Browsing by Author "Tekin, M"
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Item Autozygosity in a Turkish family with scoliosis, blindness, and arachnodactyly syndromeOrenay-Boyacioglu, S; Tekin, M; Dundar, MBACKGROUND AND OBJECTIVES: Blindness-scoliosis-arachnodactyly syndrome has been described in a family with parental consanguinity. We present the strategy employed to determine the gene locus responsible for the syndrome. DESIGN AND SETTING: A retrospective study of blindness-scoliosis-arachnodactyly syndrome patients at the Department of Medical Genetics, Erciyes University, between 2009-2010. PATIENTS AND METHODS: Whole genome single nucleotide polymorphisms (SNPs) were scanned using a 250K Affymetrix array. We visually evaluated runs of homozygosity shared by two affected brothers that segregated in the entire pedigree with different combinations due to the unclear affected status of some siblings. Two and multiple-point LOD (logarithm [base 10] of odds) score analyses were performed by easyLINKAGEplus v5.08. RESULTS: Five homozygous blocks over 2 Mb shared by two affected brothers segregated with phenotype in two affected and three unaffected siblings and in the mother whose phenotypes were unequivocal. The longest homozygous block in this analysis was on chromosome 14 between 67817621bp (rs7148416) and 82508151bp (rs17117757). When another sister with positive eye findings was added to the analysis, this region was narrowed to between 67817621bp (rs7148416) and 75657598bp (rs11626830), with a maximum LOD score of 2.3956 by two-point analysis. Three candidate genes were detected in this region. CONCLUSION: This study contributes to the existing literature on the region 67817621 bp 82508151 bp (rs17117757) on chromosome 14 and the three candidate genes, which could be responsible for the syndrome.Item RC beam strengthening using precast RC plate bonding techniqueDemir, A; Bagci, M; Tekin, M; Nuhoglu, AThe behaviour of RC beams strengthened with precast RC plates of rectangular and U cross-section is studied in the paper. An experimental investigation was conducted to assess effectiveness of strengthening with precast plates. The investigation was supported with the 2-D nonlinear finite element analysis (NLFEA). The NLFEA results showed a good level of correlation with test results. The proposed technique is considered to be a good alternative to RC jacketing and the technique is practical, economical and reliable for buildings or bridges with a greater number sisof similar beams.Item Reference ranges of liver and spleen dimensions in term infants: sonographic measurementsKahramaner, Z; Erdemir, A; Arik, B; Bilgili, G; Tekin, M; Genc, YTo determine reference values of ultrasonographic measurements of the liver and spleen in newborns and to provide a reference chart to use easily in daily practice. In this prospective study, spleen and liver dimensions were evaluated in 384 healthy newborns with a gestation age a parts per thousand yen37 weeks in an obstetrics clinic and neonatal intensive care unit with sonography within the first week of life. Relationships of all dimensions with sex, gestational age, height, and weight were statistically analyzed. No statistically significant differences were found between the two sexes in any dimensions of the liver and spleen (p > 0.05). Longitudinal and anteroposterior dimensions of the liver and spleen showed no correlation with the gestational age. All dimensions of the liver and spleen showed a high correlation with the height and weight. Weight was the best correlated with all dimensions. The reference values of spleen and liver lengths and diagrams from this study may be useful in the sonographic evaluation of the spleen and liver in newborns.Item Strengthening of RC beams with prefabricated RC U cross-sectional platesDemir, A; Tekin, M; Turali, T; Bagci, MThe topic of this study is to strengthen cracked beams with prefabricated RC U cross-sectional plates. The damaged beams were repaired by epoxy based glue. The repaired beams were strengthened using prefabricated plates. The strengthening plates were bonded to the bottom and side faces of the beams by anchorage rods and epoxy. The strengthened beams were incrementally loaded up to maximum load capacities. The experimental results were satisfactory since the load carrying capacities of damaged beams were increased approximately 76% due to strengthening. It was observed that strengthening plates had a dominant effect on the performance of beams in terms of both the post-elastic strength enhancement and the ductility. The experimental program was supported by a three-dimensional nonlinear finite element analysis. The experimental results were compared with the results obtained from the beam modeled with ANSYS finite element program.Item Purulent otitis media in children and adultsTekin, M; Schachern, PA; Mutlu, C; Jaisinghani, VJ; Paparella, MM; Le, CTThis study was designed to compare tympanic membrane (TM) and middle ear (ME) pathologies of temporal bones from children and adults with purulent otitis media (POM). Thirty-four temporal bones were used from 22 subjects ages 2 days to 76 years with histopathologic evidence of POM. There were 55 age-matched controls. Histopathologic findings of the TM and ME in children and adults with POM were compared. Clinical histories and the presence of complications were recorded. The incidence of POM was more common in male children than in females. There was a significant increase in the thickness of the posterosuperior and posteroinferior quadrants in children with POM compared to non-OM children. In adults with POM, there was a significant decrease in the thickness of the posteroinferior and anteroinferior quadrants compared to non-OM adults. Children with POM showed a significant increase in the anterioinferior and posteroinferior quadrants and the umbo compared to adults with POM. Pathology of the TM and ME occurred in adults and children, but severity was greater in children. Residual mesenchyme was frequently observed in temporal bones of children. Serious complications such as labyrinthtis and meningitis were observed more frequently in children. All cases with meningitis had labyrinthitis, previous histories of otitis media and had been treated with antibiotics. Although POM occurs in both children and adults, pathologic changes of the middle ear are more severe, and complications (labyrinthitis and meningitis) occur more often in children. Our findings suggest the need to monitor children carefully under the age of 2 years who have POM.Item Reference ranges of kidney dimensions in term newborns: sonographic measurementsErdemir, A; Kahramaner, Z; Arik, B; Bilgili, G; Tekin, M; Genc, YUltrasonographic measurement of kidney dimensions is important in evaluation of renal disease during the neonatal period, when renal abnormalities are common and renal size rapidly changes with age. To determine the reference ranges of kidney dimensions in newborns and to provide a reference chart for daily practice. In this prospective study, kidney dimensions were evaluated in 385 healthy newborns with a gestational age a parts per thousand yen37 weeks. Each neonate seen at an obstetrics clinic and neonatal intensive care unit was examined with sonography within the first week of life. Relationships of all dimensions with gender, gestational age, height and weight were statistically analyzed. All dimensions of the kidneys were smaller in girls than in boys (P < 0.05). The dimensions of the left kidney were larger than those in the right kidney in both genders (P < 0.01). Longitudinal and anteroposterior dimensions of the right and left kidneys showed no correlation with the gestational age in either gender. The dimensions correlated with the height in boys (P < 0.01), while no correlation was seen between the dimensions and height in girls (P < 0.05). Weight had the best correlation with all dimensions in both genders. The reference values of kidney lengths and diagrams from this study may be useful in the sonographic evaluation of kidneys in newborns.