MCBÜ Açıkerişim Sistemi :: Browsing by Author "Ulman C."

Browsing by Author "Ulman C."

Now showing 1 - 20 of 46

Recreational and master athletic activity does not affect free and total prostate-specific antigen levels but lowers the free-to-total prostate-specific antigen ratio
(Cambridge Medical Publications, 2004) Ulman C.; Buyukyazi G.; Taneli F.; Uyanik B.S.
Prostate-specific antigen (PSA) and the ratio of free-to-total PSA are widely used tumour markers, but the effect of exercise on these parameters is unclear. We aimed to determine whether long-term physical training was associated with changes in serum PSA by comparing PSA concentrations in middle-aged master athletes (n = 12), recreational athletes (n = 12) and sedentary controls (n = 12). Serum total PSA and free PSA concentrations were assessed using an electrochemiluminescence immunoassay; there were no significant differences among the groups. The free-to-total PSA ratio was significantly lower statistically in master athletes compared with recreational athletes, but this is not clinically significant as both values (0.22 versus 0.31, respectively) were within the normal range. These results indicate that the free-to-total PSA ratio may be affected by long-term athletic training, and could be important when evaluating athletes with prostate-related disorders.
Biochemical analysis of urethral collagen content after tubularized incised plate urethroplasty: An experimental study in rabbits
(Springer Verlag, 2004) Taneli F.; Ulman C.; Genc A.; Yilmaz O.; Taneli C.
The aim of the present study was the biochemical analysis of tissue hydroxyproline levels in incised urethral plates in order to show the total collagen content after the Snodgrass operation in the hypospadiac rabbit model. The study comprised 21 male New Zealand rabbits, (2.2-2.4 kg). The animals were randomly allocated to three groups each containing seven rabbits as follows: group 1, the ventral urethra was completely excised and a model of hypospadias formed. A full-thickness incision was made on the distal dorsal urethra, a feeding tube was placed as an urethral catheter and both urethral wings were sutured ventrally. Group 2, inserting an iris knife into the urethra, the ventral wall was incised mimicking an urethrotome. Group 3 consisted of normal control rabbits to determine the basal tissue hydroxyproline level. A slight increase in the hydroxyproline level was observed in the ventral part of the urethral tissue compared to the dorsal part in both groups 1 and 2; however, these differences were not significant. After the Snodgrass operation in the rabbit model, no significant differences were observed in the hydroxyproline levels of the dorsal and ventral parts of the urethra or between these and of the controls. Further studies are required in order to determine the mechanism underlying urethral healing through normal re-epithelization without excess collagen deposition after incised urethral plate urethroplasty.
The relationship of pregnancy complications and AFP, HCG and estriol level detected in maternal serum; [Maternal kanda AFP, HCG ve ankonjuge östriol düzeylerinin gebelik komplikasyonlari i̇le i̇lişkisi]
(2004) Bülbül Baytur Y.; Ulman C.; Laçin S.; Özçakir H.T.; Taneli F.; Çelik T.; Uyar Y.
OBJECTIVE: The aim of the study was to determine the relationship of intrauterine death, prematurity, intrauterine growth retardation, surmaturation and preeclampsia with high and low AFP. high HCG and low estriol levels detected in maternal serum. STUDY DESING: 1020 patients who had undergone tripple test during pregnancy for intrauterine death, prematurity, surmaturation, intrauterine growth retardation and preeclampsia rates between 1999-2003 at Celal Bayar University Hospital were determined. The patients with high AFP levels (>2 MoM), high HCG levels (>2 MoM), low AFP levels (<0.5 MoM) and low estriol levels (<0.5 MoM) were compared to those with normal levels. The relationship of pregnancy complications and our findings examined. Statistical analysis were done with student t test and Chi square test by using SPSS for Windows version 10.0. RESULTS: Among 428 patients of whose files were useful for inclusion criteria, 30 of 31 patients of whom tripple test results were over the critical limit; 1/270 had undergone amniosynthesis. 4 of those 30 had Down syndrome. No other Down syndrome detected in other 26 patients who had a risky tripple test result neither with amniosynthesis nor in delivery. There were 14 patients with high AFP (>2 MoM). 55 patients with high HCG (>2 MoM), 13 patients with low AFP (<0.5 MoM) and 8 patients with low estriol levels (<0.5 MoM) among the patients those included to the study group. Those patients compared to the others with normal findings which consisted of 317 pregnants. There was statistically significant difference between low estriol levels and prematurity (p<0.05), however, there was no difference between high or low AFP levels and pregnancy complications. High HCG was significantly related with preeclampsia (p<0.05). CONCLUSION: Preeclampsia develoment with high HCG levels and the relation between low estriol and prematurity indicate that the patients with abnormal findings of tripple test are under the risk of obstetric complications. These patients should be consulted carefully for obstetric complications in addition to detection of cromozomal abnormality and malformation.
