Browsing by Author "Ulusoy O."

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    Vitreoretinal interface in asymptomatic fellow eyes of patients with unilateral macular holes; [Tek tarafli idiopatik maküla deliǧi olan olgularin asemptomatik diǧer gözlerinde vitreoretinal arayüzey özellikleri]
    (2013) Seymenoǧlu G.; Ulusoy O.; Başer E.; Kayikçioǧlu Ö.; Kurt E.; Ilker S.S.
    Purpose: To compare the vitreoretinal interface of the asymptomatic fellow eyes of patients with unilateral idiopathic macular holes (MH) with the asymptomatic fellow eyes of patients with idiopathic epiretinal membranes (ERM) and with the healthy eyes. Materials and Methods: Thirty-tree patients with unilateral MH (group 1), 33 patients with unilateral ERM (group 2) and 33 healthy eyes were included in the study. All patients underwent a comprehensive ophthalmologic examination and spectral domain optical cohorence tomography (OCT) was performed on all eyes. The incidence of the features of the vitreoretinal interface and foveal micro-structures in the OCT images were compared among the asymptomatic fellow eyes of patients with unilateral MH, ERM and one of the randomly selected healthy eyes of normal individuals which have any ophthalmic pathology except refractive errors. A complete posterior vitreus detachment (PVD) was considered to be present if the Weiss ring was seen on biomicroscopy or a hiper-reflective band representing a posterior hyaloid membrane over the entire macula was seen on OCT. Results: The incidence of perifoveal PVD was 45.5% in group 1, 21.2% in group 2 and 24.2% in group 3. The OCT scans showed different types of foveal deformations associated with vitreofoveal adhesions in eyes without a total PVD. The incidence of the foveal deformations associated with vitreofoveal adhesions was significantly higher (p<0.039) in the fellow eyes of the unilateral MH group (27%) than that in the other groups (0%). The OCT scans also showed residual foveal deformations in eyes with total PVD. The incidence of residual foveal deformation in eyes with total PVD was similar between MH and ERM groups (33%-27%, p=0,75), but it was significantly higher in the MH (33%) and ERM (27%) groups than that in healthy eyes (19%, p<0.01). Conclusion: The higher incidence of foveal deformations in the asymptomatic fellow eyes of patients with unilateral MH with vitreofoveal adhesions suggests that patients in whom MH may develop have abnormally strong vitreofoveal adhesions sufficient to cause foveal deformation and macular holes.
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    The role of water-soluble meconium subfraction and lipid-soluble meconium subfraction on the superior mesenteric artery vasoconstriction in chick embryos
    (W.B. Saunders, 2017) Şiyve S.; Ulusoy O.; Karakuş O.Z.; Murat N.; Uslu M.E.; Ateş O.; Hakgüder G.; Olguner M.; Akgür F.M.
    Objective Intraamniotic meconium has been responsible for intestinal damage in gastroschisis and meconium-dependent intestinal ischemia has been proposed to induce additional intestinal damage in gastroschisis. This study is aimed to determine the effects of lipid and water-soluble meconium subfractions on the contractility of the superior mesenteric artery (SMA). Materials and methods The study was conducted on 18-day fertilized chick embryos (Gallus Domesticus). Meconium is fractioned into water and lipid-soluble components. Only one SMA tissue was prepared from each embryo and suspended in the organ bath. Isometric contraction responses (ICR) were created in SMA tissues by one hour of incubation in Krebs–Henseleit solution for each group. Groups consisted of control, meconium, water-soluble meconium subfraction and lipid-soluble meconium subfraction. ICR of the SMA specimens were evaluated with a transducer-amplifier system on a computer. The data were expressed (mean ± 1SD) as milliNewton (mN). Results The ICR of the meconium, water-soluble meconium subfraction and lipid-soluble meconium subfraction groups were significantly high when compared to the control group (p < 0.01). The meconium and water-soluble meconium subfraction created more contraction response than the lipid-soluble meconium subfraction (p < 0.01). The ICR of the meconium group was not different from the ICR of the water-soluble meconium subfraction group (p > 0.05). Conclusion Water-soluble meconium subfraction has a profound vasoconstrictor effect on the SMA compared to the lipid-soluble meconium subfraction. © 2016 Elsevier Inc.