Browsing by Author "Tepe D."

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    Growth curves for Turkish girls with turner syndrome: Results of the Turkish turner syndrome study group
    (Galenos Yayincilik,, 2015) Darendeliler F.; Yeşilkaya E.; Bereket A.; Baş F.; Bundak R.; Sarı E.; Aydın B.K.; Darcan Ş.; Dündar B.; Büyükinan M.; Kara C.; Mazıcıoğlu M.M.; Adal E.; Akıncı A.; Atabek M.E.; Demirel F.; Çelik N.; Özkan B.; Özhan B.; Orbak Z.; Ersoy B.; Doğan M.; Ataş A.; Turan S.; Gökşen D.; Tarım Ö.; Yüksel B.; Ercan O.; Hatun Ş.; Şimşek E.; Ökten A.; Abacı A.; Döneray H.; Özbek M.N.; Keskin M.; Önal H.; Akyürek N.; Bulan K.; Tepe D.; Emeksiz H.C.; Demir K.; Kızılay D.; Topaloğlu A.K.; Eren E.; Özen S.; Demirbilek H.; Abalı S.; Akın L.; Eklioğlu B.S.; Kaba S.; Anık A.; Baş S.; Ünüvar T.; Sağlam H.; Bolu S.; Özgen T.; Doğan D.; Çakır E.D.; Şen Y.; Andıran N.; Çizmecioğlu F.; Evliyaoğlu O.; Karagüzel G.; Pirgon Ö.; Çatlı G.; Can H.D.; Gürbüz F.; Binay Ç.; Baş V.N.; Sağlam C.; Gül D.; Polat A.; Açıke C.; Cinaz P.
    Objective: Children with Turner syndrome (TS) have a specific growth pattern that is quite different from that of healthy children. Many countries have population-specific growth charts for TS. Considering national and ethnic differences, we undertook this multicenter collaborative study to construct growth charts and reference values for height, weight and body mass index (BMI) from 3 years of age to adulthood for spontaneous growth of Turkish girls with TS. Methods: Cross-sectional height and weight data of 842 patients with TS, younger than 18 years of age and before starting any therapy, were evaluated. Results: The data were processed to calculate the 3rd, 10th, 25th, 50th, 75th, 90th and 97th percentile values for defined ages and to construct growth curves for height-for-age, weight-for-age and BMI-for-age of girls with TS. The growth pattern of TS girls in this series resembled the growth pattern of TS girls in other reports, but there were differences in height between our series and the others. Conclusion: This study provides disease-specific growth charts for Turkish girls with TS. These disease-specific national growth charts will serve to improve the evaluation of growth and its management with growth-promoting therapeutic agents in TS patients. © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing.
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    Turner syndrome and associated problems in turkish children: A multicenter study
    (Galenos Yayincilik,, 2015) Yeşilkaya E.; Bereket A.; Darendeliler F.; Baş F.; Poyrazoğlu Ş.; Aydın B.K.; Darcan Ş.; Dündar B.; Büyükinan M.; Kara C.; Sarı E.; Adal E.; Akıncı A.; Atabek M.E.; Demirel F.; Çelik N.; Özkan B.; Özhan B.; Orbak Z.; Ersoy B.; Doğan M.; Ataş A.; Turan S.; Gökşen D.; Tarım Ö.; Yüksel B.; Ercan O.; Hatun Ş.; Şimşek E.; Ökten A.; Abacı A.; Döneray H.; Özbek M.N.; Keskin M.; Önal H.; Akyürek N.; Bulan K.; Tepe D.; Emeksiz H.C.; Demir K.; Kızılay D.; Topaloğlu A.K.; Eren E.; Özen S.; Abalı S.; Akın L.; Eklioğlu B.S.; Kaba S.; Anık A.; Baş S.; Ünüvar T.; Sağlam H.; Bolu S.; Özgen T.; Doğan D.; Çakır E.D.; Şen Y.; Andıran N.; Çizmecioğlu F.; Evliyaoğlu O.; Karagüzel G.; Pirgon Ö.; Çatlı G.; Can H.D.; Gürbüz F.; Binay Ç.; Baş V.N.; Fidancı K.; Polat A.; Gül D.; Açıkel C.; Demirbilek H.; Cinaz P.; Bondy C.
    Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology.