The effect of spermatic vessel ligation on testicular nitric oxide levels and germ cell-specific apoptosis in rat testis
(Elsevier GmbH, 2005) Taneli F.; Vatansever S.; Ulman C.; Yilmaz O.; Giray G.; Genç A.; Taneli C.
Management of high testis may vary but the most popular method in surgical treatment is the Fowler-Stephens maneuver. The aim of the present study was to investigate the effects of spermatic vessel ligation on testicular nitric oxide (NO) levels, expression of inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) and germ cell-specific apoptosis in both ipsilateral and contralateral testes in rats. Twenty-eight animals were randomly allocated into four groups (n=7 each). The spermatic vessels were ligated as a simulation of the Fowler-Stephens maneuver. The groups of animals were sacrificed at 2 h (group 1), 4 h (group 2) and 24 h (group 3) after ligation, respectively. Sham-operated animals served as controls (group 4). Biochemical assessment of testicular NO levels was performed by the Griess method. iNOS and eNOS expression and apoptosis were studied in ipsilateral and contralateral testes. Testicular NO levels at 24 h after the simulated Fowler-Stephens maneuver were found to be significantly increased in both ipsilateral and contralateral testes when compared with the sham-operated group. eNOS expression was clearly increased in ipsilateral testes, whereas moderate expression was detected in the contralateral seminiferous tubules at 24 h after ligation. Mild focal iNOS immunostaining was also observed in seminiferous tubules of the ipsilateral testis at 24 h after the simulated Fowler-Stephens maneuver. Apoptosis was dramatically increased in ipsilateral testes; however, it was only detected in single cells in the contralateral side at 24 h after ligation. In conclusion, the simulated Fowler-Stephens maneuver induces testicular nitric oxide synthesis and germ cell-specific apoptosis in the ipsilateral testis. These results suggest that high levels of NO induce apoptosis and may impair spermatogenesis thus explaining the unsuccessful outcome of the Fowler-Stephens maneuver. © 2004 Elsevier GmbH. All rights reserved.
The long-term effect of mesh bioprosthesis in inguinal hernia repair on testicular nitric oxide metabolism and apoptosis in rat testis
(2005) Taneli F.; Aydede H.; Vatansever S.; Ulman C.; Ari Z.; Uyanik B.S.
Polypropylene mesh is the most widely used material in inguinal hernia repair. Although polypropylene mesh is known as an inert material, it is experimentally proven that mesh generates a chronic inflammatory tissue reaction. The aim of the present study was to investigate the long-term effects of polypropylene mesh material used in inguinal hernia operations on testicular function, testicular nitric oxide (NO) metabolism and germ cell-specific apoptosis in rats. The study comprised 40 male rats that were randomly allocated into two groups. In group 1, the left spermatic cord was elevated and a 0.5 × 1 cm polypropylene mesh was placed behind the left inguinal spermatic cord and group 2 consisted of the sham-operated controls. Blood samples were taken at 6 months preoperatively and postoperatively after to assess luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels for hormonal evaluation. Testicular NO was evaluated by the Griess method, apoptosis by a TUNEL method and inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) expressions by immunohistochemical staining. Mild (+) eNOS expression was observed in all specimens. Mild (+) iNOS expression was only detected in ipsilateral testis of the mesh-implanted study group. Apoptotic cells were not detected in any samples. We are of the opinion that long-term polypropylene mesh implantation has no effect on testicular hormonal function and only a limited effect on nitric oxide levels and this effect is not sufficient to cause apoptosis in testis that could lead to infertility. It seems that mesh implantation is a reliable method in inguinal hernia repair; however, further work is required by more sensitive methods to fully elucidate the potential testicular damage. Copyright © 2004 John Wiley & Sons, Ltd.
