MCBÜ Açıkerişim Sistemi :: Browsing by Author "Tikiz, C"

Browsing by Author "Tikiz, C"

Now showing 1 - 20 of 52

Comparison of the Efficacy of Low-Level Laser Therapy and Pulsed Ultrasound Treatment in Carpal Tunnel Syndrome: A Placebo-Controlled Study
Tikiz, C; Duruöz, T; Ünlü, Z; Cerrahoglu, L; Yalçinsoy, E
Objective: To evaluate the effect of low-level laser treatment (LLLT) and pulsed ultrasound (US) treatment in carpal tunnel syndrome (CTS) and to compare the effects of both treatment modalities. Materials and Methods: 60 patients diagnosed with CTS were randomly divided into four groups as US group (group 1), placebo US group (group 2), LLLT group (group 3) and plasebo LLLT group (group 4). Both treatments were applied five days a week for three weeks. Clinical and electrophysiological assessments were performed before and 3, 6 and 12 months after treatment. Pain, hypoesthesia and handgrip strength were evaluated. The Boston Questionnaire was used to assess the severity of symptoms and functional status. Results: 52 patients with 101 hands completed the study. Demographic and electrophysiological parameters were similar in the four groups. Both pulsed US treatment and LLLT were found to provide significant improvements in clinical parameters such as pain, sensory loss, symptom severity score and functional capacity score (p<0.05). No significant beneficial effect was observed in both placebo groups (p<0.05). Evaluations of the electrophysiological parameters showed no significant difference between the groups (p>0.05). In terms of clinical efficacy, pulsed US was found to be superior to LLLT (p<0.05). Conclusion: The two treatment modalities showed significant improvements in subjective clinical symptoms while no significant changes were observed in any electrophysiological parameters.
Effectiveness of radial extracorporeal shock wave therapy in post-stroke spasticity patients: Evaluation with shear wave elastography
Özbek, IC; Tikiz, C
Objectives: This study aimed to evaluate the effectiveness of radial extracorporeal shock wave therapy (ESWT) in treating spasticity in post-stroke patients using shear wave elastography (SWE). Patients and methods: This randomized controlled trial was conducted with 42 patients (29 males, 13 females; mean age: 64.0 +/- 8.5 years; range, 47 to 80 years) between June 2022 and August 2023. Stroke patients with biceps muscle spasticity were randomly assigned to either an active ESWT treatment group or a control group. Both groups underwent conventional rehabilitation programs. The ESWT group received four treatment sessions once a week for four weeks. Primary assessment criteria included SWE measurement values. Secondary criteria included the Modified Ashworth Scale, Modified Tardieu Scale, Fulg-Meyer Upper Extremity Assessment, and Functional Independence Measures. Evaluations were performed before treatment, immediately after treatment, one month after treatment, and three months after treatment. Results: In the ESWT group, significant decreases in Modified Ashworth Scale and Modified Tardieu Scale scores observed one month after treatment were not maintained at three months. Improvements in Fulg-Meyer Upper Extremity Assessment and Functional Independence Measures scores were noted immediately after treatment and at one and three months after treatment, whereas these improvements were only observed at three months in the control group. Significant decreases in SWE measurements at 90 degrees flexion and 180 degrees extension observed one month after treatment in the ESWT group were not sustained at three months. Conclusion: Our study highlights the short-term efficacy of ESWT as an adjunct to conventional rehabilitation in reducing spasticity in post-stroke patients with biceps muscle involvement. The correlation of SWE with physical examination methods emphasizes its potential role in the assessment and follow-up of spasticity treatment.
Endothelial dysfunction in patients with primary Sjogren's syndrome
Pirildar, T; Tikiz, C; Özkaya, S; Tarhan, S; Ütük, O; Tikiz, H; Tezcan, UK
\The aim of this study was to determine the endothelial function in patients with primary Sjogren's syndrome ( SS). We also aimed to determine whether endothelial ( dys) function correlates with extraglandular manifestations, specific autoantibodies and the severity of salivary gland involvement of SS. Endothelium dependent vasodilation and endothelium- independent vasodilation of the brachial artery were assessed by a high- resolution ultrasound on 25 patients with primary SS and on 29 healthy controls. Patients with primary SS had significantly less mean endothelium- dependent vasodilation than did controls ( 3.0 +/- 0.4% vs 4.2 +/- 0.3%; p= 0.012). Endothelium- independent vasodilation induced by sublingual glycerol trinitrate was not different between the two groups ( 12.9 +/- 1.4% vs 14.1 +/- 1.2%; p= 0.86;). We concluded that endothelium- dependent vasodilation was impaired in primary SS patients, in particular those presenting with Raynaud's phenomenon, when compared with the healthy controls and this impairment was not associated with the presence of RF, ANA, anti- Ro/ SS- A, anti- La/ SS- B and with the other extraglandular manifestations of the disease.
