Browsing by Author "Tuncel E.T."

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    Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer
    (AVES, 2023) Tuncel E.T.; Parvizi M.; Kut E.; Aydın M.; Kasap E.
    Background: We aimed to investigate the effect of hemoglobin/prognostic nutritional index and hemoglobin/red blood cell distribution, which are indicators of inflammation and nutrition, on prognosis and survival in patients with rectal cancer. Methods: The retrospective study reviewed medical records of 138 patients with rectal cancer who were followed up between 2010 and 2021. The effects of hemoglobin/red blood cell distribution, hemoglobin/prognostic nutritional index, tumor stage, and lymph node status on survival and prognosis were evaluated using univariate and multivariate analyses. Overall survival and disease-free survival were calculated for both groups. Results: Survival and prognosis were found to be significantly better in nonanemic patients with the hemoglobin/prognostic nutritional index higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/prognostic nutritional index. Similarly, survival and prognosis were found to be significantly better in nonanemic patients with a hemoglobin/red blood cell distribution higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/red blood cell distribution. Conclusion: The results indicated that nutrition and inflammatory markers have independent prognostic significance in rectal cancer. These markers are simple, inexpensive, and useful biomarkers commonly used in clinical practice, and they were found to predict overall survival and disease-free survival independently. Copyright © Author(s)
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    Evaluation of irritable bowel syndrome in patients with systemic sclerosis based on Rome IV criteria; [Bewertung des Reizdarmsyndroms bei Patienten mit systemischer Sklerose nach den Rom-IV-Kriterien]
    (Georg Thieme Verlag, 2024) Tuncel E.T.; Sahinoglu I.; Uslu S.
    Objectives The gastrointestinal system is the second most frequently affected organ system in patients with systemic sclerosis (SSc). Patients with SSc experience gastrointestinal dysmotility due to pathophysiological changes, including alterations in intestinal microbiota, inflammation, fibrosis, vascular ischaemia, and muscle atrophy. The aim of this study was to determine the prevalence of functional gastrointestinal disorders in patients with SSc. Material and Methods This study included 66 patients with SSc. Demographic data, including age, gender, and clinical findings, were recorded. The Rome IV criteria were used to assess gastrointestinal complaints. Results A total of 66 (F = 61, M = 5) patients (limited cutaneous SSc (lcSSc = 31), diffuse cutaneous SSc (dcSSc = 35)) were included in this study. In lcSSs patients, the prevalence of functional dyspepsia, irritable bowel syndrome (IBS), constipation, and diarrhoea was 29.0 %, 12.9 %, 6.5 % and 3.2 %, respectively, whereas in dcSSc, the prevalence of these disorders was 37.1 %, 8.6 %, 8.6 %, and 0.0 %, respectively. There was no statistically significant difference regarding the presence of functional gastrointestinal disorders between lcSSc and dcSSc patients. When patients with SSc were compared based on functional gastrointestinal disorders, no significant differences were observed between the groups in terms of mean age, disease duration, smoking, lung involvement, and presence of body mass index ≥ 25. Conclusion Alterations in gut microbiota and inflammatory changes have been proposed as contributing factors in IBS. Chronic inflammatory diseases, such as SSc, may therefore predispose individuals to its development. In our study, IBS was found in 10.7 % of the SSc patients. To identify patients at high risk of IBS, further studies are required. © 2024. Thieme. All rights reserved.
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    Serum salusin levels in diarrhea- and constipation-predominant irritable bowel syndrome
    (PeerJ Inc., 2025) Tuncel E.T.; Ozcan S.S.; Korkmaz M.; Börekci E.
    Objective: Inflammation and immunity play major roles in the etiopathogenesis of functional intestinal disorders. The salusins that were identified in this study are important because of their ease of collection, sensitivity and reliability. For that reason, the aim of this study was to analyze the importance of the levels of salusin in the blood, an inflammation-related parameter, in the diagnosis and prediction of irritable bowel disease. Methodology: The study participants included 28 diagnosed with constipation-predominant IBS, 29 (34.1%) diagnosed with diarrhea-predominant IBS (D-IBS), and 28 (32.9%) controls. Enzyme-linked immune-sorbent assay (ELISA) method has been used for the measurement of salusin levels. Results: Participants were 50 (58.8%) female and 35 (41.2%) male. The serum levels of salusin-a were substantially reduced in the diarrhea-predominant IBS group vs controls. There was also no major difference in the levels of salusin between the constipation-predominant-IBS and the diarrhea-predominant IBS group. Conclusion: A major prognostic relationship was found between the level of salusins and the subgroup of D-IBS. It is well known that salusins have been related to inflammatory processes and oxidative injury in previous studies. The relationship between salusin and gastrointestinal diseases should be further investigated. Low-grade submucosal intestinal inflammation is also associated with irritable bowel syndrome. It is our belief that salusins may be useful in diagnosing, predicting or treating IBS. Copyright 2025 Tuncel et al.