Pre-ischemic administration of nitric oxide synthase inhibitors reduced germ cell apoptosis after spermatic vessel ligation in the rat testis
(2005) Taneli F.; Vatansever S.; Ulman C.; Giray G.; Genc A.; Taneli C.
Introduction: The Fowler-Stephens maneuver, a mode of spermatic vessel ligation, is a method of choice in the management of high testes. The aim of the present study is to investigate the effects of pre-ischemic administration of NG-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase (NOS) inhibitor, in preventing testicular ischemic damage and germ cell-specific apoptosis in rats. Materials and Methods: 30 min before ligation of the spermatic vessels, L-NAME was administered intraperitoneally to a group of rats and saline was given to another group of rats (controls). Biochemical assessments of NO and germ cell-specific apoptosis were performed. Results: Testicular NO levels in the L-NAME group showed significant decreases in the ipsilateral (p = 0.004) and contralateral (p = 0.015) testes in relation to those of the control group. The apoptotic indices were found in 2.3% of the L-NAME group and 3.1% of the control group. Conclusion: Pre-ischemic administrations of the NOS inhibitor, L-NAME, effectively decreased NO production and to some degree caused a reduction in germ cell apoptosis in the rat testes after spermatic vessel ligation. Further studies are mandatory to confirm our preliminary results and to address the potential introduction of NOS inhibitors into clinical practice. Copyright © 2005 S. Karger AG.
Subcutaneous administration of live lactobacillus prevents sepsis-induced lung organ failure in rats
(2005) Ilkgul O.; Aydede H.; Erhan Y.; Surucuoglu S.; Gazi H.; Vatansever S.; Taneli F.; Ulman C.; Kose C.; Bengmark S.
The leading cause of death in intensive care units around the world is the syndrome of exaggerated and prolonged systemic inflammation response (SIRS), which if not controlled will lead to irreversible, often multiple, organ dysfunction and organ failure syndrome (MODS). Host phagocytic cells, predominantly macrophages and neutrophils, and their soluble products, play a central role. Accumulation of neutrophils is often observed, especially in the lungs, intestines, liver and kidneys. Neutrophilic infiltration of distant organs, and especially of the lungs, has been a characteristic finding of patients dying from sepsis. However, the mechanisms responsible for the exuberant inflammation and neutrophil infiltration are not yet fully understood. It has recently been demonstrated that this, at least in part, is due to an inhibition of neutrophil apoptosis, and there is a suggested association with activation of nuclear factor - κB (NF-κB), reduced activity of caspases-9 and -3 and maintenance of mitochondrial transmembrane potential.
Zinc-deficient sprouting blight potatoes and their possible relation with neural tube defects
(2005) Ulman C.; Taneli F.; Oksel F.; Hakerlerler H.
Maternal nutritional zinc deficiency is blamed in the pathogenesis of neural tube defects. In animal and plant domains zinc is required for growth and development. The objective of the present study was to show that sprouting blighted potato tuber is zinc deficient. In five potato varieties, zinc was measured by atomic absorption spectrophotometry in wet-ashed paired slices of edible potato tuber and in its peel, in blighted potato tuber and in its sprout. Zinc contents were measured as the mean (± SEM) and the following values were found, 0.388 ± 0.036, 0.623 ± 0.059, 0.550 ± 0.030 and 1.089 ± 0.181 mg per 100 g wet weight, respectively. In conclusion, we believe that long-term consumption of zinc-depleted, blight potato tuber by pregnant woman could be potentially teratogenic with the consequent birth of a baby with neural tube defects. Copyright © 2004 John Wiley & Sons, Ltd.
Increased serum leptin concentrations in patients with chronic stable angina pectoris and ST-elevated myocardial infarction
(2006) Taneli F.; Yegane S.; Ulman C.; Tikiz H.; Bilge A.R.; Ari Z.; Uyanik B.S.
