MCBÜ Açıkerişim Sistemi :: Browsing by Author "Temiz C."

Browsing by Author "Temiz C."

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Secondary Brucellar psoas abscess
(2002) Tünger Ö.; Arýsoy A.S.; Özbakkaloǧlu B.; Temiz C.; Borand H.
PSOAS ABSCESSES are rarely seen and usually misdiagnosed infections of the musculoskeletal system. A case of secondary psoas abscess due to Brucella spp. that was successfully treated with percutaneous computed tomography-guided aspiration and antimicrobial therapy is presented. The reported cases, diagnostic and therapeutic recommendations are also reviewed.
B cell immunoblastic lymphoma of central nervous system: Case report
(Turkish Neurosurgical Society, 2003) Umur A.S.; Temiz C.; Selçuki M.; Mirzai H.; Okudur I.; Özkal B.; Işisaǧ A.
Primary central nervous system lymphoma (PCNSL) is defined as the lymphoma effecting only spinal axis and cranium without systemic symptoms. PCNSL is very rare. Hystologic type of lymphoma that arising in the CNS is most commonly B cell lymphoma. In our study we reported a 47 years old female patient with B cell non-hodgkin's lymphoma of CNS with no evidence of lymphoma outside the CNS. There was no evidence of systemic acquired immundeficiency syndrome.
Clear cell meningioma: Case report and literature review
(Churchill Livingstone, 2003) Kuzeyli K.; Çakir E.; Usul H.; Karaarslan G.; Reis A.K.; Temiz C.; Baykal S.
The clear cell meningioma is rare and a recently described histologic variant of meningioma. The most interesting aspect of clear cell meningioma is the high recurrence rate and agressiveness. Until now 17 intracranial clear cell meningioma cases had been reported in the English language literature. We present 2 new cases of clear cell meningioma which is discussed with the relevant literature. © 2003 Elsevier Science Ltd. All rights reserved.
Clinical and histological changes of intrathecally administered gadopentate dimeglumine (Gd-DTPA) in normal rats
(Centauro SRL, 2005) Mavioglu H.; Tuglu I.; Temiz C.; Ozbilgin K.; Cilaker S.; Selcuki D.; Selcuki M.
Objectives: This study is carried out to explore clinical and histological changes induced in rats by intrathecal administration of Gd-DTPA via suboccipital spinal injection. 2.5, 5, 10 μmol/g-brain of Gd-DTPA were injected intrathecally to 43 adult male rats and sucrose as control solution with same volume and osmolarity were injected to 18 rats. Animals were sacrificed on day 4 and 14. Sections from the cortex, brain stem, cerebellum and medulla spinalis were obtained to examine for cell loss and apoptosis. In this study, no clinical abnormalities were observed in 69.8% of rats of Gd-DTPA group and in 83.3% of rats of sucrose group. Transient neurological signs such as ataxia and paresis were seen in 11.6% of rats in the Gd-DTPA group and in 5.5% of rats in the sucrose group. They were seen more frequently in the Gd-DTPA group especially in the highest dose and volume. Histological examination did not revealed necrosis or apoptosis in both groups. This study suggests that intrathecally administered Gd-DTPA may be safe in humans when lower doses per gram of brain are used than rats.
Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion
(2005) Temiz C.; Dogan A.; Baskaya M.K.; Dempsey R.J.
Polyamines have been shown to play an important role in the disturbance of the blood-brain barrier (BBB) in a number of pathological states including ischemia. BBB disturbances may be almost completely prevented by treating animals with the ornithine decarboxylase (ODC) inhibitor, α- difluoromethylornithine (DFMO). DFMO has been also shown to prevent N-Methyl-d-aspartate (NMDA) toxicity in tissue cultures. It has been suggested that the pathological disturbances in polyamine metabolism observed following cerebral ischemia, particularly the post-ischemic increase in putrescine, may contribute to the ischemic injury that is most evident in the CA1 subfield of the hippocampus. In this study, effects of DFMO in cerebral ischemia and reperfusion were examined. The results showed that inhibition of the polyamine system by DFMO decreased ischemic injury volume and brain tissue water content in a dose-dependent manner, without change in vital signs, including systemic arterial blood pressure, arterial partial oxygen pressure, regional cerebral blood flow and body temperature. © 2005 Published by Elsevier Ltd.
