Browsing by Author "Tekin, G"
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Item Metabolic and demographic characteristics of children with urolithiasis in Western TurkeyErtan, P; Tekin, G; Öger, N; Alkan, S; Horasan, GDPediatric urolithiasis is an endemic disease in Turkey. We evaluated the clinical, radiological and metabolic features of children with urolithiasis in Western Turkey. We retrospectively reviewed the records of 85 children with urolithiasis who were followed-up between 2004 and 2010 in Pediatric Nephrology Department of Celal Bayar University, Manisa. The male/female ratio was 1.23/1. The mean age at diagnosis was 66.1 months (range 3-210 months). Family history of urolithiasis was found in 58 (68.2%) patients. 23 (27%) patients were born from consanguineous marriages. Stones were located in the upper urinary tract in 79 (92.9%) patients. In 66 (77.6%) patients, stones were single-sided and 41 (48.2%) patients had multiple stones. Calcium oxalate stones were the most common one among patients in whom stone analysis was performed (78.5%). Hypocitraturia was the most commonly detected urinary metabolic risk factor. In patients who were under 12 months of age at diagnosis, hypercalciuria was the most commonly seen urinary metabolic risk factor. At the end of follow-up period, 24 patients became free of stone disease and 4 patients had recurrence. In conclusion, metabolic abnormalities are common in pediatric stone patients and are strongly associated with recurrence. Considering that urolithiasis in children is an important risk factor for renal failure, early diagnosis, detailed metabolic evaluation and implementing appropriate treatment and follow-up protocols may prevent recurrence and renal damage.Item SPP1 Gene Polymorphisms Associated With Nephrolithiasis in Turkish Pediatric PatientsTekin, G; Ertan, P; Horasan, G; Berdeli, APurpose: To investigate the association between SPP1 gene polymorphisms and nephrolithiasis. Materials and Methods: A total of 65 pediatric patients and 50 healthy controls were enrolled in this study. Two known polymorphisms of the SPP1 gene, c.240T > C and c.708C > T nucleotide substitutions, both of which were also known as synonymous aminoacid polymorphisms, D80D and A236A, respectively, at SPP1 gene cDNA level, were investigated. SPP1 gene polymorphism was evaluated using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism method. Results: In c.240T > C polymorphism, C allele frequency [Odds Ratio (OR), 2.13; 95% Confidence Interval (CI), 1.170 to 3.880; P = .013] and CC genotype distribution (OR, 2.946; 95% CI, 0.832 to 10.431; P = .094) and in c.708C > T polymorphism, T allele frequency (OR, 2.183; 95% CI, 1.197 to 3.980; P = .011) and TT genotype distribution (OR, 3.056; 95% Cl, 0.861 to 10.839; P = .084) were found to be higher in the patient group. Conclusion: SPP1 polymorphisms were found to be associated with nephrolithiasis and it may be suggested that SPP1 gene polymorphism could be a useful marker for evaluation of the early genetic risk factor in childhood nephrolithiasis.Item A Case of Henoch-Schonlein Purpura with P369S Mutation in MEFV GeneErtan, P; Tekin, G; Sahin, GE; Kasirga, E; Taneli, F; Kandioglu, AR; Sözeri, BBackground: Henoch-Schonlein purpura (HSP) is the most common vasculitis of childhood. HSP can affect multiple organs presenting with a characteristic rash in most of the patients. Familial Mediterranean Fever (FMF) is an inherited inflammatory disease common in mediterranean populations. HSP is the most common vasculitis seen in children with FMF. Case Presentation: A 16 year old boy was referred with history of abdominal pain lasting for 20 days. He was hospitalized and had appendectomy. Due to the persistence of his abdominal pain after surgery he was admitted to our hospital. His physical examination showed palpable purpuric rashes symmetrically distributed on lower extremities. Abdominal examination revealed periumbilical tenderness. Laboratory tests showed elevated erythrocyte sedimentation rate, C-reactive protein and fibrinogen. Urinalysis revealed microscopic hematuria and severe proteinuria. The fecal occult blood testing was positive. Based on these clinic findings, the patient was diagnosed as HSP with renal, gastrointestinal tract and skin involvement. We performed DNA analysis in our patient because he had diagnosis of vasculitis with severe symptoms and found that he was carrying heterozygote P369S mutation. Conclusion: Our case is noteworthy as it indicates that it may be important not to overlook presence of FMF mutations in patients with a diagnosis of severe vasculitis.Item SPP1 gene polymorphisms associated with nephrolithiasis in