Browsing by Author "Tansug N."

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    The concentration of insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in maternal sera during pregnancy with normal and growth retarded fetuses; [Normal ve yetersiz fetal gelisim gosteren gebelerde gebelik suresince serum insulin benzeri buyume faktoru-1 (IGF-1) ve insulin benzeri buyume faktoru baglayici protein-3 (IGFBP-3) konsantrasyonlari]
    (2000) Lacin S.; Oruc S.; Kuscu K.; Ersoy B.; Tansug N.; Uyanik B.S.; Yildirim Y.; Koyuncu F.
    Objective: To determine the concentrations of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in maternal sera of pregnancies with normal and growth retarded fetuses and investigate the relationship between these substances and fetal growth. Materials and Methods: Blood samples of 148 pregnant women were collected at 14-16 and 30-31 weeks and during delivery. Also cord blood samples were obtained during delivery. For the determination of IGF-1 and IGFBP-3, double-sided IRMA method was used. Infants were divided into two groups as normal and growth retarded fetuses based upon their patterns of growth using the percentile curves and the serum levels were compared. Correlation analysis and Mann-Whitney U test were used as statistical calculations. Results: Both IGF-1 and IGFBP-3 levels increased while approaching term in all pregnant women. In growth retarded cases, maternal IGF-1 levels were found to be significantly lower than pregnancies with normal fetuses (p< 0.005), but maternal IGFBP-3 levels were not different between two groups. IGF-1 levels in cord blood during delivery were not different while IGFBP-3 levels were significantly higher in growth retarded fetuses. Conclusion: Our study did not support the hypothesis that fetal growth retardation is due to IGF-1 deficiency. High binding protein levels may cause a relative free IGF-1 deficiency, but the levels of binding protein is probably secondary to metabolic changes or placental insufficiency. Low levels of IGF-1 and high levels of binding proteins implies the necessity of further investigation of placental transfer.
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    Non-invasive evaluation of the adaptations of cardiac function in the neonatal period: A comparison of healthy infants delivered by vaginal route and caesarean section
    (2001) Coskun S.; Yüksel H.; Bilgi Y.; Lacin S.; Tansug N.; Onag A.
    Postnatal adaptations of cardiac hemodynamics in infants born vaginally or by caesarean section may be different. These cardiac functions were evaluated by Doppler echocardiography to assess adaptation differences. Cardiac output, heart rate, stroke volume, mean arterial pressure, total systemic vascular resistance, ejection fraction, and ductus arteriosus diameter were determined and compared at 1, 24 and 72 h of life in 22 infants born vaginally (group 1) and 23 born by caesarean section (group 2). One hour after delivery, heart rate, mean blood pressure, and total systemic resistance were found to be higher in group 1 infants (P < 0.01, P < 0.05, P < 0.05 respectively). Stroke-volume measurements were significantly higher in group 2 (P < 0.05). The ejection fraction and cardiac output values were similar in both groups. At 24 and 72 h, no significant differences were observed in measurements of infants born vaginally or by caesarean section. We did not find a parameter negatively affecting healthy newborns in either mode of delivery. However, under pathological conditions affecting the cardiovascular system at 1 h of life, including perinatal infections and hypoxemia, a lower stroke volume, higher heart rate, higher mean blood pressure, and higher peripheral resistance may cause additional work load to the cardiovascular system in infants born vaginally.
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    Serological prevalence of Helicobacter pylori in children with recurrent abdominal pain in Manisa region, Western Turkey
    (2002) Kasirga E.; Ertan P.; Tosun S.; Sanlidag T.; Tansug N.; Onag A.
    Objective: The purpose of this study was to evaluate the serological prevalence of Helicobacter pylori infection in asymptomatic and symptomatic (recurrent abdominal pain) children in Manisa region, Western Turkey. Design: To study the rate of infection by Helicobacter pylori in children, the prevalence of IgG antibodies to Helicobacter pylori was determined. Materials and Methods: Fifty-five symptomatic (25 boys and 30 girls) and one hundred sixty-four asymptomatic (82 boys and 82 girls) children between 3-15 years of age were tested for anti-Helicobacter pylori IgG. Serum samples collected were tested for IgG antibodies against Helicobacter pylori by enzyme-linked immunosorbent assay (ELISA) using commercial kits. Mean titers >20 U/ml were considered positive for specific IgG antibody. Results: The prevalence of anti-H. pylori IgG antibody was 65.5% in symptomatic and 35.4% in asymptomatic children. The seroprevalence was increased significantly with age in children with recurrent abdominal pain (chi-square= 18.09; p< 0.001). There was a significant difference in the appearance rate of IgG antibodies between asymptomatic and symptomatic children (chi-square= 15.22; p< 0.001). Conclusion: This study shows that Helicobacter pylori seropositivity is more common in children with recurrent abdominal pain than in asymptomatic children living in Manisa region, Western Turkey.
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    Children with recurrent abdominal pain in Manisa Region, Western Turkey: An evaluation of serological prevalence of Helicobacter Pylori
    (2003) Kasirga E.; Ertan P.; Tosun S.; Sanhdag T.; Tansug N.; Onag A.