Leptin is an adipocytokine that is produced mainly by adipose tissue; it is also identified in atherosclerotic lesions in human coronary atherosclerosis. However, the relation of serum leptin concentrations to ischemic heart disease (IHD) is still obscure. The aims of the present study were to investigate serum leptin concentrations in patients with ST-elevated myocardial infarction (STEMI) and with chronic stable angina pectoris (CSAP) and to evaluate the possible correlations of leptin to other atherosclerotic risk factors; including serum high sensitive C-reactive protein (Hs-CRP), serum homocysteine, and fibrinogen concentrations. For this purpose, 35 patients with CSAP, 40 with acute STEMI, and 30 control subjects with normal findings from coronary angiography were taken into the study prospectively. Serum leptin concentrations were significantly higher in patients with CSAP and STEMI compared to the control group (7.74 ± 1.34 vs 6.37 ± 1.85 ng/mL, p = 0.021 and 8.22 ± 3.13 vs 6.37 ± 1.85 ng/mL, p = 0.023, respectively). In addition, serum homocysteine concentrations were significantly increased in patients with CSAP (15.23 ± 5.96 vs 11.40 ± 2.11 μmol/L, p = 0.025) and patients with STEMI (15.90 ±5.02 vs 11.40 ±2.11 μmol/L, p = 0.012) compared to the control group. Serum fibrinogen concentrations were significantly increased only in the CSAP group as compared to controls (4.15 ± 1.39 vs 3.45 ± 1.19 g/L, p = 0.025). No significant correlation was found between leptin levels and selected risk factors. In conclusion, serum leptin concentrations were significantly higher in both the CSAP and STEMI groups. However, owing to the lack of correlation between the leptin levels and selected classical coronary risk factors, it may be considered that leptin can be evaluated as one of the independent risk factors for IHD. Further randomized and controlled studies will be required to determine the pathophysiological meaning of the increased leptin levels and the central role between adipocyte function and atherosclerosis. ©2006 Westminster Publications, Inc.
Pretreatment with pro- and synbiotics reduces peritonitis-induced acute lung injury in rats
(Lippincott Williams and Wilkins, 2007) Tok D.; Ilkgul O.; Bengmark S.; Aydede H.; Erhan Y.; Taneli F.; Ulman C.; Vatansever S.; Kose C.; Ok G.
BACKGROUND: To study whether enteral pretreatment with a synbiotic composition of lactic acid bacteria and bioactive fibers can reduce peritonitis-induced lung neutrophil infiltration and tissue injury in rats. MATERIALS AND METHODS: Rats were divided into five groups, and subjected to induction of peritonitis-induced lung injury using a cecal ligation and puncture model (CLP). All animals were pretreated for 3 weeks prior the CLP by daily gavage with either (1) a synbiotic composition (10 CFU of Pediococcus pentosaceus 5-33:3, 10 CFU of Leuconostoc mesenteroides 77:1, 10 CFU of L. paracasei subspecies paracasei, 10 CFU of L. plantarum 2362 plus fermentable fibers), (2) fermentable fibers alone, (3) nonfermentable fibers, (4) a probiotic composition (10 CFU of P. pentosaceus 5-33:3, 10 CFU of L. mesenteroides 77:1, 10 CFU of L. paracasei subsp. paracasei, 10 CFU of L. plantarum 2,362), or (5) a heat-killed probiotic composition. All animals were killed 24 hours after CLP and lung tissue samples were studied for degree of neutrophil infiltration and levels of tumor necrosis factor (TNF)-α, Interleukin (IL)-1β. In addition the lung wet-to-dry tissue weight ratio, the myeloperoxidase activity, and malondialdehyde content were also assessed. RESULTS: No mortality was encountered in any of the groups. Histologic signs of lung injury (number of neutrophils and TNF-α, IL-1β staining) were observed in all groups except the synbiotic and probiotic treated groups. Myeloperoxidase activity and malondialdehyde content were significantly lower in the two lactobacillus- pretreated groups, with no difference between them. Heavy infiltration of lung tissue with neutrophils was observed only in fiber-treated (302.20 ± 7.92) and placebo-treated (266.90 ± 8.92) animals. This was totally abolished in the synbiotic-treated group (34.40 ± 2.49). Lung edema (wet-to-dry lung weight ratio) was significantly reduced in the synbiotic-treated group (4.92 ± 0.13 vs. 5.07 ± 0.08 and 5.39 ± 0.10, respectively). CONCLUSION: Three weeks of preoperative enteral administration of a synbiotic composition reduced peritonitis-induced acute lung injury in rats in a CLP model. © 2007 Lippincott Williams & Wilkins, Inc.