Penetrating injury of cranium: A case report
(Turkish Association of Trauma and Emergency Surgery, 2005) Temiz C.; Umur A.Ş.; Baǧdatoǧlu C.; Tosun C.; Selçuki M.
A 38 year-old male patient treated for paranoid schizophrenia for five years was found on a chain saw table at his workplace with a great parasagittal, linear active bleeding wound from left occiput to medial portion of left orbita. He was unconscious with a Glascow coma score of 5 points as 1-3-1. Cranial radiographies revealed a bone defect from left occipital region to left medial border of orbita. CT scan showed also a great linear tissue damage involving left lateral ventricle, and an intracerebral hematoma located mainly at left frontoparietal region. An emergent left frontoparietal craniotomy was performed. Four centimetres laterally midline, there was a linear, vertical tissue wound. Hemostasis was achieved at first and intracerebral haematoma evacuated. At one week postoperatively his eyes started to react to verbal commands. At 7 months postoperatively he was attempting to cooperate with eye movements and writing. He was right hemiplegic, aphasic and on the right side deep tendon reflexes were hyperactive. His Karnofsky score was almost 40 points. Cranial injuries due to chain saw accidents are very rare. Early surgical procedures (incl. decompression) combined with aggressive antibiotherapy seem to have a great survival benefits. However best long- term results show that this type of injuries have a great rate of mortality and morbidity despite all surgical and medical treatment procedures.
High-velocity gunshot wounds to the head: Analysis of 135 patients
(2005) Bakir A.; Temiz C.; Umur S.; Aydin V.; Torun F.
Head injuries due to high-velocity missiles and shrapnel as a result of military conflicts have become a very important cause of death or severe neurological deficits. Military-type missiles have high velocities and transfer higher amounts of energy to neural tissue, compared to civil-type missiles. This physical phenomenon also causes greater neural tissue destruction. Shrapnel particles derive from blasts and cause less severe injury because of the irregular particle shape and low energy transmission. This study analyzed 135 patients with head trauma, 80 patients (59%) injured by missiles and 55 patients (41%) by shrapnel. Glasgow Coma Scale (GCS) scores at admission were 3 to 7 in 69 patients, 8 to 10 in 29 patients, and 11 to 15 in 37 patients. The most common anatomical localizations were the right frontoparietal region in 42 patients and the left frontoparietal region in 40 patients. One hundred patients (74%) were operated on immediately and 35 patients (26%) were treated conservatively in the intensive care unit. Ten of the 135 patients died (7.4%), seven from missile injury and three from shrapnel injury. In this study, we found that high mortality was associated with low GCS score at admission, presence of multilobar or skull base injuries, and involvement of ventricles. Early and aggressive surgical intervention decreased the mortality.
Radiologic features of lumbar spine in ochronosis in late stages
(2006) Bayindir P.; Yilmaz Ovali G.; Pabuşçu Y.; Temiz C.; Duruoz T.
Ochronosis is a rare hereditary disorder of tyrosine metabolism. Severe degenerative arthritis and spondylosis occur in the later stages of this disease. Radiologic examinations may reveal changes considered almost pathognomonic for ochronosis. We present the radiologic features of the lumbar spine in two ochronotic patients who were diagnosed after radiologic examinations in the late stages of the disease. © Clinical Rheumatology 2005.
Chondroid chordoma of the thoracic spine: Case report [7]
(Taylor and Francis Ltd., 2007) Demireli P.; Ovali G.Y.; Yegen G.; Temiz C.; Tarhan S.
[No abstract available]
Apoptosis seems to be the major process while surface and neural ectodermal layers detach during neurulation
(2008) Selçuki M.; Vatansever S.; Umur A.S.; Temiz C.; Sayin M.