Relationship Between Cyclic Citrullinated Peptide Antibodies Positivity and HLA-DRB1 Shared Epitope Alleles in Patients with Rheumatoid Arthritis in Turkey
Dayan, I; Tikiz, C; Taneli, F; Ulman, C; Ulutas, G; Tüzün, C
Objective: The most characteristic genetic risk factors for rheumatoid arthritis (RA), the HLA-DRB1 shared epitope (SE) alleles, encode for a common amino acid sequence in the peptide-presenting part of the HLA class II molecule. These SE alleles have been described recently to be a risk factor for the development of antibodies against citrullinated proteins in RA. The current study was performed to investigate the association between the cyclic citrullinated peptide antibodies (anti-CCP) and HLA-DR1 HLA-DRB1 shared epitope alleles in patients with RA in Turkey. Materials and Methods: Sixty patients with RA who were newly diagnosed or under conventional treatment in our clinic and 60 healthy volunteers as controls were enrolled in the study. In patients with RA anti-CCP levels were investigated with enzyme-linked immunosorbent assay and HLA-DRB1 subtyping and SE was assessed by polymerase chain reaction. Only anti-CCP was measured in healthy volunteers. Results: SE was positive in 50% of the patients with RA. Amongst the SE carriers, 30% of them were carrying double copy of SE. While anti-CCP was positive in 73,3% of patients with RA, this ratio was 0% in healthy volunteers. We determined that the existence of SE increases the positivity of anti-CCP (OR=4,3, 95% [CI], P=0.04), and a significant relationship was found between the anti-CCP positivity and the RF positivity. (OR=5,3, 95% [CI] P<0.05). Conclusion: The results of the present study revealed that Turkish patients with RA carrying SE with HLA-DRB1 genes is significantly related with the production of anti-CCP. The diagnostic sensitivity and specificity of anti-CCP for RA is determined as 73,3% and 100% respectively. (Turk J Rheumatol 2010; 25: 12-8)
The Effect of Abdominal Massage on Constipation in the Elderly Residing in Rest Homes
Çevik, K; Çetinkaya, A; Gökbel, KY; Menekse, B; Saza, S; Tikiz, C
Constipation is a health problem commonly seen in the elderly. In the present study, the effect of abdominal massage on constipation in the elderly was examined. The study sample consisted of 22 elderly people residing in a nursing home in the province of Manisa who were suffering from constipation in June 2014 to February 2015. The following were used to collect data: a case identification form; the Rome III Functional Constipation Diagnosis Criteria Form; the Bristol Stool Scale, consisting of the Recall Bias and Visual Scale Analog; and the Standard Diary Constipation Monitoring Form. The comparison of the mean scores obtained before, during, and after the implementation of abdominal massage in the elderly revealed that the number of bowel movements, stool weight, and stool consistency scores increased during and after the implementation. The differences between the mean intra- and postimplementation scores in terms of stool weight and between the pre- and postimplementation mean scores in terms of stool consistency were not statistically significant. There was a statistically significant difference between straining scores except for those obtained during intra- and postimplementation application. It was determined that abdominal massage increased the number of bowel movements, stool weight, and stool consistency, decreased the mean scores for straining, and decreased inability to completely empty the bowels (except on the implementation days).