Serum Her-2/neu and survivin levels and their relationship to histological parameters in early-stage breast cancer
(Cambridge Medical Publications, 2007) Goksel G.; Taneli F.; Uslu R.; Ulman C.; Dinc G.; Coskun T.; Kandiloglu A.R.
This study was conducted to investigate the serum levels of her-2/neu and survivin in patients with early-stage breast cancer and their relationship with known histological parameters. Forty-one patients with early-stage breast cancer were investigated. Serum samples were collected from patients on their first admission before adjuvant chemotherapy, and from healthy controls. Serum her-2/neu and survivin levels were determined using an enzyme-linked immunosorbent assay. There was no difference in the levels of serum her-2/neu and survivin between the breast cancer patients and the control group. Serum her-2/neu concentration showed moderate correlations with disease stage and the Ki-67 level, and the serum survivin level showed a moderate correlation with progesterone receptor concentration. Serum levels of her-2/neu and survivin were not significantly related to age and histological parameters in patients with early-stage breast cancer. However, much research continues on the prognostic value of serum her-2/neu and survivin levels, and important new knowledge may ultimately emerge. Copyright © 2007 Cambridge Medical Publications.
The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia
(2008) Sendur O.F.; Tastaban E.; Turan Y.; Ulman C.
We examined the association between serum trace elements and clinical findings such as number of sensitive tender points, severity of fatigue and functional status in patients with fibromyalgia (FM). Thirty-two patients diagnosed as having FM according to the ACR 1990 criteria and 32 normal healthy controls (NHC) were included in this study. The demographic data, disease duration, number of tender points and accompanying symptoms (fatigue, sleep disorders, headache, paresthesia, irritable bowel syndrome, sicca symptoms, Raynaud's phenomena) of the patients were noted. Visual analog scale (10 cm) was implemented to estimate daily severity of pain and fatigue. Fibromyalgia impact questionnaire was used for functional assessment. Serum selenium (μg/dL) and serum zinc (μg/dL) levels were measured by atomic absorption spectrometer. Serum magnesium (mmol/L) level was measured by the original kits of Abbott Aeroset auto-analyzer. The mean age of patients in FM group and NHC were calculated as 42.9 (SD = 7.7) years and 41.3 (SD = 9.7) years, respectively. Serum levels of zinc (P = 0.001) and magnesium (P = 0.002) were significantly decreased by FM groups, whereas there was no considerable difference with selenium levels of both groups (P > 0.05). Association between serum zinc level and number of tender points (P = 0.008) and that between fatigue and magnesium level (P = 0.003) was found as meaningful. According to the results of this study, it was asserted that serum magnesium and zinc levels may play an important role in the pathophysiology of FM. © 2008 Springer-Verlag.
Do walking programs affect C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappaβ ligand?
(2009) Esen H.; Büyükyazi G.; Ulman C.; Taneli F.; Ari Z.; Gözlükaya F.; Tikiz H.