Objective: The aim of this study is to demonstrate the process of detaching neural and surface ectodermal layers soon after the neurulation completes. Materials and methods: Specific pathogen-free chicken egg embryos were used to investigate the neurulation procedure. Ten eggs were saved as controls. The other ten eggs were opened at the 30th hour of embryo development and cultured with Z-VAD-FMK (peptide caspase inhibitor) to investigate the results of the apoptosis inhibition. Embryos were placed and developed up to 48 h in the culture medium. To detect apoptotic cells between neural and surface dermal layers, immunoreactivity of p53 and terminal uridine deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay were used. Results: While the control group shows positive immunoreactivity of p53 and TUNEL-positive apoptotic cells at the site where the neural folds detach from the surface ectoderm, no TUNEL activity and no detachment were detected in the apoptosis-inhibited group. Conclusion: As inhibition of apoptosis prevented the detachment of the neural and surface ectodermal layers from each other at the end of the neurulation, inhibition of apoptosis seemed to cause a considerable embryological error accounted for congenital dermal sinus tractus maldevelopment. © Springer-Verlag 2007.
Effect of cepea extract-heparin and allantoin mixture on epidural fibrosis in a rat hemilaminectomy model; [Cepea ekstresi-allantoin ve heparinin rat hemilaminektomi modelinde oluşturulan epidural fibrozisi önlemedeki etkinliǧi]
(Turkish Neurosurgical Society, 2009) Temiz C.; Temiz P.; Sayin M.; Ucar K.
Aim: Epidural fibrosis following a laminectomy procedure is a serious problem that results in failed back surgery syndrome. Aserious number of manuscripts have explained its possible mechanism and results but no effective preventive surgical technique or treatment is currently present. Material and methods: We used a rat hemilaminectomy model at lumbar fourth level. In the treatment group (n:10), the hemilaminectomy sites were filled with cepea extract-allantoin and heparin mixture as sterile cream form. In the second group, the same surgical procedure was performed and the site was filled with physiological saline. All animals were terminated after 6 weeks and laminectomy sites removed en-bloc. Epidural fibrosis was evaluated and compared using semi-quantitative histopathological scoring scales. Results: In the physiological saline group, the fibrosis score was 10.3 points and 90% of the subjects had acute inflammatory reaction, 80% chronic inflammatory reaction and 100% showed bone destruction and reparation process. In the cepea extract group, these values were fibrosis score 4.2 points, 0% acute inflammatory reaction, 33.3% chronic inflammatory reaction and 10% bone destruction and reparation process, respectively. Conclusion: This study showed that aloe cepea extract-allantoin and heparin mixture diminished epidural scarring formation effectively with decreased scores of acute and chronic inflammation, compared to the physiological saline solution group.
Effect of sodium phenytoin concentration on neural tube development in the early stages of chicken embryo development
(2009) Temiz C.; Temiz P.; Demirel A.; Sayin M.; Umur A.S.; Özer F.D.
Animal and human research has shown that anticonvulsants are teratogens and pose a risk of causing fetal malformations. In various studies, the teratogenic effects of sodium phenytoin (PTH) in several systems have been investigated. Toe and finger, renal, and even facial malformations have been described in the literature. However, there is debate about whether the true risk of teratogenesis is lower or higher than previously reported for PTH. There is also little published information on the effect of this agent on neural tube closure in an embryological model. In this study, 0.1 mL of three different concentrations of PTH solution (mg/mL: 1, 3, 5) or vehicle was applied under the embryonic disc of specific pathogen-free Leghorn chicken embryos after 24 hours' incubation. Incubation was continued until 72 hours of maturation. At 72 hours, all embryos were evaluated macroscopically and microscopically. There were serious neural tube closure defects in the embryos administered large amounts (0.5 mg) of PTH, but doses of 0.1 mg (subtherapeutic concentration for humans) and 0.3 mg (therapeutic concentration for humans) produced no statistically significant defects (p = 0.05). The difference between the defects in the high concentration group and the other three groups was statistically significant. In our study PTH administered in a strict concentration regimen produced a lower level of neural tube closure-related defects than previously reported. © 2008 Elsevier Ltd. All rights reserved.