    Objective- To evaluate the serological prevalence of Helicobacter Pylori infection in asymptomatic and symptomatic children with recurrent abdominal pain. Design- A cohort was used to study the rate of infection by Helicobacter Pylori in children, the prevalence of IgG antibodies to Helicobacter Pylori was determined. Setting- Manisa region, Western Turkey. Materials and Methods- Fifty-five symptomatic (25 boys and 30 girls) and one hundred sixty-four asymptomatic (82 boys and 82 girls) children between 3-15 years of age were tested for anti-Helicobacter pylori IgG. Serum samples collected were tested for IgG antibodies against Helicobacter pylori by enzyme-linked immunosorbent assay using commercial kits. Mean titers >20 U/ml were considered positive for specific IgG antibody. Result- The prevalence of anti-H. pylori IgG antibody was 65.5% in symptomatic and 35.4% in asymptomatic children. The seroprevalence was increased significantly with age in children and recurrent abdominal pain (chi-square = 18.09; p<0.001). There was a significant difference in the appearance rate of IgG antibodies between asymptomatic and symptomatic children (chi-square = 15.22; p<0.001). Conclusion- This study shows that Helicobacter pylori seropositivity is more common in children with recurrent abdominal pain than in asymptomatic children living in Manisa region, Western Turkey.
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    Premature labor and leukoerythroblastosis in a newborn with parvovirus B19 infection.
    (2005) Gulen H.; Basarir F.; Hakan N.; Ciftdogan D.Y.; Tansug N.; Onag A.
    Leukoerythroblastosis is a rarely observed disease characterized by the presence of leukocytosis, erythroid and myeloid blast cells in peripheral blood. To our knowledge, it had not been diagnosed in a premature newborn before the case we report have.A female baby weighing 1164 grams, who was born prematurely at the 29th week of gestation by Cesarean section was referred to our newborn intensive care unit due to prematurity and respiratory distress with no prenatal pathological findings. Physical examination revealed tachypnea and hepatosplenomegaly. Routine laboratory measurements showed significant leukocytosis (85,000/mm3) and anemia (Hb: 9.6 g/dL and Hct: 27.6%). The platelet count was normal. The peripheral blood smear suggested leukoerythroblastosis with the presence of nucleated erythrocytes, monocytosis, and 4% blasts. Bone marrow cytogenetic examination was normal. Parvovirus B19 Ig G and M serology were detected to be positive.The etiological factors observed in leukoerythroblastosis occurring during neonatal and early childhood period are congenital-postnatal viral infections, juvenile myelomonocytic leukemia and osteopetrosis. To our knowledge, no case of leukoerythroblastosis in such an early phase has been reported in the in literature. As a result, premature delivery and leukoerythroblastosis were thought to have developed secondary to intrauterine parvovirus B19 infection.Leukoerythroblastosis is a rarely observed disease characterized by the presence of leukocytosis, erythroid and myeloid blast cells in peripheral blood. It is reported that it can be observed following hematologic malignancies especially juvenile myelomonocytic leukemia, acute infections, hemolytic anemia, osteopetrosis, myelofibrosis, neuroblastoma and taking certain medicines. To our knowledge, it has not been diagnosed in a premature newborn before. Here we the case of a newborn who was referred to our intensive care unit due to being born prematurely at the 29th week of gestation and diagnosed with leukoerythroblastosis.
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    Primary orbital neuroblastoma in a neonate
    (Medknow Publications and Media Pvt. Ltd, 2006) Mirzai H.; Baser E.; Tansug N.; Nese N.; Isisag A.
    Neuroblastoma is an undifferentiated malignant tumor of the primitive neuroblasts. Orbital neuroblastoma is typically a metastatic tumor. We describe a two-days-old girl, who presented with a large tumor in her left orbit. Magnetic resonance imaging revealed that the tumor originated from the retrobulbar area, extending into the upper and lateral orbit. She was operated on the fifth day of life. A histopathologic diagnosis of neuroblastoma was made. Medical evaluation including chest roentgenogram, ultrasonography of the abdomen, whole body computerized tomogram and bone scintigraphy showed no evidence of systemic involvement or metastasis. Neuroblastoma should be considered in the differential diagnosis of neonatal orbital tumors.
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    Changes in quantitative ultrasound in preterm and term infants during the first year of life
    (2011) Tansug N.; Yildirim S.A.; Canda E.; Özalp D.; Yilmaz O.; Taneli F.; Ersoy B.
    Since most of in utero bone mass accretion occurs during the third trimester and postnatal need for bone nutrients is increased, preterm infants have an increased risk of low bone mass. Early identification of the risk is of crucial importance. Quantitative ultrasound, which is a relatively inexpensive, portable, noninvasive, and radiation-free method, gives information about bone density, cortical thickness, elasticity and microarchitecture. The aim of this study was to obtain quantitative ultrasound measurements of tibial speed of sound of preterm and term infants and to assess clinical factors associated with these measurements during the first year of life. Seventy-eight preterm and 48 term infants were enrolled in this study. Measurements were made on the 10th day of life in both groups, and were repeated on the 2nd, 6th and 12th months for preterm infants and on the12th month for the term infants. Speed of sound on preterm infants was significantly decreased on the 2nd month but significantly increased on the 12th month (P = 0.00). Comparing speed of sound of term and preterm infants, 10th day measurements were significantly different (P = 0.00), but there was not any significant difference between the 12th month values (P = 0.26). There was not any relation between biochemical parameters and speed of sound. The technique has potential clinical value for assessment of bone status. Further studies with long term follow up are needed to evaluate the value of quantitative ultrasound with other bone markers to predict the risk of fracture. © 2010 Elsevier Ireland Ltd. All rights reserved.