Browsing by Author "Tuna, M"

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    ASSESMENT OF DAYLIGHTING PERFORMANCES OF CLASSROOMS: A CASE STUDY IN KIRKLARELI UNIVERSITY, TURKEY
    Yüksek, I; Görgülü, S; Kocabey, S; Tuna, M; Dursun, B
    This study was conducted to evaluate the daylighting performances of classrooms. For this study, a classroom in Kayali Campus and two classrooms in Kavakli Campus of Kirklareli University have been selected. In these buildings, the illuminance levels have been measured and standards and design rules have been investigated. Modelling in the Velux Daylight Visualiar simulation program, the classrooms have been evaluated in terms of daylighting parameters. Consequently, window properties that can provide better natural lighting in the classroom have been identified. According to the measurements and the results of the simulation, daylight illuminance levels in these environments has been found to vary by directions. The buildings' orientation, the window openings on the facade of buildings and the shading elements should be designed at the point of the natural lighting idea by expert designers in the field.
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    Cutaneous findings in patients with acromegaly and its relationship with concomitant endocrinopathies
    An, IS; Kahraman, FC; Bilgic, A; Aktürk, AS; Albayrak, H; Kartal, D; Cinar, SL; Solak, SS; Uslu, M; Sanli, HE; Yildizhan, IK; Sahin, MT; Zindanci, I; Savas, S; Ayhan, E; Cinel, M; Atas, ENS; Aydemir, M; Selek, A; Elbueken, G; Zuhur, SS; Karaca, Z; Bülbül, BY; Ünübol, M; Demir, O; Hekimsoy, Z; Tuna, M; Asilsoy, M; Çetin, S
    ObjectivesSkin changes in acromegaly are often the first sign of the disease. The aim of this study was to describe the cutaneous findings in patients with acromegaly. In addition, a secondary aim was to investigate the possible association of these findings with remission status and concomitant endocrinopathies.Design, Patients, and MeasurementsIn this prospective multicenter study, 278 patients over the age of 18 years with acromegaly who were followed up in 14 different tertiary healthcare institutions were included. These patients, who were followed up by the Endocrinology Department, were then referred to a dermatologist for dermatological examination. The frequency of skin lesions was investigated by detailed dermatologic examination. Dermatological diagnosis is reached by clinical, dermatological and/or dermoscopic examination, and rarely skin punch biopsy examinations in suspicious cases. The possible association of the skin findings between remitted and nonremitted patients and with concomitant endocrinopathies were evaluated.ResultsThe most common skin findings in patients with acromegaly in our study were skin tags (52.5%), cherry angiomas (47.4%), seborrhoea (37%), varicose veins (33%), acneiform lesions (28.8%), hyperhidrosis (26.9%) and hypertrichosis (18.3%). Hypertrichosis was significantly more prevalent in patients nonremitted (p: .001), while xerosis cutis was significantly more prevalent in patients remitted (p: .001). The frequency of diabetes mellitus and hypothyroidism was significantly higher in patients with varicose veins and seborrhoeic keratosis than those without. Additionally, the coexistence of hypothyroidism, hyperthyroidism and galactorrhea was significantly higher in patients with Cherry angioma than in those without Cherry angioma (p-values: .024, .034 and .027, respectively). The frequency of hypogonadism in those with xerosis cutis was significantly higher than in those without (p: .035).ConclusionsCutaneous androgenization findings such as skin tag, seborrhoea, acne and acanthosis nigricans are common in patients with acromegaly. Clinicians should be aware that skin findings associated with insulin resistance may develop in these patients. It can be said that the remission state in acromegaly has no curative effect on cutaneous findings. Only patients in remission were less likely to have hypertrichosis. This may allow earlier review of the follow-up and treatment of acromegaly patients presenting with complaints of hypertrichosis. Additionally, it can be said that patients with skin findings such as cherry angioma may be predisposed to a second endocrinopathy, especially hypothyroidism. Including dermatology in a multidisciplinary perspective in acromegaly patient management would be beneficial to detect cutaneous findings earlier.
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    The genus Crocus, series Crocus (Iridaceae) in Turkey and 2 East Aegean islands: a genetic approach
    Erol, O; Kaya, HB; Sik, L; Tuna, M; Can, L; Tanyolaç, MB
    In this study, a total of 26 Crocus specimens from different locations across Turkey and 2 East Aegean islands (Chios and Samos) were analyzed using 12 amplified fragment length polymorphism (AFLP) primer combinations to obtain information on genetic diversity, population structure, and genetic relationships. A total of 369 polymorphic AFLP bands were generated and scored as binary data. Genetic similarities were determined. Cluster analysis revealed 4 major groups among the 26 genotypes examined in this study. The nuclear DNA contents (2C) of the 26 Crocus specimens were found to range from 5.08 pg in C. asumaniae to 9.75 pg in C. sativus. Polymorphic information content (PIC) values were used to examine the capacity of the various primer pairs to amplify polymorphisms in the Crocus specimens. The PIC values ranged from 0.218 (M-CAA/E-AGC) to 0.512 (M-CAT/E-AAG) and showed an average of 0.34. In sum, we herein used AFLP analysis to identify a high level of polymorphism among Crocus specimens collected from various locations in Turkey and Greece, and our structural analysis yielded 2 reconstructed populations. These findings provide new insight into the relationships among different Crocus genotypes and show that AFLP analysis can be useful for Crocus diversity studies.