Aim: To examine the effects of 10-week walking programs on maximal oxygen consumption, body composition, serum lipids, highly-sensitive C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappaβ ligand. Method: Twenty-seven middle-aged men (40-60years) walked for ten weeks, five days per week, 40-52min per day at either moderate or high intensity (∼5.95±0.26km/h and ∼7.64±0.36km/h; 50-55% and 70-75% maximum heart rate reserve, respectively). Non-walking, sedentary men served as controls (n=13). Estimated maximal oxygen consumption, body composition, lipid profile, highly-sensitive C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappaβ ligand were determined before and after the study. Results: After 10 weeks, estimated maximal oxygen consumption improved in both exercise groups (p<.05), favoring high-intensity group (p<.05). Body weight, percent body fat, and body mass index reduced significantly in both exercise groups (p<.05). Walking programs did not cause any significant changes in blood lipids, highly-sensitive Creactive protein, and osteoprotegerin levels; however, soluble receptor activator of nuclear factor-kappaβ ligand levels were found to decrease in high-intensity group (p<.05) and the change observed in both exercise groups was different from the change in control group (p<.05). Conclusion: For protective effects against cardiac risk factors and arterial calcification, high-intensity walking programs are advisable due to the greater improvements in soluble receptor activator of nuclear factor-kappaβ ligand and estimated maximal oxygen consumption. © TurkJBiochem.com.
The Factor v G1691A, Factor v H1299R, prothrombin G20210A polymorphisms in children with family history of premature coronary artery disease
(2009) Çiftdoǧan D.Y.; Coşkun Ş.; Ulman C.; Tkz H.
Atherosclerosis, the major cause of coronary artery disease (CAD), has a very long asymptomatic development phase, which begins in childhood. In this study, we describe the Factor V G1691A, Factor V H1299R and prothrombin G20210A gene polymorphisms in children with a family history of premature CAD. Evidence of these polymorphisms in these children may predict the probability of having atherosclerosis in the future. Our study included a total of 140 children, 72 males and 68 females between the ages of 4.9 and 15.7 years. Among these children, 73 had a parental history of premature CAD and the remaining 67 belonged to our control group. The participants were screened for the mutations Factor V G1691A, Factor V H1299R and prothrombin G20210A by polymerase chain reaction amplified DNA products with specific oligonucleotide probes. Our results suggested that frequencies of the mutated allele of Factor V G1691A and prothrombin G20210A are higher in children with a parental history of premature CAD. In conclusion, Factor V G1691A and prothrombin G20210A polymorphisms which were detected in higher frequencies in children with a parental history of premature CAD may indicate a risk for developing atherosclerosis and might be useful in screening for CAD in children; however, large population-based research is necessary to investigate further genetic risk assessment for CAD. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Relationship between cyclic citrullinated peptide antibodies positivity and HLA-DRB1 shared epitope alleles in patients with rheumatoid arthritis in Turkey; [Türk romatoid artritli hastalarda siklik sitrüline peptit antikor pozitifliǧi ile HLA-DRB1 ortak epitop alelleri arasındaki i̇lişki]
(Aves Yayincilik, 2010) Dayan I.; Tikiz C.; Taneli F.; Ulman C.; Ulutaş G.; Tüzün C.
Objective: The most characteristic genetic risk factors for rheumatoid arthritis (RA), the HLA-DRB1 shared epitope (SE) alleles, encode for a common amino acid sequence in the peptide-presenting part of the HLA class II molecule. These SE alleles have been described recently to be a risk factor for the development of antibodies against citrullinated proteins in RA. The current study was performed to investigate the association between the cyclic citrullinated peptide antibodies (anti-CCP) and HLA-DR1 HLA-DRB1 shared epitope alleles in patients with RA in Turkey. Materials and Methods: Sixty patients with RA who were newly diagnosed or under conventional treatment in our clinic and 60 healthy volunteers as controls were enrolled in the study. In patients with RA anti-CCP levels were investigated with enzyme-linked immunosorbent assay and HLA-DRB1 subtyping and SE was assessed by polymerase chain reaction. Only anti-CCP was measured in healthy volunteers. Results: SE was positive in 50% of the patients with RA. Amongst the SE carriers, 30% of them were carrying double copy of SE. While anti-CCP was positive in 73,3% of patients with RA, this ratio was 0% in healthy volunteers. We determined that the existence of SE increases the positivity of anti-CCP (OR=4,3, 95% [CI], P=0.04), and a significant relationship was found between the anti-CCP positivity and the RF positivity. (OR=5,3, 95% [CI] P<0.05). Conclusion: The results of the present study revealed that Turkish patients with RA carrying SE with HLA-DRB1 genes is significantly related with the production of anti-CCP. The diagnostic sensitivity and specificity of anti-CCP for RA is determined as 73,3% and 100% respectively.