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    Anthropometric findings from birth to adulthood and their relation with karyotpye distribution in Turkish girls with Turner syndrome
    (Wiley-Liss Inc., 2016) Sari E.; Bereket A.; Yeşilkaya E.; Baş F.; Bundak R.; Aydin B.K.; Darcan S.; Dündar B.; Büyukinan M.; Kara C.; Adal E.; Akinci A.; Atabek M.E.; Demirel F.; Çelik N.; Özkan B.; Özhan B.; Orbak Z.; Ersoy B.; Doğan M.; Ataş A.; Turan S.; Gökşen D.; Tarim O.; Yüksel B.; Ercan O.; Hatun S.; Şimşek E.; Ökten A.; Abaci A.; Döneray H.; Özbek M.N.; Keskin M.; Önal H.; Akyürek N.; Bulan K.; Tepe D.; Emeksiz H.C.; Demir K.; Kizilay D.; Topaloğlu A.K.; Eren E.; Özen S.; Demirbilek H.; Abali S.; Akin L.; Eklioğlu B.S.; Kaba S.; Anik A.; Baş S.; Unuvar T.; Sağlam H.; Bolu S.; Özgen T.; Doğan D.; Çakir E.D.; Şen Y.; Andiran N.; Çizmecioğlu F.; Evliyaoğlu O.; Karagüzel G.; Pirgon O.; Çatli G.; Can H.D.; Gürbüz F.; Binay C.; Baş V.N.; Fidanci K.; Gül D.; Polat A.; Acikel C.; Cinaz P.; Darendeliler F.
    To evaluate the anthropometric features of girls with Turner syndrome (TS) at birth and presentation and the effect of karyotype on these parameters. Data were collected from 842 patients with TS from 35 different centers, who were followed-up between 1984 and 2014 and whose diagnosis age ranged from birth to 18 years. Of the 842 patients, 122 girls who received growth hormone, estrogen or oxandrolone were excluded, and 720 girls were included in the study. In this cohort, the frequency of small for gestational age (SGA) birth was 33%. The frequency of SGA birth was 4.2% (2/48) in preterm and 36% (174/483) in term neonates (P<0.001). The mean birth length was 1.3cm shorter and mean birth weight was 0.36kg lower than that of the normal population. The mean age at diagnosis was 10.1±4.4 years. Mean height, weight and body mass index standard deviation scores at presentation were -3.1±1.7, -1.4±1.5, and 0.4±1.7, respectively. Patients with isochromosome Xq were significantly heavier than those with other karyotype groups (P=0.007). Age at presentation was negatively correlated and mid-parental height was positively correlated with height at presentation. Mid-parental height and age at presentation were the only parameters that were associated with height of children with TS. The frequency of SGA birth was found higher in preterm than term neonates but the mechanism could not be clarified. We found no effect of karyotype on height of girls with TS, whereas weight was greater in 46,X,i(Xq) and 45,X/46,X,i(Xq) karyotype groups. © 2016 Wiley Periodicals, Inc.
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    Reliability and Validity of the Turkish Version of Impact of Weight on Quality of Life for Kids
    (AVES, 2022) Kızılay D.Ö.; Sapmaz Ş.Y.; Tepe D.; Ersoy B.
    Objective: The Impact of Weight on Quality of Life—Kids is a self-reported weight-related quality of life measure that has been validated for children and adolescents aged between 11 and 19. Impact of Weight on Quality of Life—Kids does not have a Turkish version. The aim of this study was to explore the reliability and validity of the Impact of Weight on Quality of Life—Kids in Turkish. Materials and Methods: The Impact of Weight on Quality of Life—Kids was translated into Turkish using Mapi Research Institute's suggested international translation technique. The psychometric evaluation included test-retest reliability, internal consistency, discriminant validity, concurrent validity, exploratory factor analysis, and confirmatory factor analysis. Results: For the total score, the internal consistency of the scale (Cronbach's alpha coefficient) was 0.93. The item-total score correlation coefficients ranged from 0.178 to 0.785. The testretest coefficients were found to be 0.94 for the total score and the subscales ranged from 0.66 to 0.89 after 2 weeks. Discriminant validity analysis demonstrated that the instrument dif- ferentiated well between the obese and non-obese samples. Five variables were discovered via factor analysis that explained 66.9% of the total variation. The chi-square/degree of freedom ratio value was 3.535, the comparative fit index value was 0.834, and the value of root mean square error of approximation was 0.10, as determined by confirmatory factor analysis. Conclusion: Our results demonstrated the adequate reliability and validity of the Impact of Weight on Quality of Life—Kids, suggesting that this scale is a useful tool for screening Turkish children and adolescents for weight-related quality of life. © 2022, AVES. All rights reserved.