Browsing by Author "Taskin, T"

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    Musinous cystic neoplasia mimicking hydatid cyst in the liver: Two rare cases
    Tekin, E; Taskin, T; Ayhan, S
    Mucinous cystic neoplasm of the liver (MCN-L) is a rare tumor which accounts for less than 5% of all liver cysts. Although they are considered to be benign cysts radiologically and clinically because of their slow growth, they are considered as premalignant. We present two radiologically misdiagnosed cases that operated in a short time range, in order to increase awareness for these rare tumors. A 47-year-old female patient who had no active complaints 58 x 40 mm cystic lesion was detected in the liver, which was diagnosed hydatid cyst radiologically. The pathological examination showed multiloculated cysts which was covered by low-grade mucinous epithelium and ovarian-type stroma on the cyst wall. A 50-year-old female patient presented with abdominal distention. The radiographical screening revealed a 204 x 140 mm cystic lesion that completely fills left lobe of liver which interpreted in favor of hydatid cyst. Histopathologically, the inner surface of the cyst was covered with low grade mucinous epithelium. Ovarian-type stroma was detectable only by immunohistochemistry due to significant bleeding and edema on the wall. The diagnosis of both of our cases was low grade MCN-L. Since cysts were not intact at the time of gross examination, we could not make any comment about surgical margins or total excision. MCN-L is a tumor that creates difficulty in presurgical differential diagnosis because of its rarity and lack of specific radiologic features. Although the prognosis is excellent as a result of total excision in the benign group, relapses have also been reported.
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    Genetic Relationships Among Some Hawthorn (Crataegus spp.) Species and Genotypes
    Yilmaz, KU; Yanar, M; Ercisli, S; Sahiner, H; Taskin, T; Zengin, Y
    The genus Crataegus is well distributed in Turkey as a wild plant, with numerous, inherently variable species and genotypes. RAPD markers were used to study 17 hawthorn genotypes belonging to Crataegus monogyna ssp. monogyna Jacq (2 genotypes), C. monogyna ssp. azarella Jacq (1), Crataegus pontica K.Koch (3), Crataegus orientalis var. orientalis Pallas Ex Bieb (3), Crataegus pseudoheterophylla Pojark (1), Crataegus aronia var. dentata Browicz (1), C. aronia var. aronia Browicz (4), and Crateagus x bornmuelleri Zabel (2). The 10 RAPD primers produced 72 polymorphic bands (88% polymorphism). A dendrogram based on Jaccard's index included four major groups and one outgroup according to taxa. The lowest genetic variability was observed within C. aronia var. aronia genotypes. The study demonstrated that RAPD analysis is efficient for genotyping wild-grown hawthorns.
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    Tumor Budding Should Be in Oral Cavity Cancer Reporting: A Retrospective Cohort Study Based on Tumor Microenvironment
    Tan, AY; Taskin, T
    Simple Summary In our study, which started with the hypothesis that there is a histopathological marker that can be used to predict prognosis in oral squamous cell carcinomas, we found that tumor budding is quite significant. The fact that this finding will provide us with very important data in routine practice and play a key role in the treatment management of patients will be a significant finding and contribution to the literature. The utility of histological grading, which is useful in predicting prognosis in many tumors, is controversial for oral squamous cell carcinoma (OSCC). Therefore, new histopathological parameters should be added to histopathology reports of OSCCs. The study aimed to evaluate the parameters of worst invasion pattern (WPOI) and tumor budding in patients with OSCC, to compare them with other histopathological parameters, clinical data and overall survival, and to evaluate these results within the literature. A total of 73 OSCC cases with excisional biopsies were included in this study. WPOI, tumor budding, cell nest size, tumor-stroma ratio, stromal lymphocyte infiltration and stroma type, as well as classical histopathological parameters, were evaluated on hematoxylin-eosin-stained sections. Perineural invasion, lymph node metastases, advanced stage, presence of more than five buds and single cell invasion pattern in univariate survival analyses are characterized by a shortened overall survival time. While there was no significant difference between WPOI results and survival in the survival analysis, WPOI 5 was associated with more frequent lymph node metastasis and advanced stage at the time of diagnosis compared to WPOI 4. We concluded that tumor budding and single-cell invasion should be considered prognostic histopathologic parameters in OSCC.
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    PHYSICO-CHEMICAL AND BIOLOGICAL ACTIVITY OF HAWTHORN (Crataegus spp. L.) FRUITS IN TURKEY
    Ercisli, S; Yanar, M; Sengul, M; Yildiz, H; Topdas, EF; Taskin, T; Zengin, Y; Yilmaz, KU
    Hawthorn (Crataegus spp. L.) is a native fruit of great economic importance in Turkey and has been widely using in folk medicine particularly for the treatment of mild heart diseases for a long time. In the study, 18 previously selected hawthorn genotypes belong to several Crataegus species grown in the hawthorn repository collection in Malatya province in Turkey were evaluated. Fruit mass and soluble solid content of selected genotypes ranged from 0.76 to 4.27 g and 6.71 to 15.83%, respectively. The genotype 44MA12 belongs to C. monogyna subsp. azarella had distinct and the highest anthocyanin (516 mg per 100 g fresh fruit) content and the strongest 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity (2.91 mu g.g(-1)). The genotype 44MA11 belongs to C. meyeri had the highest phenolic content (3460 mg per 100 g gallic acid equivalent in fresh fruits). All hawthorn genotypes displayed high antioxidant activity. The results suggest that hawthorn fruits including significant human health benefit substances and may be used for developing functional foods because of its high phenolic, anthocyanin content and antioxidant properties.
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    1000 Mitoses Project: An International Consensus Study On Mitotic Figures
    Lin, S; Tran, C; Chu, M; Romagnoli, T; Hardy, N; Gibier, JB; Folaranmi, O; Semerci, O; Aneja, A; Stueck, A; Wiebe, N; Mondragon, LB; Schulte, J; Collins, K; Usubutun, A; Kendall, T; Laury, A; Ozamrak, B; Polonia, A; Panizo, A; Erana-Rojas, I; Hodgson, A; Qayoom, S; Baskota, SU; Morini, A; Suster, D; San, TH; Gul, G; Galea, L; Agoumi, M; Perret, R; Tran, TT; Hanna, M; Olteanu, GE; Kravtsov, O; Reed, R; Escobar, D; Maclean, F; Nova-Camacho, L; Cooper, C; Trinidad, CM; Taskin, T; Menon, A; Nguyen, V; Oswald, N; Li, JJX; Jiang, XY; Suleiman, D; van der Griend, R; Rosen, Y; Kukkonen, TM; Karunanithi, J; Cima, L; Pillappa, R; Sundar, PM; Eisenloffel, C; Gonzalez, R; Zahra, N; Muller, L; Bopoto, S; Patil, S; Rodriguez-Velandia, Y; Kholova, I; Kostiukov, A; Machado, I; Sansano, I; Tomikawa, C; Muscara, M; Rutland, T; Dallmann, A; Manucha, V; Peters, C; Dorward, D; Ribeiro, RRE; Sundari, A; Ordulu, Z; Charles, P; Dabner, M; Zhang, Q; Aljufairi, E; Cockenpot, V; Kini, J; Cienfuegos, J; Rajeswaran, P; Prendeville, S; Braubach, P; Patil, N; Cecchini, M