Relationship of insulin resistance in chronic haemodialysis patients with inflammatory indicators, malnutrition, echocardiographic parameters and 24 hour ambulatory blood pressure monitoring
(2010) Kurat S.; Colak H.B.; Toraman A.; Tekçe H.; Ulman C.; Bayturan O.
Objective. The relationship between malnutrition, echocardiographic parameters, 24 h ambulatory blood pressure (ABP) parameters and decreased insulin sensitivity index (ISI-S) in chronic haemodialysis patients was investigated. Material and methods. ISI-S and inflammatory indicators were measured. The nutritional state was assessed by malnutrition score. Echocardiography and 24 h ABP were performed 1 day before the second haemodialysis session of the week. Results. ISI-S was inversely correlated with the night-time mean blood pressure (BP)/day-time mean BP ratio (p 0.021) and malnutrition score (p < 0.01). High-sensitivity C-reactive protein, night-time mean BP/day-time mean BP and vena cava collapse index were independent risk factors affecting ISI-S (p < 0.001; β 0.412, p 0.025; β 0.204, p < 0.001; β 0.465). Conclusions. The decrease in ISI-S along with the hypervolaemia suggests that volume overload is a contributory factor in the pathogenesis of insulin resistance in patients with chronic renal failure. This study indicates that, in addition to the traditional cardiovascular risk factors in these patients, insulin resistance can be regarded as a risk factor, but not an independent one, mainly a reflection of the underlying culprit, hypervolaemia. © 2010 Informa Healthcare.
The effects of different intensity walking programs on serum blood lipids, high-sensitive C-reactive protein, and lipoprotein-associated phospholipase A2 in premenopausal women; [Effets de programmes de marche de différentes intensités sur les lipides sériques, la protéine C réactive ultrasensible et la phospholipase A2 associée à une lipoprotéine chez des femmes pre]
(2010) Buyukyazi G.; Ulman C.; Taneli F.; Esen H.; Gozlukaya F.; Ozcan I.; Tikiz H.
Aim: This study examined the effects of 12 weeks of walking programs on serum lipids, high-sensitive C-reactive protein, and lipoprotein-associated phospholipase A2. Methods: Twenty-six pre-menopausal women (30-49 years) completed 12 weeks of walking programs either at moderate or high intensity (50-55%, 70-75% maximum heart rate reserve, respectively). Estimated maximal oxygen consumption was assessed with a 2-km walking test; body composition, blood lipids, high-sensitive C-reactive protein, and lipoprotein-associated phospholipase A2 were measured before and after the study. Results: Maximal oxygen consumption increased, favoring high-intensity group; body weights, percent body fat (p<0.01) and body mass index (p<0.05) decreased in both exercise groups. There were no significant changes in the measured blood lipids in any of the groups, except for a significant reduction in low-density lipoprotein-cholesterol in high-intensity group (p<0.05). High-sensitive C-reactive protein and lipoprotein-associated phospholipase A2 levels reduced significantly in high-intensity (p<0.01) and moderate-intensity (p<0.05) groups, which were also different from the changes in the control group. Conclusion: Walking programs with different intensity result in favorable changes; however, for protective effects against cardiovascular diseases, high-intensity walking may be advised due to greater reductions in low-density lipoprotein-cholesterol, and high-sensitive C-reactive protein and lipoprotein-associated phospholipase A2. © 2010 Elsevier Masson SAS.
Examining acute changes in some serum biochemical markers of brain tissue damage after free and Greco-Roman style wrestling; [serbest ve grekoromen güreşi takiben beyin doku hasarını gösteren bazı serum biyokimyasal markerlerindeki akut deǧişimin i̇ncelenmesi]
(Turkish Biochemistry Society, 2010) Arslan F.; Büyükyazi G.; Ulman C.; Taneli F.; Gözlükaya F.; Çalkan M.