Sexual dysfunction in female subjects with fibromyalgia
Tikiz, C; Muezzinoglu, T; Pirildar, T; Taskin, EO; Firat, A; Tuzun, C
Purpose: We investigated sexual function in females with fibromyalgia (FM) and evaluate whether coexistent major depression (MD) has an additional negative effect on sexual function. Materials and Methods: A total of 100 female subjects were enrolled in the study, including 40 with FM only, 27 with FM plus MD and 33 healthy volunteers as a control group. The diagnosis of MD was made according to Structured Clinical Interview for Diagnostic and Statistical Manual-IV interview and the Hamilton Depression Rate Scale was used to grade depression. Widespread pain and quality of life were assessed with the Lattinen Pain Scale and Fibromyalgia Impact Questionnaire, respectively. The Female Sexual Function Index (FSFI) was used to assess sexual dysfunction. Results: All subjects were comparable in age, occupation and education. Mean FSFI total score +/- SD was significantly decreased in the FM and FM plus MD groups compared with that in healthy controls (21.83 +/- 5.84 and 22.43 +/- 7.0 vs 28.10 +/- 6.52, respectively, p = 0.001). However, the FSFI score was not significantly different between patients with FM only and FM plus MD (p > 0.05). Correlation analysis revealed a negative moderate correlation between total Lattinen pain score and FSFI score in the FM only and FM plus MD groups (r = -0.366, p = 0.047 and r = -0.403, p = 0.018, respectively). FSFI score did not correlate with FIQ and HDRS scores (p > 0.05). Conclusions: This study demonstrates that female patients with FM have distinct sexual dysfunction compared with healthy controls and coexistent MD has no additional negative effect on sexual function. Thus, female subjects with FM should be evaluated in terms of sexual function to provide better quality of life.
The effect of anti-tumor necrosis factor (TNF)-alpha therapy with etanercept on endothelial functions in patients with rheumatoid arthritis
Tikiz, H; Arslan, Ö; Pirildar, T; Tikiz, C; Bayindir, P
Objective: To investigate the effects of tumor necrosis factor (INF)-alpha antagonism with etanercept (ENC) on endothelial functions in patients with active rheumatoid arthritis (RA). Methods: A total of 21 patients with RA were enrolled in this prospective study. Eleven of them (8 women, 3 men mean age 47.0 +/- 10.1 years) with high disease activity despite the conventional treatment were assigned to Group 1 and were given ENC treatment twice a week (25 mg SC injection) for 12 weeks. Ten patients with RA (8 women, 2 men mean age 55.0 +/- 6.4 years) under conventional methotrexate and prednisone therapy were assigned as Control group (Group 2). Endothelium-dependent and -independent vasodilator responses of the brachial artery were assessed by high-resolution ultrasound. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured at baseline and at the post treatment period. Mann-Whitney U and Wilcoxon tests were used to compare the data and correlation analysis was performed using Pearson correlation test. Results: Endothelium-dependent vasodilatation improved from 5.2 +/- 0.8% to 7.9 +/- 1.3% (p=0.04) in ENC group, while no significant change was observed in the control group (from 6.6 +/- 1.1% to 7.0 +/- 1.8% p=0.67). No significant changes were found in endothelium-independent vasodilatation and baseline brachial artery diameters in both groups. A significant reduction in ESR and CRP were observed in patients receiving ENC (from 16.2 +/- 6.8 to 9.2 +/- 5.1 mm/h, p=0.003 and from 14.68 +/- 3.4 to 9.25 +/- 3.7 mg/L, p=0.003, respectively). Conclusion: Treatment with ENC for 12 weeks significantly improved endothelial function in patients with active RA compared to those under conventional therapy. The findings of the present study support the hypothesis that the use of TNF-alpha blockers in patients with active RA may reduce the high incidence of cardiovascular complications. (Anadolu Kardiyol Derg 2010; 10: 98-103)
Peripheral polyneuropathy in patients receiving long-term statin therapy
Özdemir, IH; Copkiran, Ö; Tikiz, H; Tikiz, C
Objective: Peripheral neuropathy is an important potential side effect of statin use. This study was an investigation of the incidence of peripheral neuropathy in patients taking atorvastatin or rosuvastatin for hypercholesterolemia and the relationship to the dose and duration of the treatment. Methods: In all, 50 patients using a statin treatment and 50 healthy controls matched for age and gender who had never taken a statin were included in the study. Polyneuropathy was assessed with a neurological examination and electroneuromyography (ENMG). Results: While no polyneuropathy was detected in the control group, polyneuropathy was seen in 33 (66%) of the patients in the statin group (p<0.01). There was no significant difference between the 2 statin groups in the results of the neurological examination or the ENMG findings regarding the incidence of polyneuropathy (p=0.288 and p=0.720, respectively). Neuropathy was observed in a neurological examination performed within the first year in 50% of the rosuvastatin users and 18% of those taking atorvastatin. The severity of the polyneuropathy increased with the duration of the treatment in the atorvastatin group (p=0.030). Conclusion: This study revealed an increased risk of peripheral neuropathy with long-term statin use (>1 year). Electrodiagnostic changes have been detected in motor and sensory nerves in nerve conduction studies of patients on long-term statin treatment. The assessment of neurological symptoms, like tingling, numbness, pain and tremor in the hands and feet, and unsteadiness during walking associated with peripheral neuropathy may be useful in the follow-up of the patients on long-term statin treatment. Early detection of peripheral neuropathy and changing hypercholesterolemia treatment may prevent permanent nerve damage.
