subcutaneous adipose tissue and muscle mass to reach the normal amount or by significant intrauterine loss. The major hormones regulating fetal growth, fetal energy metabolism and adipogenesis are insulin, leptin, ghrelin and adiponectin. Cholesterol and triglycerides are very important in fetal growth in the last period of pregnancy. In this study, it was aimed to compare the glucose, insulin, leptin, ghrelin, adiponectin, cholesterol and triglyceride levels in the cord blood of newborn babies with and without fetal malnutrition. Materials and Methods: Term babies born in our hospital were included in this study. Babies with a Clinical Assessment of Nutritional Status of 24 or below were considered as cases with fetal malnutrition, and those over 24 were considered as cases without fetal malnutrition. Glucose, insulin, leptin, ghrelin, adiponectin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, very-lowdensity lipoprotein cholesterol and triglyceride levels were studied from blood samples taken from the umbilical cord after delivery. Results: A total of 80 term newborn babies (40 babies with fetal malnutrition and 40 babies without fetal malnutrition) were included in this study. Birth weight, glucose and insulin values were found to be significantly lower in the group with fetal malnutrition (p<0.001; p<0.001; p=0.047, respectively), and adiponectin levels were found to be significantly higher (p<0.001). Conclusion: In our study, adiponectin levels in cord blood were found to be high in infants with fetal malnutrition. Considering the antiinflammatory role of adiponectin, high adiponectin levels in infants with fetal malnutrition may directly or indirectly reflect a protective mechanism. ©Copyright 2022 by Ege University Faculty of Medicine, Department of Pediatrics and Ege Children's Foundation.
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    Effects of Hesperidin and Diosmin on Necrotizing Enterocolitis: An Experimental Study
    (Brieflands, 2023) Şenel U.; Tanriverdi H.I.; Tanriverdi S.; Sapmaz H.I.; Akbaş A.; Gevrek F.; Uysal M.; Taş U.
    Background: Necrotizing enterocolitis (NEC) is a serious intestinal illness in newborns. Objectives: We aimed to investigate the potential protective effects of hesperidin (Hsd) and diosmin on NEC. Methods: Thirty newborn rats were divided into 3 groups: the control group (n = 10), the NEC group (n = 10), and the treatment group (n = 10). The treatment group was given 100 mg/kg of the flavonoid by oral gavage twice daily. On day 5 of the study, animals were sacrificed under anesthesia. After laparotomy, the tissue samples were obtained from the stomach, cecum, and ileum. NEC scoring was performed histopathologically. Apoptotic changes were evaluated by TUNEL (terminal deoxynucleotidyl transferase–mediated biotin–deoxyuridine triphosphate nick-end labeling) staining. Furthermore, levels of oxidants and antioxidants were determined by biochemical analyzes of the tissues. Results: Glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) levels were significantly higher in the NEC group than in the control group in all gastrointestinal tract regions examined. Similar to the control group, GSH-Px and MDA were found to be low only in the cecum in the group treated with flavonoids. NEC damage score and apoptotic index in all 3 regions examined were significantly higher in the NEC group than in the control and treatment groups. The apoptotic index values in the treatment group were similar in the stomach and cecum, and the NEC damage score was similar to those in the control group only in the cecum. Conclusions: Hsd and diosmin treatment significantly reduces the severity of NEC-induced damage and apoptotic cell death, especially in the cecum. © 2023, Author(s).