Browsing by Author "Tunca S."

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    Destiny of airway disease: interplay between epithelial barrier and the innate immune system
    (Taylor and Francis Ltd., 2022) Yüksel H.; Tunca S.
    When the organism encounters a foreign substance, it responds with mutual and regular interactions at different stages of the immune system. In airway diseases, the first encounter is at the epithelial level, where innate immune cells and their responses form the first leg of the protective mechanism. The most important barrier for environmental damage is the epithelial barrier. However, the epithelial barrier is not just a mechanical barrier. The formation of the microbiome on the epithelium and the tolerance or intolerance to environmental factors are vital. This vital balance is maintained between the epithelial surface and the subepithelial innate immune system. This is achieved by the epithelial line, which is a mechanical and functional barrier between them. In this respect, epithelial barrier function preservation has an important role in the development and prognosis of airway disease. © 2021 Taylor & Francis Group, LLC.
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    Angioedema Related to Infectious Mononucleosis
    (Galenos Publishing House, 2022) Dağlı D.L.; Yüksel H.; Tunca S.; Yılmaz Ö.
    Epstein-Barr virus (EBV), a member of the Herpes-viridae family, is a microorganism could be present in various clinical presentations, from upper respiratory tract infection findings to asymptomatic liver function test elevation, from facial paralysis to angioedema. This case report has been prepared to emphasize EBV infection as a rare factor in the etiology of angioedema. © 2022 by the Aydın Pediatric Society / Trends in Pediatrics published by Galenos Publishing House.
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    Inflammatory markers in exhaled breath condensate in nonasthmatic children with food allergy
    (Institute of Physics, 2024) Yilmaz O.; Tunca S.; Yasar A.; Ocalan M.; Taneli F.; Yuksel H.
    Allergy is a systemic inflammation; therefore, although the allergic symptom may be seen in a specific organ system, the effects of this inflammation may be seen in other organs. interleukin (IL) IL4, IL5 and IL13 are the major Th2 cytokines and e-cadherin is an epithelial barrier protein. The objective of this research was to assess indicators of inflammation specific to Th2 responses and proteins related to the protective barrier of the airway’s inner lining. These assessments were conducted using exhaled breath condensate (EBC), which provides insights into peripheral airway conditions of children suffering from food allergies. The study had 24 patients with food allergy and 24 control individuals younger than three years of age with no history of food reaction. The diagnosis of food allergy was based on food allergen-specific IgE and skin prick test positivity in our clinic and oral food testing in selected cases. EBC samples were obtained by Ecoscreen (Jaegar, Hoechberg, Germany). IL4, IL5, IL13 and E-cadherin levels were measured in these samples by enzyme linked immunoassay. The group of children with food allergies, consisting mainly of 14 girls, had a median age of 16 months, whereas the control group, which included 11 girls, had a median age of 15 months (p = 0.89). Comparing the two groups, children with food allergies exhibited notably lower levels of IL-13 in the EBC compared to the control group (median values of 59.14 and 76.36, respectively, p = 0.02). Conversely, the concentration of IL-4 in the EBC was significantly higher in children with food allergies (median values of 1.94 and 1.29, respectively, p = 0.003). However, the levels of IL-5 and e-cadherin showed no significant differences between the two groups (with p-values of 0.74 and 0.09, respectively) as shown in table 1. High level of IL-4 despite the low level of IL-13 in the EBC of children having food allergy may be indicative of an early inflammatory phase that is not yet in the effector phase. Studies about the evolution of this process later in life are needed to assess the role of airway inflammation in children with food allergy who develop asthma. © 2023 IOP Publishing Ltd.