The effects of botulinum-A toxin on bladder function and histology in spinal cord injured rats: Is there any difference between early and late application?
Temeltas, G; Tikiz, C; Dagci, T; Tuglu, I; Yavasoglu, A
Purpose: We explored the effects of early and late application of botulinum-A toxin (BTX-A) on reservoir function and histological bladder changes in spinal cord injured rats. Materials and Methods: The study was done in 30 Sprague-Dawley rats randomly allocated into 5 groups. Group 1 of 6 rats underwent sham operation only. Group 2 of 6 rats underwent spinal cord transection. Group 3 of 6 rats underwent spinal cord transection followed by BTX-A application into the detrusor muscle 7 days later. Group 4 of 6 rats underwent spinal cord transection, followed by BTX-A application into the detrusor muscle 28 days later. Group 5 of 6 rats underwent spinal cord transection followed by saline injection into the detrusor muscle after 28 days. Spinal cord injury was created by transecting the cord at the T9 to T10 level. All rats underwent cystometric examination initially and on day 42 before sacrifice. The bladders were removed and examined histologically for fibrosis and hyperplasia. Results: On cystometric examination BTX-A caused an improvement in baseline pressure, and the frequency and amplitude of uninhibited detrusor contractions (p < 0.001). No significant differences were observed in maximal bladder capacity or urethral opening pressure (p > 0.05). Histologically BTX-A led to decreased fibrosis and hyperplasia (p < 0.001). No significant differences were found between histological or cystometric among the groups with respect to receiving BTX-A in the early and late periods (p > 0.05). Conclusions: BTX-A has a functional and histological healing effect on detrusor hyperreflexia subsequent to spinal cord injury in rats. Although administering BTX-A in the early period had better quantifiable functional and histological outcomes compared to the late period, the difference was not statistically significant.
Comparison of the effects of alendronate and risedronate on bone mineral density and bone turnover markers in postmenopausal osteoporosis
Sarioglu, M; Tuzun, C; Unlu, Z; Tikiz, C; Taneli, F; Uyanik, BS
The aim of the study was to compare the effects of once-weekly alendronate sodium and daily risedronate sodium treatment on bone mineral density (BMD) and bone turnover markers in postmenopausal osteoporotic subjects. For this purpose, 50 patients were included in this study and randomly classified into two groups. Group I (n=25) received risedronate (5 mg/day) and group II (n=25) received alendronate Na (70 mg/week). The study duration was limited to 12 months. The efficacy of the treatment was evaluated by BMD measurements at spine and hip at 6th and 12th months of the treatment, as well as by the measurement of bone turnover markers such as serum osteocalcin (OC), bone-specific alkaline phosphatase (BASP), urine deoxypyridinoline (DPD) and calcium/creatine ratio in 24-h urine at 1st, 3rd, 6th and 12th months. The evaluation of the changes in BMD in all regions revealed a significant increase in BMD in both groups compared to baseline values except for spine (L2-L4) in alendronate group at 6th and 12th month and femoral neck in risedronate group at 6th month. However, the difference in percentage increase in BMD measurements was not statistically significant between the two groups at 6th and 12th months. In both groups, serum OC, BSAP and urine DPD were found to be significantly attenuated at 1st month of the treatment period, and continued to be lowered throughout the 3rd, 6th and 12th months (P < 0.05). However, there was no statistically-significant difference between both groups of patients (P > 0.05). In conclusion, our results suggest that both treatment protocols provide treatment options of similar efficiencyfor postmenopausal osteoporosis, and have almost-similar effects in enhancing the BMD and in slowing the bone turnover. Risedronate seems to havea more potent effect in the spinal region than that of alendronate, although this potency was not statistically significant.