Frontal sinus osteoma complicated with intracranial inflammatory polyp: A case report and review of the literature
(2009) Umura S.; Gunhan K.; SonguM; Temiz C.; YuceturkAV
Background: Osteomas of the paranasal sinuses rarely cause intracranial manifestations. A neurological symptom may be the first sign of a previously unrecognized osteoma. Case description: A 28-year-old male was referred with one episode of witnessed tonic-clonic seizure and loss of consciousness. Radiologic examination revealed a calcific mass in the frontal sinus and a cystic structure was detected in the posterior component of the lesion. The patient underwent a combined nasal endoscopic approach and a bilateral frontal osteoplastic craniotomy. The ossifying tumoral tissue and the polypoid soft tissue mass were removed. The histo-pathologic diagnosis of the hard, bony tumor was consistent with an osteoma and the polypoid soft tissue was an inflammatory polyp. Conclusion: This case report illustrates a rare and life threatening complication of a frontal sinus osteoma with an intracranial extension of an inflammatory polyp.
Genetical and histological investigation of Turkish siblings with spina bifida occulta who had neurosurgical intervention
(2009) Altintas N.; Umur Ş.; Vatansever S.; Temiz C.; Selçuki M.; Selçuki D.; Örenay S.; Arslan E.
Spina bifida is the one of the most frequently occurring birth defects. More children have spina bifida than muscular dystrophy, multiple sclerosis, and cystic fibrosis combined. Occulta present type is a mild very common form of spina bifida. The reported frequency of occurrence of spina bifida occulta (SBO) varies widely, depending largely on the age groups included in a particular study. The most accurate estimate of occurrence rate is 17% of examined spines. In present study we have examined and compared two Turkish siblings with spina bifida occulta who had neurosurgical intervention. Clinical, histopathological and cytogenetical analyses had been performed on mother and both siblings (brother and sister) diagnosed with spina bifida occulta. Hypertrichosis on their low-backs was diagnosed in both siblings. Magnetic resonance imaging (MRI) studies revealed low conus medullaris and thick filum terminale in brother and sister. The brother somatosensory evoked potential (SEP) results showed lumbar conduction blockade which was not found in sister. Despite the brothers's thick and fatty filum terminale sisters's seemed to be normal. Filum terminale sections from both siblings had normal appearance but atypical structure with increased amount of connective tissue and hyalinization areas. Sections from 9 years old boy were also prominent in glial cells. Genetical analysis revealed normal caryotype in 13 years old sister (46,XX) , however deletions on chromosome 17 have been detected in 9 year-old brother [46,XY/46,XY,del(17)(q25) /47,+mar] and their mother [46,XX/46,XX,del(17)(q25)]. Our results show on strong correlation between the deletion of chromosome 17(q25) with genetical and histological results in both siblings with SBO. This is the first report of chromosome 17 (q25) deletion related to the SBO and its genetic connection with neural tube defects.
Effects of nitric oxide-vascular endothelial growth factor systems in chick embryo cerebral vasculogenesis and angiogenesis; [Civciv Embriyosunda Serebral Vaskülogenezis ve Anjiogenezis Üzerine Nitrik Oxid-Vasküler Endotelyal Growth Faktörün Etkileri]
(Derman Medical Publishing, 2012) Temiz C.; Arslan M.; Sayın M.; Vatansever S.; Giray G.; Var A.
Aim: Studies have depicted that nitric oxide and vascular endothelial growth factor systems have important biological effects in the development of vasculogenesis and angiogenesis. Material and Method: In this study; specific pathogen free white Leghorin type fertilised eggs were used. Result: Three main subgroups were designed regarding time points of 48; 72 and 80 hours of incubation. In 48 hours old embryos anjioblasts were seen; but no mature endothelial structure was present. In 72 hours old embryos endothelial maturation began. In the 80 hours there was a high level of endothelial maturation. In all 48 hours groups; tissue nitrite-nitrate concentrations were high but in the 72 hours group these values were higher than in the first group. In the 80 hours group; concentrations were lower and were statistically significant when compared to the 48 and 72 hours groups. Discussion: NO seems to be effective in early phases of vasculogenesis and angiogenesis; but its effect decreases with time. © 2012, Derman Medical Publishing. All rights reserved.
Balanced anesthesia with dexmedetomidine added desflurane or sevoflurane in spinal surgery
(2012) Keles G.T.; Ozer M.; Dede G.; Temiz C.; Horasan G.D.; Civi M.
