Browsing by Author "Temel, M"
Now showing 1 - 8 of 8
Results Per Page
Sort Options
Item Effect of PACAP (Pituitary Adenylate Cyclase Activating Polypeptide) and Its Receptor on Oocyte in Vitro MaturationTemel, M; Önal, T; Bilgin, M; Öztatlici, M; Vatansever, SH; Inan, S; Özbilgin, KMItem A possible post-synaptic role of Histamine H3 Receptor or its isoform in isoproterenol-induced myocardial ischemia model in miceÖzel, HF; Özbek, M; Temel, M; Vatansever, HSItem Damage Mechanisms in Rat Brain for JWH-018 from New Synthetic CannabinoidsSen, G; Tozduman, B; Ekerbiçer, N; Çöllü, F; Temel, M; Demet, MM; Kutlu, N; Çavusoglu, TG; Tuglu, MIItem THE IMPORTANCE OF PACAP RECEPTORS IN THE RAPAMYCIN-TREATED LUNG CANCER CELL LINEOnal, T; Temel, M; Ozgul, M; Uluer, ET; Man, S; Ozbilgin, KItem The Effect of Chronic Administration of the Synthetic Cannabinoids, a Psychoactive Agent on Some Physiological Parameters in RatsSen, G; Ekerbiçer, N; Tozduman, B; Temel, MItem Electrocardiographic and Histopathologic Evaluations on Possible Role of H3 Receptors in β-adrenergic Stimulation-Induced Myocardial Damage in MiceÖzel, HF; Özbek, M; Temel, M; Vatansever, HSItem POMC expression of the urothelium of the urinary bladder of mice submitted to pelvic radiationOzbilgin, MK; Aktas, C; Temel, M; Önal, T; Uluer, ET; Vatansever, HS; Kurtman, CObjective: Patients who have had pelvic radiotherapy as part of their cancer therapy may develop subsequent urinary bladder injury. The acute changes that the urothelium undergo after radiation are known, but the healing mechanism of the urothelium of the urinary bladder after pelvic radiotherapy is not clearly understood. Proopiomelanocortin (POMC) peptides, which have immunomodulatory effects, are produced locally in sites outside of the central nervous system. This study aims to determine the role of POMC expression in the urothelium during radiation injury. Methods: Twenty-four male Swiss Albino mice were divided into four groups. A single-fractioned 10 Gy of ionizing radiation was applied to the pelvic zone of all mice with Cobalt-60 radiotherapy. The first group 1, which consisted intact animal and not irradiated was the control group, and the second, third, and fourth groups were euthanized after 24 h (Group 2), 48 h (Group 3), and 7 days (Group 4) after irradiation. All bladders were prepared for histochemical analysis using hematoxylin eosin (H&E) and immunohistochemical analysis using anti-POMC antibody. Results: No morphological differences were seen in all the group samples stained with H&E. POMC expression of the urothelium of bladder tissue samples shows different staining levels. Group 1 (96.7 +/- 7.68), Group 2 (88.3 +/- 8.04), and Group 3 (85.10 +/- 10.9) were very weakly stained, but the POMC immunoreactivity of Group 4 (113.0 +/- 12.8) was observed to be strong. Conclusion: Expression of POMC from urothelium seems to prevent bladder damage from radiation supplying differentiation and restoration of the urothelium.Item Ophthalmic findings in GAPO syndromeIlker, SS; Öztürk, F; Kurt, E; Temel, M; Gül, D; Sayli, BSBackground: The main manifestations of GAPO syndrome are growth retardation (G), alopecia (A), pseudoanodontia (P), and optic atrophy (O). Cases: This syndrome has been described in 21 patients from 16 different families. Four cases are from Turkey and have been presented by Sayli and Gul. The purpose of our study is to document: the cases from Turkey and discuss the ophthalmological and neuro-ophthalmolgical findings of these and other reported GAPO cases. Observations: All patients in the literature and our 4 cases have severe growth retardation with delayed bone age in infancy, characteristic facial appearance thigh and bossed forehead, midface hypoplasia), alopecia or severe hypotrichosis, and pseudoanodontia. Optic atrophy was present in 1 of our cases and in 5 previous cases. Glaucoma was present in 5 cases, including 2 of ours. Buphthalmia and keratopathy secondary to glaucoma were also observed. White eyelashes, seen only in our cases, may be a sign of early senility. Conclusions: Optic atrophy is not a constant finding in GAPO syndrome. Glaucoma may accompany the ocular findings. This syndrome has been attributed to either ectodermal dysplasia or the accumulation of extracellular connective tissue matrix, due to an enzyme deficiency involved in its metabolism. Current studies show that an elastin defect and secondary changes in collagen may be important: in the pathogenesis of the disease. Jpn J Ophthalmol 1999;43:48-52 (C) 1999 Japanese Ophthalmological Society.