Acute Pseudogout Arthritis in a Patient Using Diuretics
Akkoç, F; Tikiz, C; Akgül, Ö
Sensitivity to change of Istanbul low back pain disability index (ILBPDI)
Duruöz, T; Cerrahoglu, L; Tikiz, C; Dincer-Turan, Y
Effects of simvastatin on bone mineral density and remodeling parameters in postmenopausal osteopenic subjects
Tikiz, C; Tikiz, H; Taneli, F; Gümüser, G; Tüzün, Ç
Observational studies suggest that statin use may be associated with lower incidence of fracture. However, there are conflicting data for their effects on bone remodeling parameters and bone mineral density (BMD). In the present study, we aimed to investigate the effects of simvastatin on bone metabolism and BMD in subjects with hypercholesterolemia (> 240 mg/dl). For this purpose, 32 postmenopausal osteopenic subjects who were given simvastatin treatment (20 mg/day) and not on osteoporosis treatment were included in the study. During the 1-year follow-up period, the total cholesterol level decreased from 262.1 +/- 30.9 to 202.2 +/- 30.1 mg/dl (p < 0.0001). At a period as early as the 3rd month, levels of the anabolic markers, e.g., bone-specific alkaline phosphatase (BSAP) and osteocalcin (OCL), were found to be significantly increased (from 120.8 +/- 56.6 to 149.5 +/- 57.6 IU/l, p = 0.008, and from 20.8 +/- 12.6 to 34.7 +/- 118.4 mu g/l, p = 0.015, respectively) while no significant change was observed in the resorptive marker of serum N-telopeptide of type I collagen (CTX). At the 6th and 12th month, BSAP and OCL were both found to be decreased below the pretreatment values. While a significant reduction was found in BSAP levels (from 120.8 +/- 56.6 to 55.9 +/- 18.8 IU/l, p < 0.001), no significant change was observed in CTX levels after the 6-month treatment period. Parathyroid hormone showed a gradual profound increase during the follow-up period (from 62.7 +/- 41.5 to 108.4 +/- 51.7 pg/ml, p < 0.001). No significant change was found in BMD levels at the spine, femoral neck, Ward's triangle, and trochanter at the end of the 1-year follow-up period. In conclusion, simvastatin treatment showed a short-lasting anabolic effect on bone metabolism. However, this effect was lost by prolongation of therapy. The decrease in both anabolic and resorptive markers at the 6th and 12th month suggests that simvastatin affects bone metabolism mostly in favor of inhibition of the bone turnover in a long-term observation period although this inhibitory effect was not reflected in BMD.
Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa B Ligand in Post-Menopausal Women
Karaarslan, S; Büyükyazi, G; Taneli, F; Ulman, C; Tikiz, C; Gümüser, G; Sahan, P
Objective: To investigate the effects of 12-week two-different intensity resistance training programs on bone turnover markers, bone mineral density (BMD), osteoprotogerin (OPG), and soluble receptor activator of nuclear factor kappa p ligand (sRANKL) in postmenopausal women. Material and Methods: Forty healthy women (aged 45-60 years) participated in the study. High-intensity group (HIG; n=14) worked 4 days a week and performed two sets of 8-10 repetitions at similar to 70-80% of I repeat maximum (RM). Low-intensity group (LIG; n=13) worked in the same duration, with 13-17 repetitions, at similar to 40-50% of IRM. Control group (CG; n=13) did not perform any exercises. Body composition, I RM value for 10 exercises, repetitions of sit-ups for 30 seconds, bone formation and resorption markers, serum osteocalcine (OC). bone alkaline phosphatase (BAP), beta CrossLabs. OPG, and sRANKL levels were measured before and after the training program. BMD was measured via dual energy X-ray absorptiometry. Results: Resistance training caused increases in spine BMD in HIG and LIG (p<0.05). and OC levels increased in the HIG (p<0.05). We observed a significant difference between the percent change in HIG versus the percent change in CC in the spine BMD values (p<0.01). sRANKL levels decreased significantly in all three groups. Strength measures increased in both exercise groups (p<0.001), favoring the HIG. Conclusion: High-intensity resistance training may be more effective for increasing muscle strength and protecting against osteoporosis and fractures. Due to insignificant changes in OPG levels and significant reductions in sRANKL in all groups, measures of circulating OPG and sRANKL levels seem not to be so useful to predict BMD or bone turnover status after resistance training programs. Therefore, these parameters remain to be determined directly in the bone microenyironments together with BMD measures and bone turnover markers.