Objectives: Sevoflurane and desflurane inhalational anesthetics are used for fast-track neuroanesthesia. Dexmedetomidine is used to provide analgesia, sedation and hemodynamic stability. Other anesthetic and analgesic requirements decrease when dexmedetomidine is administered, thus it is an interesting option for intraoperative agent for general anesthesia. We aim to compare desflurane and sevoflurane with dexmedetomidine in the operating room (OR) and Post-Anesthesia Care Unit (PACU) by using Fast-Tract -Criteria (FTC) and Aldrete Criteria (AC) for spinal surgery patients. Methods: A double-blind study was conducted. One hundred ASA I-II patients aged 18-65 were randomly divided into two groups. Following the standard anesthesia induction, Group (D+D) (n=50) received 2-4 % desflurane + 0.2 μg/kg/h dexmedetomidine and Group (S+D) (n=50) received 1-3 % sevoflurane + 0.2 μg/kg/h dexmedetomidine in 60 % N2O for anesthesia management. Extubation times, and FTC and AC were evaluated in the OR at the 5th and 10th minutes and in PACU at the 5th, 15th and 25th minutes. P< 0.05 was considered significant. Results: Demographic features of the patients in the two groups were similar. Extubation time in Group (D+D) was shorter than that in Group (S+D) (5.9 ± 2.4 and 8.3 ± 3.9 min respectively, p=0.001). In OR at the 10th min, and in PACU at the 5th min; Group (D+D) had a higher AC score than did Group (S+D) (p=0.001), and also at the 15th min., Group (D+D) had a higher FTC (P=0.01) and AC (p=0.007) scores than did Group (S+D). In all the patients, targeted discharge points were achieved at the 25th minute in PACU Conclusions: Balanced anesthesia with desflurane / dexmedetomidine combination is superior to sevoflurane / dexmedetomidine in extubation time and time to reach an AC ≥ 9 and FTC ≥ 13 in spinal surgery. © 2012 Keles GT, et al.
The effects of lornoxicam on brain edema and blood brain barrier following diffuse traumatic brain injury in rats; [Lornoksikamin siçanlarda diffüz travmatik beyin hasarinda beyin ödemi ve kan beyin bariyeri üzerine etkileri]
(Turkish Association of Trauma and Emergency Surgery, 2013) Topçu I.; Gümüşer G.; Bayram E.; Aras F.; Çetin I.; Temiz C.; Çivi M.
BACKGROUND In this experiment, the effects of lornoxicam on brain edema and the blood brain barrier (BBB) following diffuse traumatic brain injury (TBI) were studied. METHODS Twenty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by the Marmarou method. After head injury, the rats were randomly divided into two groups: Group I was the control group, to which 2 ml saline was administered intraperitoneally, and Group II was the lornoxicam group, to which 2 ml 1.3 mg kg-1 lornoxicam was administered intraperitoneally. Twenty-four hours after head trauma, 99 mTc pentetate (DTPA) was injected at a dose of 37 MBq, and posterior planar images of each rat were obtained using an Infinia gamma camera. After imaging of BBB permeability, brain tissues were dissected from the cranium. The brain water content (BWC) of each sample was calculated using the wet-dry method. RESULTS The lesion/background (L/b) ratio of Group I was 3.76±0.46 and 3.02±0.66 for early (5th min) and late (60th min) imaging, respectively. In Group II, the L/b ratios were 3.52±0.96 and 2.63±0.63 for early and late imaging, respectively (p>0.05). BWC was 79.6±2.5% and 77.5±1.1% for Groups I and II, respectively (p<0.05). CONCLUSION In this rat model of TBI, lornoxicam reduced brain edema but did not affect BBB permeability.
Histologic changes at the intervertebral disc tissue after laser nucleotomy; [Lazer nükleotomi sonrasi{dotless} i̇ntervertebral disk dokusunda histolojik deǧişiklikler]
(2013) Ösün A.; Samancioǧlu A.; Temiz P.; Temiz C.; Sayin M.