Purpose: This study aimed to examine the acute changes in some serum biochemical markers due to overloading in one match of Greco-Roman and free style wrestling competitions. Method: In a repeated measures design, serum samples were collected before and 20 minutes after the first matches of the wrestlers during local wrestling competitions; subsequently analyzed for S-100B and heart-type fatty acid-binding protein. Study groups composed of Greco-Roman (n=15) and free style (n=16) wrestling groups of ≥19 year-old, healthy, male wrestlers. All matches were video-recorded for trauma analyses for each player. Results: Study results showed increments of 109% (p=.007) and 145% (p=.001) in serum S-100B; 63% (p=.023) and 198% (p=.002) in heart-type fatty acid-binding protein levels from pre to post match in the free and Greco-Roman style groups, respectively. The comparison of the increases obtained in the measured parameters did not reveal significant differences between the groups. Conclusion: Due to the significant increases in serum markers, there may be a possible additive effect of traumas in causing brain injuries/head traumas in free and Greco-Roman style wrestling. However, different style wrestling did not affect serum markers indicating brain tissue damage differently. © TurkJBiochem.com.
Can urinary gamma glutamyl transferase be used as a bone resorption marker in postmenopausal osteoporosis?; [Üriner gamma glutamil transferaz postmenapozal osteoporozlu olgularda kemik yıkım belirteci olarak kullanılabilir mi?]
(Turkish Biochemistry Society, 2011) Tikiz C.; Ulman C.; Taneli F.; Acar E.Y.; Gümüşer G.; Horasan G.D.
Objectives: To evaluate whether γ-glutamyl transferase can be used as a new novel bone resorption marker in postmenopusal osteoporotic subjects. Design and methods: 156 postmenopausal subjects were divided into three groups according to their lumbar spine T-score measured by dual-energy X-ray absorptiometry as normal, (control group, n=56), osteopenic (n=50) and osteoporotic (n=50). Deoxypyridinoline and γ-glutamyl transferase from urine samples and osteocalcin and bone specific alkaline phosphates from blood samples were assessed. Results: Osteocalcin and bone specific alkaline phosphates levels were increased in osteoporotic group (p<0.05). Although there is a tendency to increase in deoxypyridinoline values in osteoporotic group, this difference did not reach to a statistical significance. No significant differences were observed in urinary γ-glutamyl transferase levels between the three groups (p>0.05). No significant correlation was found between urinary γ-glutamyl transferase and deoxypyridinoline, bone specific alkaline phosphates and osteocalcin (p>0.05). Urinary γ-glutamyl transferase levels showed no significant correlation with neither bone mineral density nor T scores in all subjects (r= 0.058 p= 0.625, r=-0.074 p=0.533 respectively). Conclusions: Our primary findings did not support the suggestion that urinary γ-glutamyl transferase could be used as a potential marker for bone resorption in postmenopusal osteoporotic subjects. © 2011 TurkJBiochem.com.
Acute oxidative stress and antioxidant status responses following an American football match
(2011) Rudarli Nalçakan G.; Nalçakan M.; Var A.; Taneli F.; Ulman C.; Güvenç Y.; Onur E.; Karamizrak O.
Aim. Intense physical activity is known to induce oxidative stress. Though regular physical training enhances the antioxidant defence system, the effects of diminished training periods are unclear. American football is one of the recently popular sports in Türkiye and is defined as a mixed activity. The aim of the research was to examine some markers of oxidative stress and antioxidant status in occasionally competitive American football players following a match, and relations with aerobic power and playing position. Methods. Twenty two male players volunteered for the study. To determine oxidative stress and antioxidant status from blood samples collected before and immediately following a match, plasma malondialdehyde (MDA) and nitric oxide (NO) levels, erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, and total antioxidant status (TAS) were assessed, using spectrophotometric methods. Wilcoxon's signed rank test was used to determine the match effect, and Mann-Whitney U test was used to compare playing position and VO2max effects. Results. Plasma MDA (P<0.001) and NO (P<0.05) levels increased significantly following the match. Antioxidant parameters were unchanged following the match when compared with the resting level, except for a V02max related effect (P<0.05) on TAS. Conclusion. Collected data revealed that an American football match caused excessive production of free radicals and oxidative stress. The training loads players underwent were not high enough to cause positive effects on the antioxidant status. To enhance training-induced antioxidant status adaptation, higher amounts of physical activity may be required.

Browsing by Author "Ulman C."

Results Per Page

Sort Options