Effects of physical exercise on quality of life, pulmonary function and symptom score in children with asthma
Yüksel, H; Sögüt, A; Yilmaz, Ö; Günay, Ö; Tikiz, C; Dündar, P; Onur, E
Objective: To evaluate the effects of regular exercise on asthma symptom score, quality of life and pulmonary function in asthmatic children. Materials and Methods: Thirty children with newly diagnosed mild-moderate asthma (mean age 9.8 +/- 1.78 years) were randomly allocated into exercise group (group 1) and control group (group 2). Both groups received inhaled fluticasone and montelukast treatment. Children in the exercise group were also included in an exercise training program. The program consisted of condition bicycle for one hour two times a week for 8 weeks. Pediatric Asthma Quality of Life Questionnaire (PAQLQ), a disease spesific quality of life questionnaire, and KINDL, a generic quality of life questionnaire, were used to assess health related quality of life in both groups. Spirometric tests were also performed and asthma symptom scores were recorded. Results: The degree of improvement in all scores of PAQLQ (total, activity, symptom, emotion) and symptom score in group 1 were significantly higher than those in group 2 in final evaluation, (p= 0.005, 0.000, 0.003, 0.009, respectively). Moreover, the scores of self-esteem and family subscales of KINDL in group 1 were significantly higher than those in group 2 (p=0.047, 0.030, respectively). Although insignificant, the degree of improvement in pulmonary function values (FEV1, FVC and FEV1/FVC) in group 1 were higher than those group 2. (Asthma Allergy Immunol 2009; 7: 58-65) Conclusion: Regular exercise added to conventional treatment in children with asthma significantly improves quality of life besides symptoms score.
Can Urinary Gamma Glutamyl Transferase be Used as a Bone Resorption Marker in Postmenopausal Osteoporosis?
Tikiz, C; Ulman, C; Taneli, F; Acar, EY; Gümüser, G; Horasan, GD
Objectives: To evaluate whether gamma-glutamyl transferase can be used as a new novel bone resorption marker in postmenopusal osteoporotic subjects. Design and methods: 156 postmenopausal subjects were divided into three groups according to their lumbar spine T-score measured by dual-energy X-ray absorptiometry as normal, (control group, n=56), osteopenic (n=50) and osteoporotic (n=50). Deoxypyridinoline and gamma-glutamyl transferase from urine samples and osteocalcin and bone specific alkaline phosphates from blood samples were assessed. Results: Osteocalcin and bone specific alkaline phosphates levels were increased in osteoporotic group (p<0.05). Although there is a tendency to increase in deoxypyridinoline values in osteoporotic group, this difference did not reach to a statistical significance. No significant differences were observed in urinary gamma-glutamyl transferase levels between the three groups (p>0.05). No significant correlation was found between urinary gamma-glutamyl transferase and deoxypyridinoline, bone specific alkaline phosphates and osteocalcin (p>0.05). Urinary gamma-glutamyl transferase levels showed no significant correlation with neither bone mineral density nor T scores in all subjects (r=0.058 p=0.625, r=-0.074 p=0.533 respectively). Conclusions: Our primary findings did not support the suggestion that urinary g-glutamyl transferase could be used as a potential marker for bone resorption in postmenopusal osteoporotic subjects.
Effects of physical exercise on lung injury and oxidant stress in children with asthma
Gunay, O; Onur, E; Yilmaz, O; Dundar, PE; Tikiz, C; Var, A; Yuksel, H
Background: The aim of this study was to investigate the influence of exercise training on oxidative stress and markers of lung inflammation in children with asthma. Methods: Thirty children aged 8-13 years diagnosed with asthma were enrolled in the study as well as 13 healthy children. One group received only pharmacological treatment and the other group was also enrolled in an exercise programme. Venous blood and 24-hour urine samples were obtained from the children enrolled in the study at the beginning and end of the study. Leukotriene E4 and creatinine levels were measured in the urine and matrix metallopeptidase (MMP-9), endothelin-1 (ET-1), malnodialdehyde (MDA), IgE and specific IgE levels were measured in blood samples. Results: Leukotriene E4, MDA and MMP9 levels decreased significantly with treatment in both groups (p<0.001). However, ET-1 levels decreased significant only in the exercise group (26.5 +/- 3.6 vs 21.3 +/- 2.4 pg/ml respectively, p=0.001). Moreover, ET-1 levels were found to be significantly lower in the exercise group compared to the only pharmacotherapy group (24.2 +/- 3.1 vs 21.3 +/- 2.4 pg/ml, p=0.007). Conclusions: Positive influences of exercise training in children with asthma may be mediated by decrease in ET-1 levels. (C) 2010 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.