Minimally invasive surgical techniques have become widely used for lumbar disc disease. Each of these techniques have a different physical effect in terms of retracting the prolapsed disc tissue and decompressing the adjacent nerve root by reducing the intradiscal pressure. Various types of laser generators with different wave lengths and electrode systems have been used for percutaneous laser disc decompression (PLDD). There are numerous studies regarding the clinical effectiveness of PLDD but histologic parameters which can prove the effectivity are few. Three patients with L4-5 disc prolapsus had undergone open microdiscectomy three months after PLDD because of the unsatisfactory results. The disc tissues were evaluated histologically. Fibrous fibrillary degeneration, integrity deformation of the fibres and chondrocyte proliferation were seen at the site of the microdiscectomy tissue. Previously laser irradiated disc materials had more severe fibrillary degeneration and the chondroid component degeneration was significant. In addition, degenerative calcification and massive necrosis of the chondrocytes were seen. Changes in fibronectin, tissue inhibitors of metalloproteinases (TIMP) and matrix metalloproteinases (MMPs) of the disc tissue were examined with immunohistochemical dyes. As a result, we found that PLDD causes a decrease in the water content of the disc tissue, hyaline degeneration, fibrillary destruction and chondrocyte depletion. Immunostaining showed that the extracellular matrix was effected, the metalloproteinase activity and protein compound of the extracellular matrix had changed.The findings were discussed in light of the literature.
Preoperative and postoperative evaluation of somatosensorial evoked potentials of upper extremities in cervical intervertebral disc herniation
(Turkish Neurosurgical Society, 2013) Umur A.S.; Selcuki M.; Selcuki D.; Temiz C.; Akbasak A.
This study aims to determine the dysfunction caused by existing pathological condition in structures involved in the transfer of sensory functions of the neural system in cervical disc herniation, and to establish whether or not the level and degree of this anatomical damage can be anticipated by SEP (Somatosensorial Evoked Potentials). We compared the obtained SEP values for statistical significance using the Friedman Variation Analysis. In parameters with statistical significance, the Wilcoxon Signed Rank test was used to identify when significant improvements occurred. The study found that the statistical data of the latency of the N14 wave originating from the dorsal column nuclei of the medulla spinalis and dorsal column gray matter improved (p<0.05) in the postoperative period compared with the preoperative values. Using the Wilcoxon Signed Rank test, we studied postoperative months separately in regard to the difference in the latency of the N14 wave, and found the statistically significant improvement to be marked particularly in months 3 and 6 postoperatively (p<0.05). In conclusion, we suggest that SEP is a useful tool to check the functional condition of the dorsal spinal column. The benefit of the SEP utilization is the ability to determine the severity of the pathological condition preoperatively and follow the patient's functional postoperative improvement.
Hyperbaric oxygen treatment in the experimental spinal cord injury model
(Elsevier Inc., 2014) Yaman O.; Yaman B.; Aydin F.; Var A.; Temiz C.
Background context Spinal cord trauma is a major cause of mortality and morbidity. Although no known treatment for spinal cord injury exists, a limited number of effective treatment modalities and procedures are available that improve secondary injury. Hyperbaric oxygen (HBO) treatment has been used to assist in neurologic recovery after cranial injury or ischemic stroke. Purpose To report the findings on the effectiveness of HBO treatment on rats with experimental traumatic spinal cord injury. Improvement was evaluated through motor strength assessment and nitrite level assay testing. Study design We randomly distributed 40 rats among 5 groups of 8 rats each: sham incurable trauma, induced trauma, HBO treatment begun at the 1st hour, HBO treatment begun at the 6th hour, and HBO treatment begun at the 24th hour. Method The HBO treatment was administered to rats in three of the groups and conducted in two 90-minute sessions, under an absolute atmospheric pressure of 2.4 at 100% oxygen for 5 days. In the motor strength evaluations, all the rats were observed during the inclined plane test and clinical motor examination on the first, third, and fifth days. In addition, the nitrite levels of spinal cord tissues on the sixth day were also studied. Results Results from the inclined plane levels and motor strength test from all the three groups undergoing HBO treatment were higher than those from Group 2. It was also determined that early HBO treatment resulted in higher recovery rates (groups 3 and 4). The highest levels were seen in the group in which the HBO treatments were started in the first hour (Group 3). It was noted that nitrite levels of rats in the group exposed to trauma increased, compared with the sham group, but increased levels also diminished after HBO treatments. Again, the greatest decrease in nitrite levels was evident in the group where the HBO treatment was started the earliest (Group 3). Conclusions Prompt HBO treatment after trauma significantly contributed to the clinical, histopathologic, and biochemical recovery of the rats. © 2014 Elsevier Inc. All rights reserved.

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