Turkish pediatric patientsTekin, G; Ertan, P; Horasan, GD; Berdeli, AItem Relationship of sleep and life quality with children monosymptomatic enuresis nocturna by using actigraphyAlkan, S; Ertan, P; Tekin, G; Yüksel, H; Yilmaz, Ö; Yilmaz, HItem Ambulatory Blood Pressure Parameters in Office Normotensive Obese and Non-Obese Children: Relationship with Insulin Resistance and Atherosclerotic MarkersTekin, N; Ersoy, B; Coskun, S; Tekin, G; Polat, MObjectives: To determine differences in ambulatory blood pressure (ABP) parameters between office normotensive obese and non-obese children and to evaluate correlations of ABP parameters with insulin resistance and the lipid profile. Subjects and Methods: Thirty-eight obese [body mass index (BMI) above the 95th percentile] and 38 non-obese children aged 9-17 years were recruited. All subjects who were normotensive during office visits and who underwent 24-hour ABP monitoring were evaluated. Insulin resistance and the lipid profile were also evaluated. Results: The mean daytime, night-time and 24-hour systolic blood pressure (SBP) and the daytime and 24-hour diastolic blood pressure (DBP) in normotensive obese children were significantly higher compared to the values in non-obese children (p < 0.05). There was no difference in the frequency of nocturnal non-dippers and nocturnal hypertension (night-time SBP at or above the 95th percentile) between the two groups (p > 0.05). Children with night-time SBP at or above the 95th percentile and non-dippers had higher atherosclerotic markers than children with night-time SBP below the 95th percentile and dippers (p < 0.05). In logistic regression analysis, the low-density lipoprotein cholesterol (LDL-C): high-density lipoprotein cholesterol (HDL-C) ratio and night-time SBP had significantly positive associations with being obese in adolescents (OR 6.54, 95% CI 1.15-37.07, p = 0.03, and OR 1.1, 95% CI 1.01-1.19, p = 0.02, respectively). Conclusion: Normotensive obese children had higher ABP parameters. A high LDLC: HDL-C ratio and night-time SBP were associated with an increased risk of being obese. High LDL-C: HDL-C ratios and total cholesterol: HDL-C levels in children and adolescents may be risk factors for night-time hypertension. (C) 2013 S. Karger AG, BaselItem DOES HELICOBACTER PYLORI INFECTION HAVE A ROLE IN THE PATHOGENESIS OF MESENTERIC LYMPHADENOPATHY IN CHILDREN WITH ABDOMINAL PAIN?Ozguven, AA; Kasirga, E; Cebe, A; Tekin, G; Sahin, GItem Relationship Between Sleep and Life Quality of Children with Monosemptomatic Nocturnal Enuresis by Assessing ActigraphyÖzdemir, SA; Ertan, P; Tekin, G; Yilmaz, Ö; Yüksel, H; Yilmaz, HObjective: In this study, it was aimed to compare the sleep quality of healthy children with the actigraphic evaluation and quality of life of monosymptomatic enuresis children of similar age groups. Materials and Methods: This prospective study was conducted in Celal Bayar University Faculty of Medicine and has been submitted to the Department of Pediatric Nephrology. Patients included in the study were suffering from urinary incontinence for two years and only from monosymptomatic enuresis nocturna. The study group consisted of healthy children with monosymptomatic enuresis nocturna who volunteered to participate and those who did not have any systemic disease of similar age and sex. The demographic data, quality of life and activity of all the cases that were taken into the study were tried to be evaluated with sleep quality. Results: Forty children with 40 monosymptomatic enuresis nocturna diagnoses matching the study criteria were included. The control group consisted of 20 healthy children. There were no difference in demographic characteristics between the groups (p>0.05). The Kid-KINDL total score was 59.6 +/- 12.9 in children with monosymptomatic enuresis nocturna and 74.8 +/- 6.3 in healthy children (p=0.001). The effective sleep duration was statistically lower in children with monosymptomatic enuresis nocturna, and the effective duration of wakefulness, number of naps and fragmentation index were found to be higher in children with monosymptomatic enuresis nocturna (p=0.001). Conclusion: This is the first study in the literature to compare actigraphic analysis and quality of life of healthy children with enuretic children. We think that children with monosymptomatic enuresis nocturna have a significant deterioration in their quality of life compared to healthy children in sleep quality and this leads to an effect on the quality of life.Item Sera levels of homoarginine, homocysteine and ischemia modified albumin in patients with breast cancerKosova, F; Abusoglu, S; Beksaç, ÖK; Tekin, G; Çetin, B; Dinçel, AS; Ari, Z; Ünlü, A