Effects of angiotensin-converting enzyme inhibition and statin treatment on inflammatory markers and endothelial functions in patients with longterm rheumatoid arthritis
Tikiz, C; Utuk, O; Pirildar, T; Bayturan, O; Bayindir, P; Taneli, F; Tikiz, H; Tuzun, C
Objective. To investigate the effects of angiotensin-converting enzyme (ACE) inhibitors and statins (hydroxy-methyl-glutaryl-CoA reductase inhibitors) on inflammatory markers and endothelial functions in patients with rheumatoid arthritis (RA). Methods. A total of 45 patients with longterm RA were randomized into 3 groups to receive 8 weeks of treatment with placebo (n = 15), simvastatin (20 mg/day, n = 15), or quinapril (10 mg/day, n = 15) as an adjunct to existing antirheumatic drug treatment. Factors with a role in the development of endothelial dysfunction, such as C-reactive protein (CRP), fibrinogen, nitric oxide (NO), and serum cytokine concentrations including interleukin 1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) were measured at baseline and in the posttreatment period. Brachial artery vasodilator responses were assessed by high resolution ultrasound to evaluate endothelial functions. Results. Simvastatin treatment significantly decreased serum CRP and TNF-alpha [from 14 6 to 7 3 mg/l (p = 0.025) and 30 +/- 5 to 16 +/- 4 pg/ml (p = 0.012), respectively], while quinapril had no significant changes in these 2 measures. IL-1 beta and IL-6 showed insignificant changes in patients in the 2 drug groups. Endothelium-dependent vasodilatation was improved significantly in the simvastatin group [from 5.3 +/- 1.1% to 8.9 +/- 1.4% (p = 0.025)], while there was no difference in endothelium-independent vasodilatation [9.0 +/- 1.8% to 11.2 +/- 2.5% (p = 0.17)]. The quinapril group showed no significant changes in both types of vasodilation although there was a tendency to an increase in endothelium-dependent vasodilatation [from 6.1 +/- 0.8% to 7.8 +/- 0.7% (p = 0.06)]. Treatment with the 2 drugs had no significant effects on resting arterial diameter. Conclusion. We show that simvastatin 20 mg daily improves endothelial function in patients with RA. Its beneficial effect may be attributed to lowering CRP and TNF-a concentrations. ACE inhibition with daily 10 mg quinapril was found to have no significant effects on inflammatory markers and endothelial vasodilator response.
Low-Level Laser Therapy is More Effective Than Pulse Ultrasound Treatment on Wound Healing: Comperative Experimental Study
Tikiz, C; Angin, A; Demireli, P; Taneli, F; Özyurt, B; Tüzün, Ç
Objective: To investigate and compare the effects of pulse ultrasound (US) and low-level laser therapy (LLLT) on wound healing. Material and Methods: Thirty-two rats were included in the study and two full-thickness skin wounds were made on dorsum area of the rats bilaterally, with a 17 mm hole-punch. The animals were divided into two groups. Pulsed US (with a power of 0.1 W/cm(2), a frequency of 1 MHz, 5 minutes daily) was applied to to the right sided wounds of Group A (n=16) and Ga-As laser (830 nm wavelength, 0.5 J/cm(2) dosage of 1 MHz frequency for 1 minute duration) was applied to right sided wounds of Group B (n=16). Left sided wound were considered as controls and same procedures were applied without any current (sham). Biochemical and histopathological evaluations were performed in each group on 7(th) and 15(th) days. Results: Inflammatory cells tended to decrease in both treatment groups on the 7(th) day, however, this finding did not reach a statistical significance (p>0.05). Fibroblasts and collagen were found to be significantly increased in the laser group when compared to the other group on the 7(th) day (p<0.05). Angiogenesis was found to be significantly increased only in the laser group when compared to the other group on the 15(th) day (p<0.05). There were no significant differences in tissue nitric oxide values between the groups although the values in the laser group tended to be higher on the 15th day (p=0.058) Conclusion: In this comparative study. LLLT was found to significantly accelerate mainly proliferative phase while pulse US had no effect on wound healing. Our results support the consideration that LLLT may constitute a beneficial treatment modality for wound healing.
Multifocal Osteonecrosis in Spinal Cord Injury
Tikiz, C; Özbek, IC; Onag, E

Browsing by Author "Tikiz, C"

Results Per Page

Sort Options