Browsing by Author "Tuncgovde E.B."

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    Development an optical sensor using lyotropic cholesteric liquid crystals for the detection of toxic gases
    (Elsevier GmbH, 2021) Kemiklioglu E.; Gurboga B.; Tuncgovde E.B.
    In the current study, a lyotropic cholesteric liquid crystal (ChLC) based sensor for the identification of vapors of polar (toluene and phenol) and apolar (1,2 dicholoropropane) toxic gases was investigated. The lyotropic ChLC sample including cholesteryl oleyl carbonate, cholesteryl pelargonate, and cholesteryl benzoate was supported on the chemically modified glass surfaces as an optical sensor for the detecting of these toxic gases vapors. The glass surfaces were modified by coating Dimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride (DMOAP). The optical signal generated by the incorporation of different toxic gases vapors in the lyotropic ChLC layers which disturbs the pitch length. These toxic gases were evaporated at different temperatures and the exposure time was differentiated. Increasing solvent evaporation temperature lead a shift in the wavelength maximum to smaller wavelengths which can be observed by a naked eye. © 2021 Elsevier GmbH
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    Development of liquid crystal biosensor for the detection of amyloid beta-42 levels associated with Alzheimer's disease
    (Elsevier B.V., 2021) Kemiklioglu E.; Tuncgovde E.B.; Ozsarlak-Sozer G.
    This study represents the development of a biosensor which is based on the liquid crystal (LC) orientation as a function of the peptide concentration to detect an amyloid-beta-42 (Aβ42) antibody–antigen binding events. The Aβ42 peptide binds to the Aβ42 antibody forming an immunocomplex which is immobilized on the Dimethyloctadecyl[3-(trimethoxysilyl)propyl] ammonium chloride (DMOAP) coated surface. The disturbed orientation of LCs as a result of the binding of the formed immunocomplex was observed using the polarized optical microscope (POM) as a function of decreasing Aβ42 peptide concentration from 1000 to 1 pg/ml. The concentration, as low as 1 pg/ml of Aβ42 peptide was able to be successfully detected in our system. Apolipoprotein E4 (ApoE4), that specifically bound to the Aβ42 peptide, was added into the system and a remarkable change in reflection spectra of samples was observed with increasing Aβ42 peptide concentration. The concentration of ApoE4 protein was detected in the range of 0.1–30 nM by this system due to the interaction between the two proteins. © 2021 The Society for Biotechnology, Japan
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    Liquid crystal-based elastomers in tissue engineering
    (John Wiley and Sons Inc, 2022) Gurboga B.; Tuncgovde E.B.; Kemiklioglu E.
    Liquid crystal elastomers (LCEs) play role in tissue engineering investigations, with the combination of orientational ordering generated by liquid crystal (LC) moieties and the elastic capabilities of polymers. Liquid crystal-based polymer materials require a thorough understanding of their features that set them apart from other smart materials for proper design and application. LCEs offer many advantages for their widespread use in the field of biomaterials, by virtue of their simplicity of processing, anisotropic behavior, and responding to numerous external stimuli. Especially, LCEs have widespread usage in bioengineering applications such as scaffolds due to their biocompatibility, viability, and proliferation properties of these materials. This study introduces a brief overview of the new areas of liquid crystal-based elastomer applications combining both biomaterials and engineering. © 2022 Wiley Periodicals LLC.